284 results on '"Xu Su"'
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2. Effects of the MR-DTI Characteristics of the Trigeminal Ganglion Target on Radiofrequency Treatment in Patients with Trigeminal Neuralgia: A Retrospective Observational Clinical Study
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Xu Su, Zhengming Wang, Min Cheng, Yu Tian, and Chao Du
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Anesthesiology and Pain Medicine ,Neurology - Abstract
Background. In the percutaneous treatment of trigeminal neuralgia (TN), the difficulty in accessing the foramen ovale (FO) has been widely recognized. However, the most efficient percutaneous treatment target is the so-called trigeminal ganglion target (TGT). We propose that the TGT in a puncture can be identified by magnetic resonance diffusion tensor imaging (MR-DTI). Objectives. To observe the effect of the characteristics of the TGT as detected by MR-DTI on percutaneous stereotactic radiofrequency rhizotomy (PSR) in TN patients. Methods. In our observational study, we preoperatively performed MR-DTI and/or 3D-CT for 48 TN patients, analyzed the characteristics of the TGT and/or FO, and designed appropriate surgical schemes for producing an accurate PSR trajectory according to these characteristics. The position and size of the TGT aided in adjusting the puncture angle and guiding the approach. Then, we successfully performed a customized PSR guided by the characteristics of the FO or TGT. During the postoperative and follow-up periods, we assessed the effect of treatment with pain scores and MR-DTI findings. Results. The characteristics of the TGT vary from patient to patient. We performed PSR with a single puncture guided by MR-DTI and 3D-CT in 16 patients, and only one patient required three punctures. All three of these punctures reached the FO target, as confirmed by intraoperative C-arm X-ray. We finally reached the TGT successfully after 2 additional attempts, confirming that the probe reached the TGT that accurately covered the pain territory with an electrophysiology test. The characteristics of the TGT were negatively correlated with the number of PSR punctures. Fewer complications occurred for PSRs guided by the TGT than for PSRs guided by the FO. Conclusions. The characteristics of the TGT are correlated with the number of punctures in the PSR. The application of MR-DTI for detecting the size of the TGT is an important step in predicting the difficulty of puncture. The PSR approach can be guided by the TGT and FO for TN patients who present with multiple adverse factors and thus may be beneficial in reducing the number of complications.
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- 2023
3. The role of PRX1-expressing cells in periodontal regeneration and wound healing
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Zhen Huang, Xu Su, Miliya Julaiti, Xiaotao Chen, and Qingxian Luan
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Physiology ,Physiology (medical) - Abstract
The ideal outcome of wound healing is the complete restoration of the structure and function of the original tissue. Stem cells are one of the key factors in this process. Currently, the strategy of periodontal regeneration based on mesenchymal stem cells (MSCs) is generally used to expand stem cells in vitro and then transplant them in vivo. However, their clinical application is limited. In fact, the human body has the capacity to regenerate through stem cells residing in different tissues, even without external therapeutic intervention. Stem cell niches are present in many adult tissues, such as the periodontal ligament and gingiva, and stem cells might remain in a quiescent state in their niches until they are activated in response to a regenerative need. Activated stem cells can exit the niche and proliferate, self-renew, and differentiate to regenerate original structures. Thus, harnessing the regenerative potential of endogenous stem cells in situ has gained increasing attention as a simpler, safer, and more applicable alternative to stem cell transplantation. Nevertheless, there are several key problems to be solved in the application of periodontal mesenchymal stem cells. Thus, animal studies will be especially important to deepen our knowledge of the in vivo mechanisms of mesenchymal stem cells. Studies with conditional knockout mice, in which the expression of different proteins can be eliminated in a tissue-specific manner, are especially important. Post-natal cells expressing the paired-related homeobox protein 1 (PRX1 or PRRX1), a transcription factor expressed in the mesenchyme during craniofacial and limb development, have been shown to have characteristics of skeletal stem cells. Additionally, following wounding, dermal Prx1+ cells are found out of their dermal niches and contribute to subcutaneous tissue repair. Postnatal Prx1+ cells are uniquely injury-responsive. Meanwhile, current evidence shows that Prx1+ cells contribute to promote dentin formation, wound healing of alveolar bone and formation of mouse molar and periodontal ligament. Initial result of our research group also indicates Prx1-expressing cells in bone tissue around the punch wound area of gingiva increased gradually. Collectively, this review supports the future use of PRX1 cells to stimulate their potential to play an important role in endogenous regeneration during periodontal therapy.
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- 2023
4. A phase I, single‐sequence, open‐label study to evaluate the drug–drug interaction between hetrombopag and cyclosporine in healthy Chinese subjects
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Fengshan Li, Hongda Lin, Shiyin Feng, Linrui Cai, Lingli Zhang, Sheng Feng, Xiaohong Liu, Zhuo Chen, Qin Zou, Yiwen Wu, Xu Su, Kai Shen, and Qin Yu
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Pharmacology ,Pharmacology (medical) - Published
- 2023
5. Comparative genomics provides insights into the origin, adaptive evolution and further diversification of two closely related grass genera
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Kunjing Qu, Ai Liu, Mou Yin, Wenjie Mu, Shuang Wu, Hongyin Hu, Xu Su, and Guangpeng Ren
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Ancient whole-genome duplication (WGD) or polyploidization is prevalent in plants and has played a crucial role in plant adaptation. However, the underlying genomic basis of ecological adaptation and subsequent diversification after WGD are still poorly understood in most plants. Here, we report a chromosome-scale reference genome assembly for the genus Orinus (Orinus kokonorica as representative) and preformed comparative genomics with its closely related genus Cleistogenes (Cleistogenes songorica as representative), both belonging to a newly named subtribe Orininae of the grass subfamily Chloridoideae. The two genera may share one paleo-allotetraploidy event before 10 million years ago, and their two subgenomes display neither fractionation bias nor global homoeolog expression dominance. Recent expansion of transposable elements and enormous contraction in gene families in O. kokonorica have maintained a similar genome size compared to C. songorica. Further comparative genomic analyses reveal substantial genome rearrangements and extensive structural variations (SVs) between the two species. With comparative transcriptomics, we demonstrate that functional innovations of orthologous genes have played an important role in promoting adaptive evolution and diversification of the two genera after polyploidization. In addition, copy number variations in flower and rhizome development related genes and extensive SVs between orthologs may contribute to the morphological differences between the two genera. Our results provide significant new insights into the adaptive evolution and subsequent diversification of the two genera after polyploidization.
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- 2023
6. Spectroscopic investigations of Pr3+:CaWO4 at liquid-helium temperatures
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Tian-Shu Yang, Ming-Xu Su, Jian-Yin Huang, You-Cai Lv, Zong-Quan Zhou, Chuan-Feng Li, and Guang-Can Guo
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- 2023
7. Transverse circular photogalvanic effect associated with Lorentz-violating Weyl fermions
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Yahyavi, Mohammad, Jin, Yuanjun, Zhao, Yilin, Cheng, Zi-Jia, Cochran, Tyler A., Hung, Yi-Chun, Chang, Tay-Rong, Ma, Qiong, Xu, Su-Yang, Bansil, Arun, Hasan, M. Zahid, and Chang, Guoqing
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Condensed Matter - Materials Science ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Physics - Optics ,Optics (physics.optics) - Abstract
Nonlinear optical responses of quantum materials have recently undergone dramatic developments to unveil nontrivial geometry and topology. A remarkable example is the quantized longitudinal circular photogalvanic effect (CPGE) associated with the Chern number of Weyl fermions, while the physics of transverse CPGE in Weyl semimetals remains exclusive. Here, we show that the transverse CPGE of Lorentz invariant Weyl fermions is forced to be zero. We find that the transverse photocurrents of Weyl fermions are associated not only with the Chern numbers but also with the degree of Lorentz-symmetry breaking in condensed matter systems. Based on the generic two-band model analysis, we provide a new powerful equation to calculate the transverse CPGE based on the tilting and warping terms of Weyl fermions. Our results are more capable in designing large transverse CPGE of Weyl semimetals in experiments and are applied to more than tens of Weyl materials to estimate their photocurrents. Our method paves the way to study the CPGE of massless or massive quasiparticles to design next-generation quantum optoelectronics.
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- 2023
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8. Quantum metric nonlinear Hall effect in a topological antiferromagnet
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Gao, Anyuan, Liu, Yu-Fei, Qiu, Jian-Xiang, Ghosh, Barun, Trevisan, Thaís V., Onishi, Yugo, Hu, Chaowei, Qian, Tiema, Tien, Hung-Ju, Chen, Shao-Wen, Huang, Mengqi, Bérubé, Damien, Li, Houchen, Tzschaschel, Christian, Dinh, Thao, Sun, Zhe, Ho, Sheng-Chin, Lien, Shang-Wei, Singh, Bahadur, Watanabe, Kenji, Taniguchi, Takashi, Bell, David C., Lin, Hsin, Chang, Tay-Rong, Du, Chunhui Rita, Bansil, Arun, Fu, Liang, Ni, Ni, Orth, Peter P., Ma, Qiong, and Xu, Su-Yang
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Strongly Correlated Electrons (cond-mat.str-el) ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,FOS: Physical sciences - Abstract
Quantum geometry - the geometry of electron Bloch wavefunctions - is central to modern condensed matter physics. Due to the quantum nature, quantum geometry has two parts, the real part quantum metric and the imaginary part Berry curvature. The studies of Berry curvature have led to countless breakthroughs, ranging from the quantum Hall effect in 2DEGs to the anomalous Hall effect (AHE) in ferromagnets. However, in contrast to Berry curvature, the quantum metric has rarely been explored. Here, we report a new nonlinear Hall effect induced by quantum metric by interfacing even-layered MnBi2Te4 (a PT-symmetric antiferromagnet (AFM)) with black phosphorus. This novel nonlinear Hall effect switches direction upon reversing the AFM spins and exhibits distinct scaling that suggests a non-dissipative nature. Like the AHE brought Berry curvature under the spotlight, our results open the door to discovering quantum metric responses. Moreover, we demonstrate that the AFM can harvest wireless electromagnetic energy via the new nonlinear Hall effect, therefore enabling intriguing applications that bridges nonlinear electronics with AFM spintronics., Just appeared in Science. Originally submitted to Science on Oct. 5, 2022
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- 2023
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9. Evaluation of salt and drought tolerances of Populus talassica × Populus euphratica seedlings using leaf anatomical structures and physiological processes
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Yang Sun, Ying Liu, Meng Xu Su, Zhan Jiang Han, and Jian Yin Shi
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Plant Science - Published
- 2023
10. Electronic ratchet effect in a moiré system: signatures of excitonic ferroelectricity
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Zheng, Zhiren, Wang, Xueqiao, Zhu, Ziyan, Carr, Stephen, Devakul, Trithep, de la Barrera, Sergio, Paul, Nisarga, Huang, Zumeng, Gao, Anyuan, Zhang, Yang, Bérubé, Damien, Evancho, Kathryn Natasha, Watanabe, Kenji, Taniguchi, Takashi, Fu, Liang, Wang, Yao, Xu, Su-Yang, Kaxiras, Efthimios, Jarillo-Herrero, Pablo, and Ma, Qiong
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Strongly Correlated Electrons (cond-mat.str-el) ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences - Abstract
Electronic ferroelectricity represents a new paradigm where spontaneous symmetry breaking driven by electronic correlations, in contrast to traditional lattice-driven ferroelectricity, leads to the formation of electric dipoles. Despite the potential application advantages arising from its electronic nature, switchable electronic ferroelectricity remains exceedingly rare. Here, we report the discovery of an electronic ratchet effect that manifests itself as switchable electronic ferroelectricity in a layer-contrasting graphene-boron nitride moiré heterostructure. Our engineered layer-asymmetric moiré potential landscapes result in layer-polarized localized and itinerant electronic subsystems. At particular fillings of the localized subsystem, we find a ratcheting injection of itinerant carriers in a non-volatile manner, leading to a highly unusual ferroelectric response. Strikingly, the remnant polarization can be stabilized at multiple (quasi-continuous) states with behavior markedly distinct from known ferroelectrics. Our experimental observations, simulations, and theoretical analysis suggest that dipolar excitons are the driving force and elementary ferroelectric units in our system. This signifies a new type of electronic ferroelectricity where the formation of dipolar excitons with aligned moments generates a macroscopic polarization and leads to an electronically-driven ferroelectric response, which we term excitonic ferroelectricity. Such new ferroelectrics, driven by quantum objects like dipolar excitons, could pave the way to innovative quantum analog memory and synaptic devices.
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- 2023
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11. Differentially expressed genes in Mythimna separata under chlorantraniliprole exposure and functional identification
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Bai-Zhong Zhang, Gui-Lei Hu, Xu Su, Kang-Sheng Ma, Wen-Yang Dong, Xi-Ling Chen, and Xi-Wu Gao
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Insect Science ,Agronomy and Crop Science - Published
- 2022
12. Intraspecific trait variation in alpine plants relates to their elevational distribution
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Christian Rixen, Sonja Wipf, Sabine B. Rumpf, Justyna Giejsztowt, Jules Millen, John W. Morgan, Adrienne B. Nicotra, Susanna Venn, Shengwei Zong, Katharine J. M. Dickinson, Grégoire T. Freschet, Claudia Kurzböck, Jin Li, Hongli Pan, Beat Pfund, Elena Quaglia, Xu Su, Wei Wang, Xiangtao Wang, Hang Yin, and Julie R. Deslippe
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Ecology ,FOS: Biological sciences ,Plant Science ,Ecology, Evolution, Behavior and Systematics - Abstract
Climate warming is shifting the distributions of mountain plant species to higher elevations. Cold-adapted plant species are under increasing pressure from novel competitors that are encroaching from lower elevations. Plant capacity to adjust to these pressures may be measurable as variation in trait values within a species. In particular, the strength and patterns of intraspecific trait variation along abiotic and biotic gradients can inform us whether and how species can adjust their anatomy and morphology to persist in a changing environment. Here, we tested whether species specialized to high elevations or with narrow elevational ranges show more conservative (i.e. less variable) trait responses across their elevational distribution, or in response to neighbours, than species from lower elevations or with wider elevational ranges. We did so by studying intraspecific trait variation of 66 species along 40 elevational gradients in four countries in both hemispheres. As an indication of potential neighbour interactions that could drive trait variation, we also analysed plant species’ height ratio, its height relative to its nearest neighbour. Variation in alpine plant trait values over elevation differed depending on a species’ median elevation and the breadth of its elevational range, with species with lower median elevations and larger elevational range sizes showing greater trait variation, i.e. a steeper slope in trait values, over their elevational distributions. These effects were evidenced by significant interactions between species’ elevation and their elevational preference or range for several traits: vegetative height, generative height, specific leaf area and patch area. The height ratio of focal alpine species and their neighbours decreased in the lower part of their distribution because neighbours became relatively taller at lower elevations. In contrast, species with lower elevational optima maintained a similar height ratio with neighbours throughout their range. Synthesis. We provide evidence that species from lower elevations and those with larger range sizes show greater intraspecific trait variation, which may indicate a greater ability to respond to environmental changes. Also, larger trait variation of species from lower elevations may indicate stronger competitive ability of upslope shifting species, posing one further threat to species from higher ranges.
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- 2022
13. CYP4CJ6-mediated resistance to two neonicotinoid insecticides in Sitobion miscanthi (Takahashi)
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Gui-Lei Hu, Liu-Yang Lu, Ya-She Li, Xu Su, Wen-Yang Dong, Bai-Zhong Zhang, Run-Qiang Liu, Ming-Wang Shi, Hong-Liang Wang, and Xi-Ling Chen
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Insect Science ,General Medicine ,Agronomy and Crop Science - Abstract
The wheat aphid Sitobion miscanthi (CWA) is an important harmful pest in wheat fields. Insecticide application is the main method to effectively control wheat aphids. However, CWA has developed resistance to some insecticides due to its extensive application, and understanding resistance mechanisms is crucial for the management of CWA. In our study, a new P450 gene, CYP4CJ6, was identified from CWA and showed a positive response to imidacloprid and thiamethoxam. Transcription of CYP4CJ6 was significantly induced by both imidacloprid and thiamethoxam, and overexpression of CYP4CJ6 in the imidacloprid-resistant strain was also observed. The sensitivity of CWA to these two insecticides was increased after the knockdown of CYP4CJ6. These results indicated that CYP4CJ6 could be associated with CWA resistance to imidacloprid and thiamethoxam. Subsequently, the posttranscriptional regulatory mechanism was assessed, and miR-316 was confirmed to participate in the posttranscriptional regulation of CYP4CJ6. These results are crucial for clarifying the roles of P450 in the resistance of CWA to insecticides.
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- 2022
14. Characterization and Phylogenetic Analysis of the Complete Chloroplast Genome of Xanthopappus subacaulis (Asteraceae), an Endemic Species from the Qinghai-Tibet Plateau in China
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Zi-Lan Ma, Shan-Shan Xu, Yang Zhang, Marcos A. Caraballo-Ortiz, Xu Su, and Zhu-Mei Ren
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Genetics ,Cell Biology ,Agricultural and Biological Sciences (miscellaneous) - Published
- 2022
15. Cellulose sulfate lithium as a conductive binder for LiFePO4 cathode with long cycle life
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Xu Su, Han Fang, Hao Yang, Fangfang Zou, Gang Li, Lian Wang, Hongxin Liao, Wei Guan, and Xuebu Hu
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Polymers and Plastics ,Organic Chemistry ,Materials Chemistry - Published
- 2023
16. Effects of biochar on soil water and temperature, nutrients, and yield of maize/soybean and maize/peanut intercropping systems
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Ce Luan, Wei He, Xu Su, Xuanming Wang, Yikui Bai, and Lixue Wang
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Fluid Flow and Transfer Processes ,Soil Science ,General Agricultural and Biological Sciences ,Water Science and Technology - Published
- 2021
17. Untargeted metabolomics identified kynurenine as a predictive prognostic biomarker in acute myocardial infarction
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Xiaolin, Zhang, Yi, Cai, Xu, Su, Quanmin, Jing, Haiwei, Liu, Kun, Na, Miaohan, Qiu, Xiaoxiang, Tian, Dan, Liu, Tianxiao, Wu, Chenghui, Yan, and Yaling, Han
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Inflammation ,Sirtuin 3 ,Immunology ,Myocardial Infarction ,Humans ,ST Elevation Myocardial Infarction ,Metabolomics ,Immunology and Allergy ,Prognosis ,Kynurenine ,Biomarkers - Abstract
ObjectiveThe occurrence of cardiovascular adverse events in the first year after ST-acute myocardial infarction (STEMI) remains high; therefore, identification of patients with poor prognosis is essential for early intervention. This study aimed to evaluate the prognostic value of metabolomics-based biomarkers in STEMI patients and explore their functional mechanisms.MethodsMetabolite profiling was performed using nuclear magnetic resonance. The plasma concentration of Kynurenine (Kyn) was measured using ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. Major adverse cardiac and cerebral events were assessed for 1 year. A functional metabolomics strategy was proposed for investigating the role of Kyn in both vitro and vivo models.ResultsThe adjusted hazard ratios in STEMI patients for Kyn in the 4th quartile 7.12(5.71-10.82) was significantly higher than that in the 3rd quartile 3.03(2.62-3.74), 2nd quartile 1.86(1.70-2.03), and 1st quartile 1.20(0.93-1.39).The incidence of MACCE was significantly different among Kyn quartiles and the highest incidence of MACCE was observed in the 4th quartile when compared with the 1st quartile (9.84% vs.2.85%, Pin vitro.ConclusionsPlasma Kyn levels were positively associated with the occurrence of STEMI. Kyn could induce macrophage cells inflammation and oxidative stress by activating the Sirt3-acSOD2/IL-1β pathway following myocardial ischemia injury. Kyn could be a robust biomarker for STEMI prognosis and reduction of Kyn could be beneficial in STEMI patients.
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- 2022
18. Measuring system for elongation at break of cable insulation sheath based on machine vision
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Xu Su, Gangwei Wang, Zhiqiang Zhang, Jiale Yang, and Zhijia Zhang
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- 2022
19. Synthesis and Antifungal and Insecticidal Activities of Novel N-Phenylbenzamide Derivatives Bearing a Trifluoromethylpyrimidine Moiety
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Meihang Chen, Haijiang Chen, Xu Su, Wenjun Lan, Wenneng Wu, Shuhong He, Xiaoxi Luo, Qiang Fei, and Xuetong Yu
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Article Subject ,biology ,Stereochemistry ,viruses ,fungi ,Botryosphaeria dothidea ,General Chemistry ,Spodoptera ,biology.organism_classification ,In vitro ,Chemistry ,chemistry.chemical_compound ,Mythimna separata ,Phomopsis ,chemistry ,Moiety ,Pyrimethanil ,QD1-999 ,Botrytis cinerea - Abstract
Seventeen novel N-phenylbenzamide derivatives bearing a trifluoromethylpyrimidine moiety were synthesized via four-step reactions. Their antifungal and insecticidal properties were evaluated. Antifungal test results demonstrated that some of the synthesized compounds showed better in vitro bioactivities against Phomopsis sp., Botryosphaeria dothidea (B. dothidea), and Botrytis cinerea (B. cinerea) at 50 μg/mL than pyrimethanil. Unfortunately, the synthesized compounds revealed lower insecticidal activities against Spodoptera frugiperda (S. frugiperda) and Mythimna separata (M. separata) at 500 μg/mL than chlorantraniliprole.
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- 2021
20. Population genetic structure and evolutionary history of Psammochloa villosa (Trin.) Bor (Poaceae) revealed by AFLP marker
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Yuping Liu, Tao Liu, Aj Harris, Xu Su, Ruifang Liang, Zilan Ma, and Ting Lv
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Genetic diversity ,In situ conservation ,education.field_of_study ,desert grasslands ,Ecology ,Population ,population genetics ,Population genetics ,Biology ,Gene flow ,Inner Mongolian Plateau ,Genetic distance ,Evolutionary biology ,SAMOVA ,Genetic variation ,Genetic structure ,education ,ecological niche modeling ,QH540-549.5 ,Ecology, Evolution, Behavior and Systematics ,Original Research ,Nature and Landscape Conservation - Abstract
Psammochloa villosa is an ecologically important desert grass that occurs in the Inner Mongolian Plateau where it is frequently the dominant species and is involved in sand stabilization and wind breaking. We sought to generate a preliminary demographic framework for P. villosa to support the future studies of this species, its conservation, and sustainable utilization. To accomplish this, we characterized the genetic diversity and structure of 210 individuals from 43 natural populations of P. villosa using amplified fragment length polymorphism (AFLP) markers. We obtained 1,728 well‐defined amplified bands from eight pairs of primers, of which 1,654 bands (95.7%) were polymorphic. Results obtained from the AFLPs suggested effective alleles among populations of 1.32, a Nei's standard genetic distance value of 0.206, a Shannon index of 0.332, a coefficient of gene differentiation (G ST) of 0.469, and a gene flow parameter (Nm) of 0.576. All these values indicate that there is abundant genetic diversity in P. villosa, but limited gene flow. An analysis of molecular variance (AMOVA) showed that genetic variation mainly exists within populations (64.2%), and we found that the most genetically similar populations were often not geographically adjacent. Thus, this suggests that the mechanisms of gene flow are surprisingly complex in this species and may occur over long distances. In addition, we predicted the distribution dynamics of P. villosa based on the spatial distribution modeling and found that its range has contracted continuously since the last interglacial period. We speculate that dry, cold climates have been critical in determining the geographic distribution of P. villosa during the Quaternary period. Our study provides new insights into the population genetics and evolutionary history of P. villosa in the Inner Mongolian Plateau and provides a resource that can be used to design in situ conservation actions and prioritize sustainable utilization., 1. There is abundant genetic diversity in Psammochloa villosa, but limited gene flow. 2. Within P. villosa, there is limited but noteworthy geographic structuring of populations, of which 64.2% show significant genetic variation. 3. The species experienced continuous range contraction since the last interglacial period, and the dry and cold climates were critical in determining the distribution of P. villosa during the Quaternary period.
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- 2021
21. A Phase I, Single-sequence, Open-label Study to Evaluate the Drug-Drug Interaction Between Hetrombopag and Cyclosporine in Healthy Chinese Subjects
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Fengshan Li, Hongda Lin, Qin Yu, Kai Shen, Lingli Zhang, Sheng Feng, Yiwen Wu, Shiyin Feng, Xiaohong Liu, Linrui Cai, Zhuo Chen, Qin Zou, and Xu Su
- Abstract
Aims: This study aims to evaluate the drug-drug interaction(DDI) between hetrombopag and cyclosporine in healthy Chinese subjects. Methods: Twenty-six eligible subjects enrolled in this single-center, single-sequence, open-label, DDI study with three treatment periods, receiving 5 mg hetrombopag once on day 1, 100 mg cyclosporine twice daily from day 11 to day 15, and 5 mg hetrombopag + 100 mg cyclosporine on day 16. Serial blood samples were collected for pharmacokinetic evaluation. Adverse events were monitored throughout the study. Results: The plasma hetrombopag geometric mean ratios (GMRs) (90% CI) of Cmax, AUC0-t and AUC0-∞ of co-administration of hetrombopag with cyclosporine vs hetrombopag alone are 95.97% (70.08%, 131.43%), 105.75% (75.04%, 149.04%) and 104.19% (74.71%, 145.32%), respectively, indicating multiple doses of cyclosporine had minimal effects on hetrombopag exposure. The GMRs (90% CI) of Cmax and AUCss,tau for blood cyclosporine of co-administration vs cyclosporine alone were 100.49% (91.89%, 109.89%) and 100.81% (107.88%, 103.82%), respectively, suggesting a single dose of hetormbopag had no impact on the exposure of cyclosporine. Co-administration of hetormbopag with cyclosporine was generally well tolerated. Conclusion: No clinically significant DDI was observed when co-administration of hetrombopag with cyclosporine. No additional dose adjustment is warranted for this combination.
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- 2022
22. Variation among the Complete Chloroplast Genomes of the Sumac Species
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Yujie, Xu, Jun, Wen, Xu, Su, and Zhumei, Ren
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Chloroplasts ,Rhus ,Genome, Chloroplast ,Phylogeny ,Microsatellite Repeats - Abstract
The sumac
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- 2022
23. A review of literature and meta-analysis of one-puncture success rate in radiofrequency thermocoagulation with different guidance techniques for trigeminal neuralgia
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Zhengming Wang, Xu Su, Yin Yu, Zhijun Wang, Kai Li, Yufei Gao, Yu Tian, and Chao Du
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Treatment Outcome ,Trigeminal Ganglion ,Electrocoagulation ,Humans ,Punctures ,General Medicine ,Trigeminal Neuralgia - Abstract
Objectives Radiofrequency thermocoagulation (RFT) is a type of Gasserian ganglion-level ablative intervention that is used for the treatment of trigeminal neuralgia. Guidance technologies are used to assist in the cannulation of the foramen ovale (FO) or foramen rotundum (FR) target. We conducted a systematic review to assess the value of different guidance technologies for RFT. Methods We searched PubMed, Embase, the Cochrane database, Web of Science, and PROSPERO for studies published from January 2005 until December 2020. Randomized or nonrandomized comparative studies and nonrandomized studies without internal controls were included. The Cochrane Risk of Bias Tool and the nonrandomized studies of interventions-I tool were used to assess individual study characteristics and overall quality. Results Our query identified 765 publications, and we were able to analyze 11 studies on patients suffering from trigeminal neuralgia. Only one study involved randomized controlled trials, whereas the others featured nonrandomized designs, predominantly before-and-after comparisons. Most of them were observational studies. A total of 222 participants were included, with a median number (range) of 20 (3–53) participants. The objective response rate (ORR) of the one-puncture success rate of RFT using puncture guidance for trigeminal neuralgia was 92% [95% CI (0.79–1), P P Conclusions RFT with puncture guidance technology has an absolute advantage in puncturing the foramen ovale or foramen rotundum.
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- 2022
24. Identification and Validation of METTL3-Related Molecules for Predicting Prognosis and Efficacy of Immunotherapy in Gastric Cancer Based on m6A Methylome and Transcriptome Sequencing Analysis
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Shuran, Chen, Xu, Su, Jing, Wang, Ni, Zheng, Yuan, Tang, Guisen, Peng, Rui, Dong, Fei, Lu, Mulin, Liu, Yunli, Zhao, and Huazhang, Wu
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Cancer Research ,Oncology - Abstract
Abnormal N6-methyladenosine (m6A) modification levels caused by METTL3 have been identified to be a critical regulator in human cancers, and its roles in the immune microenvironment and the relationship between targeted therapy and immunotherapy sensitivity in gastric cancer (GC) remain poorly understood. In this study, we assessed the transcriptome-wide m6A methylation profile after METTL3 overexpression by m6A sequencing and RNA sequencing in BGC-823 cells. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to analyze the function of core targets of METTL3. Eighteen methylation core molecules were identified in GC patients by combining transcriptome and methylome sequencing. GC patients can be separated into two subtypes based on the expression of 18 methylation core molecules. Furthermore, subgroup analysis showed that patients with different subtypes had a different OS, PFS, stage, grade, and TMB. Gene set enrichment analysis (GSEA) showed that immune-related pathways were enriched among subtype A. The ESTIMATE analysis suggested that the extent of infiltration of immune cells was different in two subtypes of GC patients. Tumor Immune Dysfunction and Exclusion (TIDE) and The Cancer Immunome Atlas (TCIA) database also showed that there were significant differences in the efficacy of immunotherapy among different types of GC patients. Altogether, our results reveal that METTL3-mediated m6A methylation modification is associated with the immune microenvironment and the effects of immunotherapy in GC patients. Our findings provide novel insights for clinicians in the diagnosis and optimal treatment of GC patients.
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- 2022
25. Integrative proteomics and m6A microarray analyses of the signatures induced by METTL3 reveals prognostically significant in gastric cancer by affecting cellular metabolism
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Guisen Peng, Shuran Chen, Ni Zheng, Yuan Tang, Xu Su, Jing Wang, Rui Dong, Di Wu, Mingjie Hu, Yunli Zhao, Mulin Liu, and Huazhang Wu
- Subjects
Cancer Research ,Oncology - Abstract
METTL3-mediated RNA N6-methyladenosine (m6A) is the most prevalent modification that participates in tumor initiation and progression via governing the expression of their target genes in cancers. However, its role in tumor cell metabolism remains poorly characterized. In this study, m6A microarray and quantitative proteomics were employed to explore the potential effect and mechanism of METTL3 on the metabolism in GC cells. Our results showed that METTL3 induced significant alterations in the protein and m6A modification profile in GC cells. Gene Ontology (GO) enrichment indicated that down-regulated proteins were significantly enriched in intracellular mitochondrial oxidative phosphorylation (OXPHOS). Moreover, the protein-protein Interaction (PPI) network analysis found that these differentially expressed proteins were significantly associated with OXPHOS. A prognostic model was subsequently constructed based on the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases, and the high-risk group exhibited a worse prognosis in GC patients. Meanwhile, Gene Set Enrichment Analysis (GSEA) demonstrated significant enrichment in the energy metabolism signaling pathway. Then, combined with the results of the m6A microarray analysis, the intersection molecules of DEPs and differential methylation genes (DMGs) were significantly correlated with the molecules of OXPHOS. Besides, there were significant differences in prognosis and GSEA enrichment between the two clusters of GC patients classified according to the consensus clustering algorithm. Finally, highly expressed and highly methylated molecules regulated by METTL3 were analyzed and three (AVEN, DAZAP2, DNAJB1) genes were identified to be significantly associated with poor prognosis in GC patients. These results signified that METTL3-regulated DEPs in GC cells were significantly associated with OXPHOS. After combined with m6A microarray analysis, the results suggested that these proteins might be implicated in cell energy metabolism through m6A modifications thus influencing the prognosis of GC patients. Overall, our study revealed that METTL3 is involved in cell metabolism through an m6A-dependent mechanism in GC cells, and indicated a potential biomarker for prognostic prediction in GC.
- Published
- 2022
26. A transcriptomic approach to develop a novel set of low-copy nuclear gene primers for the sand whip grass, Psammochloa villosa (Trin.) Bor (Poaceae), a dominant species from the inner Mongolia plateau
- Author
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Ting Lv, Yu-Ping Liu, Tao Liu, Gui Fu, Zi-Lan Ma, Chang-Yuan Zheng, and Xu Su
- Subjects
Plant Science - Published
- 2022
27. Abstract 5201: TNFR2 humanized mice: an ideal model for studying anti-TNFR2 antibodies
- Author
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Huiyi Wang, Ying Li, Mingkun Zhang, Xu Su, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao, and Cunxiang Ju
- Subjects
Cancer Research ,Oncology - Abstract
Tumor necrosis factor (TNF) receptor 2 (TNFR2) is mainly expressed on the surface of regulatory T cells (Tregs) and CD8+ T cells, which can stimulate the proliferation of these cells through NF-kB activation. TNFR2 is also highly expressed on the surface of various human tumors, such as colorectal cancer and lung cancer. Therefore, a TNFR2 antagonist blocking the binding of TNFR2 to its ligand that targets TNFR2+ tumor-infiltrating Tregs can directly enhance the killing ability of effector T cells (Teff) against TNFR2-expressing tumors. Many pharmaceutical and biotech companies have lined up TNFR2-targeting drugs, and most TNFR2 antibodies related research is in the early preclinical/clinical stage. We established a humanized TNFR2 (hTNFR2) genetically engineered mouse model on the BALB/c background, in which the extracellular domain of the mouse TNFR2 was replaced with its human counterpart, and the murine transmembrane and cytoplasmic domain kept intact. The hTNFR2 chimeric protein is mainly expressed on Teff and Treg cells in BALB/c-hTNFR2 and BALB/c-hPD1/hPDL1/hTNFR2 mice, which is similar to mouse TNFR2 protein expression profiles in wild-type mice. Our data showed that anti-TNFR2 antibodies could significantly inhibit tumor growth in BALB/c-hTNFR2 mice bearing CT26 tumor cells or BALB/c-hTNFR2 mice bearing CT26-hTNFR2 tumors. Furthermore, within the tumor-infiltrating lymphocytes, there was a reduction in Tregs cells and an increase in cytotoxic CD8 T cells, which accurately mimics the mechanism of action of anti-TNFR2 antibodies. In conclusion, BALB/c-hTNFR2 and BALB/c-hPD1/hPDL1/hTNFR2 mice are ideal models for studying the efficacy and pharmacodynamics of anti-TNFR2 antibodies as a single agent or in combination with anti-PD-1/PD-L1 therapies. Citation Format: Huiyi Wang, Ying Li, Mingkun Zhang, Xu Su, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao, Cunxiang Ju. TNFR2 humanized mice: an ideal model for studying anti-TNFR2 antibodies. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5201.
- Published
- 2023
28. Solar Cycle 25 Prediction Using N-BEATS
- Author
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Xu Su, Bo Liang, Song Feng, Wei Dai, and Yunfei Yang
- Subjects
Space and Planetary Science ,Astronomy and Astrophysics - Abstract
Solar activities lead to Sun variation with an 11 yr periodicity. The periodic variation affects space weather and heliophysics research. So it is important to accurately predict solar cycle variations. In this paper, we predicted the ongoing Solar Cycle 25 using neural basis expansion analysis for the interpretable time series deep learning method. 13 months of smoothed monthly total sunspot numbers taken by sunspot Index and Long-term Solar Observations are selected to train and evaluate our model. We used root mean square error (RMSE) and mean absolute time lag (MATL) to evaluate our model performance. RMSE and MATL measure the difference between our predicted values and the actual values along the Y- and X-axis, respectively. The RMSE value is 26.62 ± 1.56 and the MATL value is 1.34 ± 0.35, demonstrating that our model is able to better predict sunspot number variation. Finally, we predicted the variation of the sunspot numbers for Solar Cycle 25 using the model. The sunspot number of Solar Cycle 25 will peak around 2024 February with an amplitude of 133.9 ± 7.2. This means that Solar Cycle 25 will be slightly more intense than Solar Cycle 24.
- Published
- 2023
29. Metabolic Defects of Peripheral T Cells in COVID-19 Patients
- Author
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Shuye Zhang, Xu Su, Haiyan Wang, Wan Wang, Xiaoju Liu, Juanjuan Zhao, Jian Sun, Xuejiao Liao, and Zheng Zhang
- Subjects
chemistry.chemical_classification ,medicine.medical_specialty ,medicine.diagnostic_test ,T cell ,Immunology ,Fatty acid ,Flow cytometry ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Immune system ,Endocrinology ,chemistry ,Apoptosis ,Internal medicine ,medicine ,Immunology and Allergy ,Glycolysis ,Ex vivo ,CD8 ,030215 immunology - Abstract
The relatively low partial pressure of oxygen, reduced oxygen saturation, and aberrant plasma metabolites in COVID-19 may alter energy metabolism in peripheral immune cells. However, little is known regarding the immunometabolic defects of T cells in COVID-19 patients, which may contribute to the deregulated immune functions of these cells. In this study, we longitudinally characterized the metabolic profiles of resting and activated T cells from acutely infected and convalescent COVID-19 patients by flow cytometry and confirmed the metabolic profiles with a Seahorse analyzer. Non–COVID-19 and healthy subjects were enrolled as controls. We found that ex vivo T cells from acutely infected COVID-19 patients were highly activated and apoptotic and displayed more extensive mitochondrial metabolic dysfunction, especially cells in CD8+ T cell lineages, than those from convalescent COVID-19 patients or healthy controls, but slightly disturbed mitochondrial metabolic activity was observed in non–COVID-19 patients. Importantly, plasma IL-6 and C-reactive protein (CRP) levels positively correlated with mitochondrial mass and negatively correlated with fatty acid uptake in T cells from COVID-19 patients. Additionally, compared with those from healthy controls, in vitro–activated T cells from acutely infected COVID-19 patients showed signs of lower glycolysis, a reduced glycolytic capacity, and a decreased glycolytic reserve, accompanied by lower activation of mTOR signaling. Thus, newly identified defects in T cell mitochondrial metabolic functions and metabolic reprogramming upon activation might contribute to immune deficiency in COVID-19.
- Published
- 2021
30. Hair Attribute Transfer via Deep Feature Fusion
- Author
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Lizhuang Ma, Xu Su, Zhifeng Xie, Siwei Liu, and Guisong Zhang
- Subjects
Feature fusion ,business.industry ,Computer science ,Transfer (computing) ,Pattern recognition ,Artificial intelligence ,business ,Computer Graphics and Computer-Aided Design ,Software - Published
- 2021
31. A Universal Ratio Snow Index for Fractional Snow Cover Estimation
- Author
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Gongxue Wang, Jiancheng Shi, Xu Su, and Lingmei Jiang
- Subjects
Index (economics) ,Mean squared error ,Pixel ,0211 other engineering and technologies ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,Snow ,Stability (probability) ,Thematic Mapper ,Linear regression ,Moderate-resolution imaging spectroradiometer ,Electrical and Electronic Engineering ,021101 geological & geomatics engineering ,Mathematics ,Remote sensing - Abstract
The moderate resolution imaging spectroradiometer (MODIS) snow algorithm has been used to generate global fractional snow cover (FSC) at a pixel size of 500 m using a linear regression relationship (called “FRA6T”) between FSC and the normalized difference snow index (NDSI). However, the linear relationship is problematic because of the considerable NDSI variation in nonsnow conditions. In this letter, we propose a universal ratio snow index (URSI), which is the ratio of the visible reflectance and the sum of the near infrared and shortwave infrared reflectances. It is called “universal” because it has weak sensitivity under snow-free ground conditions and, therefore, can improve the stability of the linear snow index methodology. A comparison between NDSI and URSI with regard to estimate FSC using the linear snow index methodology is carried out for the Tibetan Plateau. The scatter plots of MODIS NDSI/URSI and Landsat-7 Enhanced Thematic Mapper Plus (ETM+) FSC indicate that a linear relationship can be assumed for both NDSI and URSI for barren land conditions and is more appropriate for URSI than it is for NDSI in forested areas. Validation efforts show that the linear relationship using URSI (designated “FracURSI”) achieves fewer errors in FSC estimation compared with the developed NDSI method (“FracNDSI”), particularly for forested areas and for moderate FSC values. Averaged over all comparisons, the root-mean-square error (RMSE) of FSC estimates for FRA6T is 0.13, and for FracNDSI is 0.12, whereas FracURSI RMSE is 0.11.
- Published
- 2021
32. Impact of agro-forestry systems on the aroma generation of coffee beans
- Author
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Xu, Su, Liu, Yuze, Ma, Fengwei, Yang, Ni, Virginio Filho, Elias de Melo, and Fisk, Ian Denis
- Subjects
Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Food Science - Abstract
A long experiment has been established since 2000 at CATIE (Tropical Agricultural Research and Higher Education Center), Turrialba, Costa Rica. Twenty agro-forestry systems with different shade types and managements (organic and non-organic) consisting of an incomplete randomized block-design with shade tree as main effect and subplots represented by management were set up. The effects of different managements and shade types on the aroma and color generation of roasted coffee beans were investigated. The total protein content was significantly higher (P < 0.05) under the intensive conventional (IC) (168 g/Kg) and intensive organic (IO) (167 g/Kg) managements than under the moderate conventional (MC) (153 g/Kg in IC vs. MC group, 157 g/Kg in MC vs. IO group). Comparing with the moderate conventional (MC) management, the intensive organic (IO) management had a stronger ability to generate more flavor and color. The total protein content was significantly higher (P < 0.05) under the full sun system (172 g/Kg) than under the shaded (159 g/Kg) and Erythrina system (155 g/Kg), under the service system (165 g/Kg) than under the timber system (146 g/Kg), under the legume timber system (170 g/Kg) than under the non-legume timber system (152 g/Kg). The full sun system had a greater flavor generation and color after roasting. Comparing with the timber system, the service system produced roasted beans with the more flavor and color. Comparing with the non-legume shade tree, the legume shade tree improved the performance of flavor and color in the roasted coffee beans.
- Published
- 2022
33. Transcriptomic Profile Analysis of
- Author
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Ying, Liu, Zhan Jiang, Han, Meng Xu, Su, and Min, Zhang
- Subjects
Plant Breeding ,Populus ,Stress, Physiological ,Salt Tolerance ,Transcriptome - Abstract
A new
- Published
- 2022
34. Closing the Gap: Horizontal Transfer of
- Author
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Aftab, Ahmad, Xu, Su, A J, Harris, and Zhumei, Ren
- Abstract
Horizontal transfer of transposons (HTT) is an essential source of genomic evolution in eukaryotes. The HTT dynamics are well characterized in eukaryotes, including insects; however, there is a considerable gap in knowledge about HTT regarding many eukaryotes' species. In this study, we analyzed the events of the HTT between
- Published
- 2022
35. Closing the Knowledge Gap: Horizontal Transfer of Mariner Transposons between Rhus Gall Aphids and Other Insects
- Author
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Aftab Ahmad, Xu Su, AJ Harris, and Zhumei Ren
- Abstract
Horizontal transfer of transposons (HTT) is an important source of genomic evolution in eukaryotes. The HTT dynamics is well characterized in eukaryotes including insects however, but there is a huge gap of knowledge about HTT regarding many eukaryotes’ species. In this study we analyzed the events of the HTT between Rhus gall aphids (Hemiptera) and other insects. We analyzed the Mariner-like transposable elements (MLEs) belongs to Rhus gall aphids for the possible HT events. The MLEs have patchy distribution and have high similarity over the entire length of element with insects MLEs from different orders. We selected representative sequences from the Rhus gall MLEs and identified five events of HT between MLEs of Rhus gall aphids and other insects from five different orders. We also found multiple HTT events among the MLEs of insects from the five orders which demonstrate that these Mariner elements have been involved in recurrent HT between these six order of insects. Our current study closed the knowledge gap of HTT and reported the events between Rhus gall aphids and other insects for the first time. We believe that this study about HTT events will help to understand the evolution and spread of transposable elements in the genomes of Rhus gall aphids.
- Published
- 2022
36. Characterization of the Complete Chloroplast Genome of Meconopsis punicea (Papaveraceae), an Endemic Species from the Qinghai-Tibet Plateau in China
- Author
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Yuping Liu, Xu Su, Marcos A. Caraballo-Ortiz, and Ruifang Liang
- Subjects
0106 biological sciences ,0301 basic medicine ,Phylogenetic tree ,biology ,Inverted repeat ,Cell Biology ,biology.organism_classification ,01 natural sciences ,Agricultural and Biological Sciences (miscellaneous) ,Genome ,Chloroplast ,03 medical and health sciences ,030104 developmental biology ,Meconopsis ,Botany ,Genetics ,Papaveraceae ,Clade ,Gene ,010606 plant biology & botany - Abstract
Meconopsis punicea Maxim. (Papaveraceae) is an alpine perennial herb endemic to the Qinghai-Tibet Plateau in southwestern China. In this study, we sequenced and analyzed its whole chloroplast genome using an Illumina HiSeq platform. This represents the second complete chloroplast genome for a species of Meconopsis after the recent publication of a first one (M. racemosa) in 2018. Our result shows that the chloroplast genome of M. punicea is 153 260 bp in length with a relatively high A + T content (61.5%), and has a standard quadripartite structure with the large (LSC, 84 122 bp) and small (SSC, 17 730 bp) single copy regions separated by two copies of an inverted repeat (IRs, 25 704 bp each). The chloroplast genome encodes a total of 110 genes, including 78 protein-coding genes, 29 tRNAs genes and three rRNAs genes. The majority (94) of genes occur within the single copy regions. When comparing these results to the previously published chloroplast genome of M. racemosa, both species share similar gene type, number and G + C content. In addition, the maximum likelihood phylogenetic analysis based on 33 chloroplast genomes suggested that M. punicea is basal in the Meconopsis clade within Papaveraceae.
- Published
- 2021
37. Complete Chloroplast Genome of Psammochloa villosa (Poaceae), a Pioneer Grass Endemic to Sand Dunes in Northwest China
- Author
-
Zh. Ren, Ting Lv, Yuping Liu, and Xu Su
- Subjects
0106 biological sciences ,0301 basic medicine ,Subfamily ,Phylogenetic tree ,Villosa ,Inverted repeat ,Cell Biology ,Biology ,biology.organism_classification ,01 natural sciences ,Agricultural and Biological Sciences (miscellaneous) ,Pooideae ,Genome ,03 medical and health sciences ,030104 developmental biology ,Botany ,Genetics ,Poaceae ,Gene ,010606 plant biology & botany - Abstract
Psammochloa villosa is a sandy perennial grass (Poaceae) endemic to the northwest China, which has extremely important ecological and genetic values. To explore characterization and phylogenetic analysis of the complete chloroplast (cp) genome of Psammochloa villosa, we firstly sequenced and compared it with other cp genomes within Poaceae in this study. The result showed that the cp genome of P. villosa was 135 541 bp in size with a high A + T content of 61.2%, and had a typical quadripartite structure with the large (LSC, 80 272 bp) and small (SSC, 12 453 bp) single copy regions separated by two copies of inverted repeats (IRs, 21 408 bp each). We successfully annotated 134 genes, including 79 protein-coding genes, 42 tRNAs genes and ten rRNAs genes. Among these genes, 42 genes locate in IR regions. Additionally, we constructed a phylogenetic tree based on 40 cp genome sequences, which indicated that P. villosa has a closer relationship with the other species in subfamily Pooideae.
- Published
- 2020
38. Untargeted Metabolomics Identified Kynurenine as a Predictive Prognostic Biomarker in Acute Myocardial Infarction
- Author
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Xiaolin Zhang, Yi Cai, Xu Su, Kun Na, Miaohan Qiu, Xiaoxiang Tian, Dan Liu, Tianxiao Wu, Chenghui Yan, and Yaling Han
- Published
- 2022
39. Supplemental Material - Effects of a Two-Tier Test Strategy on Students’ Digital Game-Based Learning Performances and Flow Experience in Environmental Education
- Author
-
Wang, Xiao-Ming, Wang, Shi-Man, Wang, Jia-Ni, Hwang, Gwo-Jen, and Xu, Su
- Subjects
Education - Abstract
Supplemental Material for Effects of a Two-Tier Test Strategy on Students’ Digital Game-Based Learning Performances and Flow Experience in Environmental Education by Xiao-Ming Wang, Shi-Man Wang, Jia-Ni Wang, Gwo-Jen Hwang, and Su Xu in Journal of Educational Computing Research
- Published
- 2022
- Full Text
- View/download PDF
40. On-demand Integrated Quantum Memory for Polarization Qubits
- Author
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Tian-Xiang Zhu, Chao Liu, Ming Jin, Ming-Xu Su, Yu-Ping Liu, Wen-Juan Li, Yang Ye, Zong-Quan Zhou, Chuan-Feng Li, and Guang-Can Guo
- Subjects
Quantum Physics ,81P45 ,General Physics and Astronomy ,FOS: Physical sciences ,Quantum Physics (quant-ph) - Abstract
Photonic polarization qubits are widely used in quantum computation and quantum communication due to the robustness in transmission and the easy qubit manipulation. An integrated quantum memory for polarization qubits is a fundamental building block for large-scale integrated quantum networks. However, on-demand storing polarization qubits in an integrated quantum memory is a long-standing challenge due to the anisotropic absorption of solids and the polarization-dependent features of microstructures. Here we demonstrate a reliable on-demand quantum memory for polarization qubits, using a depressed-cladding waveguide fabricated in a 151Eu3+: Y2SiO5 crystal. The site-2 151Eu3+ ions in Y2SiO5 crystal provides a near-uniform absorption for arbitrary polarization states and a new pump sequence is developed to prepare a wideband and enhanced absorption profile. A fidelity of 99.4\pm0.6% is obtained for the qubit storage process with an input of 0.32 photons per pulse, together with a storage bandwidth of 10 MHz. This reliable integrated quantum memory for polarization qubits reveals the potential for use in the construction of integrated quantum networks., Comment: 20 pages, 5 figures
- Published
- 2022
- Full Text
- View/download PDF
41. Using full-length metabarcoding and DNA barcoding to infer community assembly for speciose taxonomic groups: a case study
- Author
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Meng-di Hao, Jin Qian, Shanlin Liu, John-James Wilson, Chungkun Shih, Xu Su, Shenzhou Yang, Cai-qing Yang, Min Tang, Jing Li, Yinan Li, Yiran Sun, Dan Zhang, Guanliang Meng, Zhi-yong Shi, Xin Zhou, and Ai-bing Zhang
- Subjects
0106 biological sciences ,0301 basic medicine ,Sanger sequencing ,Phylogenetic tree ,Ecology (disciplines) ,media_common.quotation_subject ,Biology ,010603 evolutionary biology ,01 natural sciences ,DNA barcoding ,Competition (biology) ,03 medical and health sciences ,symbols.namesake ,030104 developmental biology ,Habitat ,Animal ecology ,Evolutionary biology ,symbols ,Taxonomic rank ,Ecology, Evolution, Behavior and Systematics ,media_common - Abstract
How insect communities are assembled in nature remains largely unknown. In particular, whether habitat filtering or competition serves as the main mechanism in forming insect communities is rarely subject to an in-depth investigation. One bottleneck lies in the difficulty of species identification when dealing with a large number of diverse insects. However, high-throughput sequencing technology coupled with classic DNA barcoding offers a great opportunity to infer community assembly for this speciose group. In this study, using 13,909 full-length barcodes obtained by Sanger sequencing or the full-length metabarcoding method (SOAPBarcode), we showed that competition was the main assembly mechanism for the moth communities in the younger Taihang Mountain, while habitat filtering for those in the old Yanshan Mountain. The two sequencing methods showed highly consistent results with regards to both diversity composition and community assembly mechanism. Significant phylogenetic signals and structure suggested that the focal moth communities were the result of the non-neutral assembly process, which was further confirmed by results of neutral assembly test that accounted for immigration and speciation rates. Our study showed that the full-length metabarcoding method can facilitate community assembly inferences, even for speciose taxonomic groups.
- Published
- 2020
42. 12-ns Frequency Chirped Pulse for Self-Calibrated Gas Sensing
- Author
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Xu Su, Yizheng Zhu, Daniel S. Homa, Gary Pickrell, Anbo Wang, and Guannan Shi
- Subjects
Materials science ,Spectral power distribution ,business.industry ,Oscillation ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Pulse (physics) ,Optics ,Modulation ,Temporal resolution ,Chirp ,Transient (oscillation) ,Electrical and Electronic Engineering ,business ,Absorption (electromagnetic radiation) - Abstract
We present the generation of 12.1 ns frequency chirped pulses from a distributed feedback laser diode via injection current modulation and demonstrate its application to absorption-based methane sensing at 1650.9 nm. The chirp spectral distribution is found to be significantly impacted by the transient dynamics of these short pulses. A simplified, two-part model is used to evaluate the chirp property, suggesting spectral mixing and oscillation. The chirp enables intra-pulse self-calibrated gas sensing by taking the amplitude ratio between the absorption peak and a reference, which is demonstrated for methane concentrations from 0 to 22.6% with a detection limit of 25 ppm. It also provides resistance to power fluctuation from various sources. These short pulses offer high spatial and temporal resolution and can potentially enable reflection-based, highly multiplexed gas sensing systems.
- Published
- 2020
43. Controlled Synthesis of Densely Grafted Bottlebrushes That Bear Helical Polyisocyanide Side Chains on Polyisocyanide Backbones and Exhibit Greatly Increased Viscosity
- Author
-
Lei Xu, Zong-Quan Wu, Yi-Xu Su, Na Liu, Xiao-Hua Hou, and Xun-Hui Xu
- Subjects
Inorganic Chemistry ,chemistry.chemical_classification ,Viscosity ,Materials science ,Polymers and Plastics ,Polymer science ,chemistry ,Organic Chemistry ,Materials Chemistry ,Side chain ,Polymer - Abstract
The precise synthesis of a new series of densely grafted bottlebrushes that bear helical polyisocyanide side chains on polyisocyanide backbones is described. New C1 polymers, polyisocyanides that b...
- Published
- 2020
44. Self-assembly and fluorescence emission of UV-responsive azobenzene-containing helical poly(phenyl isocyanide) copolymers
- Author
-
Na Liu, Zong-Quan Wu, Yong-Yuan Chen, Qian-Wei Li, Hui Zou, Xiao-Hua Hou, Li Zhou, and Yi-Xu Su
- Subjects
Materials science ,Aqueous solution ,Polymers and Plastics ,Isocyanide ,Organic Chemistry ,Bioengineering ,Polyethylene glycol ,Biochemistry ,Micelle ,chemistry.chemical_compound ,Monomer ,Azobenzene ,chemistry ,Polymerization ,Polymer chemistry ,Copolymer - Abstract
Azobenzene (Azo)-containing phenyl isocyanide (AzoPI, monomer 1) was synthesized via the combination of Williamson etherification and a transesterification reaction, and it could be polymerized to afford poly-1n with the phenyl alkyne–Pd(II) complex as the initiator in a living/controlled manner. Since the obtained poly-1n was living, helical copolymers were obtained through the polymerization of oligo polyethylene glycol group-functionalized phenyl isocyanide (monomer 2) using poly-140 as the macroinitiator. The obtained copolymers were optically active and exhibited light-responsive properties. The poly(140-b-2m) copolymers were amphiphilic and could self-assemble into supramolecular aggregates in aqueous solutions. The TEM results showed that poly(140-b-220) self-assembled to form hollow spindly aggregates with an average length of ∼430 nm and an average diameter of ∼160 nm, while poly(140-b-240) self-assembled into wormlike micelles with an average length of ∼280 nm and an average width of ∼48 nm, and poly(140-b-280) self-assembled into spherical micelles with an average diameter of ∼82 nm. Meanwhile, when α-cyclodextrin (α-CD) was added into the aqueous solution of poly(140-b-240), the wormlike micelles of poly(140-b-240) changed into spherical micelles of the poly(140-b-240)/α-CD complex with an average diameter of ∼104 nm. What's more, due to the UV-response of Azo groups, irregular aggregates of poly(140-b-240) and poly(140-b-240)/α-CD were observed upon UV irradiation. In the meantime, the fluorescence emission of Azo groups was unexpectedly observed in THF solution. When water was added into the THF solution, the intensity of the fluorescence emission became higher. Moreover, the fluorescence intensity increased with the increase in the ratio of water to THF.
- Published
- 2020
45. Chemical Constituents of Pedicularis longiflora var. tubiformis (Orobanchaceae), a Common Hemiparasitic Medicinal Herb from the Qinghai Lake Basin, China
- Author
-
Yuping Liu, Feng Liu, Xu Su, Zilan Ma, Hui Zhang, and Marcos A. Caraballo-Ortiz
- Subjects
biology ,Physiology ,food and beverages ,Plant Science ,Structural basin ,biology.organism_classification ,Biochemistry ,Pedicularis longiflora ,Orobanchaceae ,Chemical constituents ,Botany ,Medicinal herbs ,Qinghai lake ,China - Abstract
Background: Pedicularis longiflora var. tubiformis (Orobanchaceae) is an abundant parasitic herb mainly found in the Xiaopohu wetland of the Qinghai Lake Basin in Northwestern China. The species has an important local medicinal value, and in this study, we evaluated the chemical profile of its stems, leaves and seeds using mass spectrometry. Methods: Dried samples of stems, leaves and seeds were grinded, weighted, and used for a series of extractions with an ultrasonic device at room temperature. The chemical profiles for each tissue were determined using Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS). Results: Twenty-seven amino acids and organic acids were identified and quantified from stems, leaves and seeds. The content of amino acids detected in leaves and seeds was higher than the amount found in stems. Eight flavonoids were also detected, including isoorientin, orientin, luteolin-7-O-glucoside, verbascoside, scopoletin, luteolin, apigenin and tricin. The concentrations of verbascoside, luteolin and tricin were the highest and more concentrated in leaves, while that of orientin and scopoletin were the lowest and mainly found in stems. Soluble monosaccharides and oligosaccharides below tetramer were also examined, and our analyses detected the presence of arabitol, fructose, galacturonic acid, glucose, glucuronic acid, inositol, sucrose, and trehalose. Conclusions: This is the first study to identify and quantify the main components of amino acids, organic acids, flavonoids and soluble sugars from stems, leaves and seeds of P. longiflora var. tubiformis . Eight of the amino acids detected are essential for humans, highlighting the medicinal importance of this species. Results shown here can be used as a reference case to develop future studies on the chemical constituents of Pedicularis herbs and other medicinal plants from the Tibetan region.
- Published
- 2020
46. Characterization and Phylogenetic Analysis of the Complete Chloroplast Genome of Orinus kokonoricus (Poaceae), an Endemic Species from the Qinghai-Tibet Plateau
- Author
-
Tao Liu, Yuping Liu, Ting Lv, and Xu Su
- Subjects
0106 biological sciences ,0301 basic medicine ,Phylogenetic tree ,Inverted repeat ,Intron ,Cell Biology ,Biology ,biology.organism_classification ,01 natural sciences ,Agricultural and Biological Sciences (miscellaneous) ,Genome ,03 medical and health sciences ,030104 developmental biology ,Evolutionary biology ,Genetics ,Chloridoideae ,Orinus ,Clade ,Gene ,010606 plant biology & botany - Abstract
Orinus kokonoricus is an alpine perennial grass (Poaceae) endemic to the Qinghai-Tibet Plateau (QTP) in China, which has extremely important ecological and genetic values. To explore characterization and phylogenetic analysis of the complete chloroplast (cp) genome of O. kokonoricus, we first sequenced and assembled its cp genome with Illumina HiSeq4000 platform in the present study. The results showed that the complete cp genome of O. kokonoricus is 134,466 bp in length with a high AT content of 61.6% and displays a standard quadripartite structure including one large single copy region (LSC, 79,932 bp), one small single copy region (SSC, 12,490 bp) and two inverted repeat regions (IRA and IRB, 21,022 bp each). It totally encodes 137 genes containing 81 protein-coding genes, 45 tRNAs genes and eight rRNAs genes. Moreover, most of these genes occur in the single copy regions. Among all annotated genes of the cp genome of O. kokonoricus, none of them harbors introns. In addition, phylogenetic analysis based on 40 complete cp genome sequences of Poaceae revealed that O. kokonoricus is sister clade to the clade of Eragrostis species in Chloridoideae.
- Published
- 2019
47. Author response for 'Intraspecific trait variation in alpine plants relates to their elevational distribution'
- Author
-
null Christian Rixen, null Sonja Wipf, null Sabine B. Rumpf, null Justyna Giejsztowt, null Jules Millen, null John W. Morgan, null Adrienne B. Nicotra, null Susanna Venn, null Shengwei Zong, null Katharine J. M. Dickinson, null Grégoire T. Freschet, null Claudia Kurzböck, null Jin Li, null Hongli Pan, null Beat Pfund, null Elena Quaglia, null Xu Su, null Wei Wang, null Xiangtao Wang, null Hang Yin, and null Julie R. Deslippe
- Published
- 2021
48. The First Two Imported Cases of SARS-CoV-2 Omicron Variant - Tianjin Municipality, China, December 13, 2021
- Author
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Zhaolin, Tan, Zhixiao, Chen, Aiping, Yu, Xiaoyan, Li, Yenan, Feng, Xiang, Zhao, Wenbo, Xu, and Xu, Su
- Published
- 2021
49. Comprehensive Analysis of the Mechanism of Periodontitis-Related mRNA Expression Combined with Upstream Methylation and ceRNA Regulation
- Author
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Xu Su, Yifang Yuan, Xiaotao Chen, and Bo Zhu
- Subjects
RNA, Untranslated ,Computational biology ,Biology ,microRNA ,Databases, Genetic ,medicine ,Humans ,Gene Regulatory Networks ,Epigenetics ,RNA, Messenger ,KEGG ,Periodontitis ,Gene ,Genetics (clinical) ,Competing endogenous RNA ,Computational Biology ,High-Throughput Nucleotide Sequencing ,General Medicine ,Methylation ,Original Articles ,DNA Methylation ,medicine.disease ,MicroRNAs ,DNA methylation ,Transcriptome - Abstract
Background: Periodontitis is a multifactorial disease mainly caused by the formation of plaque biofilm, which can lead to the gradual destruction of tooth-supporting tissues. Current research on the genetics and epigenetics of periodontitis remains relatively limited, and the molecular mechanisms remain largely unknown. Objective: Our aims were to construct competitive endogenous RNA (ceRNA) network and determine DNA methylation patterns of target genes to help elucidate the pathogenesis of periodontitis. Methods: We analyzed the expression profiles of the GSE16134, GSE54710, GSE10334, and GSE59932 datasets from the Gene Expression Omnibus database through the weighted gene coexpression network analysis system and screened mRNAs that are regulated by the level of methylation and are associated with the occurrence of periodontitis. Next, a lncRNA-miRNA-mRNA ceRNA network was constructed using databases including miRanda and TargetScan. Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted for genes in the clinically significant modules. Finally, a protein-protein interaction network was built. Results: We finally identified four mRNAs, four miRNAs, and six lncRNAs as shared differentially expressed genes related to the periodontitis inflammation pathway. IL-6, IFNA17, CXCL12, and TNFRSF13C were identified as key genes whose expression was significantly enriched in the nuclear factor κB and TLR4 pathways. Moreover, the expression of 28 genes were downregulated by hypermethylation and 70 genes were upregulated by hypomethylation. Conclusions: The constructed ceRNA network can improve our understanding of the pathogenesis of periodontitis. Candidate mRNAs from the ceRNA network could serve as new therapeutic targets and prognostic biomarkers in periodontitis.
- Published
- 2021
50. Identification of genes involved in drought tolerance in seedlings of the desert grass, Psammochloa villosa (Poaceae), based on full-length isoform sequencing and de novo assembly from short reads
- Author
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Tao Liu, Yuping Liu, Gui Fu, Jinyuan Chen, Ting Lv, Dandan Su, Yanan Wang, Xiayu Hu, Xu Su, and AJ Harris
- Subjects
Physiology ,Gene Expression Regulation, Plant ,Seedlings ,Stress, Physiological ,Chlorophyll A ,Gene Expression Profiling ,Protein Isoforms ,Plant Science ,Poaceae ,Transcriptome ,Agronomy and Crop Science ,Droughts - Abstract
Psammochloa villosa is a perennial herbaceous plant that is dominant within arid regions of the Inner Mongolian Plateau and the Qinghai-Tibet Plateau in China, where it is an endemic species and exhibits strong drought tolerance and wind resistance. To study drought tolerance in P. villosa and determine its molecular basis, we simulated high and moderate drought stress in a controlled environment and then analyzed transcriptome sequences by combining long-read sequences from a representative, wild-grown individual with short reads from the treatment groups. We obtained 184,076 high-quality isoforms as a reference and 168,650 genes (91.6%), which we were able to annotate according to public databases. Ultimately, we obtained 119,005 unigenes representing the transcriptome of P. villosa under drought stress and, among these, we identified 3089 differentially expressed genes and 1484 transcription factors. Physiologically, P. villosa that was exposed to high and moderate drought stress had reduced germination rates and shorter buds but generated more chlorophyll, which is atypical under drought stress and possibly reflects an adaptation of these plants to their arid environment. We inferred that significantly upregulated genes were annotated as 'Chlorophyll a-b binding protein' and 'Light-harvesting chlorophyll-protein' among drought and control groups. Broadly, our analyses revealed that drought stress triggered many genome-level responses, especially related to mitigation of radical oxygen species (ROS), which increase in concentration under drought stress. In particular, in the high drought stress group compared with the control, GO enrichment analysis revealed a significant enrichment of upregulated genes (n = 10) involved in mitigation of oxidative stress. Similarly, using KEGG we found significant enrichment of genes in the phenylpropanoid biosynthesis pathway (11 genes), which yields phenols that scavenge ROS. We also inferred that many genes involved in metabolism of arginine and proline, which may serve as both scavengers of ROS and osmoprotectants that interact with stress response genes based on our protein-protein interaction network analysis. We verified the relative expression levels of eight genes associated with mitigation of ROS, DNA repair, and transmembrane transporter activity using qRT-PCR, and the results were consistent with our inferences from transcriptomes. This study provides insights into the genomic and physiological basis of drought tolerance in P. villosa and represents a resource for development of the species as a forage crop via molecular breeding within arid lands.
- Published
- 2021
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