7 results on '"Yaqun Ding"'
Search Results
2. Albumin-to-Fibrinogen Ratio is an Independent Prognostic Parameter in De Novo non-M3 acute myeloid leukemia
- Author
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Yaqun Ding, Xiangyu Qi, Yang Li, Yanni Sun, Jia Wan, Chengxin Luo, Yarui Huang, Qingrong Li, Guixian Wu, Xiaoqing Zhu, and Shuangnian Xu
- Abstract
Inflammation and nutrition related proteins participate in the development of acute myeloid leukemia (AML). It has been reported that the albumin-to-fibrinogen ratio (AFR) could serve as a prognostic indicator in patients with malignancy, but the precise relevance of AML is unclear. This study aimed to evaluate the effect of AFR on survival prognosis in patients with AML. We analyzed 227 patients newly diagnosed with non-M3 AML. AFR was calculated as albumin divided by fibrinogen. Based on the cutoff point from X-tile program, patients were divided into AFR-high (38.8%) and AFR-low (61.2%) groups. AFR-low group showed poorer complete remission rate (P P = 0.026); while the mortality was higher (P = 0.009) than AFR-high ones. According to the log-rank test, AFR-low group had shorter OS (P P = 0.034). Multivariate analysis identified AFR, ELN risk, bone marrow transplant, and hemoglobin as independent prognostic variables associated with OS. A visualized nomogram for predicting OS was performed. The C-index (0.75), calibration plots, and decision curve analyses of new model showed better discrimination, calibration, and net benefits than the ELN risk model. The time-dependent receiver operating characteristic (ROC) curve of 1-, 2-, and 3-year also functioned well (AUC, 0.81, 0.93, 0.90, respectively). Our study provided a comprehensive view of AFR which could be an independent prognostic indicator in AML patients. The prognostic model utilized readily available information from ordinary clinical practice to improve predictive performance, identify risks, and assist in therapeutic decision-making.
- Published
- 2023
3. Prognostic value of soluble urokinase-type plasminogen activator receptor in coronary artery disease: A meta-analysis
- Author
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Yang Li, Yaqun Ding, Yinjie Zhao, Yongqing Gui, Yajing Shen, and Qiang Xiang
- Subjects
Clinical Biochemistry ,Humans ,General Medicine ,Coronary Artery Disease ,Prognosis ,Biochemistry ,Biomarkers ,Receptors, Urokinase Plasminogen Activator ,Proportional Hazards Models - Abstract
A potential inflammatory biomarker, soluble urokinase-type plasminogen activator receptor (suPAR) has been utilized to assist the prognostic assessment of coronary artery disease (CAD) patients; however, outcomes have been inconsistent. The prognostic relevance of suPAR as a predictor of CAD patient adverse outcomes was therefore examined.Research articles published as of 1 January 2022 were retrieved from PubMed, Embase, the Web of Science and the Cochrane Library. All-cause mortality, cardiovascular mortality and other major cardiovascular events (nonfatal myocardial infarction, heart failure or stroke) were analysed as a subset of relevant studies' results. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for each study. The broad EQUATOR guidelines were conformed. Risk of bias was assessed with ROBINS-I tool.In total, this analysis included nine studies including 14,738 CAD patients. All included studies made a correction for certain potential confounders. However, risk of bias ranged from moderate to critical. When the ROBINS-I tool was used. Patients with CAD that exhibited increased suPAR levels had a substantially higher risk of all-cause mortality (HR = 2.24; 95% CI 1.97-2.55) or cardiovascular mortality (HR = 2.02; 95% CI 1.58-2.58), but not of developing other major cardiovascular events (HR = 1.63; 95% CI 0.86-3.11). Considerable heterogeneity across studies was observed in our meta-analyses, but no significant publication bias was detected.In patients with coronary disease, suPAR may have prognostic value for both all-cause and cardiovascular mortality but not for other major cardiovascular events.
- Published
- 2022
4. The Use of Hydrogel-Based Materials for Radioprotection
- Author
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Yang Li, Han Liu, Yaqun Ding, Wanyu Li, Yuansong Zhang, Shenglin Luo, and Qiang Xiang
- Subjects
Biomaterials ,Polymers and Plastics ,Organic Chemistry ,Bioengineering - Abstract
Major causes of the radiation-induced disease include nuclear accidents, war-related nuclear explosions, and clinical radiotherapy. While certain radioprotective drug or bioactive compounds have been utilized to protect against radiation-induced damage in preclinical and clinical settings, these strategies are hampered by poor efficacy and limited utilization. Hydrogel-based materials are effective carriers capable of enhancing the bioavailability of compounds loaded therein. As they exhibit tunable performance and excellent biocompatibility, hydrogels represent promising tools for the design of novel radioprotective therapeutic strategies. This review provides an overview of common approaches to radioprotective hydrogel preparation, followed by a discussion of the pathogenesis of radiation-induced disease and the current states of research focused on using hydrogels to protect against these diseases. These findings ultimately provide a foundation for discussions of the challenges and future prospects associated with the use of radioprotective hydrogels.
- Published
- 2023
5. Identification of important extracellular vesicle RNA molecules related to sperm motility and prostate cancer
- Author
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Yu Zhang, Ning Ding, Shenmin Xie, Xiangdong Ding, Li Jiang, Yaqun Ding, and Mengna Huang
- Subjects
Transcriptome ,Prostate cancer ,Chemistry ,medicine ,RNA ,Identification (biology) ,Extracellular vesicle ,medicine.disease ,Sperm motility ,Cell biology - Published
- 2021
6. Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets
- Author
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Yaqun Ding, Zhen Tan, Qin Zhang, Li Jiang, Xiangdong Ding, and Wanting Dong
- Subjects
0301 basic medicine ,DNA, Bacterial ,lcsh:QH426-470 ,Firmicutes ,Swine ,030106 microbiology ,suckling pigs ,DNA, Ribosomal ,Article ,Microbiology ,Dysentery ,03 medical and health sciences ,Lactobacillus ,RNA, Ribosomal, 16S ,Genetics ,Animals ,Genetics(clinical) ,16s rrna gene ,Genetics (clinical) ,Phylogeny ,porcine epidemic diarrhea virus ,Swine Diseases ,biology ,Bacteria ,Microbiota ,Bacteroidetes ,Fusobacteria ,Sequence Analysis, DNA ,biology.organism_classification ,colonic mucosa ,lcsh:Genetics ,030104 developmental biology ,Fusobacterium ,Animals, Newborn ,Proteobacteria ,Porcine epidemic diarrhea virus ,Coronavirus Infections ,colonic microbiota - Abstract
Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated microbiota from the colonic mucosa and content in healthy and PED piglets. High-throughput 16S rRNA gene sequencing was performed to identify inter-group differences. Firmicutes, Fusobacteria, Proteobacteria, and Bacteroidetes were the top four affected phyla. The proportion of Proteobacteria was higher in infected than in healthy piglets, and the opposite was observed for Bacteroidetes (more than four-fold higher in the healthy group). In the infected group, Fusobacterium accounted for 36.56% and 21.61% in the colonic mucosa and contents, respectively, while in the healthy group, they comprised 22.53% and 12.67%, respectively. The percentage of Lactobacillus in healthy colons (15.63%) was considerably higher than that in the disease group (<, 10%). In both the colonic mucosa and contents, functional enrichment differed significantly between healthy and diseased groups. Overall, infection with the PED virus increased the proportion of harmful bacteria and decreased the proportion of beneficial bacteria in the colons of piglets. Targeting intestinal microbiota could be a promising method for PED prevention, thus opening new avenues for future research.
- Published
- 2019
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7. Changes in cecal microbiota community of suckling piglets infected with porcine epidemic diarrhea virus
- Author
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Yaqun Ding, Zhen Tan, Li Jiang, Wanting Dong, Xiangdong Ding, and Qin Zhang
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Bacterial Diseases ,Swine ,Pathology and Laboratory Medicine ,medicine.disease_cause ,Feces ,RNA, Ribosomal, 16S ,Medicine and Health Sciences ,Phylogeny ,Swine Diseases ,Mammals ,Multidisciplinary ,biology ,Fusobacterium Infection ,Eukaryota ,General Medicine ,Genomics ,Bacterial Pathogens ,Diarrhea ,Infectious Diseases ,Medical Microbiology ,Vertebrates ,Medicine ,Anatomy ,Pathogens ,medicine.symptom ,General Agricultural and Biological Sciences ,Coronavirus Infections ,Research Article ,Science ,Gastroenterology and Hepatology ,Microbial Genomics ,Microbiology ,General Biochemistry, Genetics and Molecular Biology ,Fusobacteria ,Signs and Symptoms ,Diagnostic Medicine ,Genetics ,medicine ,Animals ,Microbiome ,Microbial Pathogens ,Bacteria ,Porcine epidemic diarrhea virus ,Gut Bacteria ,Organisms ,Computational Biology ,Biology and Life Sciences ,Bacteroidetes ,Molecular Sequence Annotation ,Pathogenic bacteria ,biology.organism_classification ,Gastrointestinal Microbiome ,Gastrointestinal Tract ,Fusobacterium ,Amniotes ,Fusobacterium Infections ,Metagenome ,Metagenomics ,Digestive System - Abstract
Diarrhea, caused by porcine epidemic diarrhea virus (PEDV), is a catastrophic gastrointestinal disease among suckling piglets, with high infectivity, morbidity, and mortality, causing huge economic losses to the pig industry. In the present study, we investigated the different microbiota from the cecal mucosa and cecal contents between healthy and PEDV-infected piglets. High-throughput 16S rRNA gene sequencing was performed to explore differences. The results revealed that microbial dysbiosis by PEDV infection occurred in the cecal mucosa and contents of suckling piglets at each microbial taxonomic level. The abundance of pathogenic bacteria associated with diseases, including diarrhea, was increased. The abundance of Fusobacterium was 26.71% and 33.91% in cecal mucosa and contents of PEDV-infected group, respectively, whereas that in the healthy groups was 17.85% and 9.88%. The proportion of Proteobacteria in the infected groups was relatively high (24.67% and 22.79%, respectively), whereas that in the healthy group was 13.13% and 11.34% in the cecal mucosa and contents, respectively. Additionally, the proportion of Bacteroidetes in the healthy group (29.89%, 37.32%) was approximately twice that of the PEDV-infected group (15.50%, 15.39%). “Nitrate reduction”, “Human pathogens diarrhea”, “Human pathogens gastroenteritis”, “Nitrite respiration”, and “Nitrite ammonification” were the enriched functional annotation terms in the PEDV-infected groups. Porcine epidemic diarrhea virus infection increased the proportion of harmful bacteria and decreased the proportion of beneficial bacteria in the cecal mucosa and contents of suckling piglets. Our findings suggest that determining the intestinal microbiota might provide a promising method to prevent PEDV and open a new avenue for future research.
- Published
- 2019
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