Search

Background: One of the most prestigious competitions in the world is the World Robot Conference. This paper presents the winning solution to the supervised motor imagery (MI) task in the BCI Controlled Robot Contest in World Robot Contest 2021. Methods: Data augmentation, preprocessing, feature extraction, and model training are the main components of the solution. The model is based on EEGNet, a popular convolutional neural networks model for classifying electroencephalography data. Results: Despite the model’s lack of stability, this solution was the most successful in the task. The channels closest to the vertex were the most helpful in feature extraction. Conclusion: This solution is suitable for supervised MI tasks not only in this competition but also in future scenarios.

To investigate current patterns and outcomes of intravesical bacillus Calmette-Guérin treatment in Japanese patients with bladder cancer, including the proportion of patients completing induction therapy, and time to subsequent treatments.This retrospective cohort study utilized administrative claims data from the Medical Data Vision Co., Ltd. database to identify patients with a diagnosis of bladder cancer who had received ≥1 prescription of intravesical bacillus Calmette-Guérin between April 2008 and September 2015, and had ≥1 database record dated ≥12 weeks after the initial bacillus Calmette-Guérin dose. Patients were followed until September 2018, the last date of available data, or in-hospital death. Patients receiving six doses of bacillus Calmette-Guérin at intervals of21 days were considered to have completed induction according to guidelines. Time from initial bacillus Calmette-Guérin dose to subsequent bladder cancer treatment after the end of treatment was defined as the recurrence-free duration.Of 6140 patients identified (median age 73.0 years; 83.4% males), 4588 (74.7%) completed induction and 1552 (25.3%) did not. Median recurrence-free duration was 64.4, 77.7, and 31.6 months in the overall, complete-induction and incomplete-induction cohorts, respectively. Corresponding 3-year recurrence-free rate was 56.3%, 59.0%, and 48.2% in these groups. The rate of cystectomy was approximately 6% at 5 years in all cohorts.Approximately 75% of Japanese patients who undergo intravesical bacillus Calmette-Guérin treatment receive a guideline-compliant induction regimen, but outcomes were not satisfactory, highlighting the need for more effective treatments for non-muscle invasive bladder cancer.

By replacing [PF6]− with the larger [TFSA]−, the phase transition temperature is increased from 305 K to 342 K in a host–guest inclusion ferroelastic crystal, [(3,4-DFA)(18-crown-6)][TFSA], which can realize dual-channel (thermal and stress) control of ferroelastic domains.

Thouless pump with quantized transports is topologically robust against small perturbations and disorders, while breaks down under sufficiently strong disorders. Here we propose counter-intuitive topological pumps induced by disorders in noninteracting and interacting systems. We first show an extrinsic topological pump driven by the on-site quasiperiodic potential for a two-loop sequence, where the disorder inequivalently suppresses the topology of two pump loops. Moreover, we reveal an intrinsic topological pump induced by the hopping quasiperiodic disorder from a trivial single-loop pump in the clean limit, dubbed the topological Anderson-Thouless pump (TATP) as a dynamical analogue of topological Anderson insulators. We demonstrate that the mechanism of the TATP is the disorder-induced shift of gapless critical points and the TATP can even exhibit in the dynamic disorder and interacting cases. Finally, we extend the TATP to higher-order topological systems with disorder-induced quantized corner transports. Our proposed TATPs present new members of the topological pump family and could be realized with ultracold atoms or photonic waveguides., Comment: 13 pages, 13 figures (including supplemental materials)

Ferroelectricity, existing in either solid crystals or liquid crystals, gained widespread attention from science and industry for over a century. However, ferroelectricity has never been observed in both solid and liquid crystal phases of a material simultaneously. Inorganic ferroelectrics that dominate the market do not have liquid crystal phases because of their completely rigid structure caused by intrinsic chemical bonds. We report a ferroelectric homochiral cholesterol derivative, β-sitosteryl 4-iodocinnamate, where both solid and liquid crystal phases can exhibit the behavior of polarization switching as determined by polarization–voltage hysteresis loops and piezoresponse force microscopy measurements. The unique long molecular chain, sterol structure, and homochirality of β-sitosteryl 4-iodocinnamate molecules enable the formation of polar crystal structures with point group 2 in solid crystal phases, and promote the layered and helical structure in the liquid crystal phase with vertical polarization. Our findings demonstrate a compound that can show the biferroelectricity in both solid and liquid crystal phases, which would inspire further exploration of the interplay between solid and liquid crystal ferroelectric phases.

Temporal interference transcranial alternating current stimulation (TI-tACS) is a new technique of noninvasive brain stimulation. Previous studies have shown the effectiveness of TI-tACS in stimulating brain areas in a selective manner. However, its safety in modulating human brain neurons is still untested. In this study, 38 healthy adults were recruited to undergo a series of neurological and neuropsychological measurements regarding safety concerns before and after active (2 mA, 20/70 Hz, 30 min) or sham (0 mA, 0 Hz, 30 min) TI-tACS. The neurological and neuropsychological measurements included electroencephalography (EEG), serum neuron-specific enolase (NSE), the Montreal Cognitive Assessment (MoCA), the Purdue Pegboard Test (PPT), an abbreviated version of the California Computerized Assessment Package (A-CalCAP), a revised version of the Visual Analog Mood Scale (VAMS-R), a self-assessment scale (SAS), and a questionnaire about adverse effects (AEs). We found no significant difference between the measurements of the active and sham TI-tACS groups. Meanwhile, no serious or intolerable adverse effects were reported or observed in the active stimulation group of 19 participants. These results support that TI-tACS is safe and tolerable in terms of neurological and neuropsychological functions and adverse effects for use in human brain stimulation studies under typical transcranial electric stimulation (TES) conditions (2 mA, 20/70 Hz, 30 min).

A deeper understanding of the human side of human-robot interaction determined by studying the human brain when we perceive robots should help solve the biggest challenges of successful social encounters with robots. However, current social neuroscience studies mainly focus on explicit perception of robots, and implicit perception of robots is rather unexplored. Here, our behavioral analysis indicated that despite self-reported positive attitudes, participants had negative implicit attitudes toward humanoid robots. Our neuroimaging analysis indicated that subthreshold presentation of humanoid robot vs. human images led to significant left amygdala activation that was associated with negative implicit attitudes toward robots. After successfully weakening the negative attitudes, the left amygdala response to subthreshold presentation of humanoid robot images decreased, and the decrease in the left amygdala response was positively associated with the decrease in negative attitudes. Our results reveal that the processing of information about humanoid robots displays automaticity with regard to the recruitment of amygdala activation. Our findings that people may implicitly perceive humanoid robots as a threat may guide more appropriate interaction with social robots.Significance statementSocial interactions with robots are one of the biggest challenges in robotics, which necessitates a deeper understanding of how people perceive robots. Our results reveal automaticity for processing information about humanoid robots similar to that previously evident for threats. Given the effort currently being put into the development of robots for daily assistance, studying implicit perception of robots could be a step toward building smooth human-robot social relationships.

Introduction: Reactivation of cytomegalovirus (CMV) infection is a major threat and it causes significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). There remains, however, a paucity of evidence regarding the economic burden of current CMV management in Japan. The aim of this study is to characterize the healthcare resource utilization (HCRU) and cost incurred for CMV management post allo-HSCT, using a Japanese hospital claims database. Methods: Patients who underwent allo-HSCT between April 2010 and March 2018 were identified and followed up for 180 days. Results: In total, 916 patients were included for analysis and categorized into CMV (−) group and CMV (+) group based on the presence of a CMV episode within 100 days post allo-HSCT. A CMV episode was defined as evidence of receiving at least one dose of the following anti-CMV drugs, ganciclovir, foscarnet, or valganciclovir. The mean (± standard deviation [SD]) total length of stay was 93.6 (± 43.7) days in the CMV (+) group, which was significantly longer than 55.9 (±40.6) days in the CMV (−) group, and this trend was more pronounced in patients with multiple CMV episodes. The mean (±SD) total medical cost within 180 days post allo-HSCT was US$122,328 (±56,977) in the CMV (+) group, while the mean total medical cost was US$75,344 (±43,821) in the CMV (−) group. Moreover, transfusion and antimicrobial use was observed as the major medication cost component, which is suggestive of the indirect effect of CMV episodes. Conclusion: This study demonstrated that CMV episodes post allo-HSCT were associated with increased HCRU and cost.

Disorders and long-range hoppings can induce exotic phenomena in condensed matter and artificial systems. We study the topological and dynamical properties of the quasiperiodic Su–Schrier–Heeger model with long-range hoppings. It is found that the interplay of quasiperiodic disorder and long-range hopping can induce topological Anderson insulator phases with non-zero winding numbers ω = 1 , 2 , and the phase boundaries can be consistently revealed by the divergence of zero-energy mode localization length. We also investigate the nonequilibrium dynamics by ramping the long-range hopping along two different paths. The critical exponents extracted from the dynamical behavior agree with the Kibble–Zurek mechanic prediction for the path with W = 0.90 . In particular, the dynamical exponent of the path crossing the multicritical point is numerical obtained as 1 / 6 ∼ 0.167 , which agrees with the unconventional finding in the previously studied XY spin model. Besides, we discuss the anomalous and non-universal scaling of the defect density dynamics of topological edge states in this disordered system under open boundary condictions.

Background In Japan, regional differences in asthma mortality have been reported; however, regional differences in asthma exacerbations have not been studied extensively. Therefore, using a health insurance claims database, we investigated the regional differences in the incidence of asthma exacerbations in Japan. Methods This study used data from Medi-Scope (Japan Medical Information Research Institute Inc., Japan)—a nationwide health insurance claims database. Patients with asthma at the index date (the latest date of an asthma-related prescription with an asthma diagnosis before October 1, 2018) were included in the analysis. The pre-index period was defined as 1 year before the index date, and the follow-up period as 1 year after the index date. The incidence of asthma exacerbation events was analyzed for each region. Results The primary analysis population comprised 24,883 patients who were continuously prescribed ICS or ICS/LABA at least four times during the pre-index period. The incidence rate of asthma exacerbations with hospitalization was the highest in Chugoku (2.95/100 person-years [95% CI, 1.97–4.43]) and the lowest in Kanto (1.52/100 person-years [95% CI, 1.26–1.83]). The incidence rate of asthma exacerbations for the composite outcome of hospitalization, injectable corticosteroid prescription, and oral corticosteroid burst was the highest in Fukui (105.00/100 person-years [95% CI, 64.53–170.85]) and the lowest in Nagasaki (15.69/100 person-years [95% CI, 10.84–22.72]). Conclusions Regional differences in the incidence of asthma exacerbations as well as their treatments were observed in Japan.

Because of the impact of close partner's touch on psychological and physical well-being by alleviating stress, it is important to explore the influence factors that underlie the stress-alleviating effect of close partner's touch. Previous studies suggested that the stress-alleviating effect was different when individuals were touched by different persons. Specifically, the stress was reduced significantly when the individual was touched by the close partner compared with the acquaintance and the stranger. However, whether the stress-alleviating effect of touch was modulated by the close relationship quality is unknown. To examine this question, the participants (n = 61) performed a 3 (i.e., alone, partner no-touch, and partner touch) × 2 (i.e., safety and threat) within-subjects experiment. The results revealed that the stress of the participants alleviated significantly while close partners present with touch compared with without touch during facing a threat. We also found that the relationship quality of couple-members (i.e., participants perceiving the quality of alternatives and the partners' commitment level) modulated touch-induced stress alleviation. Participants perceiving the low quality of alternatives and the high partners' commitment level showed stronger touch-induced stress-alleviating effect than participants perceiving the high quality of alternatives and the low partners' commitment level. The explained variance was around 16.8% jointly for actor and partner effects. These findings provide evidence for explaining the reasons for touch-induced alleviating stress and have important implications for predicting the future effect of interactive behaviors.

We investigate the mean-field energy spectrum and dynamics in a Bose-Einstein condensate in a double-well potential with non-Hermiticity from the nonreciprocal hopping, and show that the interplay of nonreciprocity and nonlinearity leads to exotic properties. Under the two-mode and mean-field approximations, the nonreciprocal generalization of the nonlinear Schr\"{o}dinger equation and Bloch equations of motion for this system are obtained. We analyze the PT phase diagram and the dynamical stability of fixed points. The reentrance of PT-symmetric phase and the reformation of stable fixed points with increasing the nonreciprocity parameter are found. Besides, we uncover a linear self-trapping effect induced by the nonreciprocity. In the nonlinear case, the self-trapping oscillation is enhanced by the nonreciprocity and then collapses in the PT-broken phase, and can finally be recovered in the reentrant PT-symmetric phase., Comment: accepted by Frontiers of Physics

The outbreak of the novel coronavirus disease 2019 (COVID-19) has increased concern about people’s mental health under such serious stressful situation, especially depressive symptoms. Cognitive biases have been related to depression degree in previous studies. Here, we used behavioral and brain imaging analysis, to determine if and how the COVID-19 pandemic affects the relationship between current cognitive biases and future depression degree and the underlying neural basis in a nonclinical depressed population. An out-expectation result showed that a more negative memory bias was associated with a greater decrease in future depressive indices in nonclinical depressed participants during the COVID-19 pandemic, which might be due to decreased social stress. These data enhance our understanding of how the depressive degree of nonclinical depressed populations will change during the COVID-19 pandemic and also provide support for social distancing policies from a psychological perspective., Graphical Abstract, Highlights We collected depressive degree before and during the COVID-19 pandemic. Depressive degree negatively correlated with memory bias during the pandemic. Reduced social stress during the pandemic might lead to the altered relationship. Results provide extra support for social distancing policies during the pandemic.

A neuropathologic hallmark of Alzheimer’s disease (AD) is the presence of senile plaques that contain neurotoxic amyloid-β protein (Aβ) species, which are generated by the cleavage of amyloid β-protein precursor by secretases such as the γ-secretase complex, preferentially located in detergent-resistant membrane (DRM) regions and comprising endoproteolysed amino- and carboxy-terminal fragments of presenilin, nicastrin, anterior pharynx defective 1 and presenilin enhancer 2. Whereas some of familial AD patients harbor causative PSEN mutations that lead to more generation of neurotoxic Aβ42, the contribution of Aβ generation to sporadic/late-onset AD remains unclear. We found that the carboxy-terminal fragment of presenilin 1 was redistributed from DRM regions to detergent-soluble membrane (non-DRM) regions in brain tissue samples from individuals with sporadic AD. DRM fractions from AD brain sample had the ability to generate significantly more Aβ and had a lower cholesterol content than DRM fractions from non-demented control subjects. We further demonstrated that lowering the cholesterol content of DRM regions from cultured cells contributed to the redistribution of γ-secretase components and Aβ production. Taken together, the present analyses suggest that the lowered cholesterol content in DRM regions may be a cause of sporadic/late-onset AD by enhancing overall Aβ generation.

The neural type I membrane protein Alcadein α (Alcα), is primarily cleaved by amyloid β-protein precursor (APP) α-secretase to generate a membrane-associated carboxyl-terminal fragment (Alcα CTF), which is further cleaved by γ-secretase to secrete p3-Alcα peptides and generate an intracellular cytoplasmic domain fragment (Alcα ICD) in the late secretory pathway. By association with the neural adaptor protein X11L (X11-like), Alcα and APP form a ternary complex that suppresses the cleavage of both Alcα and APP by regulating the transport of these membrane proteins into the late secretory pathway where secretases are active. However, it has not been revealed how Alcα and APP are directed from the ternary complex formed largely in the Golgi into the late secretory pathway to reach a nerve terminus. Using a novel transgenic mouse line expressing excess amounts of human Alcα CTF (hAlcα CTF) in neurons, we found that expression of hAlcα CTF induced excess production of hAlcα ICD, which facilitated APP transport into the nerve terminus and enhanced APP metabolism, including Aβ generation. In vitro cell studies also demonstrated that excess expression of Alcα ICD released both APP and Alcα from the ternary complex. These results indicate that regulated intramembrane proteolysis of Alcα by γ-secretase regulates APP trafficking and the production of Aβ in vivo.

A result in a recent paper reported by Zhang et al. (Int J Adv Manuf Technol 57:1175–1181) is incorrect because job processing times are variable due to both deteriorating jobs and learning effects, which is not taken into account by the authors. In this note, we show by a counter-example that the published result is incorrect and provide the corrected result.

Measurement results of some properties of the Miyun 50m radio telescope (MRT50) of the National Astronomical Observatories, such as pointing calibration, antenna beams, system noise temperature, gain and gain variations with elevation are introduced. By using a new de-convolution technique developed by our group, the broadening effect on measured beams caused by the width of an extended radio source has been removed so that we obtained higher accuracy on the measurements of MRT50 beams.