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1. Additional file 5: Figure S5. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
inorganic chemicals, body regions, enzymes and coenzymes (carbohydrates), nervous system, fungi
Abstract

An antibody selectively recognizes phosphorylation of the GluN2A subunit at S1416. (PDF 51 kb)

Published
2015
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2. Additional file 4: Figure S4. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
body regions, nervous system, musculoskeletal, neural, and ocular physiology, fungi, education
Abstract

NMDAR internalization causes an increase in phosphorylation of the GluN2A subunit at S1416. (PDF 100 kb)

Published
2015
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3. Additional file 3: Figure S3. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Abstract

The endocytosis of GluN1-1a/GluN2B, but not GluN1-1a/GluN2A, receptors was prevented by C-tail truncation after aa 857. (PDF 90 kb)

Published
2015
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4. Additional file 1: Figure S1. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
body regions, nervous system, musculoskeletal, neural, and ocular physiology, mental disorders, fungi, 3. Good health
Abstract

The endocytosis of NMDARs (the GluN1 subunit). (PDF 62 kb)

Published
2015
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5. Additional file 5: Figure S5. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
inorganic chemicals, body regions, enzymes and coenzymes (carbohydrates), nervous system, fungi
Abstract

An antibody selectively recognizes phosphorylation of the GluN2A subunit at S1416. (PDF 51 kb)

Published
2015
Full Text
View/download PDF

6. Additional file 4: Figure S4. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
body regions, nervous system, musculoskeletal, neural, and ocular physiology, fungi, education
Abstract

NMDAR internalization causes an increase in phosphorylation of the GluN2A subunit at S1416. (PDF 100 kb)

Published
2015
Full Text
View/download PDF

7. Additional file 3: Figure S3. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Abstract

The endocytosis of GluN1-1a/GluN2B, but not GluN1-1a/GluN2A, receptors was prevented by C-tail truncation after aa 857. (PDF 90 kb)

Published
2015
Full Text
View/download PDF

8. Additional file 2: Figure S2. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
3. Good health
Abstract

The endocytosis of NMDARs (the GluN2A and GluN2B subunits). (PDF 280 kb)

Published
2015
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9. Somatotopical arrangement of rat spinal dorsal horn cells processing input from deep tissues

Author

Siegfried Mense and Yu Xian-Min

Subjects
Iontophoresis, Horn (anatomy), General Neuroscience, Central nervous system, Action Potentials, Rats, Inbred Strains, Anatomy, Biology, Grey matter, Spinal cord, Hindlimb, Rats, Electrophysiology, medicine.anatomical_structure, Spinal Cord, nervous system, Receptive field, Physical Stimulation, medicine, Animals, Neurons, Afferent, Evoked potential, Neuroscience, Skin
Abstract

Extracellular recordings were made from 29 dorsal horn neurones which could be driven by mechanical stimulation of deep tissues, in spinal segment L4 of rats. The recording sites were marked by iontophoresis of pontamine sky blue. According to the location of the receptive fields the cells were classified as deep neurones (12 cells), which had input from deep tissues only, and as cutaneo-deep neurones (17 cells), which had receptive fields in both skin and deep tissues. The deep cells showed a correlation between the recording sites in the dorsal horn and the location of the receptive fields on the hind-limb: the more distal a deep receptive field was situated on the hind-limb the more medial was the location of the recording site in the dorsal horn. In cutaneo-deep neurones the correlation was statistically significant for the deep receptive fields but not for the cutaneous ones.

Published
1990

10. Response properties and descending control of rat dorsal horn neurons with deep receptive fields

Author

Yu Xian-Min and Siegfried Mense

Subjects
Male, Stimulation, Biology, Efferent Pathways, Physical Stimulation, medicine, Animals, Receptor, Skin, Neurons, General Neuroscience, Muscles, Nociceptors, Rats, Inbred Strains, Anatomy, Spinal cord, Electric Stimulation, Hindlimb, Rats, medicine.anatomical_structure, Nociception, Spinal Cord, Receptive field, Horn (acoustic), Nociceptor, Female, Neuron, Neuroscience
Abstract

The study was designed to obtain information on the spinal processing of input from receptors in deep somatic tissues (muscle, tendon, joint). In anaesthetized rats, the impulse activity of single dorsal horn cells was recorded extracellularly. In a pilot series, the proportion of neurons responding to mechanical stimulation of deep tissues was determined: 46.7% had receptive fields in the skin only, 35.5% could only be driven from deep tissues (deep cells), and 17.7% possessed a convergent input from both skin and deep tissues (cutaneous-deep cells). In each category, neurons with low and high mechanical thresholds were encountered. Experiments employing a reversible cold block of the spinal cord showed that deep cells with high threshold were subject to a stronger descending inhibition than low-threshold deep cells. In cutaneous-deep neurons the input combination high-threshold cutaneous and high-threshold deep was the most frequent one (48.7% of the cutaneous-deep cells). In these presumably nociceptive cells the descending inhibition had a differential action in that the input from deep tissues was more strongly affected than was the cutaneous input to the same neuron. The recording sites of the neurons with deep input were located in the superficial dorsal horn and in and around lamina V. The results suggest that in the rat a considerable proportion of dorsal horn cells receives input from deep nociceptors and that this input is controlled by descending pathways in a rather selective way.

Published
1990

12. Additional file 6: Figure S6. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
3. Good health
Abstract

PKD1 phosphorylates and down-regulates NMDARs. (PDF 119 kb)

13. Additional file 8: Figure S8. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
body regions, nervous system, fungi, urologic and male genital diseases, female genital diseases and pregnancy complications, 3. Good health
Abstract

Effects of PKD1 knockdown on glutamate-mediated mEPSCs in hippocampal neurons. (PDF 78 kb)

14. Additional file 1: Figure S1. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
body regions, nervous system, musculoskeletal, neural, and ocular physiology, mental disorders, fungi, 3. Good health
Abstract

The endocytosis of NMDARs (the GluN1 subunit). (PDF 62 kb)

15. Additional file 6: Figure S6. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
3. Good health
Abstract

PKD1 phosphorylates and down-regulates NMDARs. (PDF 119 kb)

16. Additional file 7: Figure S7. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
urogenital system, fungi, embryonic structures, urologic and male genital diseases, female genital diseases and pregnancy complications, 3. Good health
Abstract

Infection of PKD1 shRNA reduces PKD1 expression. (PDF 103 kb)

17. Additional file 8: Figure S8. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
body regions, nervous system, fungi, urologic and male genital diseases, female genital diseases and pregnancy complications, 3. Good health
Abstract

Effects of PKD1 knockdown on glutamate-mediated mEPSCs in hippocampal neurons. (PDF 78 kb)

18. Additional file 7: Figure S7. of Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Author

Fang, Xiao-Qian, Qiao, Haifa, Groveman, Bradley, Feng, Shuang, Pflueger, Melissa, Wen-Kuan Xin, Ali, Mohammad, Shuang-Xiu Lin, Jindong Xu, Duclot, Florian, Kabbaj, Mohamed, Wang, Wei, Ding, Xin-Sheng, Santiago-Sim, Teresa, Jiang, Xing-Hong, Salter, Michael, and Yu, Xian-Min

Subjects
urogenital system, fungi, embryonic structures, urologic and male genital diseases, female genital diseases and pregnancy complications, 3. Good health
Abstract

Infection of PKD1 shRNA reduces PKD1 expression. (PDF 103 kb)

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