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Introduction. The phenomenon of loneliness is multidimensional and ambigu­ous. Attitudes to loneliness are heterogeneous and mediated, among many factors, by cultural and ethnic features. Territorial proximity and historically conditioned relations and migrations of Ural-Siberian territories and Kazakhstan allow conducting intercultural and interethnic re­search. This research is devoted to the study of specifics of loneliness experience by first-year students – representatives of these nations. The problem of loneliness becomes especially ur­gent as a result of growth of anxious and depressive states, and sometimes suicidal and victim behaviour among first-year students.Aim. The aim of the current research is to identify ethnic aspects of the subjective ex­perience of loneliness of first-year students studying in Russia and Kazakhstan. The research examines the specifics of experiencing loneliness by students of different ethnic backgrounds (Russians, Kazakhs), 197 students (119 males and 78 females).Research design. The research design involved the determination of loneliness factors for the entire empirical sample (factor analysis) with subsequent calculation of the values of the received factors for each respondent. Then students were compared separately for boys and girls of Kazakh and Russian ethnicity.Measurements. To conduct the research, the authors used a set of methods to study loneliness, Zung Self-Rating Depression Scale and a questionnaire to identify the level and na­ture of loneliness by G. R. Shagivaleeva.Results. The authors found that the component composition of loneliness can be repre­sented by three factors: depressive experience of loneliness, positive experience of loneliness, experience of loneliness in interpersonal relationships. It was revealed that students of Kazakh ethnicity expressed a negative perception of loneliness (p = 0.007), actualising depressive ten­dencies. A positive experience of loneliness is more characteristic of girls than boys (p = 0.02). For girls of Kazakh ethnicity, separation from the parental family enhances the feeling of lone­liness (p < 0.05).Scientific novelty. The presented research results confirm the multidimensional nature of the phenomenon of loneliness, which determines the ambiguity of attitudes towards it and gives special weight to the value attitude towards loneliness in culture. Differences in the expe­rience of loneliness by students, due to the specifics of ethnic attitudes, are revealed. Theoretical significance of the study is determined by the identified regularities in the component composition of the experience of loneliness by students of two ethnic groups (Rus­sians and Kazakhs), its content and gender-role specificity.Practical significance. Empirical data contribute to the understanding of the ethnic characteristics of students’ experiences of loneliness and can serve as the basis for the devel­opment of university programmes that enhance psychological well-being.

Russian glass-filled materials based on polyphenylene sulfide were used for the first time as a structural material of parts of miniature power supply devices based on stand-by chemical current sources. The advantages of these materials over traditional press materials are shown, the main of which are increased structural strength, reduced defectiveness of parts, reduced number of rejects, improved technical and economic production indicators. The application of polyphenylene sulfide-based materials allowed developing of power sources possessing unprecedented short activation time and building the high-tech industrial production of power supply devices.

In the fall of 2019, global health was confronted with a new RNA virus — severe acute respiratory syndrome coronavirus 2 SARS-CoV-2. Against the background of the rapid spread of infection, research centers around the world began to develop specific vaccines against COVID-19, using the accumulated experience and empirical data on the stereotypes of the structure and physiology of other viral agents of this family (severe acute respiratory syndrome virus (SARS) and Middle East respiratory syndrome (MERS). However, even before the development of anti-COVID vaccines, it was suggested that they are probably less effective in a number of individuals, in particular, in people who are overweight or obese. This hypothesis arose on the basis of past studies using vaccines for other purposes in this categories of people, as well as in numerous experiments on mice, thanks to which scientists came to the conclusion that, due to an excess amount of adipose tissue in the body, there is a state of a permanent inflammatory process, some immune dysfunction, and, as a result, a reduced local and systemic response. resistance against bacterial and viral agents.In this literature review, using current publications obtained by searching for “covid-19 vaccination and obesity” and “vaccination and obesity” in the PubMed databases and “covid-19 vaccination and obesity” and “vaccination and obesity” in the e- Library discusses changes in the immune response both to infection itself and to immunization in the presence of overweight or obesity.

The aim – to assess the influence of various external factors and stress due to a large-scale military invasion on the daily blood pressure (BP) profile.Materials and methods. This was a retrospective analysis of examined patients who underwent ABPM in the last 5 years. We conditionally divided the observation period into several time intervals: the «War» – 1st group, the «Before the war» – 2nd group, the «Covid» – 3rd group, and the «Peace» – 4th group, in each of it 20 patients were selected by the method of random numbers. All patients underwent ABPM using the Watch BP 03 device (Microlife AG, Switzerland).Results. All groups were comparable according to the age, gender, and average daily BP and heart rate parameters of participants. Patients of all groups were middle-aged, the amount of men and women was equal in all groups, groups were comparable according to the results of average daily systolic (SBP), diastolic (DBP), pulse (PBP) BP and heart rate. We found that the 1st group had a significantly lower percentage of SBP and DBP decrease at night compared to all other groups (7.6±1.3% for SBP and 10.2±1.4% for DBP). The standard deviation of SBP and DBP was significantly higher in the 2nd group (19.8±1.1 and 14.2±0.7, respectively) compared to the 1st group (16.0±0.9 and 11.7±0.6, respectively) and 3rd (16.2±0.7 and 11.8±0.7, respectively). The highest frequency of non-dippers for SBP and DBP was observed in the 1st group (60 and 45 % respectively).Conclusions. During the war, the reduction of SBP and DBP at night in patients with hypertension was significantly lower than in the period before the war, pandemic Covid-19, and peace pre-war. There was also a higher number of non-dippers in this group.

The aim – to identify patients with true resistant arterial hypertension and to assess patients’ adherence to treatment on the background of a fixed combination of antihypertensive drugs.Materials and methods. 1146 patients with resistant hypertension were included in the study. Men and women over the age of 18 were included, provided that the average level of office blood pressure (BP) was greater than 140/90 mm Hg, when taking 3 or more antihypertensive drugs. Morisky – Green Questionnaire (in a modified scale) (MMAS-8) on patient adherence to treatment. To determine adherence to treatment in some patients, determination of drugs in urine was carried out in the central laboratory. All patients were initially subjected to the following tests: measurement of office SBP, DBP and heart rate, daily monitoring of BP, biochemical blood test.Results and discussion. 51.4 % of patients took 3 antihypertensive drugs. 48.6 % took 4-6 antihypertensive drugs: among them, 4 drugs – 37.1 %, 9.1 % – took 5 drugs, and 2.4 % – 6 drugs. The degree of decrease in office BP among patients taking 3 or more antihypertensive drugs was 43.47 ± 0.65 mm Hg for systolic BP, and 20.33 ± 0.74 mm Hg for diastolic BP (p

The objective of this study was to assess the volume of consumption of anti-interleukins and janus kinase inhibitors in the period 2018–2021, used as well as preventive pathogenetic therapy of COVID-19.Materials and methods. Based on actual sales data in the segments of public procurement (including regional and federal preferential drug provision) and retail sales segment in the period 2018–2021, obtained from the IQVIA database. All data was recalculated into the number of established daily doses (DDDs), with the calculation of pharmacoepidemiological indicators «Incidence of prescribing drugs», «Cumulative risk of prescribing drugs», as well as «Prescribing prevalence per year» for tocilizumab, olokizumab, levilimab, sarilumab, kanakinumab, anakinra, baricitinib, tofacitinib and upadacitinib.Results and discussion. The growth of total sales volumes was demonstrated in all market segments, but mostly in the segment of regional purchases, primarily related to the purchase of these groups of medicines for COVID-19 therapy in the period 2020–2021. It was demonstrated that the increase in the number of cases, accompanied by the expansion of prescribing preventive pathogenetic therapy, led to a twofold increase in the number of new cases of prescribing of janus kinase inhibitors and an increase in this indicator for anti-interleukins by 1.5 times, taking into account the estimated number of patients with moderate and severe COVID-19. The cumulative risk of prescribing these classes of drugs increased proportionally: for JAK inhibitors from 14 to 32%, and for anti-IL drugs from 38 to 69%. Calculations showed that the proportion of people over 18 years of age in the Russian Federation who received at least one dose of janus kinase inhibitors and anti-interleukins increased many times, in 1000 times and 500 times.Conclusions. Taking into account the expansion of the use of these groups of medicines, careful monitoring of information about their safety is required.

Purpose. To establish the regularities of two-phase flow of “gas-solid particles” in the operating area of an annular ejector where the following processes take place: air mixture ejecting, compressed air outflow from the ejector nozzle, air mixture flows mixing in the transport pipeline. In the work, the velocity distribution is also examined for dispersed phase and air phase of air mixture during its loading and accelerating in the transport pipeline of the pneumatic transport system. Methodology. The research is based on the fundamental approaches of mass point dynamics, aerodynamics, the theory of jet flows and iteration methods of numerical solution of equations. Findings. The mechanics of the air mixture flow under the ejection and aerodynamic force in the operating area of an annular ejector and at the beginning of transport pipeline is analyzed using the method of iterations. The impact of air mixture flow in the operating area of an annular ejector on energy performance of the pneumatic transport system is evaluated. Originality. The originality is that, for the first time, the regularities describing two-phase “gas–solid particles” flow at the loading area of the pneumatic transport system with an annular ejector have been obtained. This made it possible to characterize the velocity distribution of the dispersed and air phases of the air mixture during their loading and aerodynamic acceleration in the transport pipeline. Also, an innovative approach to the effectiveness of the use of pipeline pneumatic transport is the assessment of the energy indicators of the use of ejector-type pneumatic transport equipment depending on the rate of compressed air outflow from the ejector. Practical value. The implementation of the results in the modernization of existing and in the creation of new pneumatic transport systems with an annular ejector makes it possible to increase the efficiency of their use in the technological processes of moving dispersed materials at mining and metallurgical enterprises and in other areas of technology.

THE PURPOSE. Development and creation of an experimental stand, carrying out a full-scale experiment, verification the numerical model of a NREL S809 airfoil based on its dimensionless characteristics, analyze the flow around the airfoil at different angles of attack.METHODS. A technique for studying the flow structure around a wind turbine using numerical methods of gas dynamics based on solving the system of Navier-Stokes equations is considered. Mathematical modeling methods were used using the k-ε and SST turbulence model.RESULTS. In this study, a laboratory stand is designed using CAD systems and created using additive FDM printing technologies An experimental study of the dependence of the rotation speed on the blade angle and the resulting voltage in the electric system, the change in the power factor and efficiency of a wind power plant depending on the wind speed was carried out.CONCLUSION. The developed wind turbine has a power of 2.6 W at a wind speed of 4 m / s. This invention is recommended for the purpose of teaching methods of design and construction of similar installations. For the developed wind turbine, it is possible to optimize the work using the method of numerical three-dimensional thermogasdynamic modeling, to evaluate the nature of the flow at off-design operating modes, which speeds up the process of creating the final installation and improves its efficiency parameters.

Objective: evaluation of the clinical and economic efficiency of using Levilimab in the treatment of moderate and severe COVID-19 based on real world data (RWD).Material and methods. A single-center observational retrospective case-control study was performed. According to the matching algorithm, 834 pairs of patients with moderate and 347 pairs with severe infection were selected, similar in gender, age, vaccination status, severity of the disease and the level of C-reactive protein.Results. The clinical efficiency of Levilimab with respect to in-hospital mortality was demonstrated both for the moderate course (6% in the Levilimab group and 10% in the standard therapy group; odds ratio (OR) 1.71; 95% confidence interval (CI) 1.19–2.47; pConclusion. The use of Levilimab for the treatment of moderate and severe COVID-19 is feasible both from a clinical and economic points of view. Conducting RWD trials is an important tool to understand the effectiveness of medical technologies in real clinical practice.

Aims. To consider factors associated with adverse outcome among hospitalized patients with moderate and severe COVID-19.Materials and methods. Data from 345 case histories of adult patients hospitalized with moderate to severe COVID-19 were analyzed in a single-center retrospective study. Characteristics by sex, age, number of days from disease onset to admission to hospital, duration of hospitalization, duration of disease, population characteristics by medical history of comorbidities and self-medication, outcome of hospitalization and medical technologies used in hospital conditions were given for the whole cohort of patients. All parameters were analyzed using descriptive statistics methods. Qualitative variables are given in absolute (n) and relative (%) values with 95% confidence interval. Continuous variables were presented as median and quartiles. Risk factors for mortality were determined across groups using the χ2 criterion and odds ratio.Results. There was no demonstrated effect of gender, degree of pulmonary tissue lesions on computed tomography data, or time of initiation of respiratory support on disease outcome. At the same time, the age older than 65 years as well as neoplasms, type 2 diabetes mellitus, dementia, Stage 3 arterial hypertension, chronic heart failure, coronary heart disease, myocardial infarction and stroke history, chronic obstructive pulmonary disease, bronchiectatic disease, urogenital diseases were the predictors of unfavorable outcome in patients with moderate and severe COVID-19 form. Prehospital use of antiplatelet agents, direct and indirect oral anticoagulants, drugs affecting the renin-angiotensin system, systemic glucocorticosteroids, antibiotics, antiviral drugs, and analgesics was associated with a decrease in the mortality rate in patients with moderate-to-severe COVID-19, as well as timely use of pronposition and transfer to intensive care unit.Conclusions. Our findings are partially consistent with previous reports on the effect of risk factors on COVID-19 outcomes.

The article examines issues related to the application of the principle of confidentiality of advocacy as one of the most important principles of the advocacy profession. The confidentiality of advocacy consists primarily in guaranteeing the confidentiality of the lawyer’s communication with the client. Such communication is special in nature and reflects the social purpose of advocacy in the civil society of a democratic state. The article defines that the principle of confidentiality of the lawyer’s communication with the client is revealed through the concept of lawyer’s secrecy in the regulatory legal regulation of the lawyer’s activity. Lawyer secrecy is a type of professional secrecy. Its purpose is the nondisclosure of information that became known to the lawyer as a result of the client’s appeal to him, and the very fact of such an appeal. The specified information in its totality constitutes the subject of attorney’s secrecy. The article proves that lawyer secrecy is not an absolute category and has its limits objectively recognized by the legislator. In modern conditions, such boundaries should be supplemented and detailed. Nevertheless, there are discussions in scientific circles about the character and nature of attorney’s secrecy as a guarantee of confidential communication between a lawyer and a client. The article states that the cases of violation by lawyers of the principle of confidentiality of lawyer’s activity are not isolated. Cases of disclosure by a lawyer of information that is the subject of lawyer’s secrecy have a negative impact on the legal profession in general. Such cases should be minimized. For the act of disclosing information that is the subject of attorney’s secrets, the attorney must inevitably be subject to disciplinary liability. The article proposes measures to strengthen control over lawyers’ observance of the principle of confidentiality of communication with the client by ensuring sufficient and proper conditions for storing information that is the subject of attorney’s secrecy.

This work presents research studies into the comparability of Tigerase® (inhalation solution, manufactured by JSC «GENERIUM», Russia) to the reference drug Pulmozim® (inhalation solution, manufactured by Hoffmann-La Roche Ltd., Switzerland). Both drugs contain human recombinant deoxyribonuclease I – dornase alpha as an active substance and are intended for the treatment of cystic fibrosis with pulmonary manifestations (cystic fibrosis). The specific enzymatic activity of dornase alpha was studied in vitro and ex vivo using samples of patients’ purulent sputum. The pharmacokinetic parameters of the drugs were studied in the blood serum, bronchi and lungs. The main physiological parameters (body weight and temperature, the state of the cardiovascular, respiratory, excretory systems, hematological and biochemical blood parameters, pathomorphological changes in the internal organs, including the state of the cornea of the eyes, mortality rates) were assessed in comparative studies of subchronic toxicity in juvenile and sexually mature rats using 28-day inhalation in doses of 0.2 mg/kg to sexually mature and 0.26 mg/kg to juvenile animals (the dose was 6 times higher than the recommended dose for clinical use). It was concluded that the drugs were comparable in terms of their enzymatic, mucolytic (secretolytic) DNase activity, safety profile, and basic pharmacokinetic parameters.

Eyes’ dryness continues to be the most frequent complication after LASIK. As a rule, it disappear in the vast majority of patients during the first year after surgery. The conducted studies indicate that complaints of eyes’ dryness in the preoperative period significantly increase the risk of developing a severe form of dry eye syndrome in the postoperative period, especially in middle-aged women (45–59 years) and older. The clinical case presented in this article indicates the development of a severe form of dry eye syndrome after LASIK in a middle-aged patient receiving hormone replacement therapy for menopause, complaining of a feeling of dryness and discomfort in the eyes in the preoperative period, with intolerance to contact lenses and taking antidepressants in the absence of signs of severe dry eye in the preoperative period. Consequently, surgical intervention led to the development of the mentioned above condition. It is confirmed by the literature data indicating that the above factors can cause the development of a severe form of dry eye syndrome after LASIK. Taking into account the fact that tear production tests do not always correlate with the intensity of complaints of dryness, burning sensation, pain in the eyes, the most important component at the stage of deciding on the feasibility of refractive surgery in a particular patient is the collection of anamnesis and clinical picture. When preparing patients with a history of dry eye syndrome for refractive surgery, it is necessary to inform them that they have a significantly increased risk of developing dry eye syndrome. It may persist in the long-term postoperative period, and possibly go into a chronic form. Candidates for refractive surgery in the presence of complaints characteristic of dry eye syndrome can only be those patients who respond well to therapy aimed at relieving these symptoms in the preoperative period. Taking into account the multicomponent nature of pain in dry eye syndrome — nociceptive pain, which is formed at the stage of receptor irritation in the corneal tissue, and neuropathic pain that occurs with the participation of the peripheral and central nervous system, a comprehensive approach is needed in the treatment of dry eye syndrome.

Introduction. The article examines methods and means of monitoring the fire-retardant coatings of metal structures used in turbine halls of operating NPPs during the works on the assessment of the technical state, residual service life and service life extension of fire-retardant coatings. This appears to be an extremely urgent task, especially within the framework of the NPP pre-operation and service life extension. For operating NPPs, the re-surfacing of fire-retardant coatings due to the service life expiration can represent an insurmountable task.Aim. To establish current requirements for the content and sequence of works on the assessment of the technical state, residual life and service life extension of fire-retardant coatings applied to NPP turbine hall metal structures.Materials and methods. An analysis of existing methods and techniques for assessing the technical state, residual service life and service life extension of fire-retardant coatings applied to the turbine hall metal structures of operating NPPs was carried out.Results. The acknowledged methods and techniques for assessing the technical state, residual service life and service life extension of fire-retardant coatings are examined, their effectiveness is analyzed and promising trends on the establishment/forecast of the guaranteed service life are noted, including the development of promising fire-retardant compositions with an increased service life and the development of necessary programs-procedures for the establishment and substantiation of the guaranteed storage life of fire-retardant coatings, as well as the assessment of its extension.Conclusion. The requirements for the content and sequence of works on the assessment of the technical state, residual life and service life extension of fire-retardant coatings applied to NPP turbine hall metal structures are established.

Current state of legal support for corporate relations and doctrinal approaches to determining the priority of their mandatory or dispositive regulation have been analyzed. Attention has been drawn to the fact that in order to ensure unimpeded exercise of subjective corporate rights by each participant of a corporate organisation, a balance of regulatory regulation and self-regulation should be developed, which should be built from mandatory requirements to discretionary principles. At the current stage of the corporate legislation development, there is a combination of dispositive and mandatory mechanisms of regulatory support of corporate legal relations. The regulatory framework for the establishment, operation and termination of corporations, as well as the exercise and protection of the rights of their participants (shareholders), does not allow a clear answer to the question of the priority of applying the dispositive or mandatory method to these relations. Despite the fact that corporate relations being civil are subject to the general principles of civil law, the need to ensure the stability of civil turnover and protect the rights of their participants necessitates the urgent regulation of certain aspects of corporate movement. It has been identified a tendency to expand the scope of dispositive principles in the mechanism of legal regulation of corporate relations. It is clearly crystallised in relation to certain organisational and legal forms of corporate entities. For objective reasons, it is less evident in relation to a public joint-stock company. The development of self-regulatory elements in relation to a limited liability company could be welcomed, given its intermediate position between the classic business entity such as a joint-stock company and a general or limited partnership. However, with regard to a private joint-stock company, the possibility of strengthening the dispositive principles should be taken with caution. Despite its non-public nature, such a company remains, first and foremost, a capital association and should not be transformed into a limited liability company, and its shares should not be recognised as a surrogate for securities. Although the corporate agreement contains provisions on the exercise (refusal to exercise) of corporate rights by participants (shareholders), they are not local, but are individual regulators that do not apply to the scope of the company's functioning and activities, which does not indicate the normative nature of such a contractual structure.

A modern city is a complex system that requires a unified systematic approach to ensuring public safety, law and order and environmental safety in the face of high levels of both man-made and natural risks. Due to the growing role of information technology in the functioning of a modern city, the threat of cyberattacks on critical municipal infrastructure has increased. The cost of such cyber-attacks can be very high, both for individual victims and for society as a whole. Cyberattacks can lead to the theft of sensitive information, data destruction or the disclosure of personal data. In addition, such attacks can lead to loss of working time and suspension of systems, which can have serious consequences for the city’s viability. The experience of other countries in protecting critical municipal infrastructure from cyber threats has been studied, analysed and summarised. The impact of the latest information technologies (such as the Internet of Things, artificial intelligence, blockchain) on the development of municipal infrastructure, the use of these technologies to protect critical infrastructure from cyberattacks, their advantages and disadvantages compared to classical security technologies have been considered. Particular attention has been paid to the problems of safe automation of modern city management processes such as automation of traffic control systems, environmental monitoring systems, financial systems, power grids, water and gas supply systems, communication systems, and control systems for wastewater treatment plants. The features of cyber attacks and the use of methods for protecting critical infrastructure in the context of hybrid warfare have been examined. Recommendations for a comprehensive increase in the level of protection of municipal critical infrastructure from cyber threats have been provided, taking into account the latest global trends in cybersecurity.

The aim of the work was to study the epidemiology of Alzheimer’s disease in the Odesa region. Materials and methods. The study was carried out on the basis of the Regional Mental Health Center (Odesa) in 2016–2021. The data of the primary referral of patients with a verified diagnosis of Alzheimer’s disease were analyzed. Statistical processing of the obtained data was performed by frequency analysis methods using standard MS Excel packages (Microsoft Inc., USA). The population of the Odesa region was determined according to the State Statistics Service of Ukraine. Results. According to the retrospective analysis over the past 5 years, there was a constant increase in the number of identified patients with Alzheimer’s disease, from 4.9 cases per 100,000 population in 2016 to 6.0 cases in 2020 with a slight predominance of women in the structure of cases. Brain MRI was performed only in 29 (4.6 %) patients, EEG in 41 (6.5 %) patients. There were no cases of familial Alzheimer’s disease or early-onset Alzheimer’s disease. In 2020, Alzheimer’s and dementia deaths reached 14,196 or 2.54 % of total mortality in Ukraine. Conclusions. The prevalence of Alzheimer’s disease was 6.0 cases per 100,000 in the population of the Odesa region at the end of 2021, which was an order of magnitude less than the global average. The mean score on the MMSE scale was 18.6 ± 0.5. The analysis on subscales has shown the prevalence of memory, spatial orientation and verbal disorders. The Ukrainian population is characterized by the small number of patients of the older age group (3.3 %) and the predominance of female patients (59.4 %).

Aim. To evaluate the content of calprotectin and volatile fatty acids (VFAs) in feces of patients with inflammatory bowel disease (IBD). Materials and methods. 61 patients (33 men and 28 women) with IBD aged 20 to 66 years (the mean indicator was 41.80 ± 1.14 years) were examined. The patients were treated in the Department of Intestinal Diseases of SI “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”. All the patients were divided into two groups: Group I – 46 patients with ulcerative colitis (UC) and Group II – 15 patients with Crohn’s disease (CD). The control group consisted of 10 practically healthy people (donors). Calprotectin detection in fecal samples was carried out using a kit “Immundiagnostik”, Germany. Fecal VFAs were analyzed using a hardware-software complex for medical research with a gas chromatograph Chromatek-Crystal 5000. Results. A significant increase in the content of fecal calprotectin was found. Its amount depended on the disease nosology and was more expressed in patients with UC (3.5 times higher (P < 0.05) than that in patients with CD). The observed changes were accompanied by an increase in the content of propionic (C3) acid and a decrease in acetic (C2), butyric (C4) acids in coprofiltrates of the examined patients. The detected imbalance in the fecal content of VFAs in patients led to an increase in the amount of fatty acids, which was more pronounced in patients with CD. An association between calprotectin levels and fecal VFA content was identified. Thus, correlation analysis allowed to establish a relationship between calprotectin levels and propionic acid content in patients with IBD (r = 0.370; P = 0.046). Conclusions. In the case of active bowel inflammation, there is the increase in the fecal content of calprotectin and the decrease in VFAs (acetic and butyric acids) in accordance with the degree of disease activity, which allows the use of these indicators to assess the efficacy of therapies.

The prohibition of using antibiotics with growth-stimulating properties in the European Union led to the search for new, safer, more effective, and cheaper feed additives. One of these substances was rare earth elements (REE, atomic numbers 57–71) due to their low toxicity and protective and antioxidant properties. At the same time, higher efficiency of organic forms of REE was noted. Thanks to this, it is possible to assume their even more pronounced effect in nano-sized form as feed additives and the need to conduct research in this direction. Therefore, this work aims to study the metabolic parameters of the blood in rats under long-term oral administration of nanoparticles of one of the representatives of rare earth elements – gadolinium orthovanadate (NP GdVO4:Eu3+) under food stress. Experimental samples of gadolinium orthovanadate nanoparticles activated by Europium (spindle-shaped geometry; size 8×25 nm; initial concentration 1.0 g/dm3) were used in work. Experimental studies on rats were carried out based on the vivarium of the NSC “IEKVM”. The object of research was 140 mature male Wistar rats with an initial weight of 180–200 g. Four groups of animals, 35 rats each, were formed according to the principle of analogs. During the experiment, animals of the control group received drinking water without additives; rats of the І experimental group were given a solution of NP GdVO4:Eu3+ at a dose of 0.2 mg/dm3 (≈ 0.03 mg/kg of body weight); II research group – at a dose of 1.0 mg/dm3 (≈ 0.15 mg/kg of body weight) and rats of III research group – at a dose of 2.0 mg/dm3 (≈ 0.30 mg/kg of body weight). Drinking was carried out for 56 days, then it was completed, and the rats were observed for another 14 days. A nutritionally unbalanced diet was used as a stress factor. Taking into account the results of biochemical studies, the adaptogenic effect of NP GdVO4:Eu3+ in the range of doses of 0.2–1.0 mg/dm3 of drinking water (≈ 0.03–0.15 mg/kg of body weight) on the body of white rats was established under conditions of food stress with optimal duration of action – 28–42 days. Under the conditions of administration at a dose of 2.0 mg/dm3 of drinking water (≈ 0.30 mg/kg of body weight), a hepatic(cyto-)toxic effect of nanoparticles was detected, which was accompanied by an irreversible decrease in the structural indicators of lipid metabolism, the consumption of antioxidant resources and the induction of intensity processes of lipid peroxidation against the background of alanine aminotransferase hyperenzymemia.

The subject of the article is the peculiarities of the execution of imprisonment in relation to the elderly (over 50 years old) as an independent legal institution of penitentiary law in Russia and abroad.The purpose of the article is to identify the patterns and problems of the execution of punishment in the form of imprisonment in relation to elderly people (over 50 years old) in Russia and abroad, taking into account the growth trend of this category of prisoners and propose a legal solution to the problem.Main tasks: (1) to determine using statistical indicators the change in the number of elderly prisoners and identify the main trend in quantitative indicators; (2) identify problems that arise in elderly prisoners due to the lack of legislative regulation of the organization of an accessible environment in correctional institutions; (3) conduct a comparative analysis of the organization of medical care in relation to the elderly when serving a sentence of imprisonment in Russia and abroad; (4) determine ways to improve Russian legislation in the field of punishment in the form of imprisonment in relation to elderly prisoners.Research methodology. When studying the tendency of aging convicts to imprisonment in Russia and abroad, an analysis of statistical data was used. The work is a comparative legal study as a result of the study of domestic and foreign experience in the execution of sentences in the form of imprisonment, as well as the penal policy of Russia and foreign countries in relation to elderly prisoners; specific sociological technique was used when conducting a survey of persons over 55 years old serving a sentence of imprisonment in Russia; the formal-legal method made it possible to formulate a number of proposals on the need to reform penitentiary institutions, taking into account the age characteristics of this category of convicts.Main results and scope of their application. Firstly, the possibility of allocating a separate chapter to the PEC of the Russian Federation on the peculiarities of the execution of punishment in the form of imprisonment of elderly convicts is justified. Secondly, the definition of the concept of "accessible environment", as well as the peculiarities of medical care for elderly convicts, taking into account the relevant experience of foreign countries. Thirdly, there is a need to form legal institutions for the socialization and resocialization of elderly people (over 55 years old) during the period of serving criminal sentences in the form of imprisonment, taking into account age characteristics and foreign experience.Conclusion. Age characteristics and health conditions have a direct impact on the correctional impact of those sentenced to imprisonment. Russian and foreign experience clearly show that at present there is no unified political and legal approach in relation to elderly prisoners, despite the general growth trend of this category of persons. In Russia and abroad, there is a need to build correctional institutions of a new type, which will take into account, among other things, the age characteristics of the convicts. In this case, it is necessary to start with the development of individual legal institutions.

Early detection of cervical (CC) and endometrial (EC) cancer recurrence in previously irradiated areas remains a difficult task for clinicians and radiologists. 18F-FDG PET-CT scope and limits in this matter are not clear yet.Purpose. To determine 18F-FDG PET-CT significance and diagnostic value in differential diagnosis of locoregional recurrence and post-radiation tissue changes in CC and EC patients with suspected relapse in preirradiated zones.Materials and methods. Follow-up data, including multiparametric MRI (T1-WI, T2-WI, DWI, DCE) and 18FFDG PET-CT full descriptions, were studied in 51pts., in 25(49%) CC and 26 (51%) EC Ia–IIIc FIGO, with suspected loco-regional recurrence in pre-irradiated area, 4–96 months after the end of treatment.Adjuvant combined radiotherapy (conformal pelvic EBRT – 3D-CRT, IMRT, VMAT, endovaginal 192Ir HDR brachytherapy) was performed in 33 (64,7%) pts. after radical surgery, adjuvant chemoradiation with Cisplatin 40 mg/m2 or Carboplatin AUC2 weekly – in 8 (24.2%) of them. 18 (35,3%) pts. were treated with definitive chemoradiation, median EQD2 for HR-CTV D90 81.6 ± 4.4 Gy (CI 95% 72.4 Gy – 93.7 Gy) and 54.6 ± 3.3 Gy (CI 95% 48.8–64.2 Gy) for metastatic pelvic and paraaortic lymph nodes.Indications for 18F-FDG PET-CT (Biograph True64, Siemens, 3.8–4.7 MBq/kg, total 169–356 MBq) in all pts. were suspicious clinical, cytological, complex ultrasound, and multiparametric MRI findings in pre-irradiated zones. Any areas of 18F-FDG pathologically increased uptake were considered hypermetabolic lesions, positive for cancer recurrence.Results. No evidence of loco-regional recurrence in pre-irradiated zones was confirmed in 32 (62.7%) pts. Clinical, morphological and radiological signs of progression were obtained in 16 (31.3%) 18F-FDG PET-CTpositive patients, with SUVmax 2.86–8.8 in this subgroup. 18F-FDG PET-CT false-positive results were obtained in 6 (11.8%) patients, false-negative – in 1 (1.9%) heavy pre-treated CC patient. 18F-FDG PET-CT sensitivity was 94.1%, specificity – 84.2%, positive predictive value – 72.7%, negative predictive value – 96.9%.Conclusions. 18F-FDG-PET-CT has a high diagnostic value in the differential diagnosis of loco-regional relapses and post-radiation tissue changes in CC and EC patients with suspected progression in pre-irradiated zones. But 18F-FDG-PET-CT findings evaluation and interpretation requires a multidisciplinary discussion and consensus for this cohort of patients.

The objective: to evaluate the clinical and economic efficiency and impact of mass fluorography screening of the population on tuberculosis mortality and rates of timely tuberculosis detection in four federal districts of the Russian Federation with different levels of tuberculosis detection and coverage of the population with fluorography mass screening.Subjects and Methods. Analytical materials of the Federal Center for Monitoring of Tuberculosis Transmission Control in the Russian Federation posted on official websites were used. The rates were analyzed by applied statistics methods. All statistical calculations were performed with 0.95 significance.Results. A correlation analysis was performed between the coverage, effectiveness of tuberculosis detection by mass fluorography screening of the population and main rates reflecting the epidemic situation and timeliness of tuberculosis detection in the Russian Federation and its four federal districts. There was no correlation between the detection effectiveness and main markers of timeliness of tuberculosis detection. It was found out that against the background of increased costs for mass fluorography screening, its implementation did not provide significant positive results in reducing tuberculosis incidence and mortality which indicated their low clinical and economic efficiency.

This review overview current epidemiology data of malignant tumors of the central nervous system, and determines the significance of molecular diagnostics and expression of heat shock proteins in tumorigenesis. Particular attention is paid to the description of molecular chaperones as diagnostic and prognostic markers, as well as the prospects for chaperones using in personalized therapy the central nervous system tumors. The search for literature was carried out on the database platforms Medline (via PubMed) and Scopus, Cochrane Library, The Lancet Public Health Journal published between 1988 and 2022. The material was searched for keywords and terms, including “heat shock proteins”, “tumors of the central nervous system”, “brain tumors”, “molecular diagnostics”, “expression of molecular chaperones”, Hsp110, Hsp90, Hsp70, Hsp60, Hsp40, small HSPs. Molecular chaperones, due to their important role in physiological processes in the cell, are highly expressed in brain tumors, and the expression level of HSPs strongly correlates with the degree of malignancy, invasive potential, and resistance to radiochemotherapy. For some HSPs (i.e. HSP10, HSPB1, DNAJC10, HSPA7, HSP90) a direct correlation has been found between the level of protein expression (based on IHC analysis) and a poor overall survival prognosis for patients with glial tumors. This indicates the prognostic value of these markers, which in the future may be included in the diagnostic panel when examining a tumor sample.

The impact of the transferred coronavirus infection on the musculoskeletal system still remains an urgent problem. Аrthralgia, myalgia, arthritis, autoimmune disorders and also osteonecrosis are may be development of the postCOVID period. This article discusses the case of the debut of multifocal osteonecrosis after a coronavirus infection.

Rusalkina L. G., Grigoriev E. O., Dekhtiar Yu. M., Ostapenko I. O. The issue of training foreign medical students at the modern stage. Journal of Education, Health and Sport. 2023;13(2):315-322. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.13.02.045 https://apcz.umk.pl/JEHS/article/view/43455 https://zenodo.org/record/7808530 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.02.2023. Revised: 10.02.2023. Accepted: .24.02.2023. UDK 811.111’276.6:614.233.4 THE ISSUE OF TRAINING FOREIGN MEDICAL STUDENTS AT THE MODERN STAGE L. G. Rusalkina, E. O. Grigoriev*, Yu. M. Dekhtiar, I. O. Ostapenko Odesa National Medical University, Odesa, Ukraine International European University, Kyiv, Ukraine Abstract Despite the war in Ukraine, medicine remained one of the most popular specialties for this year's applicants. Ukrainian universities should work more actively on the development of innovative solutions in the field of digitization of education, the combination of mixed and modern virtual education with academic mobility. The educational space is characterized by an increase in socio-cultural complexity, the consequence of which is the complication of relations between both Ukrainian and foreign students. With this in mind, the strategic tasks of higher education in Ukraine are the formation of multicultural relationships in the student body, since almost all student groups are multicultural. The main goal of this work is to determine the features of training foreign medical students in the multicultural environment at medical higher educational institutions. The main issue today is the problem of dialogue between cultures in a multicultural environment. The importance of this question is undeniable, since the dialogue is oriented towards the future and involves deep knowledge of the spiritual structure and intellectual system of the society with which the dialogue is carried out. Multicultural education is a process of preparing individuals for social, political and economic realities in which they gain their life experience, and as a result, the individual develops his ability to perceive a multicultural environment. One of the key principles of multicultural education and upbringing is the principle of tolerance. The foreign students education process efficacy in the created multicultural environment will be facilitated by the development of skills and interpersonal communication skills. The authors concluded that foreign students’ preparation for interpersonal communication will be hindered by organizing of their creative activity by means of interactive technologies. The development of creative abilities can be ensured through the use of interactive learning tools: solving practical medical problems, solving conflict situations with patients or colleagues, role-playing, business games, applying the project method, developing associative thinking, creative independent work. The teacher should offer students of higher education a variety of individual tasks and situations, because the more actively future doctors perform them, the better their creative abilities develop. Thus, the process of multicultural education is aimed at forming socially and professionally important qualities of an individual, at creating and expanding the circle of his relations to society, to people in the surrounding world, to himself. In view of the foregoing, we conclude that the creation of a multicultural environment in a medical institution of higher education is a necessary condition for the training of foreign students in interpersonal communication. We see the prospect of further research in defining the essence of the concept of “multicultural environment of a medical institution of higher education” and clarifying the peculiarities of training foreign students - future doctors - for interpersonal communication in this environment. Key words: multicultural education; tolerance; medical students; training; interpersonal communication; interactive learning tools

The analysis of the recent phylogeographic studies of Microtus arvalis is carried out to establish the post-glacial history of colonization of the common vole in the Central region of Europe. The authors have presented the original data on the genetic variability of the mtCytb gene of the common vole (Microtus arvalis s. l.) from 18 localities studied on the territory of Belarus. The genetic characteristics of 53 individuals of the common vole belonging to one eastern line of mitochondrial DNA were studied. It is shown that the population of the species in Belarus is characterized by a high level of genetic diversity comparable to that of other haplogroups of the eastern mtDNA line. The level of variability of mitochondrial fragments of the mtCytb gene of the common vole (Microtus arvalis) from Belarus turned outtobeq uite high (Hd ± SDHd = 0.97 ± 0.02), which is manifested in a large number of the identified mtDNA haplotypes (n = 41). The distribution of the identified haplotypes of Microtus arvalis across various landscape-geographical areas correlates well with the location of the most remote haplotypes on the parsimony network. The assumption is given about the re-settlement (about 9000 thousand years ago) and further settlement of Microtus arvalis on the modern territory of Belarus in two directions: from southeast to west and to northwest, as well as from north to southeast.

Nonlinear magnetic resonance is studied in an in-plane magnetized yttrium iron garnet (YIG) film. For YIG films magnetized perpendicular to the plane, the effect referred to as the foldover resonance is well known. It arises because the precession frequency increases with the deviation of the magnetization. When the field is reduced, the frequency of the precession remains resonant because the demagnetizing field decreases with the deviation of the magnetization. The signal disappears when the radio frequency pump power is insufficient to maintain a nonequilibrium state of the system. In the in-plane magnetized yttrium iron garnet film, the precession frequency decreases with an increase in the pump amplitude. Accordingly, the foldover effect arises under an increase in the field. The fundamental difference is that the precession in the latter case should be unstable with respect to the decay into spin wave modes. The deviation angles of magnetization of about 10° are reached, and the rate of decay of the uniform precession into spin waves, which depends on the deviation angle of the magnetization, is measured. This study opens up another way of achieving the magnon density corresponding to the formation of its Bose–Einstein condensate.