1. Subcutaneous panniculitis-like T-cell lymphoma: successful initial treatment with prednisolone and cyclosporin A
- Author
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Yoshioka Katsunobu, Hirofumi Teshima, Takeshi Inoue, Isseki Maeda, Toshihiko Sato, Manabu Hirai, Yoshio Konishi, Yuka Tsukamoto, and Yoko Omura
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Panniculitis ,Antineoplastic Agents, Hormonal ,Prednisolone ,Lymphoma, T-Cell ,Asymptomatic ,Gastroenterology ,Lymphohistiocytosis, Hemophagocytic ,Pharmacotherapy ,hemic and lymphatic diseases ,Internal medicine ,Cyclosporin a ,Biopsy ,Internal Medicine ,medicine ,Humans ,medicine.diagnostic_test ,business.industry ,Remission Induction ,General Medicine ,medicine.disease ,Pancytopenia ,Lymphoma ,Cyclosporine ,Drug Therapy, Combination ,medicine.symptom ,Hemophagocytosis ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
A case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is reported. A 27-year-old man presented with fever and abdominal swelling. His laboratory examination revealed pancytopenia and liver dysfunction. The diagnosis of SPTCL was made by biopsy based on thickened subcutaneous tissue. In addition, bone marrow specimen showed a hemophagocytosis syndrome (HPS). Methylprednisolone pulse therapy was initiated followed by prednisolone (60 mg/day) and cyclosporin A (150 mg/day). He responded to the treatment and remained asymptomatic for at least for 6 months. Our results suggest that a trial of cyclosporin A is warranted in patients with SPTCL complicated by HPS.
- Published
- 2006