92 results on '"Yingying Duan"'
Search Results
2. Coagulation performance and floc properties for synchronous removal of reactive dye and polyethylene terephthalate microplastics
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Yingying Duan, Jianhai Zhao, Xiuming Qiu, Xiaoli Deng, Xiaoyu Ren, Wenqi Ge, and Hongying Yuan
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Environmental Engineering ,General Chemical Engineering ,Environmental Chemistry ,Safety, Risk, Reliability and Quality - Published
- 2022
3. Bio-inspired modelling as a practical tool to manage giant panda population dynamics in captivity
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Haina Rong, Yingying Duan, Luis Valencia-Cabrera, Gexiang Zhang, Dunwu Qi, and Mario J. Pérez-Jiménez
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Computer Science Applications - Published
- 2022
4. Estimation of minimum viable population for giant panda ecosystems with membrane computing models
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Yingying Duan, Haina Rong, Gexiang Zhang, Dunwu Qi, Luis Valencia-Cabrera, and Mario J. Pérez-Jiménez
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Computer Science Applications - Published
- 2022
5. Genome-wide identification of R2R3-MYB Family Genes and their Response to Stress in Dendrobium nobile
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Liping Wu, Jizhou Fan, Xinglong Su, Weiyi Rao, Yingying Duan, Yuqing Wang, Weimin Jiang, Zongping Sun, Lei Zhang, Daiyin Peng, and Shihai Xing
- Abstract
R2R3-MYB is one of the largest and most important gene families, participating in the regulation of plant growth and development and response to abiotic stresses. However, the function of R2R3-MYB genes in Dendrobium nobile remains largely unknown. Here, a comprehensive genome-wide analysis of D. nobile R2R3-DnMYBs was performed, investigating phylogenic relationships, gene structures, motif composition, chromosomal locations, collinearity analysis, and cis-acting elements. Totally, 125 DnMYB genes were identified in the D. nobile genome, and they could be subdivided into 26 groups by further divided through phylogenetic analysis. Most genes with similar exon-intron structures and motif compositions in eaach subgroup exhibited similar functions. All of DnMYB genes were mapped on 19 chromosomes with the co-linearity relationship. Moreover, their expression patterns were analyzed in various tissues and abiotic stresses. The results showed that DnMYBs were significantly differential expressed in different tissues, following abiotic stresses and phytohormone treatments, indicating their possible roles in biological processes and some abiotic stress tolerance and adaptation. This work provides a comprehensive understanding of the R2R3-MYB family of D. nobile, and lays a foundation for future research on the potential function of DnMYB gene in the growth and development of D. nobile.
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- 2023
6. The crystal structure of tetra(imidazole-κ1 N)zinc(II) μ2-oxido-hexaoxido-divanadium(VI) C12H16N8O6V2Zn
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Yueyang Huo, Shiqi Fu, Yanqi Shi, Yingying Duan, and Meiyu Zhang
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Inorganic Chemistry ,General Materials Science ,Condensed Matter Physics - Abstract
C12H16N8O6V2Zn, triclinic, P 1 ‾ $P\overline{1}$ (no. 2), a = 9.5397(4) Å, b = 10.2457(4) Å, c = 11.0920(4) Å, α = 92.848(1)°, β = 110.314(1)°, γ = 94.421(1)°, V = 1010.29(7) Å3, Z = 2, Rgt (F) = 0.0358, wRref (F 2) = 0.0932, T = 293 K.
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- 2022
7. A bibliometric analysis of membrane computing (1998–2019)
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Haina Rong, Yingying Duan, and Gexiang Zhang
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Computational Theory and Mathematics ,Applied Mathematics - Published
- 2022
8. Axonal transport deficits in the pathogenesis of diabetic peripheral neuropathy
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Cunqing Yang, Xuefei Zhao, Xuedong An, Yuehong Zhang, Wenjie Sun, Yuqing Zhang, Yingying Duan, Xiaomin Kang, Yuting Sun, Linlin Jiang, and Fengmei Lian
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Endocrinology, Diabetes and Metabolism - Abstract
Diabetic peripheral neuropathy (DPN) is a chronic and prevalent metabolic disease that gravely endangers human health and seriously affects the quality of life of hyperglycemic patients. More seriously, it can lead to amputation and neuropathic pain, imposing a severe financial burden on patients and the healthcare system. Even with strict glycemic control or pancreas transplantation, peripheral nerve damage is difficult to reverse. Most current treatment options for DPN can only treat the symptoms but not the underlying mechanism. Patients with long-term diabetes mellitus (DM) develop axonal transport dysfunction, which could be an important factor in causing or exacerbating DPN. This review explores the underlying mechanisms that may be related to axonal transport impairment and cytoskeletal changes caused by DM, and the relevance of the latter with the occurrence and progression of DPN, including nerve fiber loss, diminished nerve conduction velocity, and impaired nerve regeneration, and also predicts possible therapeutic strategies. Understanding the mechanisms of diabetic neuronal injury is essential to prevent the deterioration of DPN and to develop new therapeutic strategies. Timely and effective improvement of axonal transport impairment is particularly critical for the treatment of peripheral neuropathies.
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- 2023
9. Magnesium Hydroxide Slurry Coagulation-Adsorption Performance for Reactive Orange Removal Assisted with PAM
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Xiaoli Deng, Jianhai Zhao, Xiuming Qiu, Yingying Duan, Xiaoyu Ren, Wenpu Li, Rong Mu, and Hongying Yuan
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Environmental Engineering ,Ecological Modeling ,Environmental Chemistry ,Pollution ,Water Science and Technology - Published
- 2023
10. Renoprotective Effects of Angiotensin-Converting Enzyme Inhibitors (Acei) And/Or Angiotensin Ii Receptor Blockers (Arb) in Diabetic Kidney Disease
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Yuting Sun, Ziwei Zhang, Wenjie Sun, De Jin, Xuedong An, Yuehong Zhang, Cunqing Yang, Yuqing Zhang, Yingying Duan, Xiaomin Kang, Linlin Jiang, Xuefei Zhao, and FengMei Lian
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- 2023
11. Photomagnetic-chiral anisotropy of chiral nanostructured gold films
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Zexi Liu, Jing Ai, Te Bai, Yuxi Fang, Kun Ding, Yingying Duan, Lu Han, and Shunai Che
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General Chemical Engineering ,Biochemistry (medical) ,Materials Chemistry ,Environmental Chemistry ,General Chemistry ,Biochemistry - Published
- 2022
12. Photomagnetic-chiral anisotropy of chiral nanostructured gold films
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Lu Han, Liu Zexi, Kun Ding, Yuxi Fang, Jing Ai, Shunai Che, Te Bai, and Yingying Duan
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Materials science ,Condensed matter physics ,Spin polarization ,Spins ,General Chemical Engineering ,Biochemistry (medical) ,Photomagnetic effect ,General Chemistry ,Spin–orbit interaction ,Biochemistry ,Magnetic field ,Atomic orbital ,Materials Chemistry ,Environmental Chemistry ,Condensed Matter::Strongly Correlated Electrons ,Spin (physics) ,Anisotropy - Abstract
Summary The photomagnetic effect is known to be related only to transition metal atoms with empty orbitals and spin-state changes. In general, noble metals with high electron density cannot be used as photomagnetic materials because of the absence of spin polarization. However, here, we found that photomagnetic-chiral anisotropy (PM-ChA) was generated in chiral nanostructured Au films (CNAFs), and opposite photomagnetic fields (PMFs) were created in the antipodal CNAFs under unpolarized irradiation. The PM-ChA was speculated to arise from directional alignment of opposite spins polarized by the asymmetric spin-orbit coupling due to the opposite effective magnetic fields induced by electron motion in the antipodal helical structure. PM-ChA can be applied in enantiomeric quantification, probably because of the spin polarization coupling between CNAFs and enantiomers. PM-ChA of noble metals generated by directional spin control in helical nanostructures could provide new strategies in quantum technology and theories in magnetophysics.
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- 2022
13. Enantioselective Interaction between Cells and Chiral Hydroxyapatite Films
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Chao Zhou, Shaoyang Zhang, Jing Ai, Ping Li, Yanjie Zhao, Baojie Li, Lu Han, Yingying Duan, and Shunai Che
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General Chemical Engineering ,Materials Chemistry ,General Chemistry - Published
- 2021
14. Spontaneous chiral self-assembly of CdSe@CdS nanorods
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Shunai Che, Tianwei Duan, Lu Han, Jingang Jiang, Yingying Duan, Jing Ai, Xiaoyan Cui, and Xiaowei Feng
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Materials science ,Chalcogenide ,General Chemical Engineering ,Biochemistry (medical) ,Binding energy ,General Chemistry ,Crystal structure ,Biochemistry ,Crystallography ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,Environmental Chemistry ,Nanorod ,Self-assembly ,Homochirality ,Enantiomeric excess ,Chiral symmetry breaking - Abstract
Summary The enantiomeric excess phenomenon in spontaneous chiral symmetry breaking (SCSB) is a crucial issue in the origin of homochirality in nature, whereas chiral inorganic compounds have long been reckoned as racemates. Here, we report the SCSB in the self-assembly of cadmium chalcogenide nanorods, leading to chiral biases away from the racemate. In the presence of achiral organics, helical CdSe@CdS nanorods (HCCNs) with unidirectionally rotated crystal lattices along the rod axis were stochastically formed on the epitaxial interface of the {111}cub/{0001}hex planes. The stability of helical dislocation structures, as supported by a theoretical analysis of their binding energies, suggested the possibility of the emergence of helical structures in an achiral environment. Hierarchical chiral films induced by simple solvent evaporation self-assembly of HCCNs exhibited spontaneous enantiomeric excess between batches, which was speculated to be originated from the enantiomeric excess seed assembly that induce one-handedness dominated system based on the majority rules.
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- 2021
15. DTTrack: Target Tracking Algorithm Combining DaSiamRPN Tracker and Transformer Tracker
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Yingying Duan, Wencong Wu, Liwei Liu, Siyuan Liu, Peng Liang, and Yungang Zhang
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- 2022
16. Effective prediction of potential ferroptosis critical genes in clinical colorectal cancer
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Hongliang, Huang, Yuexiang, Dai, Yingying, Duan, Zhongwen, Yuan, Yanxuan, Li, Maomao, Zhang, Wenting, Zhu, Hang, Yu, Wenfei, Zhong, and Senling, Feng
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Cancer Research ,Oncology - Abstract
BackgroundColon cancer is common worldwide, with high morbidity and poor prognosis. Ferroptosis is a novel form of cell death driven by the accumulation of iron-dependent lipid peroxides, which differs from other programmed cell death mechanisms. Programmed cell death is a cancer hallmark, and ferroptosis is known to participate in various cancers, including colon cancer. Novel ferroptosis markers and targeted colon cancer therapies are urgently needed. To this end, we performed a preliminary exploration of ferroptosis-related genes in colon cancer to enable new treatment strategies.MethodsFerroptosis-related genes in colon cancer were obtained by data mining and screening for differentially expressed genes (DEGs) using bioinformatics analysis tools. We normalized the data across four independent datasets and a ferroptosis-specific database. Identified genes were validated by immunohistochemical analysis of pathological and healthy clinical samples.ResultsWe identified DEGs in colon cancer that are involved in ferroptosis. Among these, five core genes were found: ELAVL1, GPX2, EPAS1, SLC7A5, and HMGB1. Bioinformatics analyses revealed that the expression of all five genes, except for EPAS1, was higher in tumor tissues than in healthy tissues.ConclusionsThe preliminary exploration of the five core genes revealed that they are differentially expressed in colon cancer, playing an essential role in ferroptosis. This study provides a foundation for subsequent research on ferroptosis in colon cancer.
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- 2022
17. Chiral hierarchical structure of bone minerals
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Masaya Nagai, Shunai Che, Ting Ji, Chao Zhou, Jing Ai, Yingying Duan, Xueliang Zhang, and Lu Han
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inorganic chemicals ,Acicular ,Mineral ,Materials science ,organic chemicals ,Stacking ,Structural integrity ,Condensed Matter Physics ,Fibril ,Atomic and Molecular Physics, and Optics ,Collagen fibril ,Bragg resonance ,Chemical physics ,General Materials Science ,Electrical and Electronic Engineering ,Chirality (chemistry) - Abstract
Chirality is an indispensable integral of biological system. As an important part of organisms, chiral organic structure of bone has been extensively investigated. However, the chirality of bone minerals is unclear and not fully determined. Here, we report nine levels of fractal-like chirality of bone minerals by combining electron microscopic and spectrometric characterizations. The primary helically twisted acicular apatite crystals inside collagen fibrils and between fibrils merge laterally to form secondary helical subplatelets. The chiral arrangement of several subplatelets forms tertiary spiral mineral platelets. Further coherent stepwise stacking of mineral platelets with collagen fibrils leads to quaternary to ninth levels, which reconciled the previous conflicting models. The optical activities in the UV-visible, infrared and terahertz regions demonstrated chirality from atomic to macroscopic scales based on circularly selective absorption and Bragg resonance at different levels of chirality. Our findings provide new insight into the structural integrity of bone, osteology, forensic medicine and archaeology and inspire the design of novel biomaterials.
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- 2021
18. Resistance‐Chiral Anisotropy of Chiral Mesostructured Half‐metallic Fe 3 O 4 Films
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Te Bai, Jing Ai, Jie Ma, Yingying Duan, Lu Han, Jingang Jiang, and Shunai Che
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General Medicine - Published
- 2021
19. Resistance‐Chiral Anisotropy of Chiral Mesostructured Half‐metallic Fe 3 O 4 Films
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Lu Han, Jie Ma, Jing Ai, Shunai Che, Jingang Jiang, Yingying Duan, and Te Bai
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Quantitative Biology::Biomolecules ,Materials science ,Condensed matter physics ,Spin polarization ,High Energy Physics::Lattice ,Stacking ,General Chemistry ,Crystal structure ,Catalysis ,Metal ,Electrical resistivity and conductivity ,visual_art ,visual_art.visual_art_medium ,Half-metal ,Chirality (chemistry) ,Anisotropy - Abstract
Half-metallic materials are theoretically predicted to be metallic and insulating, which have not been confirmed experimentally, and the predictions are still in doubt. We report the resistance-chiral anisotropy (R-ChA), i.e., chirality-dependent electrical conductivity, in chiral mesostructured Fe3 O4 films (CMFFs) grown on the substrates via a hydrothermal method using amino acids as symmetry-breaking agents. Two levels of chirality exist in the CMFFs: primary distortion of the crystal lattice forms twisted nanoflakes, and secondary helical stacking of nanoflakes forms fan-shaped nanoplates. At temperatures below 30 K, the CMFFs exhibited metallic conductivity and insulation for one handedness and the other, respectively. The chirality-dependent effective magnetic fields were speculated to stabilize the opposite spin in the antipodal chiral frame, which led to the free transport of electrons in one handedness of the chiral structure and immobility for the other handedness.
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- 2021
20. Self-Assembly of Chiral Nematic-Like Films with Chiral Nanorods Directed by Chiral Molecules
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Yingying Duan, Tianwei Duan, Lu Han, Shunai Che, and Jing Ai
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Crystallography ,Materials science ,Liquid crystal ,General Chemical Engineering ,Materials Chemistry ,Nanorod ,General Chemistry ,Self-assembly - Published
- 2021
21. Chiral Mesostructured Inorganic Materials with Optical Chiral Response
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Yingying Duan and Shunai Che
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Abstract
Fabricating chiral inorganic materials and revealing their unique quantum confinement-determined optical chiral responses are crucial tasks in the multidisciplinary fields of chemistry, physics and biology. The field of chiral mesostructured inorganic materials started from the synthesis of individual nanocrystals and evolved to include their assembly from metals, semiconductors, ceramics, and inorganic salts endowed with various chiral structures ranging from atomic to micron scales. This tutorial review highlights the recent research on chiral mesostructured inorganic materials, especially the novel expression of mesostructured chirality and endowed optical chiral response, and it may inspire us with new strategies for the design of chiral inorganic materials and new opportunities beyond the traditional applications of chirality. Fabrication methods for chiral mesostructured inorganic materials are classified according to chirality type, scale, and symmetry-breaking mechanism. Special attention is given to highlight systems with original discoveries, exceptional phenomena, or unique mechanisms of optical chiral response for left- and right-handedness. This article is protected by copyright. All rights reserved.
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- 2022
22. Evaluation of the coagulation properties of magnesium hydroxide for removal combined contamination of reactive dyes and microfibers
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Yingying, Duan, Jianhai, Zhao, Xiuming, Qiu, Xiaoli, Deng, Xiaoyu, Ren, Wenqi, Ge, and Hongying, Yuan
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Health, Toxicology and Mutagenesis ,Environmental Chemistry ,General Medicine ,Pollution - Abstract
Microfibers are a new type of pollutants that are widely distributed in water bodies. And the simultaneous removal of pollutants in water is popular research in the field of water treatment. In this study, magnesium hydroxide was used as coagulant to investigate the performance and mechanism of coagulation and removal of dyes (reactive orange) and microfibers (MFs). The presence of dyestuff in the composite system promoted the removal of microfibers, and the maximum removal efficiency of both could reach 95.55% and 95.35%. The coagulation mechanism was explored by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and zeta potential. The removal of reactive orange and microfibers relied on electrical neutralization, sweep flocculation and adsorption mechanisms. Turbidity can enhance the removal efficiency of both. Boosting the rotational speed can increase the removal efficiency of microfibers. This study provides an important theoretical support for an in-depth understanding of the characteristics and mechanisms of coagulation for the removal of complex pollutants from printing and dyeing wastewater.
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- 2022
23. Synchronous Analysis of Chiral Mesostructured Inorganic Crystals Using Three-dimensional Electron Crystallography
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Jing Ai, Xueliang Zhang, Te Bai, Qing Shen, Peter Oleynikov, Yingying Duan, Osamu Terasaki, Shunai Che, and Lu Han
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Chiral mesostructures exhibit distinctive twisting and helical hierarchical stacking ranging from atomic to micrometre scales. A detailed analysis of these materials is key to understanding their characteristic chiral anisotropy. However, the determination of these multilevel chirality remains challenging due to the limited information from spectroscopy, diffraction techniques, scanning electron microscopy and the two-dimensional projections in transmission electron microscopy. Herein, we report a general approach to determine chiral hierarchical mesostructures based on three-dimensional electron diffraction tomography (3D EDT), by which the structure can be solved synchronously according to the quantitative measurement of diffraction spot deformations and their arrangement in reciprocal space. This method was verified on two samples—chiral mesostructured nickel molybdate and chiral mesostructured tin dioxide—revealing hierarchical chiral structures that cannot be determined by conventional techniques. This approach provides more precise and comprehensive identification of the hierarchical mesostructures, which is expected to advance our understanding of structural–chiral anisotropy at the fundamental level.
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- 2022
24. Synchronous quantitative analysis of chiral mesostructured inorganic crystals by 3D electron diffraction tomography
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Jing Ai, Xueliang Zhang, Te Bai, Qing Shen, Peter Oleynikov, Yingying Duan, Osamu Terasaki, Shunai Che, and Lu Han
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Multidisciplinary ,General Physics and Astronomy ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Abstract
Chiral mesostructures exhibit distinctive twisting and helical hierarchical stacking ranging from atomic to micrometre scales with fascinating structural-chiral anisotropy properties. However, the detailed determination of their multilevel chirality remains challenging due to the limited information from spectroscopy, diffraction techniques, scanning electron microscopy and the two-dimensional projections in transmission electron microscopy. Herein, we report a general approach to determine chiral hierarchical mesostructures based on three-dimensional electron diffraction tomography (3D EDT), by which the structure can be solved synchronously according to the quantitative measurement of diffraction spot deformations and their arrangement in reciprocal space. This method was verified on two samples—chiral mesostructured nickel molybdate and chiral mesostructured tin dioxide—revealing hierarchical chiral structures that cannot be determined by conventional techniques. This approach provides more precise and comprehensive identification of the hierarchical mesostructures, which is expected to advance our understanding of structural–chiral anisotropy at the fundamental level.
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- 2022
25. Chiral Mesostructured NiO Films with Spin Polarisation
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Junwei Luo, Lu Han, Shunai Che, Yingying Duan, Cheng Song, Te Bai, Jing Ai, and Liyang Liao
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Materials science ,Condensed matter physics ,010405 organic chemistry ,Magnetic circular dichroism ,Non-blocking I/O ,Stacking ,General Chemistry ,General Medicine ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Magnetic field ,Electron transfer ,Electric field ,Condensed Matter::Strongly Correlated Electrons ,Chirality (chemistry) ,Spin (physics) - Abstract
Spin polarisation is found in the centrosymmetric nonferromagnetic crystals, chiral mesostructured NiO films (CMNFs), fabricated through the symmetry-breaking effect of a chiral molecule. Two levels of chirality were identified: primary nanoflakes with atomically twisted crystal lattices and secondary helical stacking of the nanoflakes. Spin polarisation of the CMNFs was confirmed by chirality-dependent magnetic-tip conducting atomic force microscopy (mc-AFM) and magnetic field-independent magnetic circular dichroism (MCD). Electron transfer in the symmetry-breaking electric field was speculated to create chirality-dependent effective magnetic fields. The asymmetric spin-orbit coupling (SOC) generated by effective magnetic fields selectively modifies the opposite spin motion in the antipodal CMNFs. Our findings provide fundamental insights for directional spin control in unprecedented functional inorganic materials.
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- 2021
26. A novel hybrid PSO based on levy flight and wavelet mutation for global optimization
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Yong Gao, Hao Zhang, Yingying Duan, and Huaifeng Zhang
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Multidisciplinary - Abstract
The concise concept and good optimization performance are the advantages of particle swarm optimization algorithm (PSO), which makes it widely used in many fields. However, when solving complex multimodal optimization problems, it is easy to fall into early convergence. The rapid loss of population diversity is one of the important reasons why the PSO algorithm falls into early convergence. For this reason, this paper attempts to combine the PSO algorithm with wavelet theory and levy flight theory to propose a new hybrid algorithm called PSOLFWM. It applies the random wandering of levy flight and the mutation operation of wavelet theory to enhance the population diversity and seeking performance of the PSO to make it search more efficiently in the solution space to obtain higher quality solutions. A series of classical test functions and 19 optimization algorithms proposed in recent years are used to evaluate the optimization performance accuracy of the proposed method. The experimental results show that the proposed algorithm is superior to the comparison method in terms of convergence speed and convergence accuracy. The success of the high-dimensional function test and dynamic shift performance test further verifies that the proposed algorithm has higher search stability and anti-interference performance than the comparison algorithm. More importantly, both t-Test and Wilcoxon’s rank sum test statistical analyses were carried out. The results show that there are significant differences between the proposed algorithm and other comparison algorithms at the significance level α = 0.05, and the performance is better than other comparison algorithms.
- Published
- 2023
27. Effect of Chinese Patent Medicines on Ocular Fundus Signs and Vision in Calcium Dobesilate-Treated Persons With Non-Proliferative Diabetic Retinopathy: A Systematic Review and Meta-Analysis
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Yuehong Zhang, Xuedong An, Liyun Duan, De Jin, Yingying Duan, Rongrong Zhou, Yuqing Zhang, Xiaomin Kang, and Fengmei Lian
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Endocrinology, Diabetes and Metabolism - Abstract
BackgroundDiabetic retinopathy (DR), one of the commonest microvascular complications in diabetic patients, is featured by a series of fundus lesions. Conventional Western medicine therapies for DR are always with modest treatment outcome. This paper is to assess the ocular fundus signs, vision and safety of Chinese patent medicines (CPMs) as an add-on treatment for DR.Method7 electronic databases were searched to determine eligible trials. Randomized controlled trials (RCTs) of non-proliferative diabetic retinopathy (NPDR) in which the intervention group received CPMs combined with calcium dobesilate (CD), and the control group received only CD were included for analysis. Two reviewers extracted the data independently. Results expressing as mean differences (MD) and relative risks (RR) were analyzed with a fixed-effects or random-effects models.Results19 RCTs involved 1568 participants with 1622 eyes met our inclusion criteria. The results suggested that compared with CD alone, CPMs plus CD for NPDR was superior at reducing the microaneurysm volume (MD -3.37; 95% confidence interval [CI], -3.59 to -3.14), microaneurysm counts (MD -2.29; 95%CI -2.97 to -1.61), hemorrhage area (MD -0.79; 95%CI -0.83 to -0.75), and macular thickness (MD -59.72; 95%CI -63.24 to -56.20). Participants in CPMs plus CD group also achieved a better vision. No obvious adverse events occurred.ConclusionCPMs as an add-on therapy for NPDR have additional benefits and be generally safe. This meta‐analysis demonstrated that CPMs combined with CD could improve retinal microaneurysm, hemorrhage, macular thickness, visual acuity, fasting blood glucose (FBG), and glycosylated hemoglobin (HbAlc) compared with CD alone. Further studies are needed to provide more conclusive evidence.Systematic Review RegistrationPROSPERO https://www.crd.york.ac.uk/prospero/, identifier CRD42021257999.
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- 2022
28. Bibliometric Analysis of Renal Fibrosis in Diabetic Kidney Disease From 1985 to 2020
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Yuqing Zhang, De Jin, Yingying Duan, Yuehong Zhang, Liyun Duan, Fengmei Lian, and Xiaolin Tong
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Male ,China ,Databases, Factual ,Public Health, Environmental and Occupational Health ,CiteSpace ,renal fibrosis ,Fibrosis ,diabetic kidney disease ,United States ,Bibliometrics ,Diabetes Mellitus ,Humans ,Diabetic Nephropathies ,Female ,Public aspects of medicine ,RA1-1270 ,cluster analysis - Abstract
BackgroundDiabetic renal fibrosis (DRF) is an irreversible renal pathological change in the end-stage of diabetic kidney disease (DKD), which plays a significant role in the development and deterioration of the disease. However, data for bibliometric analysis of renal fibrosis in DKD is currently missing. This study aimed to provide a comprehensive and visualized view of DRF research and lay the foundation for further studies.Materials and MethodsFirstly, the data was collected from the Web of Science Core Collection (WoSCC) database. Secondly, the Web of Science analytic tool was performed to analyze publication years, authors, countries/regions, organizations, and citation frequency. Finally, CiteSpace was employed to construct a visualization bibliometric network to reveal the emerging trends and hotspots of DRF.ResultsA total of 3,821 publications from 1985 to 2020 were included in this study. The number of publications has maintained a growth trend since 2003. Cooper is the most prolific author in this field, and the American Journal of Physiology-Renal Physiology ranking as first place compared with other journals. In terms of the number of publications, China contributed the most to DRF. Monash University is the organization that published the most papers. The top 5 clusters of keyword co-appearance are “chronic kidney disease”, “primary biliary cirrhosis”, “receptor”, “TGF-beta”, “renal tubulointerstitium”. The top 5 clusters of reference co-citation are “microRNAs”, “bone morphogenetic protein”, “hypertrophy”, “glomerulosclerosis”, “diabetic kidney disease”. The strongest citation burst of keyword is “diabetic kidney disease” and the strongest burst of cited reference is “Meng, 2016”.ConclusionsThe present study analyzed the research hotspots, Frontiers, and development trend of DRF and have important implications for future research.
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- 2022
29. A Review of Membrane Computing Models for Complex Ecosystems and a Case Study on a Complex Giant Panda System
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Gexiang Zhang, Yingying Duan, Mario J. Pérez-Jiménez, Dunwu Qi, Luis Valencia-Cabrera, Haina Rong, Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial, Universidad de Sevilla. TIC193: Computación Natural, and Ministerio de Economia, Industria y Competitividad (MINECO). España
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Article Subject ,General Computer Science ,Computer science ,Semantics (computer science) ,Modularity (biology) ,Population ,0102 computer and information sciences ,02 engineering and technology ,01 natural sciences ,0202 electrical engineering, electronic engineering, information engineering ,Ecosystem ,education ,Membrane computing ,education.field_of_study ,Multidisciplinary ,Syntax (programming languages) ,biology ,QA75.5-76.95 ,biology.organism_classification ,Data science ,Field (geography) ,010201 computation theory & mathematics ,Electronic computers. Computer science ,020201 artificial intelligence & image processing ,Bacteria ,Global biodiversity - Abstract
Ecosystem modelling based on membrane computing is emerging as a powerful way to study the dynamics of (real) ecological populations. *ese models, providing distributed parallel devices, have shown a great potential to imitate the rich features observed in the behaviour of species and their interactions and key elements to understand and model ecosystems. Compared with differential equations, membrane computing models, also known as P systems, can model more complex biological phenomena due to their modularity and their ability to enclose the evolution of different environments and simulate, in parallel, different interrelated processes. In this paper, a comprehensive survey of membrane computing models for ecosystems is given, taking a giant panda ecosystem as an example to assess the model performance. *is work aims at modelling a number of species using P systems with different membrane structure types to predict the number of individuals depending on parameters such as reproductive rate, mortality rate, and involving processes as rescue or release. Firstly, the computing models are introduced conceptually, describing the main elements constituting the syntax of these systems and explaining the semantics of the rules involved. Next, various modelled species (including endangered animals, plants, and bacteria) are summarized, and some computer tools are presented. *en, a discussion follows on the use of P systems for ecosystem modelling. Finally, a case study on giant pandas in Chengdu Base is analysed, concluding that the study in this field by using PDP systems can provide a valuable tool to deepen into the knowledge about the evolution of the population. *is could ultimately help in the decision-making processes of the managers of the ecosystem to increase the species diversity and modify the adaptability. Besides, the impacts of natural disasters on the population dynamics of the species should also be considered. *e analysis performed throughout the paper has taken into consideration this fact in order to increase the reliability of the prospects making use of the models designed. Ministerio de Economía, Industria y Competitividad TIN2017-89842-P (MABICAP)
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- 2020
30. Enantiomeric Discrimination by Surface‐Enhanced Raman Scattering–Chiral Anisotropy of Chiral Nanostructured Gold Films
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Zexi Liu, Jing Ai, Prashant Kumar, Enming You, Xiong Zhou, Xi Liu, Zhongqun Tian, Petr Bouř, Yingying Duan, Lu Han, Nicholas A. Kotov, Songyuan Ding, and Shunai Che
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General Medicine - Published
- 2020
31. Group Self-Paced Learning With a Time-Varying Regularizer for Unsupervised Change Detection
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Maoguo Gong, Yingying Duan, and Hao Li
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Artificial neural network ,Computer science ,business.industry ,Feature extraction ,0211 other engineering and technologies ,Pattern recognition ,02 engineering and technology ,Backpropagation ,Support vector machine ,Robustness (computer science) ,Softmax function ,General Earth and Planetary Sciences ,Artificial intelligence ,Electrical and Electronic Engineering ,business ,Change detection ,021101 geological & geomatics engineering - Abstract
Unsupervised change detection based on supervised or semisupervised classifiers has achieved strong adaptability and robustness to obtain satisfactory change detection results. However, these methods suffer from an issue that it is hard to collect reliable training samples in an unsupervised manner. In this article, a group self-paced learning (GSPL) framework is proposed to mine the reliable training samples. In the proposed method, each sample is assigned a weight to indicate its reliability. The proposed scheme is able to learn the weighted samples and update the weights iteratively in a self-paced manner to identify the reliable training samples. In the phase of updating weights, a grouping strategy is designed to avoid selecting training samples from homogeneous regions. Furthermore, a novel time-varying self-paced regularizer is proposed to automatically determine the learning scheme of self-paced learning. Finally, three classifiers, including SoftMax, backpropagation neural network, and support vector machine, are investigated under this proposed framework. Experiments on five change detection data sets demonstrate that the proposed framework can significantly outperform those state-of-art methods for change detection in terms of accuracy and robustness.
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- 2020
32. Evaluation of Jinlida Granules in Improvements to Standard-Reaching Rate of Blood Glucose and Type 2 Diabetes Mellitus Symptoms: Results of Secondary Analysis From 12-Week Trial
- Author
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De Jin, Yuqing Zhang, Yingying Duan, Xudong An, Xiaomin Kang, Fengmei Lian, and Xiaolin Tong
- Abstract
Background The previous study found that the Jinlida could significantly reduce levels of blood glucose and enhance the lowing-glucose action of metformin. However, the role of the standard-reaching rate of blood glucose and improving clinical symptoms in Jinlida has yet to be studied. We aimed to elaborate on the efficacy of Jinlida in Type 2 diabetics who experience clinical symptoms based on secondary analysis from the 12-week trial. Methods Data were analyzed from a 12-week, randomized, placebo-controlled, study of Jinlida. The standard-reaching rate of blood glucose, total symptom score, the efficacy of single symptom, symptom disappearance rate, symptom improvement rate was evaluated. Then, the correlation of the symptom effective rate and HbA1c was analyzed. Results 192 T2DM patients were randomly allocated to receive either Jinlida or a placebo for 12 consecutive weeks. The standard-reaching rate of HbA1c (
- Published
- 2021
33. Spin Selectivity of Chiral Mesostructured Iron Oxides with Different Magnetisms
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Te Bai, Jing Ai, Yingying Duan, Lu Han, and Shunai Che
- Subjects
Biomaterials ,General Materials Science ,General Chemistry ,Biotechnology - Abstract
Spin selectivity physically depends on either magnetic materials with strong internal magnetic fields or symmetry-breaking materials with large spin-orbit coupling (SOC). However, the spin selectivity of symmetry-breaking magnetic materials is not understood. Herein, the spin selectivity of iron oxides with different magnetisms arising from varying spin alignment is investigated. Chiral mesostructured films of Fe
- Published
- 2021
34. Mechanism of diastereoisomer-induced chirality of BiOBr
- Author
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Kun Ding, Jing Ai, Yingying Duan, Lu Han, Zhibei Qu, and Shunai Che
- Subjects
High Energy Physics::Lattice ,High Energy Physics::Phenomenology ,General Chemistry - Abstract
Chiral molecule-driven asymmetric structures are known to be elusive because of the intriguing chirality transfer from chiral molecules to achiral species. Here, we found that the chiral assembly of BiOBr is independent of the chirality of the organic molecular inducer but dependent on geometric structural matching between the inducer and inorganic species. Diastereoisomeric sugar alcohols (DSAs) with identical numbers of carbon chiral centers and functional groups but with different
- Published
- 2021
35. Lychee Seed as a Potential Hypoglycemic Agent, and Exploration of its Underlying Mechanisms
- Author
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Yuehong Zhang, Xuedong An, De Jin, Liyun Duan, Yingying Duan, and Fengmei Lian
- Subjects
Review ,RM1-950 ,Sapindaceae ,chemistry.chemical_compound ,Insulin resistance ,Diabetes mellitus ,lychee seed ,medicine ,pharmacological mechanisms ,Pharmacology (medical) ,Pharmacology ,diabetes ,Traditional medicine ,biology ,effect ,food and beverages ,biology.organism_classification ,medicine.disease ,chemistry ,Phytochemical ,diet supplements ,Disease prevention ,Therapeutics. Pharmacology ,Procyanidin A2 ,Quercetin ,Lipid regulation - Abstract
Food is people’s primal want. A reasonable diet and healthy food not only provide nutrients for human growth but also contribute to disease prevention and treatment, while following an unhealthy diet can lead to an increased risk of many diseases, especially metabolic disorders, such as diabetes. Nature is enriched with different food sources, and it seems that purely natural products are more in line with the current concept of health, which enhance the formation of the notion that “Food/Diet Supplements from Natural Sources as a Medicine.” As a delicious fruit, the medicinal values such as anticancer, antibacterial, antioxidation, and antiglycating properties of lychee have been found. Lychee (Litchi in Chinese) is a subtropical fruit plant belonging to the family Sapindaceae. It has been widely cultivated in warm climates worldwide, particularly in China, for thousands of years. In recent years, various phytochemical components such as quercetin, procyanidin A2, and (2R)-naringenin-7-O-(3-O-αL-rhamnopyranosyl-β-D-glucopyranoside) have been identified in a lychee seed, which may lend a lychee seed as a relatively safe and inexpensive adjuvant treatment for diabetes and diabetic complications. In fact, accumulating evidence has shown that lychee seed, lychee seed extracts, and related compounds have promising antihyperglycemic activities, including improving insulin resistance, anti-inflammatory effect, lipid regulation, neuroprotection, antineurotoxic effect, and renoprotection effect. In this review, we summarized publications on antiglycemic effects and mechanisms of lychee seed, lychee seed extracts, and related compounds, which included their efficacies as a cure for diabetes and diabetic complications in cells, animals, and humans, attempting to obtain a robust evidence basis for the clinical application and value of lychee seed.
- Published
- 2021
36. Model exploration for discovering COVID-19 targeted traditional Chinese medicine
- Author
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Yuting Sun, Xuedong An, De Jin, Liyun Duan, Yuehong Zhang, Cunqing Yang, Yingying Duan, Rongrong Zhou, Yiru Zhao, Yuqing Zhang, Xiaomin Kang, Linlin Jiang, and Fengmei Lian
- Subjects
Multidisciplinary - Abstract
In terms of treatment, a particularly targeted drug is needed to combat the COVID-19 pandemic. Although there are currently no specific drugs for COVID-19, traditional Chinese medicine(TCM) is clearly effective. It is recommended that through data analysis and mining of TCM cases (expert experience) and population evidence (RCT and cohort studies), core prescriptions for various efficacy can be obtained. Starting from a multidimensional model of regulating immunity, improving inflammation, and protecting multiple organs, this paper constructs a multidimensional model of targeted drug discovery, integrating molecular, cellular, and animal efficacy evaluation. Through functional activity testing, biophysical detection of compound binding to target proteins, multidimensional pharmacodynamic evaluation systems of cells (Vero E6, Vero, Vero81, Huh7, and caca2) and animals (mice infected with the new coronavirus, rhesus macaques, and hamsters), the effectiveness of effective preparations was evaluated, and various efficacy effects including lung moisturizing, dehumidification and detoxification were obtained. Using modern technology, it is now possible to understand how the immune system is controlled, how inflammation is reduced, and how various organs are protected. Complete early drug characterization and finally obtain effective targeted TCM. This article provides a demonstration resource for the development of new drugs specifically for TCM.
- Published
- 2022
37. Resistance-Chiral Anisotropy of Chiral Mesostructured Half-metallic Fe
- Author
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Te, Bai, Jing, Ai, Jie, Ma, Yingying, Duan, Lu, Han, Jingang, Jiang, and Shunai, Che
- Abstract
Half-metallic materials are theoretically predicted to be metallic and insulating, which have not been confirmed experimentally, and the predictions are still in doubt. We report the resistance-chiral anisotropy (R-ChA), i.e., chirality-dependent electrical conductivity, in chiral mesostructured Fe
- Published
- 2021
38. Chiral Mesostructured BiOBr Films with Circularly Polarized Colour Response
- Author
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Tianwei Duan, Kun Ding, Jing Ai, Lu Han, Jingang Jiang, Chao Zhou, Yingying Duan, Bin Huang, Quanzheng Deng, and Shunai Che
- Subjects
Materials science ,High Energy Physics::Lattice ,Stacking ,Resonance ,General Medicine ,General Chemistry ,Crystal structure ,Catalysis ,Hydrothermal circulation ,Crystallography ,Chirality (chemistry) ,Anisotropy ,Circular polarization ,Bismuth oxybromide - Abstract
Achieving strong and broadband circularly polarized colour responses in chiral inorganic materials is challenging. Here, we fabricated chiral mesostructured bismuth oxybromide (BiOBr) films (CMBFs) via hydrothermal growth using chiral sugar alcohols as symmetry-breaking agents. The layered slabs of BiOBr crystals with weak van-der-Waals interactions are prone to mismatching due to the chiral driving force, resulting in hierarchically chiral arrangements of fine size. Three levels of chirality exist in the CMBFs: primary, helical distortion crystal lattices of a nanoflake, secondary, helical stacking of nanoflakes to form nanoplates, and tertiary, chiral vortexes arranged by nanoplates. The CMBFs displayed optical activities (OAs) over a wide wavelength range of 350-2500 nm with an anisotropic factor of up to 0.99, which led to a significant chirality-dependent colour response to circularly polarized light. The high selectivity can be considered as the result of enhanced resonance due to structural-handedness matching and the synergistic effect of multiple OAs.
- Published
- 2021
39. The three syndromes and six Chinese patent medicine study during the recovery phase of COVID-19
- Author
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Yue Hong Zhang, Xiaolin Tong, Rong Rong Zhou, Fengmei Lian, Xuedong An, Shenghui Zhao, Liyun Duan, De Jin, and Yingying Duan
- Subjects
medicine.medical_specialty ,Recovery period ,Chinese patent medicine ,Three syndromes and six Chinese patent medicines ,Review ,COVID-19 sequelae ,Traditional Chinese medicine ,030204 cardiovascular system & hematology ,Other systems of medicine ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Acupuncture ,Medicine ,030212 general & internal medicine ,Pathological ,Pharmacology ,Sleep disorder ,business.industry ,COVID-19 ,Guideline ,medicine.disease ,Clinical trial ,Complementary and alternative medicine ,Pill ,business ,RZ201-999 - Abstract
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), first broke out in Wuhan, China, in 2019. SARS-CoV-2 develops many types of mutations (such as B.1.1.7), making diagnosis and treatment challenging. Although we now have a preliminary understanding of COVID-19, including pathological changes, clinical manifestations, and treatment measures, we also face new difficulties. The biggest problem is that most COVID-19 patients might face sequelae (e.g., fatigue, sleep disturbance, pulmonary fibrosis) during the recovery phase. We aimed to test six Chinese patent medicines to treat three major abnormal symptoms in COVID-19 patients during the recovery phase, including cardiopulmonary function, sleep disturbance, and digestive function. We launched the “three syndromes and six Chinese patent medicines” randomized, double-blind, placebo-controlled, multicenter clinical trial on April 10, 2020. The results showed that Jinshuibao tablets and Shengmaiyin oral liquid significantly improved the cardiopulmonary function of recovering COVID-19 patients. Shumian capsules, but not Xiaoyao capsules, significantly improved patients’ sleep disorders. This might be because the indication of Xiaoyao capsules is liver qi stagnation rather than psychological or emotional problems. Xiangsha Liujun pills and Ludangshen oral liquid significantly improved digestive function. Our research provides a guideline for treating COVID-19 sequelae in patients during the recovery period based on high-quality evidence.
- Published
- 2021
40. Efficacy of Mudan Granule (Combined With Methylcobalamin) on Type 2 Diabetic Peripheral Neuropathy: Study Protocol for a Double-Blind, Randomized, Placebo-Controlled, Parallel-Arm, Multi-Center Trial
- Author
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Rui Hao, Yingying Duan, Tongyue Yu, Xiaolin Tong, Yuehong Zhang, De Jin, Fengmei Lian, and Keyu Chen
- Subjects
medicine.medical_specialty ,Diabetic neuropathy ,efficacy ,030209 endocrinology & metabolism ,RM1-950 ,Traditional Chinese medicine ,Placebo ,Nerve conduction velocity ,Study Protocol ,03 medical and health sciences ,mudan granule ,0302 clinical medicine ,Chinese patent medicine ,Internal medicine ,medicine ,Pharmacology (medical) ,Adverse effect ,Pharmacology ,business.industry ,medicine.disease ,Clinical trial ,Peripheral neuropathy ,Methylcobalamin ,type 2 diabetic peripheral neuropathy ,Therapeutics. Pharmacology ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background: Diabetic peripheral neuropathy (DPN) characterized by nerve damage is a common and disabling chronic microvascular complication in patients with type 2 diabetic mellitus (T2DM), affecting at least half of patients diagnosed with T2DM. Unfortunately, the current treatment for DPN is not ideal. Traditional Chinese medicine (TCM), with a unique theoretical system, has made outstanding contributions in the treatment of T2DM and related complications. Mudan granule, a Chinese patent medicine, has been previously validated that could ameliorate the symptoms, promote nerve tissue repair, increase nerve conduction velocity (NCV) in patients with DPN. However, the previous studies are of variable quality, which limits the clinical application of Mudan granule. Therefore, we designed a double-blind, randomized, placebo-controlled, parallel-arm, multi-center trial to estimate the safety and efficacy of Mudan granule in conjunction with methylcobalamin in individuals suffering from type 2 diabetic peripheral neuropathy.Methods: This work is conducted as a 14-center, double-blind, randomized, placebo-controlled, parallel-arm trial. In all, 402 subjects (aged 30–70 years) will be recruited and randomized in a 1:1 ratio to an intervention group (n = 201; Mudan granule + methylcobalamin) and a control group (n = 201; placebo + methylcobalamin). Treatment is administered in 24 weeks cycles without any treatment interruption between cycles. Michigan Diabetic Neuropathy Score (MDNS) as the primary outcome will be evaluated at baseline, 12 weeks during the intervention period, and after 24 weeks of the intervention. Adverse events and safety assessments will be also documented. The analysis of all data will be carried out based on a predefined statistical analysis plan.Discussion: The outcomes from this study will offer important evidence regarding the safety and efficacy that Mudan granule can be used as an alternative and complementary therapeutic intervention in patients with type 2 diabetic peripheral neuropathy.Clinical trial registration: Registered at https://clinicaltrials.gov/. Trial registration number: NCT04711980. Registered January 2021.
- Published
- 2021
41. Chiral mesostructured SnO2 films with tunable optical activities
- Author
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Lu Han, Yingying Duan, Qing Shen, Wenting Mao, and Shunai Che
- Subjects
Circular dichroism ,Materials science ,Preferential growth ,business.industry ,Organic Chemistry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Nanomaterials ,Inorganic Chemistry ,Reflection (mathematics) ,Optoelectronics ,Symmetry breaking ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,0210 nano-technology ,Science, technology and society ,business ,Absorption (electromagnetic radiation) ,Chirality (chemistry) ,Spectroscopy - Abstract
New strategies for tunable optical activities (OAs) are of fundamental importance in the advancement of science and technology. Here, we report hierarchically chiral mesostructured SnO2 films (CMSFs) deposited on FTO substrates via a symmetry breaking agent-inducing method. Three levels of chiral structures exist in the film, including tertiary plates helically arranged in fan-like form, secondary subplates helically stacked along [001] direction and primary nanosheets twisted along [100] direction. The thickness of plates was significantly increased with decreasing reactants concentration due to slower and preferential growth of plates along [001] direction. The increasing number of nanosheets results in enhancement and red shift of circular dichroism (CD) signals based on electron-transition absorption and reflection–based OA, which is in accordance with the circular Bragg resonance theory. Such novel chiral films with tunable OAs and morphologies may bring new ideas for design and synthesis of chiral inorganic materials with specific chirality and OA in the nanomaterial field.
- Published
- 2019
42. Handedness inversion of chiral mesoporous silica: A diffuse-reflectance circular dichroism study
- Author
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Nan Wang, Yingying Duan, Ruiyu Lin, Shun'ai Che, and Minzhao Xue
- Subjects
Circular dichroism ,Materials science ,010405 organic chemistry ,Supramolecular chemistry ,Stacking ,General Chemistry ,Mesoporous silica ,010402 general chemistry ,01 natural sciences ,Porphyrin ,Spectral line ,0104 chemical sciences ,Crystallography ,chemistry.chemical_compound ,chemistry ,Amphiphile ,Diffuse reflection - Abstract
Chiral mesoporous silica ribbons and rods with inversed handedness have been synthesized with the same enantio pure N-acylaminoacidat temperatures of 0 °C and 20 °C, respectively. With involving Cu2+ and meso-tetra(4-sulfonatophenyl)porphyrin (TPPS) as probes, ribbons and rods revealed opposite signals in diffuse-reflectance circular dichroism (DRCD) spectra, indicating the existence of inversed supramolecular chiral imprintings through helical stacking of amphiphiles. The structural evolution was systematically studied by the freeze-dried products sampled at different time after the addition of silica precursors. The H-bonding-depended molecular orientation probably controls the chiral sense upon forming chiral molecular stacking, which would be the origin of such handedness inversion phenomenon
- Published
- 2019
43. Highly ordered AIEgen directed silica hybrid mesostructures and their light-emitting behaviours
- Author
-
Shunai Che, Hui Chang, Chao Zhou, Yingying Duan, Lu Han, Wanning Zhang, Wenting Mao, and Lijun Li
- Subjects
chemistry.chemical_classification ,Fluorophore ,Materials science ,Stacking ,02 engineering and technology ,General Chemistry ,Tetraphenylethylene ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Amphiphile ,Materials Chemistry ,Molecule ,Lamellar structure ,0210 nano-technology ,Alkyl ,Gyroid - Abstract
Mesostructured fluorescent silica hybrids (MFSHs) were synthesized using tetraphenylethylene (TPE)-based quaternary ammonium salts as amphiphilic organic fluorophore templates, carboxyethylsilanetriol disodium salt (CES) as a co-structure directing agent (CSDA) and tetraethylorthosilicate (TEOS) as an inorganic precursor. With increasing alkyl chain length of the templates, the mesostructures transformed from a lamellar structure (alkyl carbon chains of C4, C5, C6 and C7) to three-dimensional (3D) bicontinuous cubic gyroid structures (C8 and C10). These materials show typical aggregation-induced emission (AIE) behaviours corresponding to the molecular arrangement in the mesoscale. Compared to the pure template, the emission maximum of the material with a lamellar structure shows a red-shift phenomenon due to the higher conjugation caused by the close stacking of the AIEgens, while the emission maximum remains unchanged in the bicontinuous cubic structure owing to the loose stacking of the template molecules.
- Published
- 2019
44. Spontaneous chiral self-assembly of achiral AIEgens into AIEgen-silica hybrid nanotubes
- Author
-
Shunai Che, Jing Ai, Yingying Duan, Hui Chang, Lu Han, and Wanning Zhang
- Subjects
Microscopy, Confocal ,Nanotubes ,Materials science ,010405 organic chemistry ,Metals and Alloys ,Stereoisomerism ,General Chemistry ,Silicon Dioxide ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Stilbenes ,Amphiphile ,Materials Chemistry ,Ceramics and Composites ,Self-assembly - Abstract
Antipodal chiral AIEgen-silica hybrid mesostructures were fabricated by spontaneous chiral self-assembly of the achiral amphiphilic AIEgen 2-[4-(1,2,2-triphenylethenyl)phenoxy]-acetic acid via a co-structure directing route in the absence of any symmetry-breaking agent. The produced AIEgen-silica hybrid mesostructured nanotubes showed chiral features with optical activity originating from J-aggregation with an excess of one stereochemical hand of the helical conformation of the AIEgen.
- Published
- 2019
45. Chiral Nanostructured Bimetallic Au–Ag Films for Enantiomeric Discrimination
- Author
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Pu Yang, Quanzheng Deng, Yingying Duan, Zexi Liu, Yuxi Fang, Lu Han, and Shunai Che
- Subjects
Mechanics of Materials ,Mechanical Engineering - Published
- 2022
46. Chiral Mesostructured Carbonate with Vibrational Circular Dichroism
- Author
-
Maofu Huang, Xueliang Zhang, Lu Han, Shunai Che, and Yingying Duan
- Subjects
Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Published
- 2022
47. The Potential Effect of
- Author
-
Liyun, Duan, De, Jin, Xuedong, An, Yuehong, Zhang, Shenghui, Zhao, Rongrong, Zhou, Yingying, Duan, Yuqing, Zhang, Xinmin, Liu, and Fengmei, Lian
- Subjects
Review Article - Abstract
Background Rhizoma coptidis (RC) showed a significant effect on PCOS, but its mechanism in PCOS remains unclear. Methods The components of RC were searched by TCMSP. The Smiles number of the active ingredients was queried through PubChem, and the predicted targets were obtained from the SwissTargetPrediction database. The DrugBank, GeneCards, and DisGeNET databases were retrieved to acquire the related targets of PCOS. Then, the network of compound-target was constructed. The core targets were analyzed using protein-protein interaction (PPI) analysis, and the binding activities were verified by molecular docking. The enriched pathways of key targets were examined by GO and KEGG. Results 13 components and 250 targets of RC on PCOS were screened. The core network was filtered based on topological parameters, and the key components were palmatine, berberine, berberrubine, quercetin, and epiberberine. The key targets included DRD2, SLC6A4, CDK2, DPP4, ESR1, AKT2, PGR, and AKT1. Molecular docking displayed that the active ingredients of RC had good binding activities with potential targets of PCOS. After enrichment analysis, 30 functional pathways were obtained, including neuroactive ligand-receptor interaction, dopaminergic synapse, and cAMP signaling pathway. Conclusion In summary, this study clarified the potential effect of RC on PCOS, which is helpful to provide references for clinical practice. It is also conducive to the secondary development of RC and its monomer components.
- Published
- 2021
48. Spontaneous Chiral Self-Assembly of CdSe@CdS Nanorods
- Author
-
Xiaoyan Cui, Shunai Che, Lu Han, Jing Ai, Tianwei Duan, Xiaowei Feng, Jingang Jiang, and Yingying Duan
- Subjects
Condensed Matter::Materials Science ,Physics::Biological Physics ,Quantitative Biology::Biomolecules ,Crystallography ,Materials science ,Space group ,Racemic mixture ,Nanorod ,Self-assembly ,Crystal structure ,Homochirality ,Enantiomeric excess ,Chiral symmetry breaking - Abstract
The enantiomeric excess phenomenon in spontaneous chiral symmetry breaking (SCSB) is a crucial issue regarding the origin of homochirality in the prebiotic environment . Although the spontaneous formation of chiral inorganic compounds with chiral space groups and lattice dislocations has been extensively investigated, enantiomeric excess has rarely been considered, with the convention being to assume the presence of a racemic mixture. Here, we report the SCSB in the self-assembly of cadmium chalcogenide nanorods, leading to chiral biases away from the racemate. In the presence of achiral organics, helical CdSe@CdS nanorods (HCCNs) with unidirectionally rotated crystal lattices along the rod axis were stochastically formed on the epitaxial interface of the {111}cub/{0001}hex planes. The stability of helical dislocation structures, as supported by a theoretical analysis of their binding energies, suggested the possibility for the emergence of helical structures in an achiral environment. Hierarchical chiral films induced by simple solvent evaporation self-assembly of HCCNs exhibited spontaneous enantiomeric excess between batches, which was speculated to be originated from the enantiomeric excess seed-assembly that induce one handedness dominated system based on the majority rules.
- Published
- 2021
49. Effect of Parecoxib Sodium on Myocardial Ischemia-Reperfusion Injury Rats
- Author
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Wei Wang, Yingying Duan, Ma Tao, Guanhua Li, Fangyong Wu, and Jia Guo
- Subjects
Cardiac function curve ,Cardiotonic Agents ,NF-E2-Related Factor 2 ,Ischemia ,Apoptosis ,Myocardial Reperfusion Injury ,Pharmacology ,medicine.disease_cause ,Proinflammatory cytokine ,Rats, Sprague-Dawley ,Lipid peroxidation ,chemistry.chemical_compound ,medicine ,Animals ,chemistry.chemical_classification ,Reactive oxygen species ,Receptor Activator of Nuclear Factor-kappa B ,Lipid peroxide ,Animal Study ,Myocardium ,NF-kappa B ,Isoxazoles ,General Medicine ,medicine.disease ,Oxidative Stress ,chemistry ,Reperfusion Injury ,Heart Function Tests ,Cytokines ,Inflammation Mediators ,Reperfusion injury ,Oxidative stress ,Signal Transduction - Abstract
BACKGROUND We aimed to explore the effect of parecoxib sodium on myocardial ischemia-reperfusion (I/R) injury rats and its mechanism. MATERIAL AND METHODS The coronary artery of Sprague-Dawley rats was occluded for 6 h of myocardial ischemia, followed by reperfusion for 30 min (I/R group). Before ischemia, parecoxib sodium (10 mg/kg) was intraperitoneally injected twice a day for 3 consecutive days, followed by reperfusion for 6 h (I/R+Pare group). The cardiac function and changes in the infarction area were evaluated via echocardiography in each group. The differences in the expressions of apoptosis-related proteins were determined via immunohistochemistry and western blotting. Then, the percentage of reactive oxygen species (ROS)⁺ cells and the content of lipid peroxide were detected, based on which the degree of oxidative stress was evaluated. Next, the expressions of nuclear factor-kappaB (NF-kappaB) and nuclear factor E2-related factor 2 (Nrf-2) signaling pathways and downstream target genes were determined using real-time quantitative polymerase chain reaction (PCR). RESULTS After treatment with parecoxib sodium, the cardiac function of I/R injury rats was restored, and the infarction area and apoptosis level were reduced (P
- Published
- 2020
50. Mechanism of Astragalus Membranaceus in the Treatment of Diabetic Nephropathy Based on Network Pharmacology
- Author
-
Rongrong Zhou, Shenghui Zhao, De Jin, Yiru Zhao, YingYing Duan, Liyun Duan, Fengmei Lian, Xuedong An, and Xiaolin Tong
- Subjects
Diabetic nephropathy ,Astragalus ,biology ,business.industry ,Mechanism (biology) ,Network pharmacology ,Medicine ,Pharmacology ,business ,biology.organism_classification ,medicine.disease - Abstract
Background: Diabetic nephropathy (DN), which affects more than 40% of diabetic patients, is still the main cause of end-stage renal disease in most countries. Prescription containing Astragalus Membranaceus (AM) in the treatment of early stage DN with significant effect, but the mechanism is unclear, which we would explore based on network pharmacology.Method: First, we searched the database of China National Knowledge Internet, Wanfang Database, Chinese Biomedical Literature Database, PubMed, EMBASE, Cochrane database about the randomized, single (double) blind, controlled clinical studies of prescription containing AM in the treatment of DN, determined the effectiveness of prescription containing AM in the treatment of DN. Then, the effective components of AM in Traditional Chinese Medicine systems taxonomy database and analysis platform (TCMSP), Traditional Chinese medicine integrated database (TCMID) and Bioinformatics analysis tool for molecular mechanism of traditio Internal Chinese medicine (BATMAN-TCM) database were searched. According to the oral utilization ≥ 30% and drug-like ≥0.18, the effective components were screened. PubChem and health information technology (HIT) databases were searched for query validation targets and Simplified molecular input line entry specification (SMILES) of the effective ingredients, and Swisstarget prediction database was used to obtain prediction targets (possibility > 0). Drugbank, transient triple differential (TTD), and DisGeNET were searched for the targets related to DN. Finally, the data were integrated by the Cytoscape software, the drug-target-disease network was drawn, the protein interaction network was drawn with String database, and the signal pathway enrichment analysis was carried out with ClueGO.Result: The results showed that prescription containing AM could effectively reduce the urinary protein excretion rate [95% md-43.30 (- 57.00, - 29.61)]. 51 active components, 396 verified targets and 2330 predicted targets were searched. A total of 120 DN related targets were retrieved. 21 targets were found with Cytoscape. The main pathways were Interleukin-4 and 13 signaling, Activation of Matrix Metalloproteinases, EPH-Ephrin signaling.Conclusion: Prescription containing AM could effectively reduce the urinary protein excretion rate of DN patients. We speculated that AM mainly treated DN by regulating Angiotensin-converting enzyme (ACE), Vascular endothelial growth factor A (VEGFA), Janus Kinase 1 (JAK1), and interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling, activation of matrix metalloproteins, ephrin signaling and other signaling pathways based on network pharmacology, which would be verified by animal experiments or in vitro experiments in the later.
- Published
- 2020
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