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Additional file 1: Figure S1. The detailed gated method of flow cytometry. Figure S2. The pathology of MGRS patient. Table S1. Spearman correlation analysis of clinical parameters with BCMA expression in newly diagnosed patients. Table S2. Multivariate linear regression analysis of clinical parameters with BCMA expression in newly diagnosed patients.

This paper develops a stop line aided cooperative positioning framework for connected vehicles, which creatively utilizes the location of the stop-line to achieve the positioning enhancement for a vehicular ad-hoc network (VANET) in intersection scenarios via Vehicle-to-Vehicle (V2V) communication. Firstly, a self-positioning correction scheme for the first stopped vehicle is presented, which applied the stop line information as benchmarks to correct the GNSS/INS positioning results. Then, the local observations of each vehicle are fused with the position estimates of other vehicles and the inter-vehicle distance measurements by using an extended Kalman filter (EKF). In this way, the benefits of the first stopped vehicle are extended to the whole VANET. Such a cooperative inertial navigation (CIN) framework can greatly improve the positioning performance of the VANET. Finally, experiments in Beijing show the effectiveness of the proposed stop line aided cooperative positioning framework.

The sensory quality of cooked rice is an important factor in determining its market price, as well as consumer acceptance and breeding efforts aimed at improvement of rice grain quality. In this study, the sensory quality and physicochemical properties of three japonica rice varieties harvested in two different growing locations (Xiangshui and Hangzhou of China) were compared to determine the most important factors affecting the sensory quality. All the three varieties had higher scores for overall sensory quality in Xiangshui than in Hangzhou, indicating that the growing location is a key factor in determining the sensory quality of cooked japonica rice. In addition to growing location, variety (genotype) also had an important effect. Longdao 18 scored the highest for overall sensory quality in the two locations, whereas Longdao 30 had the lowest score in Xiangshui, and both Longdao 20 and Longdao 30 had the lowest scores in Hangzhou. Many physicochemical properties, such as apparent amylose content, protein content, thermal properties and free amino acid contents, showed significant differences between the two locations. Correlation analysis showed that apparent amylose content and protein content had contrasting effects on all the sensory attributes. The overall sensory quality was negatively correlated with protein content (r = −0.89, P

Underwater acoustic (UWA) sensor networks demand high-rate communications with high reliability between sensor nodes for massive data transmission. Filtered multitone (FMT) is an attractive multicarrier technique used in high-rate UWA communications, and can obviously shorten the span of intersymbol interference (ISI) with high spectral efficiency and low frequency offset sensitivity by dividing the communication band into several separated wide sub-bands without guard bands. The joint receive diversity and adaptive equalization scheme is often used as a general ISI suppression technique in FMT-UWA communications, but large receive array for high diversity gain has an adverse effect on the miniaturization of UWA sensor nodes. A time-reversal space-time block coding (TR-STBC) technique specially designed for frequency-selective fading channels can replace receive diversity with transmit diversity for high diversity gain, and therefore is helpful for ISI suppression with simple receive configuration. Moreover, the spatio-temporal matched filtering (MF) in TR-STBC decoding can mitigate ISI obviously, and therefore is of benefit to lessen the complexion of adaptive equalization for post-processing. In this paper, joint TR-STBC and adaptive equalization FMT-UWA communication method is proposed based on the merit of TR-STBC. The proposed method is analyzed in theory, and its performance is assessed using simulation analysis and real experimental data collected from an indoor pool communication trial. The validity of the proposed method is proved through comparing the proposed method with the joint single-input&ndash, single-output (SISO) and adaptive equalization method and the joint single-input&ndash, multiple-output (SIMO) and adaptive equalization method. The results show that the proposed method can achieve better communication performance than the joint SISO and adaptive equalization method, and can achieve similar performance with more simpler receive configuration as the joint SIMO and adaptive equalization method.

In this paper, the single-domain enthalpy model is adopted for heat transfer analysis of phase change during solidification processes. The resulting second-order parabolic partial differential equations (PDEs) with varying thermophysical coefficients is numerically solved by a hybrid generalized finite difference method (GFDM) under mixed boundary conditions. The spatial derivatives in the PDEs are approximated by the Taylor series expansions combining with the moving-least squares technique. The temporal derivative is evaluated with a six-point symmetric difference by the classical Crank-Nicholson technique. The Newton-Raphson iteration method is used to solve the resulting nonlinear algebraic equations. Finally, the transient temperature field and the moving phase-change interface are obtained by analysing the nodal temperature distribution. Several examples are presented for verify the stability and effectiveness of this meshless method.

A seismic free field input formulation of the coupling procedure of the finite element (FE) and the scaled boundary finite-element (SBFE) is proposed to perform the unbounded soil-structure interaction analysis in time domain. Based on the substructure technique, seismic excitation of the soil-structure system is represented by the free-field motion of an elastic half-space. To reduce the computational effort, the acceleration unit-impulse response function of the unbounded soil is decomposed into two functions; linear and residual. The latter converges to zero and can be truncated as required. With the prescribed tolerance parameter, the balance between accuracy and efficiency of the procedure can be controlled. The validity of the model is verified by the scattering analysis of a hemi-spherical canyon subjected to plane harmonic P, SV and SH wave incidence. Numerical results show that the new procedure is very efficient for seismic problems within a normal range of frequency. The coupling procedure presented herein can be applied to linear and nonlinear earthquake response analysis of practical structures which are built on unbounded soil.

Effects of two important factors on earthquake response of high arch dams are considered and combined into one program. These factors are: effects of radiation damping of the infinite canyon and local non-linearity of the contraction joint opening between the dam monoliths. For modeling of rock canyon, the discrete parameters are obtained based on a curve fitting, thus allowing the nonlinear dam system to be solved in the time domain. The earthquake uniform free-field input at the dam-canyon interface is used. An engineering example is given to demonstrate the significant effects of the radiation damping on the structure response.

Summary Effects of two important factors on earthquake response of high arch dams are considered and combined into one program. These factors are: effects of dam-canyon interaction and that of local nonlinearity of the contraction joint opening between the dam monoliths. The substructuring technique is employed, thus the equilibrium iteration involves only the degrees of freedom in nonlinear substructure. For modeling of rock canyon, the discrete parameters are obtained based on a curve fitting, thus allowing the nonlinear dam system to be solved in the time domain. A simplified earthquake input procedure is also used, which takes into account the radiation damping of the infinite canyon while preventing the artificial amplification of the ground motion through the rock mass. Two engineering examples are given to demonstrate the significant effects of the above-mentioned two factors on the response of the structure.