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IntroductionUnintended intake of microplastic particles has been demonstrated to exert adverse health effects, however, studies on relevant nephrotoxicity in juvenile mammals are lacking.MethodsTherefore, we investigated the potential nephrotoxicity of oral-exposed polystyrene microplastics (PSMPs) (1,000 nm, 2.0 mg/kg/d) for 28 days in juvenile rats. Levels of oxidative stress, inflammation, and endoplasmic reticulum (ER) stress in kidneys were analyzed.Results and discussionResults revealed that PSMPs noticeably decreased the growth rate of bodyweight, and organ index of the kidney, cardiac, and ovary. The intestinal injury caused by PSMPs exposure was also observed, which was distinctly alleviated with N-acetyl-cysteine (NAC) and Salubrinal (Sal) treatment compared with the single PSMPs group. PSMPs caused histological lesions of the kidney via disrupting the serum blood urea nitrogen (BUN), creatinine (CRE), and pro-inflammatory mediators IL-1β, IL-6, and TNF-α. Furthermore, PSMPs exposure induced ER stress and inflammation presumably potentially mediated by oxidative stress in kidneys of rats. Eventually, PSMPs also promoted renal cells apoptosis, manifested as an obvious increase in the number of positive cells for the dUTP nick end labeling of Terminal deoxynucleotidyl transferase, which also can be confirmed by the elevated expression of genes associated with apoptosis Bcl-2, Bax, Caspase-12, Caspase-9, Caspase-3, and IHC score of Caspase-12 in the PSMPs group. Supplementation of NAC and Sal not only ameliorated the PSMPs-induced oxidative stress and ER stress but also the inflammation and apoptosis in the kidney. Collectively, this study suggested that PSMPs caused nephrotoxicity in juvenile rats potentially through oxidative damage and ER stress, which call for greater efforts to be taken on regulating the PSMPs ingestion in children.

We study steady states of the motion of a large number of particles in a closed box that are excited by a vibrating boundary and experience a linear drag force from the interstitial fluid. The dissipation in such systems arises from two main sources: Inelasticity in particle collisions and the effects of interstitial fluid on the particles. In many applications, order of magnitude estimates suggest that the dissipation due to interstitial fluid effects may greatly exceed that due to inelasticity and one is naturally led to neglect inelastic effects. In this study, we show that, if one adopts a linear drag force and inelastic effects are neglected, a steady state only exists when the vibration speed of the boundary is below a critical value. For vibration speeds above this critical value, no steady state exists since the kinetic energy of the particles grows without bound. We show that, for vibration speeds above the critical value, inelastic effects must be included to obtain a steady state even if order of magnitude estimates suggest they are negligible. Numerical simulations confirm these theoretical predictions. We also show that inclusion of apparently small nonlinear drag terms can also play a similar role in preventing the kinetic energy of the particles growing without bound.

To better apply fiber Bragg gratings (FBGs) to various bending required situations, good understanding of their bending characteristics is crucial. In this Letter, a theoretical model to describe the changes of spectral properties of an FBG against the bending radius is proposed. This model shows that all the bend-induced spectral changes, the shift of center wavelength, decrease of reflectivity, and reduction of bandwidth, may be explained by the decrease of the effective "dc" refractive index change spatially averaged over one grating period. Experimental results are in agreement with theoretical predictions and confirm the effectiveness of the proposed model.