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Artificial intelligence(AI)-assisted method had received much attention in the risk field such as disease diagnosis. Different from the classification of disease types, it is a fine-grained task to classify the medical images as benign or malignant. However, most research only focuses on improving the diagnostic accuracy and ignores the evaluation of model reliability, which limits its clinical application. For clinical practice, calibration presents major challenges in the low-data regime extremely for over-parametrized models and inherent noises. In particular, we discovered that modeling data-dependent uncertainty is more conducive to confidence calibrations. Compared with test-time augmentation(TTA), we proposed a modified Bootstrapping loss(BS loss) function with Mixup data augmentation strategy that can better calibrate predictive uncertainty and capture data distribution transformation without additional inference time. Our experiments indicated that BS loss with Mixup(BSM) model can halve the Expected Calibration Error(ECE) compared to standard data augmentation, deep ensemble and MC dropout. The correlation between uncertainty and similarity of in-domain data is up to -0.4428 under the BSM model. Additionally, the BSM model is able to perceive the semantic distance of out-of-domain data, demonstrating high potential in real-world clinical practice.

The medical datasets are usually faced with the problem of scarcity and data imbalance. Moreover, annotating large datasets for semantic segmentation of medical lesions is domain-knowledge and time-consuming. In this paper, we propose a new object-blend method(short in soft-CP) that combines the Copy-Paste augmentation method for semantic segmentation of medical lesions offline, ensuring the correct edge information around the lession to solve the issue above-mentioned. We proved the method's validity with several datasets in different imaging modalities. In our experiments on the KiTS19[2] dataset, Soft-CP outperforms existing medical lesions synthesis approaches. The Soft-CP augementation provides gains of +26.5% DSC in the low data regime(10% of data) and +10.2% DSC in the high data regime(all of data), In offline training data, the ratio of real images to synthetic images is 3:1., Comment: 9 pages, 6 figures, 1 table

The implementation of medical AI has always been a problem. The effect of traditional perceptual AI algorithm in medical image processing needs to be improved. Here we propose a method of knowledge AI, which is a combination of perceptual AI and clinical knowledge and experience. Based on this method, the geometric information mining of medical images can represent the experience and information and evaluate the quality of medical images., Comment: 9 pages,8 figures. arXiv admin note: text overlap with arXiv:2101.02639

With the development of deep learning, the structure of convolution neural network is becoming more and more complex and the performance of object recognition is getting better. However, the classification mechanism of convolution neural networks is still an unsolved core problem. The main problem is that convolution neural networks have too many parameters, which makes it difficult to analyze them. In this paper, we design and train a convolution neural network based on the expression recognition, and explore the classification mechanism of the network. By using the Deconvolution visualization method, the extremum point of the convolution neural network is projected back to the pixel space of the original image, and we qualitatively verify that the trained expression recognition convolution neural network forms a detector for the specific facial action unit. At the same time, we design the distance function to measure the distance between the presence of facial feature unit and the maximal value of the response on the feature map of convolution neural network. The greater the distance, the more sensitive the feature map is to the facial feature unit. By comparing the maximum distance of all facial feature elements in the feature graph, the mapping relationship between facial feature element and convolution neural network feature map is determined. Therefore, we have verified that the convolution neural network has formed a detector for the facial Action unit in the training process to realize the expression recognition., Comment: 12 pages,13 figures.The paper is under consideration at Pattern Recognition Letters

Accurate registration of medical images is vital for doctor's diagnosis and quantitative analysis. In this paper, we propose a new deformable medical image registration method based on average geometric transformations and VoxelMorph CNN architecture. We compute the differential geometric information including Jacobian determinant(JD) and the curl vector(CV) of diffeomorphic registration field and use them as multi-channel of VoxelMorph CNN for second train. In addition, we use the average transformation to construct a standard brain MRI atlas which can be used as fixed image. We verify our method on two datasets including ADNI dataset and MRBrainS18 Challenge dataset, and obtain excellent improvement on MR image registration with average Dice scores and non-negative Jacobian locations compared with MIT's original method. The experimental results show the method can achieve better performance in brain MRI diagnosis., Comment: 9 pages,9 figures

Accurate segmentation of brain tissue in magnetic resonance images (MRI) is a diffcult task due to different types of brain abnormalities. Using information and features from multimodal MRI including T1, T1-weighted inversion recovery (T1-IR) and T2-FLAIR and differential geometric features including the Jacobian determinant(JD) and the curl vector(CV) derived from T1 modality can result in a more accurate analysis of brain images. In this paper, we use the differential geometric information including JD and CV as image characteristics to measure the differences between different MRI images, which represent local size changes and local rotations of the brain image, and we can use them as one CNN channel with other three modalities (T1-weighted, T1-IR and T2-FLAIR) to get more accurate results of brain segmentation. We test this method on two datasets including IBSR dataset and MRBrainS datasets based on the deep voxelwise residual network, namely VoxResNet, and obtain excellent improvement over single modality or three modalities and increases average DSC(Cerebrospinal Fluid (CSF), Gray Matter (GM) and White Matter (WM)) by about 1.5% on the well-known MRBrainS18 dataset and about 2.5% on the IBSR dataset. Moreover, we discuss that one modality combined with its JD or CV information can replace the segmentation effect of three modalities, which can provide medical conveniences for doctor to diagnose because only to extract T1-modality MRI image of patients. Finally, we also compare the segmentation performance of our method in two networks, VoxResNet and U-Net network. The results show VoxResNet has a better performance than U-Net network with our method in brain MRI segmentation. We believe the proposed method can advance the performance in brain segmentation and clinical diagnosis., Comment: 18 pages,7 figures

Accurate segmentation of MR brain tissue is a crucial step for diagnosis, surgical planning, and treatment of brain abnormalities. Automatic and reliable segmenta-tion methods are required to assist doctor. Over the last few years, deep learning especially deep convolutional neural networks (CNNs) have emerged as one of the most prominent approaches for image recognition problems in various do-mains. But the improvement of deep networks always needs inspiration, which is rare for the ordinary. Until now,there have been reasonable MR brain tissue segmentation methods,all of which can achieve promising performance. These different methods have their own characteristic and are distinctive for data sets. In other words, different models performance vary widely on the same data sets and each model has what it is skilled in. It is on the basis of this, we propose a judgement to distinguish data sets that different models are good at. With our method, the segmentation accuracy can be improved easily based on the existing models, neither without increasing training data nor improving the network. We validate our method on the widely used IBSR 18 dataset and obtain average dice ratio of 88.06%,while it is 85.82% and 86.92% when only using separate one model respectively.

Accurate segmentation of MR brain tissue is a crucial step for diagnosis,surgical planning, and treatment of brain abnormalities. However,it is a time-consuming task to be performed by medical experts. So, automatic and reliable segmentation methods are required. How to choose appropriate training dataset from limited labeled dataset rather than the whole also has great significance in saving training time. In addition, medical data labeled is too rare and expensive to obtain extensively, so choosing appropriate unlabeled dataset instead of all the datasets to annotate, which can attain at least same performance, is also very meaningful. To solve the problem above, we design an automatic segmentation method based on U-shaped deep convolutional network and obtain excellent result with average DSC metric of 0.8610, 0.9131, 0.9003 for Cerebrospinal Fluid (CSF), Gray Matter (GM) and White Matter (WM) respectively on the well-known IBSR18 dataset. We use bootstrapping algorithm for selecting the most effective training data and get more state-of-the-art segmentation performance by using only 50% of training data. Moreover, we propose a strategy of MR brain tissue images' suggestive annotation for unlabeled medical data based on the modified U-net. The proposed method performs fast and can be used in clinical.

Metabolic information obtained by proton magnetic resonance spectroscopic imaging (1H-MRSI) has been approved to be a powerful tool to identify either benign or malignant glioma, as well as to confirm the tumor level. However, 1H-MRSI data are affected by various factors, such as the thermal noise, eddy currents, susceptibility artifacts, and rigid body motion. To get accurate quantitative metabolic information, the key problem is to assess the 1H-MRSI data quality. In this paper, we introduce a new evaluating system to filter the data, and a new method, called wavelet denoising method, to improve the data quality under the evaluating system. Experimental results on 1H-MRSI glioma data demonstrate that preprocessing is prerequisite and the proposed algorithm with evaluating system is effective.

A novel scheme of external force for detecting the object boundary of medical image based on Snakes (active contours) is introduced in the paper. In our new method, an electrostatic field on a template plane above the original image plane is designed to form the map of the external force. Compared with the method of Gradient Vector Flow (GVF), our approach has clear physical meanings. It has stronger ability to conform to boundary concavities, is simple to implement, and reliable for shape segmenting. Additionally, our method has larger capture range for the external force and is useful for medical image preprocessing in various applications. Finally, by adding the balloon force to the electrostatic field model, our Snake is able to represent long tube-like shapes or shapes with significant protrusions or bifurcations, and it has the specialty to prevent Snake leaking from large gaps on image edge by using a two-stage segmentation technique introduced in this paper. The test of our models proves that our methods are robust, precise in medical image segmentation.