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In the Inter-university Upper atmosphere Global Observation NETwork (IUGONET) project, we have been creating metadata for ground observation data in space physics and populating them into the database since 2009 (http://www.iugonet.org/). These metadata followed the IUGONET metadata schema version 2.4.0.1, which is an extension of the SPASE (Space Physics Archive Search and Extract) metadata schema version 2.4.0.The IUGONET metadata database is very useful for researchers to search for data that they need and to obtain detailed information about data, but the metadata search is available only through the IUGONET page or NASA Heliophysics Data Portal. To promote data usage by a wider research community or the general public, it is needed to convert the metadata database from SPASE to more general schema so that the metadata can be ingested into other metadata databases. For that purpose, we developed a mapping table from SPASE to the JPCOAR (Japan Consortium for Open Access Repository) schema, which has been widely used for scholarly communication and data publication in Japan. Based on the mapping table, we converted part of our metadata, which describe data created in Nagoya University, to those in the JPCOAR schema. The converted metadata were registered in the institutional repository of Nagoya University (https://nagoya.repo.nii.ac.jp/). These metadata are consequently harvested by Institutional Repositories DataBase (https://irdb.nii.ac.jp/), Data Catalog Cross-Search System (https://search.ckan.jp/), and Google Dataset Search (https://datasetsearch.research.google.com/). We plan to do the same action for the other IUGONET metadata. This will significantly enhance findability and accessibility of the IUGONET metadata and their describing data., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

A multi-stage shifter allows timestamped measurements by emulsion films, which have a thin medium and high resolution ( 80 MeV), like previous balloon experiments. Furthermore, by adding a layer which move at 100 μm s-1, it achieved the 0.1 s time resolution required for high-resolution imaging above 1 GeV. We also found the possibilities of an almost three-fold improvement in the spatial resolutions in track reconstruction compared with the conventional model and of achieving time resolution on a scale of tens of milliseconds, which would enable phase resolution of a pulsar.

We report an improved measurement of the degree-scale cosmic microwave background $B$-mode angular-power spectrum over 670 square-degree sky area at 150 GHz with POLARBEAR. In the original analysis of the data, errors in the angle measurement of the continuously rotating half-wave plate, a polarization modulator, caused significant data loss. By introducing an angle-correction algorithm, the data volume is increased by a factor of 1.8. We report a new analysis using the larger data set. We find the measured $B$-mode spectrum is consistent with the $\Lambda$CDM model with Galactic dust foregrounds. We estimate the contamination of the foreground by cross-correlating our data and Planck 143, 217, and 353 GHz measurements, where its spectrum is modeled as a power law in angular scale and a modified blackbody in frequency. We place an upper limit on the tensor-to-scalar ratio $r$ < 0.33 at 95% confidence level after marginalizing over the foreground parameters., Comment: 16 pages, 9 figures, 8 tables, Published in ApJ

This study conducted an analysis of muons, protons, and charged pions emitted from $ν_μ$ charged-current interactions on iron using a nuclear emulsion detector. The emulsion detector with a 65$\,$kg iron target was exposed to a neutrino beam corresponding to 4.0$\times$10$^{19}$ protons on target with a mean neutrino energy of 1.49$\,$GeV. The measurements were performed at a momentum threshold of 200 (50)$\,$MeV/$c$ for protons (pions), which are the lowest momentum thresholds attempted up to now. The measured quantities are the multiplicities, emission angles, and momenta of the muons, protons, and charged pions. In addition to these inclusive measurements, exclusive measurements such as the muon-proton emission-angle correlations of specific channels and the opening angle between the protons of CC0$π$2$p$ events were performed. The data were compared to Monte Carlo (MC) predictions and some significant differences were observed. The results of the study demonstrate the capability of detailed measurements of neutrino-nucleus interactions using a nuclear emulsion detector to improve neutrino interaction models., 21 pages, 25 figures

IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exercises; existing literature; derivation and validation cohorts of 1879 subjects (1086 cases, 793 mimickers); and multicriterion decision analysis to identify, weight and test potential classification criteria. Two independent validation cohorts were included. A three-step classification process was developed. First, it must be demonstrated that a potential IgG4-RD case has involvement of at least one of 11 possible organs in a manner consistent with IgG4-RD. Second, exclusion criteria consisting of a total of 32 clinical, serological, radiological and pathological items must be applied; the presence of any of these criteria eliminates the patient from IgG4-RD classification. Third, eight weighted inclusion criteria domains, addressing clinical findings, serological results, radiological assessments and pathological interpretations, are applied. In the first validation cohort, a threshold of 20 points had a specificity of 99.2% (95% CI 97.2% to 99.8%) and a sensitivity of 85.5% (95% CI 81.9% to 88.5%). In the second, the specificity was 97.8% (95% CI 93.7% to 99.2%) and the sensitivity was 82.0% (95% CI 77.0% to 86.1%). The criteria were shown to have robust test characteristics over a wide range of thresholds. ACR/EULAR classification criteria for IgG4-RD have been developed and validated in a large cohort of patients. These criteria demonstrate excellent test performance and should contribute substantially to future clinical, epidemiological and basic science investigations.

Background The outcomes of patients with IgG4-RD who are not treated are unclear. This study aimed to clarify these outcomes and identify the factors related to them. Methods We retrospectively evaluated various clinical features including laboratory data and involved organs at diagnosis in 107 patients with IgG4-RD, who were followed up for more than 6 months, at a single center in Japan. We compared the clinical features of the 27 untreated patients with those of the 80 patients treated with glucocorticoid. The patient outcomes were investigated, and logistic regression analysis was performed to identify factors related to them. Results The patients comprised 73 men and 34 women (median age 67 years). The untreated patients had significantly lower IgG4-RD responder index (9 vs 12) and fewer affected organs (1 vs 3) than did those treated with glucocorticoid. Of these 27 patients, 8 experienced deterioration of IgG4-RD after the diagnosis. In the age- and sex-adjusted logistic regression analysis, serum IgG4 elevation (per 100 mg/dL, odds ratio 1.194, 95% confidence interval 1.017–1.402) was the only significant factor related to disease deterioration in untreated patients with IgG4-RD, whereas not serum IgG4 levels (per 100 mg/dL, odds ratio 0.995, 95% confidence interval 0.921–1.075) but history of allergy (OR 3.134, 95% confidence interval 1.094–8.977, P = 0.033) related to deterioration in patients who underwent treatment. Conclusions Serum IgG4 levels may be a useful predictor of unfavorable outcomes in untreated patients with IgG4-RD, who tend to have fewer affected organs and lower IgG4-RD responder index.

In trypanosomes the orthologs of human USP7 and VDU1 control abundance of a cohort of surface proteins, including invariant surface glycoproteins (ISGs) by functioning as deubiquitinases (DUBs) Silencing TbUsp7 partially inhibits endocytosis and invariant surface glycoprotein turnover. As a component of cullin E3 ubiquitin ligases, S-phase kinase-associated protein 1 (Skp1) has crucial roles in cell cycle progression, transcriptional regulation, signal transduction and other processes in animals and fungi. Unexpectedly, trypanosomes possess multiple Skp1 paralogs, including a divergent paralog designated SkpZ. SkpZ is implicated in suramin-sensitivity and endocytosis and decreases in abundance following TbUsp7 knockdown and physically interacts with TbUsp7 and TbTpr86. The latter is a tetratricopeptide-repeat protein also implicated in suramin sensitivity and located close to the flagellar pocket/endosomes, consistent with a role in endocytosis. Further, silencing SkpZ reduced abundance of TbUsp7 and TbTpr86 and many trans-membrane domain surface proteins. Our data indicate that TbTpr86, TbUsp7 and SkpZ form the ‘TUS’ complex that regulates abundance of a significant cohort of trypanosome surface proteins.

Echocardiography offers rapid and cost-effective estimations of left ventricular (LV) mass, but its accuracy in patients with cardiac disease remains unclear. LV mass was measured by M-mode-based linear method and two-dimensional echocardiography (2DE)-based area-length method in pig models and correlation with actual LV weight was assessed. Twenty-six normal, 195 ischemic heart disease (IHD), and 33 non-IHD HF pigs were included. A strong positive linear relationship to the actual LV weight was found with 2DE-based area-length method (r = 0.82, p < 0.001), whereas a moderate relationship was found with M-mode method in the overall population (r = 0.68, p < 0.001). Two correlation coefficients were significantly different (p < 0.001), and were driven mainly by incremental overestimation of LV mass in heavier hearts using the M-mode method. IHD and LV dilation were the factors contributing to overestimation using M-mode method. 2DE-based area-length method provides a better estimation of LV weight in swine models of HF, particularly in those with IHD.

A key unexplained feature of cuprate superconductors is the upturn in their normal state electrical resistivity $\rho(T)$ seen at low temperature inside the pseudogap phase. We examined this issue via measurements of the thermal conductivity $\kappa(T)$ down to 50 mK and in fields up to 17 T on the cuprate La$_{2-x}$Sr$_x$CuO$_4$ at dopings $p = 0.13$, 0.136, 0.143 and 0.18. At $p$ = 0.136, 0.143, and 0.18, we observe an initial increase of the electronic thermal conductivity $\kappa_0/T$ as a function of field, as expected in a $d$-wave superconductor. For $p$ = 0.136 and 0.143, further increasing the field then leads to a decrease of $\kappa_0/T$, which correlates with the onset of spin density-wave order as observed in neutron scattering experiments on the same samples. This decrease of $\kappa_0/T$ with field is imposed by the Wiedemann-Franz law and the high value of the resistivity in the high-field normal state of these samples. Our study therefore provides a direct link between magnetism and the resistivity upturn in the pseudogap phase of cuprates. We discuss this scenario in the broader context of other cuprates., Comment: 10 pages, 7 Figures, includes Supplementary Material

Objective IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. Methods An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exercises, existing literature, derivation and validation cohorts of 1,879 subjects (1,086 cases, 793 mimickers), and multicriterion decision analysis to identify, weight, and test potential classification criteria. Two independent validation cohorts were included. Results A 3-step classification process was developed. First, it must be demonstrated that a potential IgG4-RD case has involvement of at least 1 of 11 possible organs in a manner consistent with IgG4-RD. Second, exclusion criteria consisting of a total of 32 clinical, serologic, radiologic, and pathologic items must be applied; the presence of any of these criteria eliminates the patient from IgG4-RD classification. Third, 8 weighted inclusion criteria domains, addressing clinical findings, serologic results, radiology assessments, and pathology interpretations, are applied. In the first validation cohort, a threshold of 20 points had a specificity of 99.2% (95% confidence interval [95% CI] 97.2-99.8%) and a sensitivity of 85.5% (95% CI 81.9-88.5%). In the second, the specificity was 97.8% (95% CI 93.7-99.2%) and the sensitivity was 82.0% (95% CI 77.0-86.1%). The criteria were shown to have robust test characteristics over a wide range of thresholds. Conclusion ACR/EULAR classification criteria for IgG4-RD have been developed and validated in a large cohort of patients. These criteria demonstrate excellent test performance and should contribute substantially to future clinical, epidemiologic, and basic science investigations.

We developed a surface matching-type computed tomography (CT)-based navigation system for total hip arthroplasty (the N-navi; TEIJIN NAKASHIMA MEDICAL, Okayama, Japan). In the registration step, surface matching was performed with digitizing points on the pelvic bone surface after coarse paired matching. In the present study, we made model bones from the CT data of patients whose acetabular shapes had various deformities. We measured the distances and angles after surface matching from the fiducial points and evaluated the ability to correct surface-matching registration on each pelvic form, using several areas and numbers of points. When the surface-matching points were taken on the superior area of the acetabulum, the correction was easy for the external direction, but it was difficult to correct for the anterior and proximal directions. The correction was difficult for external and proximal directions on the posterior area. Each area of surface-matching points has particular directions that are easily corrected and other directions that are difficult to correct. The shape of the pelvis also affected the correction ability. Our present findings suggest that checking the position after coarse paired matching and choosing the surface-matching area and points that are optimal to correct will improve the accuracy of total hip arthroplasty and reduce surgical times.

Orthodontic mechanical stress induces various molecules, which cause structural changes in the proteins in periodontal tissue. The expression kinetics of HSP47 in mouse periodontal ligament (PDL) tissue after application of corrective mechanical stress and HSP47 expression during the PDL recovery were observed. Our examination data are as follows: HSP47 is constitutively expressed in the PDL and defends cells from different types of stress and maintains homeostasis under normal conditions. HSP47 is expressed in PDL fibroblasts on the pressure side damaged by application of mechanical stress and contributes to the repair of collagen tissue by activating PDL fibroblasts, supporting recovery from cell damage. These data suggests that, during bone addition to the PDL on the tension side, HSP47 also acts as molecular chaperone, which assists the maturation of bone morphogenetic proteins and aids osteoblast activation. On the other hand, it is possible that, when a mechanical stress is applied to the periodontal membrane on the tension side for a time too short for bone addition and abnormalities are caused in the collagen structure of the PDL fibroblasts, by functioning at the damage site, HSP47 inhibits extracellular secretion of abnormal collagen, stores the modified protein in the endoplasmic reticulum, thereby controlling decalcification of the PDL. HSP47 investigated in this study acts differently depending of the time of expression.

The first elastic electron scattering has been successfully performed at the self-confining RI ion target (SCRIT) facility, the world's first electron scattering facility for exotic nuclei. The SCRIT technique achieved high luminosity (over 10$^{27}$~cm$^{-2}$s$^{-1}$, sufficient for determining the nuclear shape) with only 10$^8$ target ions. While $^{132}$Xe used in this time as a target is stable isotope, the charge density distribution was firstly extracted from the momentum transfer distributions of the scattered electrons by comparing the results with those calculated by a phase shift calculation., Comment: 5 pages, 5 figures

A photoemission electron microscopy measurement system on insulating samples was established at the BL17SU beamline of SPring-8 by utilizing an Au pattern evaporation technique combined with photon-induced surface modification., The observation method of photoemission electron microscopy (PEEM) on insulating samples has been established in an extremely simple way. Surface conductivity is induced locally on an insulating surface by continuous radiation of soft X-rays, and Au films close to the area of interest allow the accumulated charges on the insulated area to be released to ground level. Magnetic domain observations of a NiZn ferrite, local X-ray absorption spectroscopy of sapphire, high-resolution imaging of a poorly conducting Li0.9CoO2 film surface, and Au pattern evaporation on a fine rock particle are demonstrated. Using this technique, all users’ experiments on poorly conducting samples have been performed successfully at the PEEM experimental station of SPring-8.

Laser desorption supersonic jet laser spectroscopy has been applied to a penta-peptide, Ser-Ile-Val-Ser-Phe-NH2 (SIVSF-NH2), which is a partial sequence of a binding site in a β2-adrenaline receptor protein. By comparing the resonance enhanced multiphoton ionization spectrum with the ultraviolet-ultraviolet hole burning (HB) spectrum, it is concluded that only a single conformer exists. The infrared (IR) spectrum of the X-H stretching region, measured by IR dip spectroscopy, shows that all of the OH and NH groups form hydrogen bonds. The structure of SIVSF-NH2 is assigned by the combination of a force field calculation (CONFLEX) and quantum chemical calculations both in S0 and S1. Over 20 000 stable conformations, given by CONFLEX, are classified into 6987 groups and 1068 groups in which all of the NH and OH bonds are hydrogen-bonded are selected. The most stable structure in each group was geometrically optimized by density functional theory (DFT) calculations, and theoretical IR spectra were calculated for the conformers for which the energies are within 10 kJ mol(-1) of the most stable one. It has been found that the most stable and the secondmost stable conformers well-reproduce the observed IR spectrum. The vibrational frequencies in S1 were also calculated for these two conformers. According to the reproduction of the vibrational frequencies in the HB spectrum, the structure of SIVSF-NH2 is assigned to the most stable conformer, which forms a hydrogen-bonded structure corresponding to a compact, distorted version of the beta hairpin of peptides and proteins.

To evaluate the safety and feasibility of virtual 3 Fr (V3), sheathless 5 Fr percutaneous coronary intervention (PCI).A small-diameter guiding catheter (GC) makes less-invasive PCI possible. The V3 is an extremely slender PCI system; however, the outcome of using this system has not yet been determined.The V3 registry is a prospective, multicenter, non-randomized study that enrolled patients who underwent elective V3-PCI. The primary endpoint was clinical success rate, and the secondary endpoints were PCI success rate in all cases, major adverse cardiac and cerebrovascular event (MACCE) at 30 days, and access-site complications.A total of 260 patients with 321 lesions were enrolled. Of this group, 70% were male and the mean age was 70.8 ± 10.0 years. Type B2/C lesions comprised 50.7% of the total. The clinical success rate was 95.8%, and the PCI success rate was 99.2%. PCI failure was reported in 2 chronic total occlusion cases. No MACCE was reported. Although there was no major bleeding, hematoma occurred at the puncture site in 12.7% of cases. There was a single radial artery occlusion (0.4%) without symptoms.PCI with the V3 was safe and feasible. Radial artery occlusion and major bleeding complications were extremely low. However, access-site hematoma frequently complicated catheter exchange.

Superconductivity in cuprates peaks in the doping regime between a metal at high p and an insulator at low p. Understanding how the material evolves from metal to insulator is a fundamental and open question. Early studies in high magnetic fields revealed that below some critical doping an insulator-like upturn appears in the resistivity of cuprates at low temperature, but its origin has remained a puzzle. Here we propose that this 'metal-to-insulator crossover' is due to a drop in carrier density n associated with the onset of the pseudogap phase at a critical doping p*. We use high-field resistivity measurements on LSCO to show that the upturns are quantitatively consistent with a drop from n=1+p above p* to n=p below p*, in agreement with high-field Hall data in YBCO. We demonstrate how previously reported upturns in the resistivity of LSCO, YBCO and Nd-LSCO are explained by the same universal mechanism: a drop in carrier density by 1.0 hole per Cu atom., Comment: 16 pages, 4 figures, Supplementary material (12 pages, 7 figures)

The one-neutron knock-out reaction H-1(C-20, C-19 gamma) was studied at RIKEN using the DALI2 array. A gamma-ray transition was observed at 198(10) keV. Based on the comparison between the experimental production cross section and theoretical predictions, the transition was assigned to the de-excitation of the 3/2(1)(+) state to the ground state.

The one neutron knock-out reaction $^1$H($^{20}$C,$^{19}$C$��$) was studied at RIKEN using the DALI2 array. A $��$ ray transition was observed at 198(10) keV. Based on the comparison between the experimental production cross section and theoretical predictions, the transition was assigned to the decay of the 3/2$_1^+$ state to the ground state., 5 pages, 3 figures, submitted in Physical Review C

The PIENU experiment at TRIUMF is aimed at a measurement of the branching ratio $R^{e/��}$ = ${��\big((��^{+} \rightarrow e^{+} ��_{e}) + (��^{+} \rightarrow e^{+} ��_{e}��)\big)}/{��\big((��^{+} \rightarrow ��^{+} ��_��)+(��^{+} \rightarrow ��^{+} ��_����)\big)}$ with precision $

Spin orbit torque has been intensively investigated because of its high energy efficiency in manipulating a magnetization. Although various methods for measuring the spin orbit torque have been developed so far, the measurement results often show inconsistency among the methods, implying that an electromotive force, such as Nernst effect, irrelevant to the spin orbit torque may affect the measurement results as an artifact. In this letter, we developed a unique method to distinguish the spin orbit torque and the anomalous Nernst effect. The measurement results show that the spin orbit torque can be underestimated up to 50% under the influence of the anomalous Nernst effect.

A 48-year-old woman with late infantile onset mental retardation developed megacolon. Although the patient had no typical clinical features of Hirschsprung disease-mental retardation syndrome, a new 3-base pair deletion, eliminating an Asn, was identified in the responsible gene ZFHX1B. This suggests that screening for ZFHX1B mutations is warranted even in the absence of typical clinical features of the syndrome.

We report the case of a middle-aged woman with Cotard's syndrome in whom clinical course was evaluated according to stages. Longitudinally this syndrome seems to have three stages, namely germination, blooming and chronic (depressive type/paranoid type) stages. In this patient, the chronic stage, primarily characterized by delusions, was observed without raising suspicion of affective disorder. She did not respond to any pharmacotherapies, but improved dramatically after ECT performed during the chronic stage. Although symptoms change according to the stage, most cases of Cotard's syndrome may belong to the affective spectrum and are probably best treated with ECT, as documented here. In evaluation of the mode of separation between emotion and cognition during follow-up it is important to consider stage and diagnosis.

There is little question that the blood clotting process is triggered and causes the vascular occlusion associated with myocardial infarction. Although it is less clear what part blood coagulation events might play in the etiology of coronary artery disease, impaired regulation of anticoagulation or fibrinolysis might be involved. Among anticoagulant and fibrinolytic factors, an elevated plasma plasminogen activator inhibitor-1 (PAI-1) concentration has been identified as a risk factor for the development of myocardial infarction. An association between one polymorphism of the PAI-1 promoter (4G/5G single nucleotide deletion/ insertion at position -675) and plasma PAI-1 levels was described in 1995. However, most recent studies seem to point to the lack of such an association. This is the first report on the frequency of this polymorphism in the Japanese population with respect to the risk of myocardial infarction. Sixty-six patients with myocardial infarction and sixty-two healthy control patients were chosen for the analysis of the PAI-1 promoter 4G/5G genotype with polymerase chain reaction-single strand conformation polymorphism. Five myocardial infarction patients and six in the control group were homozygous for the 4G/4G genotype. Twenty-eight and 27 4G/5G and 33 and 29 5G/5G genotypes were found in myocardial infarction and control groups, respectively. The total frequencies of the 4G and 5G alleles were approximately 30% and 70% in both control and myocardial infarction groups. In conclusion, the PAI-1 promoter genotype is not a risk factor for myocardial infarction in the Japanese population. This is in contrast to the first report in Caucasians, suggesting an interaction with other genetic or environmental factors which influences the risk of myocardial infarction.

Electronic band dispersions in copper oxide superconductors have kinks around 70 meV that are typically attributed to coupling of electrons to a bosonic mode. We performed angle resolved photoemission spectroscopy (ARPES) experiments on overdoped cuprate high temperature superconductors to test the relationship between the superconducting transition temperature and electron-bosonic mode coupling. Remarkably, the kinks remain strong in the heavily overdoped region of the doping phase diagram of LSCO, even when the superconductivity completely disappears. This unexpected observation is incompatible with the conventional picture of superconductivity mediated by the sharp bosonic modes that are responsible for the kink. Therefore, the pairing likely originates from something else, such as from interactions with a very broad electronic spectrum or from an unconventional mechanism without pairing glue., Comment: 5 pages, 3 figures. For the Supp. Mat., please contact the authors

Monocytes are major targets of HIV infection in patients with AIDS. In vitro infection of monocytes with HIV is associated with increased expression of beta 2 integrins, which increases both monocyte aggregation and monocyte/endothelial adhesion as well as monocyte metalloproteinase (MMP-9) expression. Treatment of primary monocytes with soluble HIV-Tat protein mimicked many of the properties of HIV infection of monocytes. Tat treatment up-regulated the expression of the beta 2 integrins, which was associated with the formation of large aggregates of monocytes and increased adhesion to endothelial monolayers. Treatment of monocytes with Tat increased their adhesion to both untreated and TNF-alpha-treated endothelial monolayers, and adhesion was inhibited by inclusion of anti-beta 2 and anti-ICAM-1 Abs. The increased adhesion of activated monocytes was accompanied by substantial disruption of the endothelial monolayers, with retraction or detachment of individual endothelial cells. Tat treatment of monocytes up-regulated the synthesis and release of the protease MMP-9, providing a potential mechanism to explain endothelial cell/basement membrane detachment. Thus, extracellular Tat is capable of activating monocytes even in the absence of HIV infection. Our studies demonstrate that many of the effects of HIV infection on monocyte homotypic and heterotypic adhesion, protease secretion, and disruption of the endothelium can be mimicked by treatment with HIV-Tat protein alone. These results suggest a mechanism where monocytes could be inappropriately activated by HIV-Tat, secreted by HIV-infected cells, causing them to extravasate into underlying tissues and ultimately contribute to tissue damage as seen during the progression of AIDS.

The steroid effect on critically ill patients remains controversial. The aim of this study is to characterize the effect of methylprednisolone on the heart in a beta-adrenergically down-regulated condition.A prospective hemodynamic study and retrospective receptor assay.Multidisciplinary ICU in a university hospital.42 patients who required pulmonary arterial catheters and an additional 4 corpses who were available for study within 3 h of their deaths.Intravenous methylprednisolone (10 mg/kg).We pursued a hemodynamic study following a glucocorticoid administration. In patients who had undergone a long term (72 h) catecholamine treatment, the cardiac index increased. In patients who had undergone a short term (1-72 h) catecholamine treatment and in patients with no record of catecholamine administration, the cardiac index showed no remarkable change. Among the corpses, who died soon after their arrival, and the patients, who later died in the ward and were available for further study, we measured beta-adrenergic receptor density in the left ventricular myocardium. It was found that receptor density was decreased after long term catecholamine treatment. Methylprednisolone, on the other hand increased the receptor density.Methylprednisolone improved the cardiac index, intriguingly, in patients with long term catecholamine treatment in circulatory shock. Myocardial beta-adrenergic receptor also increased in number after the administration of methylprednisolone. However, the hemodynamic improvement caused by methylprednisolone was not observed in patients without beta-adrenergic down-regulation.

Evidence of massive neutrinos in the pi --> e nu decay spectrum was sought with the background pi --> mu --> e decay chain highly suppressed. Upper limits (90% C.L.) on the neutrino mixing matrix element |U_ei|^2 in the neutrino mass region 60--129 MeV/c^2 were set at the level of 10^-8., 5 pages, 6 figures

Spin fluctuations and the local spin susceptibility in isovalently Zn-substituted La$_{2-x}$Sr$_{x}$Cu$_{1-y}$Zn$_y$O$_4$ ($x=0.25$, $y\approx0.01$) are measured via inelastic neutron scattering techniques. As Zn$^{2+}$ is substituted onto the Cu$^{2+}$-sites, an anomalous enhancement of the local spin susceptibility $\chi^{\prime\prime}(\omega)$ appears due to the emergence of a commensurate antiferromagnetic excitation centered at wave vector \textbf{Q}$=(\pi, \pi, 0)$ that coexists with the known incommensurate SDW excitations at \textbf{Q}$_{HK}=(\pi\pm\delta,\pi), (\pi,\pi\pm\delta)$. Our results support a picture of Zn-induced antiferromagnetic (AF) fluctuations appearing through a local staggered polarization of Cu$^{2+}$-spins, and the simultaneous suppression of T$_c$ as AF fluctuations are slowed in proximity to Zn-impurities suggests the continued importance of high energy AF fluctuations at the far overdoped edge of superconductivity in the cuprates., Comment: 10 pages, 8 figures

Purely local experimental probes of many copper oxide superconductors show that their electronic states are inhomogeneous in real space. For example, scanning tunneling spectroscopic (STS) imaging shows strong variations in real space, and according to nuclear quadrupole resonance (NQR) studies the charge distribution in the bulk varies on the nanoscale. However, the analysis of the experimental results utilizing spatially-averaged probes often ignores this fact. We have performed a detailed investigation of the doping-dependence of the energy and line width and position of the zone-boundary Cu-O bond-stretching vibration in La_{2-x}Sr_xCuO_4 by inelastic neutron scattering. Both our new results as well as previously reported angle-dependent momentum widths of the electronic spectral function detected by angle-resolved photoemission can be reproduced by including the same distribution of local environments extracted from the NQR analysis., Comment: 6 pages, 4 figures. Accepted for publication in PRB

The low energy spin excitations of La(2-x)Sr(x)NiO(4), x = 0.275 and 1/3, have been investigated by unpolarized- and polarized-inelastic neutron scattering from single crystals. A pattern of magnetic diffuse scattering is observed in both compositions, and is consistent with quasi-one-dimensional AFM spin correlations along the charge stripes. Analysis of the energy lineshape for x = 1/3 indicates that the diffuse scattering is inelastic with a characteristic energy of 1.40 +/- 0.07 meV. There is no discernible difference between the diffuse scattering from x = 0.275 and x = 1/3, suggesting that it is an intrinsic property of the charge stripes., Comment: 7 pages, 7 figures

We report electrical resistivity measurements and neutron diffraction studies under magnetic fields of Bi$_{1.75}$Pb$_{0.35}$Sr$_{1.90}$Cu$_{0.91}$Fe$_{0.09}$O$_{6+y}$, in which hole carriers are overdoped. This compound shows short-range incommensurate magnetic correlation with incommensurability $\delta=0.21$, whereas a Fe-free compound shows no magnetic correlation. Resistivity shows an up turn at low temperature in the form of $ln(1/T)$ and shows no superconductivity. We observe reduction of resistivity by applying magnetic fields (i.e., a negative magnetoresistive effect) at temperatures below the onset of short-range magnetic correlation. Application of magnetic fields also suppresses the Fe induced incommensurate magnetic correlation. We compare and contrast these observations with two different models: 1) stripe order, and 2) dilute magnetic moments in a metallic alloy, with associated Kondo behavior. The latter picture appears to be more relevant to the present results., Comment: 7 pages, 5 figures

The structure of neutron rich nitrogen nuclei has been studied by use of neutron removal reaction and inelastic scattering. Mass and charge deformations have been deduced for the first excited state of 21N, which indicates the partial persitence of the N=14 subshell closure in nitrogen isotopes. The spectroscopic information obtained on the structure of 19,20,21N confirms the results from a previous experiment.

The $(��,��)$ shadow band (SB) in La-based cuprate family (La214) was studied by angle-resolved photoemission spectroscopy (ARPES) over a wide doping range from $x=0.01$ to $x=0.25$. Unlike the well-studied case of the Bi-based cuprate family, an overall strong, monotonic doping dependence of the SB intensity at the Fermi level ($E_F$) was observed. In contrast to a previous report for the presence of the SB only close to $x=1/8$, we found it exists in a wide doping range, associated with a doping-independent $(��,��)$ wave vector but strongly doping-dependent intensity: It is the strongest at $x\sim 0.03$ and systematically diminishes as the doping increases until it becomes negligible in the overdoped regime. This SB with the observed doping dependence of intensity can in principle be caused by the antiferromagnetic fluctuations or a particular form of low-temperature orthorhombic lattice distortion known to persist up to $x\sim 0.21$ in the system, with both being weakened with increasing doping. However, a detailed binding energy dependent analysis of the SB at $x=0.07$ does not appear to support the former interpretation, leaving the latter as a more plausible candidate, despite a challenge in quantitatively linking the doping dependences of the SB intensity and the magnitude of the lattice distortion. Our finding highlights the necessity of a careful and global consideration of the inherent structural complications for correctly understanding the cuprate Fermiology and its microscopic implication., Note the revised conclusion and author list; To appear in New J. Phys

Spin correlations in the overdoped region of Bi1.75Pb0.35Sr1.90CuO6+z have been explored with Fe-doped single crystals characterized by neutron scattering, muon-spin-rotation (muSR) spectroscopy, and magnetic susceptibility measurements. Static incommensurate spin correlations induced by the Fe spins are revealed by elastic neutron scattering. The resultant incommensurability delta is unexpectedly large (~0.2 r.l.u.), as compared with delta ~ 1/8 in overdoped superconductor La2-xSrxCuO4. Intriguingly, the large delta in this overdoped region is close to the hole concentration p. This result is reminiscent of the delta ~ p trend observed in underdoped La2-xSrxCuO4; however, it is inconsistent with the saturation of delta in the latter compound in the overdoped regime. While our findings in Fe-doped Bi1.75Pb0.35Sr1.90CuO6+z support the commonality of incommensurate spin correlations in high-Tc cuprate superconductors, they also suggest that the magnetic response might be dominated by a distinct mechanism in the overdoped region., Comment: 4 pages, 5 figures. Revision in introduction, discussion, and conclusions

We measured two magnetic modes with finite and discrete energies in an antiferromagnetic ordered phase of a geometrically frustrated magnet MgCr2O4 by single-crystal inelastic neutron scattering, and clarified the spatial spin correlations of the two levels: one is an antiferromagnetic hexamer and the other is an antiferromagnetic heptamer. Since these correlation types are emblematic of quasielastic scattering with geometric frustration, our results indicate instantaneous suppression of lattice distortion in an ordered phase by spin-lattice coupling, probably also supported by orbital and charge. The common features in the two levels, intermolecular independence and discreteness of energy, suggest that the spin molecules are interpreted as quasiparticles (elementary excitations with energy quantum) of highly frustrated spins, in analogy with the Fermi liquid approximation., Comment: 2 figures (13 panels)

High Tc superconductivity in La2-xSrxCuO4 coexists with (striped and glassy) magnetic order. Here, we report NMR measurements of the 139La spin-lattice relaxation, which displays a stretched-exponential time dependence, in both pure and disordered x=0.12 single crystals. An analysis in terms of a distribution of relaxation rates T1^-1 indicates that i) the spin-freezing temperature is spatially inhomogeneous with an onset at Tg(onset)=20 K for the pristine samples, and ii) the width of the T1^-1 distribution in the vicinity of Tg(onset) is insensitive to an ~1% level of atomic disorder in CuO2 planes. This suggests that the stretched-exponential 139La relaxation, considered as a manifestation of the systems glassiness, may not arise from quenched disorder., Comment: 7 pages, to be published in Phys. Rev. B

In underdoped cuprates, only a portion of the Fermi surface survives as Fermi arcs due to pseudogap opening. In hole-doped La$_{2}$CuO$_4$, we have deduced the "coherence temperature" $T_{coh}$ of quasi-particles on the Fermi arc above which the broadened leading edge position in angle-integrated photoemission spectra is shifted away from the Fermi level and the quasi-particle concept starts to lose its meaning. $T_{coh}$ is found to rapidly increase with hole doping, an opposite behavior to the pseudogap temperature $T^*$. The superconducting dome is thus located below both $T^*$ and $T_{coh}$, indicating that the superconductivity emerges out of the coherent Fermionic quasi-particles on the Fermi arc. $T_{coh}$ remains small in the underdoped region, indicating that incoherent charge carriers originating from the Fermi arc are responsible for the apparently metallic transport at high temperatures.

Migrating cells extend protrusions, probing the surrounding matrix in search of permissive sites to form adhesions. We found that actin fibers polymerizing along the leading edge directed local protrusions and drove synchronous sideways movement of β1 integrin adhesion receptors. These movements lead to the clustering and positioning of conformationally activated, but unligated, β1 integrins along the leading edge of fibroblast lamellae and growth cone filopodia. Thus, rapid actin-based movement of primed integrins along the leading edge suggests a "sticky fingers" mechanism to probe for new adhesion sites and to direct migration.

The present study examined a new model of impaired glucose tolerance (IGT) in a nonhuman primate fed with a high-fructose and high-fat (HFF) diet that contained 15% lard, 31% fructose, and 1% cholesterol. Female cynomolgus monkeys (age, 3-4 years) were divided into two groups: 1) those fed with normal control diet (N = 5) and 2) those fed with HFF diet (N = 5). In the HFF diet group, total cholesterol and low-density lipoprotein cholesterol in blood were significantly increased four- to fivefold when compared with the normal control diet group. No difference in the blood glucose, insulin, hemoglobin A1c, and triglyceride levels was detected between the two groups. Plasma levels of adiponectin, but not of resistin, were significantly higher in HFF diet at 20 weeks after HFF diet feeding. Oral glucose tolerance test was performed before HFF diet feeding and at 12 and 24 weeks after HFF diet feeding, but no significant changes in glucose sensitivity were observed even 24 weeks after HFF diet feeding. Twenty-four weeks after HFF diet feeding, accumulated foam cells and infiltrated macrophages were histologically detected in the thoracic aorta, in addition to a fatty liver. Interestingly, the pancreatic beta cells appeared normal in the HFF diet group. These results show that a chronic HFF diet does not induce IGT but can cause atherosclerotic lesions in conjunction with the generation of a fatty liver phenotype in cynomolgus monkey; however, the present results are very preliminary and they need to be validated in larger-scale studies in the future.

The low-energy spin fluctuations in the electron-doped Pr$_{1-x}$LaCe$_{x}$CuO$_{4}$ have been investigated over a wide concentration range of 0.07$\leqslant$ $x$ $\leqslant$0.18 that spans from the antiferromagnetic and non-superconducting phase to the superconducting and paramagnetic phase. For all concentrations considered, the low energy excitations exhibit commensurate peaks centered at the ($\pi$, $\pi$) position. Our data show that the characteristics of the excitations, such as the relaxation rate and the overall spectral weight, change rapidly when the system enters the superconducting phase. The spin stiffness also decreases with increasing $x$ in the superconducting phase and is extrapolated to zero at $x$ = 0.21 when the superconductivity disappears. These indicate a close relation between the spin fluctuations and the superconductivity in the electron-doped system., Comment: 5 pages, 5 figures, 1 table

We report a Cu K-edge resonant inelastic x-ray scattering (RIXS) study of high-Tc cuprates. Momentum-resolved charge excitations in the CuO2 plane are examined from parent Mott insulators to carrier-doped superconductors. The Mott gap excitation in undoped insulators is found to commonly show a larger dispersion along the [pi,pi] direction than the [pi,0] direction. On the other hand, the resonance condition displays material dependence. Upon hole doping, the dispersion of the Mott gap excitation becomes weaker and an intraband excitation appears as a continuum intensity below the gap at the same time. In the case of electron doping, the Mott gap excitation is prominent at the zone center and a dispersive intraband excitation is observed at finite momentum transfer.

Neutron scattering experiments were performed on single crystals of layered cobalt-oxides La2-xCaxCoO4 (LCCO) to characterize the charge and spin orders in a wide hole-doping range of 0.3, 11pages, 9 figures. Submitted to J. Phys. Soc. Jpn

We use inelastic neutron scattering to study the temperature dependence of magnetic excitations (for energies up to 100 meV) in the cuprate La$_{1.875}$Ba$_{0.125}$CuO$_4$. This compound exhibits stripe order below a temperature of ~50 K; previous measurements have shown that the magnetic excitations of the stripe-ordered phase have an hour-glass-like dispersion, with a saddle point at ~50 meV. Here we compare measurements in the disordered phase taken at 65 and 300 K. At energies on the scale of $k_{\rm B}T$, there is substantial momentum-broadening of the signal, and the low-energy incommensurate features can no longer be resolved at 300 K. In contrast, there is remarkably little change in the scattered signal for energies greater than $k_{\rm B}T$. In fact, the momentum-integrated dynamic susceptibility is almost constant with temperature. We suggest that the continuity of higher-energy magnetic excitations is strong evidence for dynamic stripes in the high-temperature, disordered phase. We reconsider the nature of the magnetic dispersion, and we discuss the correspondences between the thermal evolution of magnetic stripe correlations with other electronic properties of the cuprates.