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Peixian Zhang,* Lan Shi,* Linjing Song, Yi Long, Kehua Yuan, Wanbao Ding, Lei Deng Department of Oncology, Yan’an Hospital of Kunming City & Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, People’s Republic of China *These authors contributed equally to this workCorrespondence: Lei Deng; Wanbao DingDepartment of Oncology, Yan’an Affiliated Hospital of Kunming Medical University. No. 245 East of Renmin Road, Kunming, Yunnan 650051, People’s Republic of ChinaEmail leidengkm@163.com; wabading@163.comPurpose: Synchronous colorectal liver metastasis (SCLM) had limited availability of tools to predict survival and tumor recurrence. LncRNA CRNDE and lncRNA SNHG7 have been proven to be closely related to cancer progression. However, the predictive value of lncRNA CRNDE and lncRNA SNHG7 in cancer prognosis is still unclear. The purpose of this study was to investigate whether lncRNA CRNDE and lncRNA SNHG7 could be used as promising biomarkers for prognosis prediction of SCLM patients who underwent hepatectomy.Methods: The expression profile of lncRNA CRNDE and lncRNA SNHG7 in serum of SCLM patients was examined by qRT-PCR. The relationship between lncRNA expression and clinicopathological characteristics was analyzed. The Cox proportional-hazards regression model and Kaplan-Meier analysis were performed to analyze the association between lncRNA expression and overall survival (OS) and tumor recurrence of SCLM patients.Results: Levels of lncRNA CRNDE and lncRNA SNHG7 in patients who underwent recurrence or death were significantly higher than that of patients with recurrence-free or survival (P< 0.01). Both lncRNA CRNDE high level and lncRNA SNHG7 high level showed a significant correlation with differentiation of primary tumor, invasion depth of primary focus, lymph node metastases, number of liver metastases, and liver metastasis grade. High levels of lncRNA CRNDE or lncRNA SNHG7 predicted shorter recurrence time, shorter OS time, higher recurrence rate and lower OS rate. Furthermore, lncRNA CRNDE and lncRNA SNHG7 were independent risk factors for high recurrence and poor OS in SCLM underwent hepatectomy.Conclusion: Taken together, lncRNA CRNDE and lncRNA SNHG7 could be promising biomarkers for prediction of OS and tumor recurrence in SCLM underwent hepatectomy.Keywords: lncRNA CRNDE, lncRNA SNHG7, prognosis, recurrence, synchronous colorectal liver metastasis, SCLM