227 results on '"Yang, Zong"'
Search Results
2. Earth Summit Mission 2022: Scientific Expedition and Research on Mt. Qomolangma Helps Reveal the Synergy between Westerly Winds and Monsoon and the Resulting Climatic and Environmental Effects
- Author
-
Yaoming Ma, Weiqiang Ma, Huaguang Dai, Lei Zhang, Fanglin Sun, Jinqiang Zhang, Nan Yao, Jianan He, Zhixuan Bai, Yuejian Xuan, Yunshuai Zhang, Yuan Yuan, Chenyi Yang, Weijun Sun, Ping Zhao, Minghu Ding, Kongju Zhu, Jie Hu, Bian Bazhuga, Bai Juepingcuo, Zhuo Ma, Ren Qingnima, Suo Langwangdui, Yang Zong, and Haikun Wen
- Subjects
Atmospheric Science - Published
- 2022
3. Porous organic polymer overcomes the post-treatment phototoxicity of photodynamic agents and maintains their antitumor efficiency
- Author
-
Yamin Liu, Ze-Kun Wang, Zhong-Zheng Gao, Yang Zong, Jian-Da Sun, Wei Zhou, Hui Wang, Da Ma, Zhan-Ting Li, and Dan-Wei Zhang
- Subjects
Photosensitizing Agents ,Porphyrins ,Polymers ,Biomedical Engineering ,General Medicine ,Biochemistry ,Biomaterials ,Mice ,Photochemotherapy ,Cell Line, Tumor ,Animals ,Porosity ,Molecular Biology ,Biotechnology - Abstract
Since 1995, photodynamic therapy (PDT) has been utilized as an effective method for cancer treatment. However, the residues of photosensitizers in the normal tissues after PDT can be activated by sunlight to cause severe skin phototoxicity, for which currently there are no clinical solutions. As a result, post-PDT patients need to remain out of sunlight for up to five weeks, which produces great living and mental burdens for patients. Herein, we report that a biocompatible porous organic polymer (POP) with average 3.1 nm porosity is able to suppress the skin phototoxicity of clinically used porphyrin-based photodynamic agents (PDAs), including Photofrin, Talaporfin and Hiporfin, through an adsorption-elimination mechanism. Fluorescence titration and dialysis experiments show that POP can adsorb and retain the PDAs at a micromolar concentration. In vivo experiments demonstrate that POP can significantly suppress the skin phototoxicity caused by all the three PDAs without reducing their PDT efficacy. STATEMENT OF SIGNIFICANCE: Up to now, no efficient clinical treatment for the inhibition of post-PDT phototoxicity of clinically used porphyrin-based PDAs is available. In the manuscript, a water-soluble cationic porous organic polymer has been revealed to include three clinically used PDAs. In vivo experiments show that this inclusion remarkably reduces the content of PDAs in mouse skins, leading to significant alleviation of their post-PDT phototoxicity without no negative effect on their PDT efficacy. Thus, this work provides a strategy for overcoming the drawback of clinically used photodynamic agents.
- Published
- 2022
4. 2D Materials Nanomembrane
- Author
-
Yang Zong, Binmin Wu, Xinyi Ke, Yongfeng Mei, and Jizhai Cui
- Published
- 2022
5. Supplementary Table 2 from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues
- Author
-
Owen N. Witte, Yang Zong, Atsushi Kiba, and Daniel A. Smith
- Abstract
XLSX file - 12K, Quantification of phenotypes observed in human samples across four histological sections from independent biological replicates.
- Published
- 2023
6. Supplementary Figure 2 from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues
- Author
-
Owen N. Witte, Yang Zong, Atsushi Kiba, and Daniel A. Smith
- Abstract
PDF file - 1490K, Autocrine expression of OSM with activation of AKT promotes invasive epithelial growth from benign lesions.
- Published
- 2023
7. Supplementary Figure 4 from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues
- Author
-
Owen N. Witte, Yang Zong, Atsushi Kiba, and Daniel A. Smith
- Abstract
PDF file - 3076K, Human regenerations with IL6 and OSM alone exhibit dramatic inhibition of epithelial regeneration.
- Published
- 2023
8. Supplementary Methods and Figure Legend from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues
- Author
-
Owen N. Witte, Yang Zong, Atsushi Kiba, and Daniel A. Smith
- Abstract
PDF file - 124K
- Published
- 2023
9. Supplementary Figure 1 from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues
- Author
-
Owen N. Witte, Yang Zong, Atsushi Kiba, and Daniel A. Smith
- Abstract
PDF file - 2722K, Expression of IL6 or OSM with loss of PTEN does not dramatically increase graft size or weight.
- Published
- 2023
10. Supplementary Figure 3 from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues
- Author
-
Owen N. Witte, Yang Zong, Atsushi Kiba, and Daniel A. Smith
- Abstract
PDF file - 5091K, Expression of IL6 or OSM in the context of PTEN loss drive malignant invasion of epithelial cells into the surrounding mesenchyme.
- Published
- 2023
11. Data from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues
- Author
-
Owen N. Witte, Yang Zong, Atsushi Kiba, and Daniel A. Smith
- Abstract
Chronic inflammation has been proposed as an etiological and progression factor in prostate cancer. In this study, we used a dissociated prostate tissue recombination system to interrogate the role of interleukin 6 (IL6) and the related cytokine oncostatin-M (OSM) in the initiation and progression of prostate cancer. We identified that prostatic intraepithelial neoplasia (PIN) lesions induced by PTEN loss of function (PTENLOF) progress to invasive adenocarcinoma following paracrine expression of either cytokine. Increased expression of OSM was also able to drive progression of benign human epithelium when combined with constitutively activated AKT. Malignant progression in the mouse was associated with invasion into the surrounding mesenchyme and increased activation of STAT3 in PTENLOF grafts expressing IL6 or OSM. Collectively, our work indicates that pro-inflammatory cytokines such as IL6 or OSM could activate pathways associated with prostate cancer progression and synergize with cell-autonomous oncogenic events to promote aggressive malignancy.Implications: Increased expression of IL6 or OSM synergizes with loss of PTEN to promote invasive prostate cancer.Visual Overview: http://mcr.aacrjournals.org/content/early/2013/09/02/1541-7786.MCR-13-0238/F1.large.jpg. Mol Cancer Res; 11(10); 1159–65. ©2013 AACR.
- Published
- 2023
12. Supplementary Table 1 from Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues
- Author
-
Owen N. Witte, Yang Zong, Atsushi Kiba, and Daniel A. Smith
- Abstract
XLSX file - 13K, Quantification of phenotypes observed across five histological sections from independent biological replicates.
- Published
- 2023
13. METTL3-mediated LINC00657 promotes osteogenic differentiation of mesenchymal stem cells via miR-144-3p/BMPR1B axis
- Author
-
Jun Peng, Yulin Zhan, and Yang Zong
- Subjects
MicroRNAs ,Histology ,Osteogenesis ,Humans ,Osteoporosis ,Cell Differentiation ,Mesenchymal Stem Cells ,Methyltransferases ,Cell Biology ,Bone Morphogenetic Protein Receptors, Type I ,Cells, Cultured ,Pathology and Forensic Medicine - Abstract
N6-methyladenosine (m6A) modification plays a crucial role in the progression of osteoporosis (OP). The study aimed to explore the effects of methyltransferase-like 3 (METTL3) in OP. The levels of METTL3, LINC00657, miR-144-3p and BMPR1B were detected using qPCR. Osteogenesis was assessed using alizarin red and alkaline phosphatase (ALP) staining assays. The protein expression of Bglap, Runx2 and Col1a1 was measured by western blot. The targets of LINC00657 and miR-144-3p were screened by bioinformatic analysis. The interaction between miR-144-3p and LINC00657 or BMPR1B was analyzed by dual-luciferase reporter assay and RNA pull-down assay. The results showed that METTL3 was downregulated in OP. METTL3 mediated m6A methylation of LINC00657 to promote the development of osteogenesis. Further study indicated that LINC00657 functioned as a ceRNA to upregulate BMPR1B via sponging miR-144-3p. Additionally, BMPR1B knockdown alleviated the effects of METTL3 on osteogenesis of bone marrow mesenchymal stem cells (BMSCs). Taken together, METTL3 facilitated osteogenic differentiation of BMSCs via the LINC00657/miR-144-3p/BMPR1B axis. Our findings may provide a novel insight of m6A methylation in the development of OP.
- Published
- 2022
14. Porous dynamic covalent polymers as promising reversal agents for heparin anticoagulants
- Author
-
Yang Zong, Yan-Yan Xu, Yan Wu, Yamin Liu, Qian Li, Furong Lin, Shang-Bo Yu, Hui Wang, Wei Zhou, Xing-Wen Sun, Dan-Wei Zhang, and Zhan-Ting Li
- Subjects
Heparin ,Polymers ,Biomedical Engineering ,Anticoagulants ,Water ,Hemorrhage ,General Chemistry ,General Medicine ,Heparin, Low-Molecular-Weight ,Mice ,Animals ,Humans ,General Materials Science ,Porosity - Abstract
Heparins are natural and partially degraded polyelectrolytes that consist of sulfated polysaccharide backbones. However, as clinically used anticoagulants, heparins are associated with clinical bleeding risks and thus require rapid neutralization. Protamine sulfate is the only clinically approved antidote for unfractionated heparin (UFH), which not only may cause severe adverse reactions in patients, but also is only partially effective against low molecular weight heparins (LMWHs). We here present the facile synthesis of four porous multicationic dynamic covalent polymers (DCPs) from the condensation of tritopic aldehyde and acylhydrazine precursors. We show that, as new water-soluble polymeric antidotes, the new DCPs can effectively include both UFH and LMWHs and thus reverse their anticoagulating activity, which is confirmed by the activated partial thromboplastin time and thromboelastographic assays as well as mouse tail transection assay (bleeding model). The neutralization activities of two of the DCPs were found to be overall superior to that of protamine and have wider concentration windows and good biocompatibility. This pore-inclusion neutralization strategy paves the way for the development of water-soluble polymers as universal heparin binding agents.
- Published
- 2022
15. Enhanced Organic Contaminants Degradation Via Coupling Molybdenum Powder with Tripolyphosphate in Fe(Ⅱ)-Based Peroxymonosulfate Activation
- Author
-
Zhengwei Zhou, Guojie Ye, Yang Zong, Zhenyu Zhao, Longqian Xu, and Deli Wu
- Published
- 2023
16. Physiological and transcriptome analysis of Mytilus coruscus in response to Prorocentrum lima and microplastics
- Author
-
Tang, Xiao-wen, Yu, Rong, Fan, Mei-hua, Yang, Zhi, Liao, Zhi, Yang, Zong-xin, Xie, Chen-ying, Xuan, Yu-kun, Wang, Jian-xin, Zhang, Xiao-lin, and Yan, Xiao-jun
- Subjects
Global and Planetary Change ,Ocean Engineering ,Aquatic Science ,Oceanography ,Water Science and Technology - Abstract
Nowadays, diarrheic shellfish toxicity (DSP) toxin and microplastics (MPs) are commonly found in coastal waters worldwide. Due to their widespread use, their persistence and toxicity, they may induce adverse effects on Mytilus coruscus. However, the underlying toxic mechanisms of DSP and MPs on M. coruscus remain unclear. This study explored the physiological index and transcriptome change of the digestive gland of adult M. coruscus exposed for 3 days to polystyrene (PS) MPs (0.2 mg/L, 90-100 μm) and Prorocentrum lima alone or in combination. The results showed that the CAT activity and MDA content significantly increased, respiration rate and feeding rate significantly decreased. The combination of MPs and P. lima caused more structural damage to the rough surface endoplasmic reticulum and mitochondria in the digestive glands of M. coruscus. The transcriptome analysis showed that 485 and 220 genes were up- and down-regulated, respectively, after exposure to P. lima; 1,989 up-regulated DEGs and 1,098 down-regulated DEGs were identified after exposure to MP treatment, and 1,004 up-regulated DEGs and 664 down-regulated DEGs were identified after exposure to the combination of P. lima and MPs. The DEGs were mainly enriched in the lysosome, mRNA surveillance pathway, carbon metabolism, the mTOR signaling pathway, the complement and coagulation cascades, and the TNF signaling pathway. The MP, P. lima exposure mainly induced the expression of RNA-binding protein musashi, serine/arginine repetitive matrix protein 1, low affinity immunoglobulin epsilon Fc receptor, toll-like receptor 2, caspase 7, calmodulin, E3 ubiquitin-protein ligase, serine/threonine-protein kinase PRP4, glutathione S-transferase, and heat shock 70 kDa protein. MPs and P. lima poison mainly influence the expression of RNA transport, immune related gene, apoptosis, signal related gene, and antioxidant gene change. The combination of MPs and P. lima has a synergistic toxic effect. This study provides a new insights into its physiological and molecular responses of M. coruscus to MPs and P. lima toxic exposure.
- Published
- 2022
17. Effects and Components of Herb Pair Huanglian-Banxia on Diabetic Gastroparesis by Network Pharmacology
- Author
-
Xuanyi Chen, Yang Zong, Guorong Jiang, Guoqiang Liang, Fei Wang, and Lurong Zhang
- Subjects
China ,Gastroparesis ,Databases, Factual ,Article Subject ,Alternative therapy ,Pinellia ,Active components ,Computational biology ,Traditional Chinese medicine ,Network Pharmacology ,General Biochemistry, Genetics and Molecular Biology ,Diabetes Complications ,Diabetic Neuropathies ,Network pharmacology ,Diabetes Mellitus ,Herb pair ,Humans ,Medicine ,Medicine, Chinese Traditional ,KEGG ,General Immunology and Microbiology ,business.industry ,Diabetic gastroparesis ,Computational Biology ,General Medicine ,Ppi network ,business ,Research Article ,Drugs, Chinese Herbal - Abstract
Diabetic gastroparesis (DGP) is a serious and chronic complication of long-standing diabetes mellitus, which brings a heavy burden to individuals and society. Traditional Chinese medicine (TCM) is considered a complementary and alternative therapy for DGP patients. Huanglian (Coptidis Rhizoma, HL) and Banxia (Pinelliae Rhizoma, BX) combined as herb pair have been frequently used in TCM prescriptions, which can effectively treat DGP in China. In this article, a practical application of TCM network pharmacological approach was used for the research on herb pair HL-BX in the treatment of DGP. Firstly, twenty-seven potential active components of HL-BX were screened from the TCMSP database, and their potential targets were also retrieved. Then, the compound-target network and PPI network were constructed from predicted common targets, and several key targets were found based on the degree of the network. Next, GO and KEGG enrichment analyses were conducted to obtain several significantly enriched terms. Finally, the experimental verification was made. The results demonstrated that network pharmacological approach was a powerful means for identifying bioactive ingredients and mechanisms of action for TCM. Network pharmacology provided an effective strategy for TCM modern research.
- Published
- 2021
18. Intraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives
- Author
-
Yang Zong, Thomas M. Wheeler, Rodolfo Montironi, Zhong Jiang, Matteo Santoni, Francesco Massari, Liang Cheng, Marina Scarpelli, Alessia Cimadamore, and Antonio Lopez-Beltran
- Subjects
Male ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,Pelvis ,Diagnosis, Differential ,Pathogenesis ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Prostate ,Molecular genetics ,medicine ,Carcinoma ,Humans ,skin and connective tissue diseases ,business.industry ,Carcinoma in situ ,Differential diagnosis ,Germline DNA repair gene ,Gleason grading ,Intraductal carcinoma of the prostate ,Prostatic Neoplasms ,medicine.disease ,Carcinoma, Intraductal, Noninfiltrating ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cancer cell ,Cancer research ,business - Abstract
Intraductal carcinoma of the prostate (IDC-P), a clinicopathological entity characterized by malignant prostatic epithelial cells growing within ducts and/or acini, has a distinct architectural pattern, cytological features, and biological behavior. Whereas most IDC-P tumors could be derived from adjacent high-grade invasive cancer via retrograde spreading of cancer cells along benign ducts and acini, a small subset of IDC-P may arise from the transformation and intraductal proliferation of precancerous cells induced by various oncogenic events. These isolated IDC-P tumors possess a distinct mutational profile and may function as a carcinoma in situ lesion with de novo intraductal outgrowth of malignant cells. Further molecular characterization of these two types of IDC-P and better understanding of the mechanisms underlying IDC-P formation and progression could be translated into valuable biomarkers for differential diagnosis and actionable targets for therapeutic interventions. PATIENT SUMMARY: Intraductal carcinoma of the prostate is an aggressive type of prostate cancer associated with high risk for local recurrence and distant metastasis. In this review, we discussed pathogenesis, biomarkers, differential diagnoses, and therapeutic strategies for this tumor.
- Published
- 2021
19. [miRNA-181a-5p inhibits proliferation and migration of osteosarcoma cell line HOS by targeting HOXB4]
- Author
-
Jia-Xi, Li, Xi-Jing, He, Fei, Li, Yu-Tian, Lei, Yu-Bing, Yang, Jing, Li, Gao-Yang, Zong, Min-Chao, Zhao, and Su-E, Chang
- Subjects
Homeodomain Proteins ,MicroRNAs ,Osteosarcoma ,Cell Line, Tumor ,Humans ,Apoptosis ,Bone Neoplasms ,Cell Proliferation ,Transcription Factors - Abstract
To study the effects and mechanisms of miR-181a-5p on the proliferation, cycle and migration of HOS osteosarcoma cells.Real-time quantitative PCR was used to detect the expression of miR-181a-5p and HOXB4 in osteoblast hFOB1.19 cell line and osteosarcoma cell lines (HOS, U2OS, MG63). miR-181a-5p mimics and miR-181a-5p inhibitors were respectively transfected into HOS cells by Lipofectamine 2000, and miR NC group was set as control group. CCK-8 method was used to detect the change in cell proliferation. Flow cytometry was used to detect the changes in cell cycles. Wound healing experiments and Transwell migration experiments were used to detect the changes in cell migration ability. The target gene of miR-181a-5p was predicted by Targetscan website and validated by Dual-luciferase reporter gene system and Western blot.Compared with osteoblast hFOB1.19, miR-181a-5p was low expressed in osteosarcoma cells HOS, U2OS, and MG63(miR-181a-5p is down expressed in osteosarcoma cells, and over-expression miR-181a-5p inhibits the proliferation, cell cycle and migration ability of osteosarcoma cells by targeting HOXB4.
- Published
- 2022
20. Attribution of trends in meteorological drought during 1960–2016 over the Loess Plateau, China
- Author
-
Zhang Li-ping, Yang Zong-Liang, She Dunxian, LI Lingcheng, Guo Mengyao, and Hong Si
- Subjects
Climatology ,Air temperature ,Evapotranspiration ,Nature Conservation ,Earth and Planetary Sciences (miscellaneous) ,Environmental science ,Precipitation ,Loess plateau ,Wind speed - Abstract
This study uses two forms of the Palmer Drought Severity Index (PDSI), namely the PDSI_TH (potential evapotranspiration estimated-by the Thornthwaite equation) and the PDSI_PM (potential evapotranspiration estimated by the FAO Penman-Monteith equation), to characterize the meteorological drought trends during 1960–2016 in the Loess Plateau (LP) and its four subregions. By designing a series of numerical experiments, we mainly investigated various climatic factors’ contributions to the drought trends at annual, summer, and autumn time scales. Overall, the drying trend in the PDSI_TH is much larger than that in the PDSI_PM. The former is more sensitive to air temperature than precipitation, while the latter is the most sensitive to precipitation among all meteorological factors. Increasing temperature results in a decreasing trend (drying) in the PDSI_TH, which is further aggravated by decreasing precipitation, jointly leading to a relatively severe drying trend. For the PDSI_PM that considers more comprehensive climatic factors, the drying trend is partly counteracted by the declining wind speed and solar radiation. Therefore, the PDSI_PM ultimately shows a much smaller drying trend in the past decades.
- Published
- 2021
21. Staphylococcus aureusInfection Initiates Hypoxia-Mediated Transforming Growth Factor-β1 Upregulation to Trigger Osteomyelitis
- Author
-
Wei Zhang, Yiwei Lin, Yang Zong, Xin Ma, Chaolai Jiang, Haojie Shan, Wenyang Xia, Lifu Yin, Nan Wang, Lihui Zhou, Zubin Zhou, and Xiaowei Yu
- Subjects
Physiology ,Modeling and Simulation ,Genetics ,Molecular Biology ,Biochemistry ,Microbiology ,Ecology, Evolution, Behavior and Systematics ,Computer Science Applications - Abstract
The pathogenesis of osteomyelitis induced byStaphylococcus aureusremains unclear. To develop therapeutic approaches for osteomyelitis, it is important to understand the molecular mechanisms of its pathogenesis. Our results suggests that hypoxia/HIF-1α/TGF-β1 signaling is involved in osteomyelitis pathogenesis. Thus, these findings highlight the potential of this signaling components as therapeutic targets for the treatment of osteomyelitis.
- Published
- 2022
22. Mass-Forming Gastric Heterotopia of the Rectum: A Series of 3 Cases from a Single Tertiary Health Center
- Author
-
Jeffrey D, Covington, Yang, Zong, Arslan, Talat, Cara, Strock, Keith, Tomaszewicz, Jaroslav, Zivny, and Michelle X, Yang
- Subjects
Adult ,Male ,Rectal Diseases ,Gastric Mucosa ,Rectum ,Stomach Diseases ,Humans ,Female ,General Medicine ,Choristoma ,Middle Aged - Abstract
BACKGROUND Gastric heterotopia is a benign entity found throughout the gastrointestinal tract but is rarely identified in the rectum. Since 1939, only 94 cases have ever been identified, and it can present as a mass formation with symptomatology that mimics colorectal malignancy. In some instances, malignancy has been shown to arise within rectal gastric heterotopia. Here, we present 3 cases from the past 20-year period of rectal gastric heterotopia at a single tertiary institution. CASE REPORT A 25-year-old man (case 1), a 58-year-old woman (case 2), and a 33-year-old man (case 3) were found to have polypoid mass-like lesions greater than 1.0 cm within the rectum. Following biopsy, pathology showed gastric oxyntic mucosa flanked by colorectal mucosa, thus indicating gastric heterotopia. Presenting symptoms from all patients consisted of unspecified anal pain, hematochezia, or a combination of both. All patients were treated with endoscopic mucosal resection (EMR), which provided relief of symptoms and confirmed no evidence of invasive malignancy. CONCLUSIONS Rectal gastric heterotopia can mimic malignancy and in very rare instances can harbor high-grade dysplasia as well as invasive carcinoma. EMR seems to be a definitive treatment that offers relief to patient symptomatology and reassurance that any dysplasia is identified and removed.
- Published
- 2022
23. Enhanced Oxidation of Organic Contaminants by Iron(II)-Activated Periodate: The Significance of High-Valent Iron–Oxo Species
- Author
-
Zhenyu Zhao, Binbin Shao, Yang Zong, Deli Wu, Yufei Shao, Longqian Xu, Wen Liu, and Yunqiao Zeng
- Subjects
High-valent iron ,Ligand ,Hydrogen bond ,Iron ,Periodic Acid ,Inorganic chemistry ,Periodate ,Substrate (chemistry) ,Hydrogen Peroxide ,General Chemistry ,010501 environmental sciences ,01 natural sciences ,Potassium periodate ,chemistry.chemical_compound ,chemistry ,Peroxydisulfate ,Environmental Chemistry ,Ferrous Compounds ,Oxidation-Reduction ,Iodate ,0105 earth and related environmental sciences - Abstract
Potassium periodate (PI, KIO4) was readily activated by Fe(II) under acidic conditions, resulting in the enhanced abatement of organic contaminants in 2 min, with the decay ratios of the selected pollutants even outnumbered those in the Fe(II)/peroxymonosulfate and Fe(II)/peroxydisulfate processes under identical conditions. Both 18O isotope labeling techniques using methyl phenyl sulfoxide (PMSO) as the substrate and X-ray absorption near-edge structure spectroscopy provided conclusive evidences for the generation of high-valent iron-oxo species (Fe(IV)) in the Fe(II)/PI process. Density functional theory calculations determined that the reaction of Fe(II) with PI followed the formation of a hydrogen bonding complex between Fe(H2O)62+ and IO4(H2O)-, ligand exchange, and oxygen atom transfer, consequently generating Fe(IV) species. More interestingly, the unexpected detection of 18O-labeled hydroxylated PMSO not only favored the simultaneous generation of ·OH but also demonstrated that ·OH was indirectly produced through the self-decay of Fe(IV) to form H2O2 and the subsequent Fenton reaction. In addition, IO4- was not transformed into the undesired iodine species (i.e., HOI, I2, and I3-) but was converted to nontoxic iodate (IO3-). This study proposed an efficient and environmental friendly process for the rapid removal of emerging contaminants and enriched the understandings on the evolution mechanism of ·OH in Fe(IV)-mediated processes.
- Published
- 2021
24. Stereotactic Body Radiotherapy for Palliation of Hematuria Arising From Urothelial Carcinoma of the Kidney in Unfavorable Surgical Candidates
- Author
-
Larry Z. Zheng, Jessica Yancey, Linda Ding, Jennifer K. Yates, Kriti Mittal, Yang Zong, Zhong Jiang, Jesse N. Aronowitz, and Thomas J. Fitzgerald
- Subjects
Male ,Urologic Neoplasms ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Renal function ,Radiosurgery ,urologic and male genital diseases ,Nephrectomy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Humans ,Medicine ,030212 general & internal medicine ,Dialysis ,Aged ,Hematuria ,Retrospective Studies ,Aged, 80 and over ,Carcinoma, Transitional Cell ,Creatinine ,business.industry ,Palliative Care ,Middle Aged ,Prognosis ,Kidney Neoplasms ,Surgery ,medicine.anatomical_structure ,Oncology ,chemistry ,Tolerability ,030220 oncology & carcinogenesis ,Vomiting ,Female ,medicine.symptom ,business ,Complication ,Renal pelvis ,Follow-Up Studies - Abstract
Introduction Hematuria can be a distressing and debilitating complication of urothelial carcinoma (UC) of the kidney for patients who are not candidates for surgery or ureteroscopic ablation. We retrospectively assessed the efficacy, tolerability, and safety of stereotactic body radiotherapy (SBRT) for controlling gross hematuria in this patient population. Materials and methods Institutional Review Board (IRB)-approved review of the records, laboratory values, pathology, and imaging of 8 consecutive patients treated with SBRT over a 5-year period for uncontrolled gross hematuria caused by UC of the renal pelvis or calyces. Results Therapy was delivered in 3 to 5 treatments over 1 to weeks. Individual treatments lasted an average of 17.2 minutes. No patient experienced treatment-related pain, vomiting, or diarrhea. All enjoyed cessation of bleeding within a week of completing therapy. Hematuria recurred in 2 patients in 4 and 22 months. Of the patients who have not re-bled, 3 expired of metastatic disease or co-morbidities, and 3 remain alive up to 6 years posttreatment. Of patients who have survived longer than a year, creatinine has changed by -0.05 to +0.35, and estimated glomerular filtration rate has fallen by an average of 22%. No patient has required dialysis. Conclusions SBRT appears to be an effective and well-tolerated means of palliating gross hematuria secondary to UC of the renal pelvis or calyces in patients who are unfavorable candidates for nephrectomy or ureteroscopic ablation. Treatment was associated with a moderate decline in renal function.
- Published
- 2021
25. Cytologically targeted next-generation sequencing: a synergy for diagnosing urothelial carcinoma
- Author
-
Kristine M. Cornejo, Jennifer Yates, Taylor Harris, Lukas Bubendorf, Lloyd Hutchinson, Yang Zong, Andrew H. Fischer, and Ankur Sheel
- Subjects
Oncology ,Urologic Neoplasms ,medicine.medical_specialty ,DNA Mutational Analysis ,030209 endocrinology & metabolism ,Abnormal cell ,Urinalysis ,Urine ,DNA sequencing ,Pathology and Forensic Medicine ,Ancillary test ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Early Detection of Cancer ,Microdissection ,Laser capture microdissection ,Urothelial carcinoma ,Microscopy ,medicine.diagnostic_test ,business.industry ,Carcinoma ,High-Throughput Nucleotide Sequencing ,Reproducibility of Results ,Cystoscopy ,030220 oncology & carcinogenesis ,Decreased Sensitivity ,Cytogenetic Analysis ,Mutation ,Neoplasm Grading ,Urothelium ,business - Abstract
Introduction Cytology and cystoscopy are used to detect urothelial carcinoma (UC), but together they still fail to detect some UC cases and are not suitable for screening asymptomatic individuals. Mutations are present in more than 98% of UC, mutations have therapeutic significance, and they can be detected by next generation sequencing (NGS) in urine samples. We review the role of NGS in UC detection. Materials and methods Comprehensive literature review on UC genetics, economics of NGS, and previous reports of UC detection by NGS. Results The raw costs of NGS have decreased to about 14,000 base pairs per penny, making it appear economically feasible to use NGS widely. Reported NGS assays fall short of predicted sensitivity. Decreased sensitivity is attributed to a low frequency of mutant alleles in many urine samples. Attempts to increase the percentage of mutant alleles, by using cell-free urinary DNA, or by using cell sorting and microfluidics, have been unsuccessful or remain unproven. However, cytologic examination can immediately enable NGS: Urine cytologies with sufficient proportions of abnormal cells could be directly triaged to NGS with high sensitivity for UC detection. For cases with a low proportion of abnormal cells, cytologically targeted microdissection of cells for NGS should maintain sensitivity and decrease sequencing costs. Cytologically targeted urothelial cells for NGS could allow a screening test for low grade UC. Conclusions Cytology is immediately poised to allow NGS to improve the diagnosis of UC, allowing NGS to be an ancillary test for atypical cytologies, and potentially allowing a screening test for low-grade UC.
- Published
- 2021
26. Therapeutic Erythrocytapheresis Is Effective in Treating High Altitude Polycythemia on the Qinghai-Tibet Plateau
- Author
-
Pengpeng Xu, Xiaoyang Li, Yu Zheng, Jie Fang, Ba Dun, Zong Ji, Luo Bu Zhuo Ma, Ci Ren Yang Zong, Yuexin Dong, Junmin Li, Fei Yue, and Pu Bu Wang Dui
- Subjects
Adult ,Male ,medicine.medical_specialty ,Polycythemia ,Hematocrit ,Tibet ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,Whole blood ,geography ,Plateau ,geography.geographical_feature_category ,medicine.diagnostic_test ,business.industry ,Altitude ,Public Health, Environmental and Occupational Health ,030208 emergency & critical care medicine ,030229 sport sciences ,Middle Aged ,Phlebotomy ,Cytapheresis ,Red blood cell ,medicine.anatomical_structure ,High altitude polycythemia ,Emergency Medicine ,Cardiology ,Female ,Therapeutic erythrocytapheresis ,Hemoglobin ,business - Abstract
Introduction High altitude polycythemia (HAPC) is a common chronic disease at high altitudes. It is characterized by excessive erythrocytosis (≥190 g·L-1 in females or ≥210 g·L-1 in males). HAPC severely jeopardizes the health status of plateau dwellers. The Qinghai-Tibet plateau, with an elevation above 4000 m, is the highest plateau in the world. Both Han and Tibetan populations residing there face the threat of HAPC. Therapeutic erythrocytapheresis (TE) was introduced to Tibet as an alternative to phlebotomy in 2015. Methods In this study, we retrospectively analyzed 155 patients with HAPC treated with TE in Tibet. Routine blood testing values before and after TE were compared to evaluate treatment efficacy. The efficiency rate, defined as the rate of increase in red blood cell depletion attained by TE compared with 450 mL whole blood phlebotomy, was calculated using whole blood volume and hematocrit before and after treatment and used to identify patients who maintained a normal hemoglobin level in the year after the TE procedure. Results On average, TE reduced red blood cell levels by 1.5×1012·L-1, hemoglobin concentration by 52 g·L-1, and hematocrit by 14% (P Conclusions TE is a feasible therapeutic method to treat HAPC on the Qinghai-Tibet plateau. The efficiency rate is a useful tool to predict the expected interval between TE procedures.
- Published
- 2020
27. Role of interspecies electron transfer stimulation in enhancing anaerobic digestion under ammonia stress: Mechanisms, advances, and perspectives
- Author
-
Jun Xu, Samir Kumar Khanal, Yurui Kang, Jiaxin Zhu, Xia Huang, Yang Zong, Weihai Pang, K.C. Surendra, and Li Xie
- Subjects
Electron Transport ,Environmental Engineering ,Bioreactors ,Renewable Energy, Sustainability and the Environment ,Ammonia ,Bioengineering ,Electrons ,General Medicine ,Anaerobiosis ,Waste Management and Disposal ,Methane - Abstract
Ammonia stress is a commonly encountered issue in anaerobic digestion (AD) process when treating proteinaceous substrates. The enhanced relationship between syntrophic bacteria and methanogens triggered by interspecies electron transfer (IET) stimulation is one of the potential mechanisms for an improved methane yield from the AD plant under ammonia-stressed condition. There is, however, lack of synthesized information on the mechanistic understanding of IET facilitation in the ammonia-stressed AD processes. This review critically discusses recovery of AD system from ammonia-stressed condition, focusing on H
- Published
- 2022
28. Precise manipulation of the charge percolation networks of flow-electrode capacitive deionization using a pulsed magnetic field
- Author
-
Longqian Xu, Shuai Peng, Ke Wu, Liang Tang, Minghong Wu, Yang Zong, Yunfeng Mao, and Deli Wu
- Subjects
Environmental Engineering ,Magnetic Fields ,Ecological Modeling ,Adsorption ,Sodium Chloride ,Pollution ,Waste Management and Disposal ,Electrodes ,Water Science and Technology ,Civil and Structural Engineering ,Water Purification - Abstract
Magnetic field is a simple and powerful means that enables controlled the transport of electrode particles in flow electrode capacitive deionization (FCDI). However, the magnetic particles are easily stripped from hybrid suspension electrodes and the precise manipulation of the charge percolation network remains challenging. In this study, a programmable magnetic field was introduced into the FCDI system to enhance the desalination performance and operational stability of magnetic FCDI, with core-shell magnetic carbon (MC) used as an alternative electrode additive. The results showed that the pulsed magnetic field (PMF) was more effective in enhancing the average salt removal rate (ASRR) compared to the constant magnetic field (CMF), with 51.6% and 67.7% enhancement, respectively, compared to the magnetic field-free condition. The outstanding advantage of the PMF lies in the enhancement in the trapping and mediating effects in the switching magnetic field, which keeps the concentration of the electrode particles near the current collector at a high level and greatly facilitates electron transport. In long-term operation (20,000 cycles), the pulsed magnetic FCDI achieved a stable desalinating rate of 0.4-0.68 μmol min
- Published
- 2022
29. Experimental research of high energy electron radiography at HERPL
- Author
-
zhaohui ran, jia li, zhongping li, quantang zhao, xiaokang shen, yang zong, youwei zhou, zimin zhang, and shuchun cao
- Published
- 2022
30. [Analysis of Ozone Pollution Spatio-temporal Evolution Characteristics and Identification of Its Long-term Variation Driving Factor over Hunan Province]
- Author
-
Yan-Yan, Liu, Lei-Feng, Yang, Dan-Ping, Xie, Yang-Zong, Ze-Ren, Zhi-Jiong, Huang, Jun, Yang, Peng, Zhao, Jing-Lei, Han, Wen-Chao, Jia, and Zi-Bing, Yuan
- Subjects
Air Pollutants ,China ,Ozone ,Air Pollution ,Particulate Matter ,Seasons ,Environmental Monitoring - Abstract
Despite the alleviation of particulate matter (PM), the ambient ozone (O
- Published
- 2022
31. Selective Recovery of Phosphorus from Synthetic Urine Using Flow-Electrode Capacitive Deionization (FCDI)-Based Technology
- Author
-
Changyong Zhang, Yunfeng Mao, Chao Yu, Longqian Xu, Bing Zhang, Yang Zong, Xiaomeng Zhang, Shiyu Tian, and Deli Wu
- Subjects
Chromatography ,Chemistry ,Capacitive deionization ,Phosphorus ,Extraction (chemistry) ,chemistry.chemical_element ,Urine ,Phosphate ,chemistry.chemical_compound ,Chemistry (miscellaneous) ,Electrode ,Environmental Chemistry ,Chemical Engineering (miscellaneous) ,Selectivity ,Phosphoric acid ,Water Science and Technology - Abstract
Extraction of high-purity phosphate (P) from source-separated urine has attracted growing interest, given its potential economic and environmental benefits. In this study, we present an innovative ...
- Published
- 2020
32. Optimal treatment of chronic kidney disease with uncertainty in obtaining a transplantable kidney: an MDP based approach
- Author
-
Wenjuan Fan, Subodha Kumar, and Yang Zong
- Subjects
medicine.medical_specialty ,Kidney ,021103 operations research ,business.industry ,medicine.medical_treatment ,Optimal treatment ,0211 other engineering and technologies ,General Decision Sciences ,02 engineering and technology ,Disease ,Management Science and Operations Research ,medicine.disease ,Transplantation ,medicine.anatomical_structure ,medicine ,Markov decision process ,Intensive care medicine ,business ,Kidney transplantation ,Dialysis ,Kidney disease - Abstract
Chronic kidney disease (CKD) is one of the most serious and prevalent health issues all over the world. The evolution of CKD can last for many years until the death of patients, and the method of treatment mainly includes medication, dialysis, and transplantation with the evolution of the disease. It has been validated by many empirical studies that for severe CKD patients, the optimal treatment is transplantation if a suitable kidney is available, otherwise the patients should initiate dialysis at a suitable time. It has also been validated that the initiation time of dialysis significantly impacts not only the direct treatment results, but also the success of a future possible kidney transplantation. Motivated by this consideration, we investigate the decision-making problem of the optimal treatment approach to maximize the patient’s total reward including pre-transplant reward and post-transplant reward (if applicable), considering the possibility of having a suitable kidney transplantation in the future. A Markov decision process model is established in which the status of the process is described by the patient health status. We present some structural properties of the decision-making problem, which are used to choose the optimal treatment approach in different health status of patients. We collect the clinical data in the simulation experiments to obtain the fitted curves of the evolution process of different CKD patients, and compare the simulation results with the actual clinical data to demonstrate the advantage of our model.
- Published
- 2020
33. In situ control of nanowire resistance with real time monitoring by using self-heating induced oxidation
- Author
-
Yang Zong, Danna Zhao, Hui Huang, and Zhenan Tang
- Subjects
010302 applied physics ,In situ ,Microscope ,business.industry ,Nanowire ,General Physics and Astronomy ,chemistry.chemical_element ,02 engineering and technology ,Thermal emission ,021001 nanoscience & nanotechnology ,01 natural sciences ,Oxygen ,law.invention ,Contact barrier ,chemistry ,law ,0103 physical sciences ,Electrode ,Optoelectronics ,General Materials Science ,0210 nano-technology ,Self heating ,business - Abstract
It was firstly demonstrated that the resistance of bridging GaN nanowires (NWs) can be in situ controlled via current driven self-heating. Owning to the absence of contact barrier at the electrodes of bridging NWs, the Joule-heating can be generated mainly on the NW itself rather than on the electrodes. With increase of NW bias-voltage (BiV) from 2.5 V to 10 V, the generated Joule-heating can make the NW oxidized in air, which leads to about 700 fold increase in NW resistance (from 82.5 Ω to 6 × 104 Ω). Theoretical simulation indicated that a NW temperature of 649 K can realized with a BiV of 4 V, which agrees well with the observation of thermal emission microscope. Moreover, the measured oxygen composition in the NWs was increased with increasing BiV, which indicates that the NWs were oxidized by BiV induced self-heating. This work provides a simple method for precise control of NW resistance, which can be further applied to the formation of core/shell NWs with real time monitoring.
- Published
- 2020
34. miR-26a Attenuated Bone-Specific Insulin Resistance and Bone Quality in Diabetic Mice
- Author
-
Xiaowei Yu, Fuli Yin, Haojie Shan, Yiwei Lin, Chaolai Jiang, Nan Wang, Fusong Jiang, Wenyang Xia, Yang Zong, Zubin Zhou, Lihui Zhou, and Xin Ma
- Subjects
0301 basic medicine ,medicine.medical_specialty ,miR-26a ,medicine.medical_treatment ,Carbohydrate metabolism ,bone ,Article ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Osteoclast ,Internal medicine ,Diabetes mellitus ,Drug Discovery ,medicine ,insulin receptor ,diabetes ,biology ,business.industry ,Insulin ,lcsh:RM1-950 ,Osteoblast ,medicine.disease ,Insulin receptor ,lcsh:Therapeutics. Pharmacology ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,biology.protein ,Molecular Medicine ,business - Abstract
Diabetes mellitus is a prevalent disease result in several complications, including bone problems. Previous studies have shown that microRNA (miR)-26a regulates glucose metabolism and plays a protective role in diabetes. However, whether miR-26a also affects bone quality in diabetes remains unknown. In the present study, we evaluated the potential effects of miR-26a on bone in diabetic mice. We administrated miR-26a in streptozotocin-induced diabetic mice. The metabolic parameters, bone quality, osteoblast and osteoclast markers, and insulin signaling activation were measured. miR-26a ameliorated insulin resistance and glucose tolerance, improved bone microarchitecture and quality, increased osteoblasts and bone formation, decreased osteoclasts, and promoted the insulin signaling pathway in diabetic mice. These effects were abolished in insulin receptor-compromised Col1a1-Insr+/– mice. In conclusion, miR-26a could ameliorate bone-specific insulin resistance and bone quality in diabetic mice, which depended on the insulin receptors on osteoblasts. Our findings highlight the potential of miR-26a as a therapeutic target for diabetes mellitus-related bone metabolism and diseases., Graphical Abstract, In this study, it is found that miR-26a could ameliorate bone-specific insulin resistance and bone quality in diabetic mice, which depended on the insulin receptors on osteoblasts. The findings highlight the potential of miR-26a as a therapeutic target for diabetes mellitus-related bone metabolism and diseases.
- Published
- 2020
35. LC drop process based on PS height of color filter
- Author
-
樊明雷 Fan Ming-lei, 熊奇 Xiong Qi, 杨德波 Yang De-bo, 杨宗顺 Yang Zong-shun, 胡宏波 Hu Hong-bo, 许志军 Xu Zhi-jun, 熊永 Xiong Yong, 秦祖江 Qin Zu-jiang, and 张志聪 Zhang Zhi-cong
- Subjects
Materials science ,Optics ,business.industry ,Color gel ,Drop (liquid) ,Signal Processing ,business ,Instrumentation ,Electronic, Optical and Magnetic Materials - Published
- 2020
36. Magnetic Array for Highly Efficient and Stable Flow-Electrode Capacitive Deionization
- Author
-
Longqian Xu, Shuai Peng, Yang Zong, Xiaomeng Zhang, Yunfeng Mao, and Deli Wu
- Published
- 2022
37. Overlooked Oxidative Role of Ni(Iii) in the Enhanced Mineralization of Ni(Ii)–Edta Complex by Ozonation
- Author
-
Yang Zong, Wenjie Ji, Yu Xie, and Deli Wu
- Subjects
Filtration and Separation ,Analytical Chemistry - Published
- 2022
38. Machine Learning-Based Streamflow Forecasting Approach
- Author
-
Tabassum, Sabiha, Yang, Zong-Liang, Wu, Wen-Ying, Shukla, Ashutosh, Kutanoglu, Erhan, Hasenbein, John, and King, Carey
- Published
- 2022
- Full Text
- View/download PDF
39. Trace Mn(Ii)-Catalyzed Periodate Oxidation of Organic Contaminants Not Relying on Any Transient Reactive Species: The Substrate-Dependent Dual Roles of In-Situ Formed Colloidal Mno2
- Author
-
Yang Zong, Yufei Shao, Wenjie Ji, Yunqiao Zeng, Jun Xu, Wen Liu, Longqian Xu, and Deli Wu
- Subjects
General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2022
40. IL-34 Aggravates Steroid-Induced Osteonecrosis of the Femoral Head via Promoting Osteoclast Differentiation
- Author
-
Feng Wang, Hong Sung Min, Haojie Shan, Fuli Yin, Chaolai Jiang, Yang Zong, Xin Ma, Yiwei Lin, Zubin Zhou, and Xiaowei Yu
- Subjects
Infectious Diseases ,Immunology ,Immunology and Allergy - Abstract
IL-34 can promote osteoclast differentiation and activation, which may contribute to steroid-induced osteonecrosis of the femoral head (ONFH). Animal model was constructed in both BALB/c and IL-34 deficient mice to detect the relative expression of inflammation cytokines. Micro-CT was utilized to reveal the internal structure.
- Published
- 2022
41. Sex differences in the oral microbiome, host traits, and their causal relationships
- Author
-
Xiaomin Liu, Xin Tong, Zhuye Jie, Jie Zhu, Liu Tian, Qiang Sun, Yanmei Ju, Leying Zou, Haorong Lu, Xuemei Qiu, Qiang Li, Yunli Liao, Heng Lian, Yong Zuo, Xiaomin Chen, Weiqiao Rao, Yan Ren, Yuan Wang, Jin Zi, Rong Wang, Xun Xu, Huanming Yang, Jian Wang, Yang Zong, Weibin Liu, Yong Hou, Xin Jin, Liang Xiao, Karsten Kristiansen, Huijue Jia, and Tao Zhang
- Subjects
Multidisciplinary ,Oral microbiology ,Microbiome ,Microbial metabolism - Abstract
The oral microbiome has been implicated in a growing number of diseases; however, determinants of the oral microbiome and their roles remain elusive. Here, we investigated the oral (saliva and tongue dorsum) metagenome, the whole genome, and other omics data in a total of 4,478 individuals and demonstrated that the oral microbiome composition and its major contributing host factors significantly differed between sexes. We thus conducted a sex-stratified metagenome-genome-wide-association study (M-GWAS) and identified 11 differential genetic associations with the oral microbiome (psex-difference < 5 × 10−8). Furthermore, we performed sex-stratified Mendelian randomization (MR) analyses and identified abundant causalities between the oral microbiome and serum metabolites. Notably, sex-specific microbes-hormonal interactions explained the mostly observed sex hormones differences such as the significant causalities enrichments for aldosterone in females and androstenedione in males. These findings illustrate the necessity of sex stratification and deepen our understanding of the interplay between the oral microbiome and serum metabolites. The oral microbiome has been implicated in a growing number of diseases; however, determinants of the oral microbiome and their roles remain elusive. Here, we investigated the oral (saliva and tongue dorsum) metagenome, the whole genome, and other omics data in a total of 4,478 individuals and demonstrated that the oral microbiome composition and its major contributing host factors significantly differed between sexes. We thus conducted a sex-stratified metagenome-genome-wide-association study (M-GWAS) and identified 11 differential genetic associations with the oral microbiome (psex-difference < 5 × 10−8). Furthermore, we performed sex-stratified Mendelian randomization (MR) analyses and identified abundant causalities between the oral microbiome and serum metabolites. Notably, sex-specific microbes-hormonal interactions explained the mostly observed sex hormones differences such as the significant causalities enrichments for aldosterone in females and androstenedione in males. These findings illustrate the necessity of sex stratification and deepen our understanding of the interplay between the oral microbiome and serum metabolites.
- Published
- 2023
42. Enhancing Brackish Water Desalination using Magnetic Flow-electrode Capacitive Deionization
- Author
-
Longqian Xu, Shuai Peng, Yunfeng Mao, Yang Zong, Xiaomeng Zhang, and Deli Wu
- Subjects
Environmental Engineering ,Magnetic Fields ,Ecological Modeling ,Adsorption ,Sodium Chloride ,Sodium Chloride, Dietary ,Pollution ,Waste Management and Disposal ,Electrodes ,Saline Waters ,Water Science and Technology ,Civil and Structural Engineering ,Water Purification - Abstract
Flow-electrode capacitive deionization (FCDI) is viewed as a potential alternative to the current state-of-the-art electrodriven technology for the desalination of brackish water. However, the key shortcoming of the FCDI is still the discontinuous nature of the electrode conductive network, resulting in low electron transport efficiency and ion adsorption capacity. Here, a novel magnetic field-assisted FCDI system (termed magnetic FCDI) is proposed to enhance brackish water desalination, simply by using magnetic activated carbon (MAC) as flow electrodes. The results show that the assistance from the magnetic field enables a 78.9% - 205% enhancement in the average salt removal rate (ASRR) compared with that in the absence of a magnetic field, which benefits from the artificial manipulation of the flow electrode transport behavior. In long-term tests, the stable desalination performance of magnetic FCDI was also demonstrated with a stable ASRR of 0.70 μmol cm
- Published
- 2021
43. A population-based study of precision health assessments using multi-omics network-derived biological functional modules
- Author
-
Wei Zhang, Ziyun Wan, Xiaoyu Li, Rui Li, Lihua Luo, Zijun Song, Yu Miao, Zhiming Li, Shiyu Wang, Ying Shan, Yan Li, Bangwei Chen, Hefu Zhen, Yuzhe Sun, Mingyan Fang, Jiahong Ding, Yizhen Yan, Yang Zong, Zhen Wang, Wenwei Zhang, Huanming Yang, Shuang Yang, Jian Wang, Xin Jin, Ru Wang, Peijie Chen, Junxia Min, Yi Zeng, Tao Li, Xun Xu, and Chao Nie
- Subjects
Cross-Sectional Studies ,Humans ,Female ,Precision Medicine ,Multiomics ,General Biochemistry, Genetics and Molecular Biology - Abstract
Recent technological advances in multi-omics and bioinformatics provide an opportunity to develop precision health assessments, which require big data and relevant bioinformatic methods. Here we collect multi-omics data from 4,277 individuals. We calculate the correlations between pairwise features from cross-sectional data and then generate 11 biological functional modules (BFMs) in males and 12 BFMs in females using a community detection algorithm. Using the features in the BFM associated with cardiometabolic health, carotid plaques can be predicted accurately in an independent dataset. We developed a model by comparing individual data with the health baseline in BFMs to assess health status (BFM-ash). Then we apply the model to chronic patients and modify the BFM-ash model to assess the effects of consuming grape seed extract as a dietary supplement. Finally, anomalous BFMs are identified for each subject. Our BFMs and BFM-ash model have huge prospects for application in precision health assessment.
- Published
- 2022
44. Electric field-enhanced coupled with metal-free peroxymonosulfate activactor: The selective oxidation of nonradical species-dominated system
- Author
-
Chao Yu, Zhenyu Zhao, Yang Zong, Longqian Xu, Bing Zhang, and Deli Wu
- Subjects
Environmental Engineering ,Sulfamethoxazole ,Metals ,Ecological Modeling ,Oxidation-Reduction ,Pollution ,Waste Management and Disposal ,Boron ,Peroxides ,Water Science and Technology ,Civil and Structural Engineering - Abstract
Nowadays metal-free persulfate-based advanced oxidation processes (AOPs) have been intensively investigated, however, the catalysts are often too complex to fully consider their application potential. Conventional AOPs usually suffer from severe interference in real water matrix, thus, selective oxidation is practically and scientifically challenging as it could avoid unnecessary inputs of energy and possible secondary pollutants. In this study, a remarkably synergistic effect was achieved when conventional amorphous boron/peroxymonosulfate (Boron/PMS, 0.67 × 10
- Published
- 2022
45. Membrane-Current Collector-Based Flow-Electrode Capacitive Deionization System: A Novel Stack Configuration for Scale-Up Desalination
- Author
-
Yunfeng Mao, Shuai Peng, Longqian Xu, Xiaomeng Zhang, Yang Zong, and Deli Wu
- Subjects
Salinity ,Materials science ,business.industry ,Capacitive deionization ,General Chemistry ,Energy consumption ,Sodium Chloride ,Desalination ,Water Purification ,Stack (abstract data type) ,SCALE-UP ,Electrode ,Environmental Chemistry ,Adsorption ,Performance improvement ,Process engineering ,business ,Electrodes ,Scaling - Abstract
The stack configuration in flow-electrode capacitive deionization (FCDI) has been verified to be an attractive and feasible strategy for scaling up the desalination process. However, challenges still exist when attempting to simultaneously improve the desalination scale and the cell configuration. Here, we describe a novel stack FCDI configuration (termed a gradient FCDI system) based on a membrane-current collector assembly, in which the charge neutralization enables the in situ regeneration of the flow electrodes in the single cycle operation, thereby realizing a considerable increase in the desalinating performance. By evaluating standardized metrics such as the salt rejection, productivity (P), average salt removal rate (ASRR), energy-normalized removed salt (ENRS), and TEE, the results indicated that the gradient FCDI system could be a performance-stable and energy-efficient alternative for scale-up desalination. Under optimal operating conditions (carbon content = 10 wt %, feed salinity = 3000 mg L-1, cell voltage = 1.2 V, and productivity = 56.7 L m-2 h-1), the robust desalination performance (ASRR = 1.07 μmol cm-2 min-1) and energy consumption (ENRS = 7.8 μmol J-1) of the FCDI system with a desalination unit number of four were verified at long-term operation. In summary, the stacked gradient FCDI system and its operation mode described here may be an innovative and promising strategy capable of enlarging the scale of desalination while realizing performance improvement and device simplification.
- Published
- 2021
46. Distinct biological ages of organs and systems identified from a multi-omics study
- Author
-
Chao Nie, Yan Li, Rui Li, Yizhen Yan, Detao Zhang, Tao Li, Zhiming Li, Yuzhe Sun, Hefu Zhen, Jiahong Ding, Ziyun Wan, Jianping Gong, Yanfang Shi, Zhibo Huang, Yiran Wu, Kaiye Cai, Yang Zong, Zhen Wang, Rong Wang, Min Jian, Xin Jin, Jian Wang, Huanming Yang, Jing-Dong J. Han, Xiuqing Zhang, Claudio Franceschi, Brian K. Kennedy, and Xun Xu
- Subjects
Aged, 80 and over ,Aging ,Longevity ,Humans ,Metabolomics ,Longitudinal Studies ,Nutrition Surveys ,General Biochemistry, Genetics and Molecular Biology - Abstract
Biological age (BA) has been proposed to evaluate the aging status instead of chronological age (CA). Our study shows evidence that there might be multiple "clocks" within the whole-body system: systemic aging drivers/clocks overlaid with organ/tissue-specific counterparts. We utilize multi-omics data, including clinical tests, immune repertoire, targeted metabolomic molecules, gut microbiomes, physical fitness examinations, and facial skin examinations, to estimate the BA of different organs (e.g., liver, kidney) and systems (immune and metabolic system). The aging rates of organs/systems are diverse. People's aging patterns are different. We also demonstrate several applications of organs/systems BA in two independent datasets. Mortality predictions are compared among organs' BA in the dataset of the United States National Health and Nutrition Examination Survey. Polygenic risk score of BAs constructed in the Chinese Longitudinal Healthy Longevity Survey cohort can predict the possibility of becoming centenarian.
- Published
- 2021
47. Role of reactive oxygen species in As(III) oxidation by carbonate structural Fe(II): A surface-mediated pathway
- Author
-
Zeyuan Tian, Binbin Shao, Deli Wu, and Yang Zong
- Subjects
chemistry.chemical_classification ,Reactive oxygen species ,General Chemical Engineering ,Iodide ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,chemistry.chemical_compound ,Adsorption ,chemistry ,parasitic diseases ,Environmental Chemistry ,Carbonate ,Hydroxyl radical ,Molecular oxygen ,0210 nano-technology ,Scavenging ,Arsenite ,Nuclear chemistry - Abstract
Arsenite oxidation is commonly found during the removal of arsenite by iron minerals. The influencing factors and mechanisms of As(III) oxidation in reactive carbonate structural Fe(II) (CSF) suspensions were investigated in this study. Results showed that oxidation efficiency of As(III) was susceptible to CSF dosage, initial pH and dissolved oxygen (DO). It is interesting to note that the presence of iodide could conspicuously facilitate the oxidation efficiency of As(III) by accelerating Fe(III)/Fe(II) cycle. Scavenging experiments demonstrated that H2O2 and ·O2– were the crucial ROSs in the pH range of 5.0–9.0. Besides, the other predominant ROSs accounting for As(III) oxidation were Fe(IV) and surface-bound hydroxyl radical (·OH) in acid and neutral solutions while Fe(IV) became the main oxidant in alkaline solutions. Production of ROSs was attributed to the oxygenation of Fe2+ adsorbed on Fe(III) oxyhydroxides and complexed Fe(II) under neutral condition. No ROSs could be examined in the liquid phase, a surface-mediated mechanism was thus proposed: ROSs were generated on the surface of CSF while As(III) was adsorbed on the surface of CSF and then oxidized to As(V) by surface-bound ROSs. This study may shed light on molecular oxygen activation mechanism by carbonate structural Fe(II) during arsenite oxidation.
- Published
- 2019
48. Observer-Based Capacitor Current Sensorless Control Applied to a Single-Phase Inverter System With Seamless Transfer
- Author
-
Huang Shu-Syuan, Yang Zong-Zhen, Min-Ju Hsieh, and Yoshihiro Konishi
- Subjects
Battery (electricity) ,Observer (quantum physics) ,Computer science ,020208 electrical & electronic engineering ,Ripple ,02 engineering and technology ,Inductor ,law.invention ,Capacitor ,Control theory ,law ,Capacitor voltage ,Control system ,0202 electrical engineering, electronic engineering, information engineering ,Inverter ,Digital control ,Electrical and Electronic Engineering - Abstract
In this paper, capacitor current sensorless control by using an observer is applied in a seamless transfer single-phase inverter. The proposed control system is a multiloop control system. The control loop is composed of a capacitor voltage outer control loop and capacitor current inner control loop for stand-alone mode. For on-grid mode, the grid current outer loop controller is combined with the stand-alone control structure to form a simple controller structure for mode switching. The capacitor current feedback signal is calculated using the observer in the discrete-time domain and thus sensors are not required. Use of the proposed observer for the inverter with capacitor current control has many advantages, such as sensorless capacitor current calculation, one-sample-ahead data prediction for sampling delay compensation, and an average capacitor current without ripple components. Verification of the theoretical analysis is presented through simulation and experiment. A 5-kW single-phase inverter prototype combined with a Li-ion battery is set up with a digital controller using a TI TMS320F28377D microcontroller unit to confirm the feasibility of the system.
- Published
- 2019
49. Research and solution of ESD problem for a GOA product
- Author
-
钟 野 Zhong Ye, 陶 雄 Tao Xiong, 杨宗顺 Yang Zong-shun, 李 伟 Li Wei, 王耀杰 Wang Yao-jie, and 张志聪 Zhang Zhi-cong
- Subjects
business.industry ,Computer science ,Product (mathematics) ,Signal Processing ,Process engineering ,business ,Instrumentation ,Electronic, Optical and Magnetic Materials - Published
- 2019
50. Half-life extension of porcine interferon-α by fusion to the IgG-binding domain of streptococcal G protein
- Author
-
Jingjing Xiao, Xiao Tan, Xinyu Zhang, Xiaoli Xia, Yang Zong, and Huaichang Sun
- Subjects
0106 biological sciences ,Swine ,Recombinant Fusion Proteins ,medicine.medical_treatment ,Amino Acid Motifs ,Genetic Vectors ,Biological Availability ,Gene Expression ,Peptide ,01 natural sciences ,Virus ,Cell Line ,03 medical and health sciences ,Bacterial Proteins ,010608 biotechnology ,Endopeptidases ,Escherichia coli ,medicine ,Animals ,Humans ,Cloning, Molecular ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,Protease ,Expression vector ,biology ,Tobacco etch virus ,Chemistry ,Interferon-alpha ,Epithelial Cells ,Vesiculovirus ,biology.organism_classification ,Herpesvirus 1, Suid ,Fusion protein ,Molecular biology ,Elastin ,Rats ,Vesicular stomatitis virus ,IgG binding ,Biological Assay ,Peptides ,Half-Life ,Protein Binding ,Biotechnology - Abstract
Recombinant interferon-α (rIFN-α) has been widely used for treating viral infections. However, the clinical efficacy of unmodified rIFN-α is limited due to small molecular size and rapid clearance from circulation. In this study we developed a novel strategy for half-life extension of porcine IFN-α (PoIFN-α) by fusion to the immunoglobulin (Ig)-binding C2 domain of streptococcal protein G (SPG). The coding sequences for PoIFN-α6 and SPG C2 domain, with a tobacco etch virus (TEV) protease recognition sequence introduced at the 5-end, were cloned into an elastin-like polypeptide (ELP) fusion expression vector and expressed as an ELP-PoIFNα-C2 fusion protein. After optimization of the conditions for soluble protein expression and purification, the fusion protein was purified to more than 90% purity by two rounds of inverse transition cycling (ITC) in the presence of 0.5% Triton X-100. After cleavage with self-aggregating peptide ELK-16-tagged tobacco etch virus protease, the protease was removed by quick centrifugation and PoIFNα-C2 protein was recovered by an additional round of ITC with 98% purity. Western blotting analysis showed that PoIFNα-C2 protein had the specific affinity for pig IgG binding. The antiviral assay showed that PoIFNα-C2 protein had potent antiviral activities against vesicular stomatitis virus and porcine pseudorabies virus. After single intravenous or subcutaneous injection into rats, PoIFNα-C2 protein showed 16- or 4-fold increase in serum half-life with significantly improved bioavailability.
- Published
- 2019
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.