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The aim of the study was to investigate the clinical significance of Ly-1 antibody reactive clone (LYAR) in non-small-cell lung cancer (NSCLC).The expressions of LYAR at the protein level in representative paired NSCLC tumor tissues and adjacent non-tumor tissues were measured by Western blot and immunohistochemistry. Kaplan-Meier method was used to calculate the survival curve of patients with NSCLC. Cell Counting Kit-8 assay and flow cytometry were used to estimate the cell proliferation and cell cycle, respectively. Terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay was performed to detect cell apoptosis.LYAR was dramatically overexpressed in NSCLC tissues which were closely related to the survival of patients with NSCLC. In clinical studies, the expression of LYAR was related to the clinical stage, histological differentiation, and Ki-67 expression. A positive correlation was found between LYAR and Ki-67 expression by Spearman's correlation test. After serum starvation for 72 h, serum re-addition significantly increased the expression of LYAR, PCNA, and Cyclin A and promoted the cell cycle progression. LYAR knockdown inhibited the proliferation and induced the G0/G1 cell cycle arrest and apoptosis of A549 cells.The present study revealed the clinical significance of LYAR in NSCLC. LYAR might serve as a tumor promoter in NSCLC progression by promoting the proliferation and inhibiting the apoptosis of NSCLC cells. Inhibiting the expression of LYAR was considered as a potential novel therapeutic strategy for NSCLC.

Ten compounds (1–10) were obtained from soil-derived Penicillium cremeogriseum W1-1 with the antimicrobial guided isolation procedure. Among them, 4 presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound 4 showed growth inhibition on drug-resistant pathogenic strains Escherichia coli and Candida albicans with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of C. albicans by eradicating biofilms. Interestingly, the fraction containing 4 presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.

Two rearranged triterpenoids, representing new subtypes of pentacyclic triterpenoids, with unique 6/6/6/7/5 and 6/6/5/6/6/6 ring systems were isolated from Alstonia scholaris. Their structures were established by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Both compounds exhibited potent antihyperuricemic bioactivity in vitro and in vivo.

Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and progressive external ophthalmoplegia (PEO) are established phenotypes of mitochondrial disorders. They are maternally-inherited, multisystem disorder that is characterized by variable clinical, biochemical, and imaging features. We described the clinical and genetic features of a Chinese patient with late-onset MELAS/PEO overlap syndrome, which has rarely been reported. The patient was a 48-year-old woman who presented with recurrent ischemic strokes associated with characteristic brain imaging and bilateral ptosis. We assessed her clinical characteristics and performed mutation analyses. The main manifestations of the patient were stroke-like episodes and seizures. A laboratory examination revealed an increased level of plasma lactic acid and a brain MRI showed multiple lesions in the cortex. A muscle biopsy demonstrated ragged red fibers. Genetic analysis from a muscle sample identified two mutations: TL1 m.3243A>G and POLG c.3560C>T, with mutation loads of 83 and 43%, respectively. This suggested that mitochondrial disorders are associated with various clinical presentations and an overlap between the syndromes and whole exome sequencing is important, as patients may carry multiple mutations.

Obesity and related metabolic disorders are associated with intestinal microbiota dysbiosis, disrupted intestinal barrier, and chronic inflammation. Neohesperidin (Neo), a natural polyphenol abundant in citrus fruits, is known for its preventative and therapeutic effects on numerous diseases. Here, we report that Neo administration attenuates weight gain, low-grade inflammation, and insulin resistance in mice fed high-fat diet (HFD). Also, Neo administration substantially restores gut barrier damage, metabolic endotoxemia, and systemic inflammation. Sequencing of 16S rRNA genes in fecal samples revealed that Neo administration reverses HFD-induced intestinal microbiota dysbiosis: an increase in the diversity of gut microbiota and alteration in the composition of intestinal microbiota (particularly in the relative abundances of Bacteroidetes and Firmicutes). Furthermore, systemic antibiotic treatment abolishes the beneficial effects of Neo in body weight control, suggesting that the effect of Neo on obesity attenuation largely depends on the gut microbiota. More importantly, we demonstrate that the impact of Neo on the regulation of obesity could be transferred from Neo-treated mice to HFD-fed mice via fecal microbiota transplantation. Collectively, our data highlight the efficacy of Neo as a prebiotic agent for attenuating obesity, implying a potential mechanism for gut microbiota mediated the beneficial effect of Neo.

Toxoplasma gondii is an obligate intracellular protozoan parasite which seriously threatens the health of domestic animals and humans. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts greater than 200 nucleotides, which are widely involved in transcriptional and epigenetic regulations. However, little is known about the roles of host lncRNAs in the response to T. gondii infections. In this study, using Illumina sequencing technology, we analyzed the expression profiles of mRNAs and lncRNAs in BALB/c mouse brain following infection by T. gondii PRU strain (type II genotype) cysts. The identified differentially expressed (DE) RNAs were subjected to bioinformatics analysis. A total of 2,090 annotated lncRNAs along with 3,577 novel lncRNAs were identified. In the acutely infected mouse brain, a total of 330 mRNAs and 19 lncRNAs were dys-regulated, whereas 136 DE mRNAs and 9 DE lncRNAs were identified in chronically infected mouse brain. GO analysis revealed that these DE mRNAs identified at acute infection stage were involved in immune response, whereas DE mRNAs found at chronic infection stage were mostly enriched in response to protozoan. KEGG analysis showed that DE mRNAs were significantly enriched in disease related pathways. In addition, the putative mRNA-lncRNA co-expression network was constructed, and several hub regulatory RNAs were identified based on the transcriptome data. This study firstly characterized the co-expression profile of mRNAs and lncRNAs in mouse brain infected with T. gondii and provided a framework for further studies of the roles of lncRNAs in host neuropathology during toxoplasmosis progression.

Skeletal muscle regeneration is essential for maintaining muscle function in injury and muscular disease. Myogenesis plays key roles in forming new myofibers during the process. Here, through bioinformatic screen for the potential regulators of myogenesis from 5 independent microarray datasets, we identify an overlapping differentially expressed gene (DEG) optineurin (OPTN). Optn knockdown (KD) delays muscle regeneration in mice and impairs C2C12 myoblast differentiation without affecting their proliferation. Conversely, Optn overexpression (OE) promotes myoblast differentiation. Mechanistically, OPTN increases nuclear levels of β-catenin and enhances the T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription activity, suggesting activation of Wnt signaling pathway. The activation is accompanied by decreased protein levels of glycogen synthase kinase 3β (GSK3β), a negative regulator of the pathway. We further show that OPTN physically interacts with and targets GSK3β for autophagic degradation. Pharmacological inhibition of GSK3β rescues the impaired myogenesis induced by Optn KD during muscle regeneration and myoblast differentiation, corroborating that GSK3β is the downstream effector of OPTN-mediated myogenesis. Together, our study delineates the novel role of OPTN as a potential regulator of myogenesis and may open innovative therapeutic perspectives for muscle regeneration.

A new compound named koninginin W (1) and four known polyketides (2-5) were isolated from endophytic fungus Trichoderma koningiopsis YIM PH30002 of Panax notoginseng. The structures of 1 - 5, including absolute configuration of 1, were elucidated on the detailed analysis of the HR-ESI-MS, 1D and 2D NMR, and X-ray crystallographic data. Koninginin W (1) presented weak antibacterial activity against Escherichia coli, Bacillus subtilis and Salmonella typhimurium.

Two rearranged triterpenoids, representing new subtypes of pentacyclic triterpenoids, with unique 6/6/6/7/5 and 6/6/5/6/6/6 ring systems were isolated from

Endophytic fungi play important roles for host's stress tolerance including invasion by pathogenic microbes. Small molecules are common weapons in the microbe-microbe interactions. Panax notoginseng is a widely used traditional Chinese medicinal plant and harbors many endophytes, some exert functions against pathogens. Here, we report six new compounds named myrothins A-F (1-6) produced by Myrothecium sp. BS-31, an endophyte isolated from P. notoginseng, and their antifungal activities against pathogenic fungi causing host root-rot disease. Their structures were elucidated with analysis of spectroscopic data including 1D and 2D NMR, HR-ESI-MS. Myrothins B (2) and E (5) showed the weak activity against Fusarium oxysporum and Phoma herbarum, and myrothins F (6) showed weak activity against F. oxysporum.

Background: It is generally recognized that there is a risk for humans to acquire toxoplasmosis through consumption of raw milk from infected animals. Although several studies have been conducted to detect the seroprevalence of T. gondii in cattle in China, no study has been conducted to detect T. gondii DNA in milk of cattle in China. Thus, the present study was firstly conducted to explore the prevalence of T. gondii DNA in fresh milk of cattle in China. Results: A total of 2092 blood samples and fresh bovine milk were collected from six provinces between January 2018 and June 2019, respectively, and examined by ELISA and semi-nested PCR, respectively. In total, 123/2092 (5.88%) of the blood samples and 22/2092 (1.05%) of the milk samples were positive for T. gondii, respectively. Fifteen of these 22 positive milk samples (68.18%) were animals who also recorded serologically positive. Moreover, cattle and milk from family farming have significantly higher T. gondii prevalence than those from commercial farm. Conclusions: To our knowledge, this is the first report of T. gondii DNA was found in the fresh milk of cattle in China, suggesting that the consumption of raw milk from seropositive cattle could be a potential source of human infection.

A previous study described a novel serine protease inhibitor 16 from Musca domestica (MDSPI16), which inhibited the elastase and chymotrypsin. It also exhibited a potential anti-inflammatory activity for acute lung injury (ALI), while its effects on ALI are yet to be elucidated. The present study aimed to investigate the effects and the underlying mechanisms of MDSPI16 on lipopolysaccharide (LPS)-challenged mice and bone marrow neutrophils. The ALI model based on the results of LPS-induced mice demonstrated that MDSPI16 markedly reduced the infiltration of inflammatory cells, protein exudation in lung tissues, and downregulated the level of interleukin-6 (IL-6), IL-1β and tumor necrosis factor-α (TNF-α). Furthermore, the LPS-stimulated mouse bone marrow neutrophils model was employed to determine the role of MDSPI16. The cytokine levels were quantified by both the enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qRT-PCR). Consequently, the expression of IL-6, IL-1β, and TNF-α was found to be inhibited by MDSPI16 in a dose-dependent manner. Moreover, MDSPI16 also inhibited the mouse neutrophils nuclear factor-κB (NF-κB) signaling pathway, c-Jun N-terminal kinase (JNK) signaling pathway, ERK1/2 and AP-1 signaling pathway in addition to the expression of iNOS and COX-2 proteins, which in turn, might alleviate the release of pro-inflammatory cytokines during ALI. Therefore, MDSPI16 could be proposed as a potential and novel drug therapy for ALI.

In a Tesla-type pulse generator, self-inductance of the primary coil is a crucial parameter to determine the final oscillating condition. However, the accurate value of this inductance might be changed due to the uneven primary current distribution caused by practical configuration of the primary side. Consequently, in order to precisely design the transformer, it is helpful to evaluate the primary inductance based on electromagnetic simulation instead of conventional approximate calculation. In this paper, a simulation model based on the finite integration technique is established to solve the uneven primary current problem. A primary coil with multiple contacting points is designed, and hexahedral mesh generation of the coil is also discussed. Hence, a series of verification tests using different primary structures are performed to support the results of simulation. Both results of the simulation model and the verification test presented that the variation of the primary inductance will affect the performance of the generator, and the number of contacting points is the main cause to determine the maximum current density of the coil.

Considering the atomic spatial degrees of freedom, we investigate the Bell-nonlocality dynamics of two macroscopic fields interacting with a resonant two-level atom respectively. We show that the movement of the atomic center of mass can suppress the collapse and revival of the Bell-nonlocality of the fields, and the influence is relevant with the width of the atomic wave packets. The Bell-nonlocality can disappear in a finite time for larger width of the atomic wave packets.

The Radon–Fourier transform (RFT) with a long coherent integration time has recently been proposed for detecting a moving target with an across range cell (ARC) effect. However, without effective clutter suppression, clutter will also be integrated via the RFT, which may affect weak target detection. Based on the maximal signal-to-clutter-plus-noise ratio (SCNR) criteria, a novel adaptive RFT (ARFT) is proposed in this paper to effectively detect a “low-observable” target in a clutter background. The proposed ARFT can combine RFT and adaptive clutter suppression by introducing an optimal filter weight, which is determined from the clutter's covariance matrix as well as a steering vector for a moving target with the ARC effect. In the transformed range-velocity space, the proposed ARFT can suppress background clutter and optimally integrate the target's energy. Nevertheless, with the increase in the integration time, the ARFT needs to address two difficulties in its real implementation. One is the lack of independently and identically distributed (i.i.d.) training samples in a heterogeneous clutter background, and the other is that the computational complexity is too high due to the large number of pulse samples. Therefore, a subaperture ARFT (SA-ARFT) is further proposed in this paper. It divides all coherent pulse samples into several subapertures and accomplishes adaptive clutter suppression in each subaperture. Subsequently, SA-ARFT implements coherent integration among the outputs of different subapertures. The proposed SA-ARFT method can obtain a similar SCNR improvement factor (SCNR IF) with a large number of i.i.d. training samples, while it can obtain a much higher SCNR IF than the ARFT with limited i.i.d. training samples and much lower computational complexity in a heterogeneous clutter background. Finally, some numerical results are provided to demonstrate the effectiveness of the two proposed methods.

Mitochondrial aconitase (Aco2) catalyzes the conversion of citrate to isocitrate in the TCA cycle, which produces NADH and FADH2, driving synthesis of ATP through OXPHOS. In this study, to explore the relationship between adipogenesis and mitochondrial energy metabolism, we hypothesize that Aco2 may play a key role in the lipid synthesis. Here, we show that overexpression of Aco2 in 3T3-L1 cells significantly increased lipogenesis and adipogenesis, accompanied by elevated mitochondrial biogenesis and ATP production. However, when ATP is depleted by rotenone, an inhibitor of the respiratory chain, the promotive role of Aco2 in adipogenesis is abolished. In contrast to Aco2 overexpression, deficiency of Aco2 markedly reduced lipogenesis and adipogenesis, along with the decreased mitochondrial biogenesis and ATP production. Supplementation of isocitrate efficiently rescued the inhibitory effect of Aco2 deficiency. Similarly, the restorative effect of isocitrate was abolished in the presence of rotenone. Together, these results show that Aco2 sustains normal adipogenesis through mediating ATP production, revealing a potential mechanistic link between TCA cycle enzyme and lipid synthesis. Our work suggest that regulation of adipose tissue mitochondria function may be a potential way for combating abnormal adipogenesis related diseases such as obesity and lipodystrophy.

Lanthanum molybdate, La2Mo2O9, has been attracted considerable attention owing to its high concentration of intrinsic oxygen vacancies. In this paper, pure and phosphrous-doped La2Mo2O9 (LAMOX) is prepared by means of a modified precipitation method. The properties of the series of compounds have been characterized by thermal analysis (TGA-DTA), X-ray diffraction (XRD), scanning electron microscopy (SEM) and conductivity measured by a.c. impedance spectroscopy (IS). The electrical conductivity of pure La2Mo2O9 prepared by this method reaches a value of 0.15 S/cm at 800 °C, much higher than that of the sol-gel prepared material. P-doped La2Mo2O9 underwent a slightly structural phase transition, and the transition temperature is found to decrease with increasing P content. Electrical conductivity measurements show a slightly increase in the conductivity at low temperature after the tiny doping of P.

A new species of Diogenes Dana, 1851, Diogenes bispinatus sp. nov., is described from the South China Sea. It is closely allied to Diogenes dorotheae Morgan & Forest, 1991 and D. patae Asakura & Godwin, 2006, but it morphologically differs from the latter in the length of the antennular peduncle, the number of spines on the ocular acicle, the shape of the antennal acicle and the number of spines, the shape of the palm of left cheliped and telson. A key to the species of Diogenes from China seas is provided.

A method to investigate the effect of gas bubble on cell voltage oscillations was established. The whole aluminum electrolysis cell was treated as a resistance circuit, and the dynamic simulation of the cell equivalent circuit was modeled with Matlab/Simulink simulation software. The time-series signals of cell voltage and anode current were obtained under different bubble conditions, and analyzed by spectral and statistical analysis methods. The simulation results show that higher bubble release frequency has a significant effect on the cell voltage oscillations. When the bubble coverage of one anode block exceeds 80%, the cell voltage may exceed its normal fluctuation amplitude. The simulation also proves that the anode effect detected by computer in actual production is mainly the whole cell anode effect.

The prevalence of obesity has increased dramatically worldwide in the past ~50 years. Searching for safe and effective anti-obesity strategies are urgently needed. Lactucin, a plant-derived natural small molecule, is known for anti-malaria and anti-hyperalgesia. The study is to investigate whether lactucin plays a key role in adipogenesis. To this end, in vivo male C57BL/6 mice fed a high-fat diet (HFD) were treated with 20 mg/kg/day of lactucin or vehicle by gavage for seven weeks. Compared with vehicle-treated controls, Lactucin-treated mice showed lower body mass and mass of adipose tissue. Consistently, in vitro 3T3-L1 cells were treated with 20 &mu, M of lactucin. Compared to controls, lactucin-treated cells showed significantly less lipid accumulation during adipocyte differentiation and lower levels of lipid synthesis markers. Mechanistically, we showed the anti-adipogenic property of lactucin was largely limited to the early stage of adipogenesis. Lactucin-treated cells fail to undergo mitotic clonal expansion (MCE). Further studies demonstrate that lactucin-induced MCE arrests might result from reduced phosphorylation of JAK2 and STAT3. We then asked whether activation of JAK2/STAT3 would restore the inhibitory effect of lactucin on adipogenesis with pharmacological STAT3 activator colivelin. Our results revealed similar levels of lipid accumulation between lactucin-treated cells and controls in the presence of colivelin, indicating that inactivation of STAT3 is the limiting factor for the anti-adipogenesis of lactucin in these cells. Together, our results provide the indication that lactucin exerts an anti-adipogenesis effect, which may open new therapeutic options for obesity.

The principle and cost analysis of Constraint-Based Space-Time Adaptive Monopulse (C-STAM) are given. Based on the idea of cognitive radar, a novel Knowledge-Aided Constraint-Based Space-Time Adaptive Monopulse (KA-C-STAM) is proposed. With the knowledge given by a tracking filter in data processing, the KA-C-STAM improves the performance of angle estimation. Numerical examples verify the validity of the novel method.

Oxytocin (OXT), a nonapeptide posterior hormone of the pituitary, is mainly synthesized and secreted in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON). The present study was to investigate in which level, brain or periphery, OXT effecting on the behavioral activity in the behavioral despair depression rat model. The results showed that (1) either the forced swimming or the tail suspension significantly increased OXT concentration in the brain (PVN, SON, frontal cortex, hippocampus, amygdala, lumbar spinal cord) and in the periphery (posterior pituitary and serum); (2) intraventricular injection (icv) of OXT decreased the animal immobility time, whereas OXT receptor antagonist-desGly-NH2, d(CH2)5[D-Tyr2, Thr-sup-4]OV (icv) increased the animal immobility time in a dose-dependent manner in forced swimming test (FST) and in tail suspension test (TST); (3) neither OXT nor OXT receptor antagonist (intravenous injection) influenced the animal immobility time in FST and in TST. OXT levels were increased in several areas of the brain and in the periphery following the behavioral despair, one stressor, yet pre-treatment with OXT appeared to be beneficial in term of reducing immobility time. The data suggested that behavioral despair could enhance OXT synthesis and secretion not only in the brain but also in the periphery, and OXT in the brain rather than the periphery played a role in the behavioral despair depression.

The expected number of crossings of Buffon's needle problem is linear if the distance d between the lines of the ruled paper is less than or equal to the length l of the needle. With the help of Dynamic Geometry Super Sketchpad software, two vivid simulations of the linearity of Buffon's problem are given, that is, the expected number E(l ) satisfies E(x+y) = E(x) + E(y) and E(rx) = rE(x).

In order to choose a financial and suitable wind power system, the analysis of different wind power system is necessary. The paper reviewed several kinds of commonly used wind power system, given the topology structure same and different placesgenerator types respective advantages and disadvantages and applicable range of them. Compared and analysed direct-drive PMSG system and constant speed constant frequency SCIG system .Finally discussed the development trend of wind power generation system and the work emphasis in the future. It has certain reference value for research and choose of wind power system.

An electric control loading system for aircraft simulation was analyzed and modeled to find a linear state space mathematical model and state feedback. An optimal control scheme based on the minimum integral of the squared difference between desired and actual output was shown to be effective by comparing the output values of the system with previously obtained experimental data. A linear state space mathematical model and state feedback appear to provide satisfactory means for controlling an electric control loading system can be adjusted to simulate a wide variety of real aircraft by altering input and output gains at the force analog computer when aircraft parameters are changed.

The pore structure of coal rock atYangquan Xinjing mine in Shanxi Province is analyzed with mercury intrusion porosimetry to obtain the specific pore volume data and calculate the fractal dimension of coal pore surface. The pores are divided into macropore, mesopore and micropore according to radius size considering the calculated fractal dimension. The distribution characteristics of pore radius size, specific surface area and specific pore volume of different types are effectively analyzed. The research results show that mesopore surface has significantly fractal characteristics, which features could be discussed quantitatively. The proposed method in this paper has reference significance for studying the sorption and desorption properties, the diffussion and permeation of coalbed methane.

Along with development of the internet of things technology, it is more and more used in peoples life. In view of this, it introduced a kind of the monitoring system of the household robot based on the internet of things technology. It uses Internet communication technology of internet things and sensing technology, GSM/GPRS technology, to realize to monitor and control the household robot remotely. Speech recognition and remote control function through the touch screen provide a user friendly interface; network video, a cry for help " and "a key for help system provide the elderly and the disabled life safety with more reliable security. After operated, the system works normally.

A novel horizontal sensitive inertial micro-switch with low g value was proposed and simulated in ANSYS, and was fabricated on quartz substrate based on non-silicon surface micromaching technology. Due to this special design, the micro-switch has a very good horizontal unidirectional sensitivity. The contact effect is improved by a modification of the traditional design. The flexible contact between the proof mass electrode and fixed electrode prolongs the contact time and reduces the rebound effect. The contact time is about 100μs under a half-sine wave shock with a12g peak value.

This study focuses on estimation of clutter degrees of freedom (DOFs) for airborne multiple-input multiple-output (MIMO)-phased array radar. Firstly, two equivalent clutter models are presented, according to the transmitting subarray beampattern and synthetic-phased centre, and based on the basic steering vector. Secondly, a convenient estimating rule of clutter DOFs for airborne MIMO-phased array radar under arbitrary transmitting subarray structures is presented and proofed strictly. Finally, the simulated results indicate that airborne MIMO-phased array radar is effective both in spatial selectivity and clutter suppression, and the clutter DOFs under arbitrary transmitted subarray structures can be estimated by the proposed rule exactly. The proposed models and rule are suitable for both conventional-phased array radar and airborne MIMO radar with uniform or non-uniform transmitting subarray and sparse array, and they are valuable for the improvement of space-time adaptive processing algorithm performance.

With the continuous development of LED technology, LED is more and more applied to different fields such as lighting, control. In view of today's ential safety hazard brought by illegal driving, drunk driving and driver’s fatigue driving which lead to the occurrence of automobile rear-end collision and other problems, it put forward a economic, practical treatment and control system, and gave the reasonable design of intelligent vehicle control system based on LED technology and solutions. The system used SCM Atmega16 as the core, combined with LED and communication technology to realize all functions. After tested, it works well.

Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory pathway. Our previous study has demonstrated that OXT in the central nervous system rather than the blood circulation plays an important role in rat pain modulation. The communication tried to investigate the interaction between the OXT and pain modulation in Chinese patients with headache to understand the OXT effect on human pain modulation. The results showed that (1) intranasal OXT could relieve the human headache in a dose-dependent manner; (2) OXT concentration in both plasma and cerebrospinal fluid (CSF) increased significantly in headache patients in relation with the pain level; and (3) there was a positive relationship between plasma and CSF OXT concentration in headache patients. The data suggested that intranasal OXT, which was delivered to the central nervous system through olfactory region, could treat human headache and OXT might be a potential drug of headache relief by intranasal administration.

Along with the development of information system in industry, it becomes more and more important in the people’s life and industry. It introduced an alarm and navigation and positioning system with properties of information system, the system could position and gives an alarm autonomously in the vehicle and monitor outside the vehicle. As the normal running of the vehicle, the system can carry out navigation; in case of emergency, the system could alarm automatically or manually through the vehicle terminal equipment, and then, positioning the vehicle location through the information system of internet of things. After tested, the system works well and meets the requirements.

Used Atmega 8 microcontroller as the control center, with the temperature sensor DS18B20, feeding control system, combined with radio frequency technology, intelligent control system for fish-farming was designed. The system has the whole process of intelligent automatic control and testing for feeding, supplemental oxygen, and PID temperature regulation; PC and the host processor connect each other through the RS-485 to greatly improve the transmission distance, using CRC cyclic redundancy check code ensure the accuracy of data. The machine is mainly responsible for collecting the spot parameters such as temperature and transmitting the data to the host processor, and send data to PC by the host processor through the serial port to display. Using GSM short message service directly sends the relevant data to the console or the owner of the mobile phone, so as to realize the entire fish process automation management. The system can be widely used in families, and pond pisciculture, and provides the owners efficient and convenient services.

Besides the noise and possible target signal, the data received by radar often contains interference, which can significantly degrade the detection performance. This paper considers the problem of detecting a target in partially-known interference and unknown Gaussian noise. The interference is unknown, but it is constrained in a subspace orthogonal to the signal in the whitened space. According to the generalized likelihood ratio test (GLRT) criterion, we proposed an effective detector, which has improved detection performance than the corresponding Rao and Wald tests. Remarkably, the GLRT in the presence of interference has the same form as that in the absence of interference. However, the interference affects the detection performance of the detector. The effectiveness of the proposed detector is demonstrated by Monte Carlo simulations.

Cu(In,Ga)Se2 is a very important type of absorber layer material for high efficiency solar cells in material engineering. Cu(In,Ga)Se2 thin films were prepared on polyimide (PI) substrates coated with Mo by RF magnetron sputtering in one-stage at temperature below 450 °C. Samples with high level crystallization were deposited on polyimide coated with Mo by optimizing process parameters. Lower electric resistivity, better quality of CIGS absorber layer was fabricated in lower temperature by sputtering.

We propose a method to optimize the effective magnetoelectric voltage coefficient of fibrous composites made of piezoelectric and piezomagnetic phases. The optimization of magnetoelectricity is with respect to the crystallographic orientations and the volume fraction for the two materials. We show that the effective in-plane ( α E , 11 ∗ ) and out-of-plane ( α E , 33 ∗ ) coupling constants can be enhanced many-fold at the optimal orientation compared to those at normal orientation. For example, we show that the constants are 101 and 5 times larger for the optimal orientation of CoFe 2 O 4 fibers in a BaTiO 3 matrix of the optimized volume fraction compared to the normal orientation, while they are 43 and 5 times larger for BaTiO 3 fibers in a CoFe 2 O 4 matrix. The predictions are in good agreement with the finite element analysis.