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Zhang X, Yan R, Wei Z, et al. Int J Nanomedicine. 2022;17:2493–2502. The authors wish to correct Figure 6 on page 2500 after it was found an incorrect H&E image for Liver, FA-NPs had been used. The error occurred during figure preparation and the correction does not impact the conclusions of the study. The correct Figure 6 is in Download Article. The authors apologise for this error. Read the original article

Cement emulsified asphalt mortar (CAM) is a critical and complex engineering material for slab ballastless track. Since the bubble stability of fresh CAM is a crucial and potential property to determine the construction quality of hardened CAM on site, to improve the bubble stability of CAM, the effect of the stabilizer on bubble stability was studied and evaluated by the property indexes of the workability, fluidity, time-dependent loss of air content under simulating disturbance condition and segregation of CAM in lab and on site. Moreover, to research the actual engineering application effect of the stabilizer, the bonding strength and construction quality of CAM with and without the stabilizer were tested respectively by lifting the full-scale track slab above the CAM at the age of 14 days on site along with the microstructure analysis on the interfacial morphology with SEM. Results showed that the stabilizer can enhance the consistency and improve the bubble stability of fresh CAM; reduce the segregation and improve the homogeneity of hardened CAM effectively. Moreover, the stabilizer can increase the interfacial bonding strength between the hardened CAM and the concrete bottom of track slab with fewer asphalt particles or bubbles of CAM floating up to the interfacial surface; improve the construction quality of CAM on site. Good agreements for the effect of the stabilizer have also been found between the simulating experiment result in laboratory and that on site. The effect of the stabilizer on bubble stability of CAM may be due to the three-dimensional network formed by long cellulose ether and associative polyurethane molecular chains of the stabilizer. Related model was briefly supposed. These findings show promising field applications of the stabilizer and also provide a valuable reference for the preparation and construction quality control of CAM with high workability.

The elevation control of concrete bottom slab in curve line section of high-speed railway is difficult because fresh concrete cannot hold its shape and the slope of fresh concrete cannot maintain effectively before concrete hardened. To solve this problem, air-entraining agent and attapulgite clay mineral admixture were used to improve the thixotropy of fresh concrete. Results indicated when air-entraining agent and attapulgite clay incorporated simultaneously, the static yield stress of fresh concrete increased to 9.78 Nm, the dynamic yield stress decreased to 5.56 Nm, the ratio between the static and dynamic yield stress increased to 1.9, and the ability of holding the shape and slope was improved to 95.6%. This is mainly due to fibrous gel structure and orientation distribution of attapulgite clay and spherical air bubbles introduced by air-entraining agent in fresh slurry. These will provide valuable and useful references for quality and elevation control of concrete bottom slab of ballastless track in curve line section of ballastless track.

GGGGCC repeat expansions in C9ORF72 are the most common genetic cause of both ALS and FTD. To uncover underlying pathogenic mechanisms, we found that DNA damage was greater, in an age dependent manner, in motor neurons differentiated from iPSCs of multiple C9ORF72 patients than control neurons. Ectopic expression of the dipeptide repeat (DPR) protein (GR)80 in iPSC-derived control neurons increased DNA damage, suggesting poly(GR) contributes to DNA damage in aged C9ORF72neurons. Oxidative stress was also increased inC9ORF72 neurons in an age-dependent manner. Pharmacological or genetic reduction of oxidative stress partially rescued DNA damage in C9ORF72neurons and control neurons expressing (GR)80 or (GR)80-induced toxicity in flies. Moreover, interactome analysis revealed that (GR)80 preferentially bound to mitochondrial ribosomal proteins and caused mitochondrial dysfunction. Thus, poly(GR) in C9ORF72 neurons compromises mitochondrial function and causes DNA damage in part by increasing oxidative stress, revealing another pathogenic mechanism in C9ORF72-related ALS and FTD.

Simulations for root growth, crop growth, and N uptake in agro-hydrological models are of significant concern to researchers. SWMS_2D is one of the most widely used physical hydrologically related models. This model solves equations that govern soil-water movement by the finite element method, and has a public access source code. Incorporating key agricultural components into the SWMS_2D model is of practical importance, especially for modeling some critical cereal crops such as winter wheat. We added root growth, crop growth, and N uptake modules into SWMS_2D. The root growth model had two sub-models, one for root penetration and the other for root length distribution. The crop growth model used was adapted from EU-ROTATE_N, linked to the N uptake model. Soil-water limitation, nitrogen limitation, and temperature effects were all considered in dry-weight modeling. Field experiments for winter wheat in Bouwing, the Netherlands, in 1983-1984 were selected for validation. Good agreements were achieved between simulations and measurements, including soil water content at different depths, normalized root length distribution, dry weight and nitrogen uptake. This indicated that the proposed new modules used in the SWMS_2D model are robust and reliable. In the future, more rigorous validation should be carried out, ideally under 2D situations, and attention should be paid to improve some modules, including the module simulating soil N mineralization.

It is of great importance to investigate the effect of soil physical quality index on the surface soil by the subsidence induced by coal mining to quantify the impact of land surface change on soil physical quality. In this paper, sampling locations were distributed according to the theory of mining subsidence. The soil samplings were obtained in the same location before and after mining, and the in-door experiments of seven soil physical quality index were conducted. It was proved that coal mining could reduce the average value of soil water content, cohesion and organic matter, and increase the average value of internal fraction angle, while in comparison, it did not influence soil bulk density, dry density and porisity very much. The relationship among soil physical quality index was also influenced by the subsidence induced by coal mining influences. Although the statistical analysis showed that the average values of soil water content, organic matter and cohesion were greatly affected by subsidence of coal mining, the same phenomenon may not always happen in every sampling location due to soil spatial and temporal variability. The theory of cumulative probability was proved to be suitable for describing the impact on soil physical qualities by the subsidence of coal mining before and after mining. The subsidence increased the cumulative probability to get the same value of soil water content, cohesion and organic matter, while it was decreased to get the same value of internal fraction angle.

The reaction of cerium chloride heptahydrate with salicylic acid and thioproline produced [Ce(Hsal)2·(tch)]·2H2O [Hsal = salicylate (C7H5O3−), tch = thioprolinate (C4H6NO2S−))], which was isolated and characterized by IR, elemental, chemical, and thermogravimetric analysis. The standard molar enthalpies of solution of [CeCl3·7H2O(s)], [2C7H6O3(s)], [C4H7NO2S(s)], and [Ce(Hsal)2·(tch)·2H2O(s)] in a mixed solvent of absolute ethyl alcohol, dimethyl sulfoxide (DMSO), and 3 mol·L−1 HCl were determined by calorimetry to be ΔsHmΘ[CeCl3·7H2O(s), 298.15 K] = −(42.22 ± 0.37) kJ·mol−1, ΔsHmΘ[2C7H6O3(s), 298.15 K] = (45.54 ± 0.37) kJ·mol−1, ΔsHmΘ[C4H7NSO2(s), 298.15 K] = (21.91 ± 0.60) kJ·mol−1, and ΔsHmΘ[Ce(Hsal)2·(tch)·2H2O(s), 298.15 K] = −(30.87 ± 0.39) kJ·mol−1. The enthalpy change of the reaction CeCl3·7H2O(s) + 2C7H6O3(s) + C4H7NO2S(s) = [Ce(Hsal)2·(tch)]·2H2O(s) + 3HCl(g) + 5H2O(l) was determined to be ΔrHmΘ = (263.12 ± 0.95) kJ·mol−1. From data in the literature, through Hess’s law, the standard molar entha...

The product from the reaction of neodymium chloride hexahydrate with salicylic acid and thioproline, [Nd(Hsal) 2 ·(tch)]·2H 2 O, was synthesized and characterized by IR, elemental analysis, molar conductance, thermogravimetric analysis, and chemical analysis. The standard molar enthalpies of solution of NdCl 3 ·6H 2 O(s), [2C 7 H 6 O 3 (s)], C 4 H 7 NO 2 S(s), and [Nd(Hsal)2·(tch)]·2H 2 O(s) in a mixed solvent of absolute ethyl alcohol, dimethyl sulfoxide (DMSO), and 3 mol·L ―1 HCl were determined by calorimetry to be Δ s H Θ m [NdCl 3 ·6H 2 O(s), 298.15 K] = ―(51.94 ± 0.14) kJ·mol ―1 , Δ s H Θ m [2C 7 H 6 O 3 (s), 298.15 K] = (52.96 ± 0.48) kJ·mol ―1 , Δ s H Θ m [C 4 H 7 NO 2 S(s), 298.15 K] = (23.50 ± 0.23) kJ·mol ―1 , and Δ s H Θ m {[Nd(Hsal) 2 · (tch)]·2H 2 O(s), 298.15 K} = ―(41.76 ± 0.50) kJ·mol ―1 . The enthalpy change of the reaction NdCl 3 ·6H 2 O(s) + 2C 7 H 6 O 3 (s) + C 4 H 7 NO 2 S(s) = [Nd(Hsal) 2 ·(tch)]·2H 2 O(s) + 3HCl(g) + 4H 2 O(l) was determined to be Δ r H Θ m = (172.57 ± 0.75) kJ·mol ―1 . From data in the literature, through Hess' law, the standard molar enthalpy of formation of [Nd(Hsal) 2 ·(tch)]·2H 2 O(s) was estimated to be Δ f H Θ m {[Nd(Hsal) 2 ·(tch)]·2H 2 O(S), 298.15 K} = -(2867.1 ± 8.6) kJ·mol ―1 .

The product from reaction of samarium chloride hexahydrate with salicylic acid and Thioproline, [Sm(C7H5O3)2·(C4H6NO2S)]·2H2O, was synthesized and characterized by IR, elemental analysis, molar conductance, and thermogravimetric analysis. The standard molar enthalpies of solution of [SmCl3·6H2O(s)], [2C7H6O3(s)], [C4H7NO2S(s)] and [Sm(C7H5O3)2·(C4H7NO2S)·H2O(s)] in a mixed solvent of absolute ethyl alcohol, dimethyl sulfoxide(DMSO) and 3 mol L−1 HCl were determined by calorimetry to be Δs H m Φ [SmCl3 δ6H2O (s), 298.15 K]= −46.68±0.15 kJ mol−1 Δs H m Φ [2C7H6O3 (s), 298.15 K]= 25.19±0.02 kJ mol−1, Δs H m Φ [C4H7NO2S (s), 298.15 K]=16.20±0.17 kJ mol−1 and Δs H m Φ [Sm(C7H5O3)2·(C4H6NO2S)]·2H2O (s), 298.15 K]= −81.24±0.67 kJ mol−1. The enthalpy change of the reaction (1) $$ SmCl_3 \cdot 6H_2 O(s) + 2C_7 H_6 O_3 (s) + C_4 H_7 NO_2 S(s) = Sm(C_7 H_5 O_3 )_2 \cdot (C_4 H_6 NO_2 S) \cdot 2H_2 O(s) + 3HCl(g) + 4H_2 O(1) $$ was determined to be Δs H m Φ =123.45±0.71 kJ mol−1. From date in the literature, through Hess’ law, the standard molar enthalpy of formation of Sm(C7H5O3)2(C4H6NO2S)δ2H2O(s) was estimated to be Δs H m Φ [Sm(C7H5O3)2·(C4H6NO2S)]·2H2O(s), 298.15 K]= −2912.03±3.10 kJ mol−1.

The complex from reaction of neodymium chloride six-hydrate with salicylic acid and 8-hydroxyquinoline, Nd(C7H5O3)2·(C9H6NO), was synthesized and characterized by IR, elemental analysis, molar conductance, and thermogravimatric analysis. The standard molar enthalpies of solution of [NdCl3·6H2O(s)], [2C7H6O3(s)], [C9H7NO(s)] and [Nd(C7H5O3)2·(C9H6NO)(s)] in a mixed solvent of anhydrous ethanol, dimethyl formamide (DMF) and perchloric acid were determined by calorimetry at 298.15 K. Based on Hess’ law, a new chemical cycle was designed, and the enthalpy change of the reaction (1) $$ NdCl_3 \cdot 6H_2 O(s) + 2C_7 H_6 O_3 (s) + C_9 H_7 NO(s) = Nd(C_7 H_5 O_3 )_2 \cdot (C_9 H_6 NO)(s) + 3HCl(g) + 6H_2 O(l) $$ was determined to be Δr H m Θ =117.89±0.37 kJ mol−1. From data in the literature, through Hess’ law, the standard molar enthalpy of formation of Nd(C7H5O3)2·(C9H7NO)(s) was estimated to be Δf H m Θ [Nd(C7H5O3)2·(C9H6NO)(s), 298.15 K]=−2031.80±8.6 kJ mol−1.

The complex of lanthanum chloride with Glycine and Alanine, La(Gly)2(Ala)3Cl3 · 2H2O, was synthesized and characterized by IR, elementary analysis, thermogravimetric analysis, and chemical analysis. The dissolution enthalpies of LaCl3 · 7H2O(s), 2Gly(s) + 3Ala(s) and La(Gly)2(Ala)3Cl3 · 2H2O(s) were determined in 2 mol · L−1 HCl by a solution-reaction isoperibol calorimeter. By designing a thermochemical cycle in terms of Hess' Law and through calculation, the reaction enthalpy of lanthanum chloride seven-hydrate with Glycine and Alanine was obtained: ΔrHθm(298.15 K) = (29.652 ± 0.504) kJ · mol−1, and the standard enthalpy of formation of La(Gly)2(Ala)3Cl3 · 2H2O(s) ΔfHθm[La(Gly)2 (Ala)3Cl3 · 2H2O, s, 298.15 K] = −4467.6 ± 8.3 kJ · mol−1.

The mixed complex of Nd3+ with glycine and alanine, Nd(Gly)2(Ala)3Cl3·2H2O, was synthesized and characterized by IR, elementary analysis, thermogravimatric analysis and chemical analysis, and the dissolution enthalpies of NdCl3·6H2O(s), 2Gly(s) + 3Ala(s) and Nd(Gly)2(Ala)3Cl3·2H2O(s) were determined in 2 mol/L HCl by the classical solution calorimetry. By designing a thermochemical cycle according to Hess‘ law and through calculation, we obtained the reaction enthalpy of neodymium chloride six-hydrate with glycine and alanine: Δ r H° m (298.15 K )=37.24±0.299 kJ/mol, and the standard enthalpy of formation of Nd(Gly)2(Ala)3Cl3·2H2O(s): ΔfH°m[Nd(Gly)2(Ala)3Cl3·2H2O, s, 298.15 K] = −4441.6±8.262 kJ/mol.

The product from reaction of lanthanum chloride seven-hydrate with salicylic acid and 8-hydroxyquinoline, La(C7H5O3)2·(C9H6NO), was characterized by IR, elemental analysis, molar conductance, and thermogravimetric analysis. The standard molar enthalpies of solution of [LaCl3·7H2O (s)], [2C7H6O3 (s)], [C9H7NO (s)] and [La(C7H5O3)2·(C9H6NO) (s)] in a mixed solvent of absolute ethyl alcohol, dimethyl formamide (DMF) and perchloric acid were determined by calorimetry to be Δ s H m Θ [LaCl3·7H2O (s), 298.15 K] = −96.45 ± 0.18 kJ mol−1, Δ s H m Θ [2C7H6O3 (s), 298.15 K] = 14.99 ± 0.17 kJ mol−1, Δ s H m Θ [C9H7NO (s), 298.15 K] = −3.86 ± 0.06 kJ mol−1 and Δ s H m Θ [La(C7H5O3)2·(C9H6NO) (s), 298.15 K] = −117.78 ± 0.11 kJ mol−1. The enthalpy change of the reaction (1) LaCl3·7H2O (s) + 2C7H6O3 (s) + C9H7NO (s) = La (C7H5O3)2·(C9H6NO) (s) + 3HCl (g) + 7H2O (l) was determined to be Δ r H m Θ = 91.57 ± 0.34 kJ mol−1. From data in the literature, through Hess’ law, the standard molar enthalpy of formation of La(C7H5O3)2·(C9H7NO) (s) was estimated to be Δ f H m Θ [La(C7H5O3)2·(C9H6NO) (s), 298.15 K] = − 2076.5 ± 3.9 kJ mol−1.

Environment is the foundation of human survival environment, not the human will is nowhere to hide. Since the industrial revolution, human society has undergone earth-shaking changes, it is science and technology are developing rapidly, the environmental plundered all precedents. The environment deteriorating, a direct threat to human survival and health, environmental science will come into being, establish how environmental assessment mechanism and how to realize environmental science and human health relationship is urgent.