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The nature and source of evolutionary trends in complexity is difficult to assess from the fossil record, and the driven vs. passive nature of such trends has been debated for decades. There are also questions about how effectively artificial life software can evolve increasing levels of complexity. We extend our previous work demonstrating an evolutionary increase in an information theoretic measure of neural complexity in an artificial life system (Polyworld), and introduce a new technique for distinguishing driven from passive trends in complexity. Our experiments show that evolution can and does select for complexity increases in a driven fashion, in some circumstances, but under other conditions it can also select for complexity stability. It is suggested that the evolution of complexity is entirely driven---just not in a single direction---at the scale of species. This leaves open the question of evolutionary trends at larger scales., Comment: 8 pages; In Bullock, S. et al. eds. Artificial Life XI: Proceedings of the Eleventh International Conference on the Simulation and Synthesis of Living Systems. MIT Press. Cambridge, MA. 2008

Persistent postsurgical pain (PPSP) is common after breast and thoracic surgeries. Understanding which risk factors consistently contribute to PPSP will allow clinicians to apply preventive strategies, as they emerge, to high-risk patients. The objective of this work was to systematically review and meta-analyze the literature on risk factors of PPSP after breast and thoracic surgeries. A systematic literature search using Ovid Medline, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, Embase, PsycINFO, and Scopus databases was conducted. Study screening with inclusion and exclusion criteria, data extraction, and risk of bias assessment was performed independently by 2 authors. The data for each surgical group were analyzed separately and meta-analyzed where possible. The literature search yielded 5584 articles, and data from 126 breast surgery and 143 thoracic surgery articles were considered for meta-analysis. In breast surgery, younger age, higher body mass index, anxiety, depression, diabetes, smoking, preoperative pain, moderate to severe acute postoperative pain, reoperation, radiotherapy, and axillary lymph node dissection were the main factors associated with higher risk of PPSP. In thoracic surgery, younger age, female sex, hypertension, preoperative pain, moderate to severe acute postoperative pain, surgical approach, major procedure, and wound complications were associated with PPSP. This systematic review demonstrated certain consistent risk factors of PPSP after breast and thoracic surgeries, as well as identified research gaps. Understanding the factors that increase susceptibility to PPSP can help selectively allocate resources to optimize perioperative care in high-risk patients and help develop targeted, risk-stratified interventions for PPSP prevention.

This paper updates guidelines for effective treatments of children with specific types of acquired brain injury (ABI) published in 2007 with more recent evidence. A systematic search was conducted for articles published from 2006 to 2017. Full manuscripts describing treatments of children (post-birth to 18) with acquired brain injury were included if study was published in peer-reviewed journals and written in English. Two independent reviewers and a third, if conflicts existed, evaluated the methodological quality of studies with an Individual Study Review Form and a Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Strength of study characteristics was used in development of practice guidelines. Fifty-six peer-reviewed articles, including 27 Class I studies, were included in the final analysis. Established guidelines for writing practice recommendations were used and 22 practice recommendations were written with details of potential treatment limitations. There was strong evidence for family/caregiver-focused interventions, as well as direct interventions to improve attention, memory, executive functioning, and emotional/behavioural functioning. A majority of the practice standards and guidelines provided evidence for the use of technology in delivery of interventions, representing an important trend in the field.

Artificial Life is an interdisciplinary effort to investigate the fundamental properties of living systems through the simulation and synthesis of life-like processes in artificial media. The field brings a powerful set of tools to the study of how high-level behavior can arise in systems governed by simple rules of interaction. This tenth volume marks two decades of research in this interdisciplinary scientific comunity, a period marked by vast advances in the life sciences. The field has contributed fundamentally to our understanding of life itself through computer models, and has led to novel solutions to complex real-world problems -- from disease prevention to stock market prediction -- across high technology and human society. The proceedings of the biennial A-life conference -- which has grown over the years from a small workshop in Santa Fe to a major international meeting -- reflect the increasing importance of the work to all areas of contemporary science.