8 results on '"Xiucheng Nong"'
Search Results
2. Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot
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Wei, Mai, Aizhen, Zhang, Qiang, Liu, Liying, Tang, Yichen, Wei, Jiahui, Su, Gaoxiong, Duan, Jinlong, Teng, Xiucheng, Nong, Bihan, Yu, Chong, Li, Lijuan, Shao, Demao, Deng, Shangjie, Chen, and Lihua, Zhao
- Abstract
To explore the effect of moxa cone moxibustion onOne hundred eight patients with MCI were served as the MCI group, and 67 age-matched subjects were enrolled as the normal control group. The MCI group was randomized and allocated into acupoint group, drug group, and sham acupoint group, with 36 cases in each group. Some patients in each group withdrew. Finally, 25 cases were included in the acupoint group, 24 cases in the drug group, and 20 cases in the sham acupoint group. The drug group was treated with oral donepezil hydrochloride. The acupoint group and sham acupoint group received moxa cone moxibustion treatment. Mini-mental state exam (MMSE) and Montreal cognitive assessment (MoCA) scores were recorded before intervention, at the end of the first and the second months of intervention, and in the 5th month of follow-up. The NAA/tCr and Cho/tCr ratios in the HIP and PCG were bilaterally measured byBefore intervention, compared with the normal control group, the MMSE and MoCA scores, the Cho/tCr ratio in the right HIP, the NAA/tCr ratio in the bilateral HIP, and the NAA/tCr ratio in the left PCG in the three treatment groups decreased significantly (bothOur findings suggest that moxibustion could improve the cognitive function of patients with MCI. The mechanism may be related to the improvement of abnormal brain metabolism in HIP and PCG.
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- 2021
3. Effect of acupoint with moxa cone on 1H-MRS of hippocampus and posterior cingulate gyrus in patients with mild cognitive impairment
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Chong Li, Jinlong Teng, Demao Deng, Shangjie Chen, Lijuan Shao, Jiahui Su, Yichen Wei, Bihan Yu, Liying Tang, Xiucheng Nong, Wei Mai, Gaoxiong Duan, Zhuocheng Zou, Lu Zhou, and Lihua Zhao
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Text mining ,nervous system ,Posterior cingulate gyrus ,business.industry ,Hippocampus ,Medicine ,In patient ,Cognitive impairment ,business ,behavioral disciplines and activities ,Neuroscience ,Cone (formal languages) - Abstract
Background: Mild cognitive impairment (MCI) is often the prodromal stage to Alzheimer's disease (AD). Most patients with MCI harbor the pathologic changes of AD and experience progressive brain metabolites change. We investigated the changes of metabolites in bilateral hippocampus (HIP) and posterior cingulate gyrus (PCG) in MCI patients, and observed the effects of moxa cone moxibustion on the metabolites of bilateral hippocampus and posterior cingulate gyrus in patients with MCI.Methods: Sixty-nine patients with MCI and sixty-seven cases of age-matched normal controls (NC) were enrolled in this study.MCI patients were randomly divided into drug group(Drug, n=24),sham acupoint group(Sham, n=20) and acupoint group(Acupoint, n=25).All subjects received proton magnetic resonance spectroscopy (1H-MRS) for measurement of NAA/tCr and Cho/tCr ratios in bilateral hippocampus and posterior cingulate gyrus before and after treatment. Mini-Mental Status Examination(MMSE) and Montreal Cognitive Assessment(MoCA) were used to evaluate cognitive function.Results: MCI patients were characterized by lower NAA/tCr in bilateral hippocampus and posterior cingulate gyrus and Cho/tCr in right hippocampus compared to those in NC group(P < 0.05). After two months treatment, NAA/tCr in bilateral hippocampus and posterior cingulate gyrus and Cho/tCr in right hippocampus were increased in the three treatment groups, and there was no significant difference compared to NC group(P > 0.05).NAA/tCr in right hippocampus and Cho/tCr of right posterior cingulate gyrus of acupoint group was significantly higher than those in sham acupoint group(P < 0.05) and NC group(P < 0.05).The scores of MMSE and MOCA in the acupoint group and sham acupoint group were better than those in the drug group, especially in the long-term efficacy.Conclusions: Moxa cone moxibustion may improve the cognitive function of MCI patients by regulating the abnormal metabolites of bilateral hippocampus and posterior cingulate gyrus. MRS can provide objective imaging basis for moxibustion prevention and treatment of MCI.Trial Registration: ChiCTR-IPR-16009144 (Retroactively registered on 26 AUG 2016)
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- 2021
4. Additional file 1 of Recurrent and concurrent patterns of regional BOLD dynamics and functional connectivity dynamics in cognitive decline
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Lingyan Liang, Yueming Yuan, Yichen Wei, Bihan Yu, Mai, Wei, Gaoxiong Duan, Xiucheng Nong, Li, Chong, Jiahui Su, Lihua Zhao, Zhiguo Zhang, and Demao Deng
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Data_FILES - Abstract
Additional file 1.
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- 2021
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5. Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment
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Bihan Yu, Qirong Li, Jinlong Teng, Xiucheng Nong, Liying Tang, Jinsong Liang, Xiangming Deng, Zhuocheng Zou, Lihua Zhao, Lu Zhou, and Qiang Liu
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medicine.medical_specialty ,Neuropsychiatric Disease and Treatment ,Population ,Urine ,Traditional Chinese medicine ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Statistical significance ,mental disorders ,constitutions of traditional Chinese medicine ,medicine ,MoCA score ,education ,Cognitive impairment ,Original Research ,cognitive impairment ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,biomarkers ,Cognition ,030227 psychiatry ,business ,030217 neurology & neurosurgery - Abstract
Xiangming Deng,1 Jinlong Teng,1 Xiucheng Nong,1 Bihan Yu,1 Liying Tang,2,* Jinsong Liang,3 Zhuocheng Zou,1,* Qiang Liu,2,* Lu Zhou,4 Qirong Li,5 Lihua Zhao1 1Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530023, People’s Republic of China; 2The Xinhu Outpatient Clinic of the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People’s Republic of China; 3Department of Clinical Laboratory of the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530023, People’s Republic of China; 4Medical Examination Center of the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530023, People’s Republic of China; 5Renai Branch of the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530023, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lihua ZhaoDepartment of Acupuncture and Moxibustion, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Dongge Road & 89-9, Nanning, 530023, People’s Republic of ChinaTel +86 130 06913108Email zhaolh67@163.comQirong LiDepartment of Acupuncture and Moxibustion, Renai Branch of the First Affiliated Hospital of Guangxi University of Chinese Medicine, Mingxiu East Road & 179, Nanning, 530023, People’s Republic of ChinaTel +86 136 07717755Email 632481428@qq.comIntroduction: The incidence of Alzheimer’s disease is on the rise, early detection of cognitive impairment of the elderly is very important. In traditional Chinese medicine, constitution is related to the susceptibility of the human body to diseases. Based on the theory of constitution of traditional Chinese medicine (TCM), the human population can be classified into 9 constitutions. However, little is known about the characteristics of medical constitution and related biomarkers in subjects with mild cognitive impairment (MCI).Methods: We measured the TCM Constitution of 214 subjects by using the Constitution in Chinese Medicine Questionnaire (CCMQ). MMSE and MoCA were used to assess cognitive function. The subjects were divided into mild cognitive impairment group (MCI, n = 152) and normal control group (NC, n = 62). The levels of serum Hcy and serum/urine 8-iso-PGF 2α were determined.Results: 1) It was found that there was a significant difference in constitution types between MCI and NC. There were significant differences in MMSE and MoCA score, serum Hcy and serum/urine 8-iso-PGF 2a levels between the two groups. 2) In logistic regression analysis, the variables with statistical significance were TCM Constitution of Yang-Deficient, Phlegm-Dampness, Blood-Stasis and abnormal increase of Hcy (OR> 1). 3) The MoCA scores had a positive correlation with the MMSE. A statistically significant inverse association was found between serum Hcy, blood and urine 8-iso-PGF 2a and scores of cognitive assessment in MCI.Conclusion: Constitution types (Yang-Deficient, Phlegm-Dampness and Blood-Stasis) and abnormal serum Hcy elevation can be used as risk factors for MCI. MoCA scores can serve to detect MCI at early stage. Serum/urine 8-iso-PGF 2α has a certain relationship with MCI. Higher levels of serum/urine 8-iso–PGF 2α are more likely to be associated with MCI risk.Keywords: cognitive impairment, constitutions of traditional Chinese medicine, biomarkers, MoCA score
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- 2020
6. Recurrent and Concurrent Patterns of Regional BOLD Dynamics and Functional Connectivity Dynamics in Cognitive Decline
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Yichen Wei, Demao Deng, Jiahui Su, Lihua Zhao, Xiucheng Nong, Lingyan Liang, Bihan Yu, Wei Mai, Zhiguo Zhang, Chong Li, Yueming Yuan, and Gaoxiong Duan
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medicine.medical_specialty ,Neurology ,Cognitive Neuroscience ,Fractional amplitude of low-frequency fluctuations ,Normal aging ,lcsh:RC346-429 ,050105 experimental psychology ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Humans ,Medicine ,Cognitive Dysfunction ,0501 psychology and cognitive sciences ,Cognitive decline ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,lcsh:Neurology. Diseases of the nervous system ,Default mode network ,Dynamic functional connectivity ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,Research ,Functional connectivity ,05 social sciences ,Mild cognitive impairment ,Brain ,Cognition ,Magnetic Resonance Imaging ,Subjective cognitive decline ,Neurology (clinical) ,business ,Functional magnetic resonance imaging ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Background The brain’s dynamic spontaneous neural activity and dynamic functional connectivity (dFC) are both important in supporting cognition, but how these two types of brain dynamics evolve and co-evolve in subjective cognitive decline (SCD) and mild cognitive impairment (MCI) remain unclear. The aim of the present study was to investigate recurrent and concurrent patterns of two types of dynamic brain states correlated with cognitive decline. Methods The present study analyzed resting-state functional magnetic resonance imaging data from 62 SCD patients, 75 MCI patients, and 70 healthy controls (HCs). We used the sliding-window and clustering method to identify two types of recurrent brain states from both dFC and dynamic regional spontaneous activity, as measured by dynamic fractional amplitude of low-frequency fluctuations (dfALFF). Then, the occurrence frequency of a dFC or dfALFF state and the co-occurrence frequency of a pair of dFC and dfALFF states among all time points are extracted for each participant to describe their dynamics brain patterns. Results We identified a few recurrent states of dfALFF and dFC and further ascertained the co-occurrent patterns of these two types of dynamic brain states (i.e., dfALFF and dFC states). Importantly, the occurrence frequency of a default-mode network (DMN)-dominated dFC state was significantly different between HCs and SCD patients, and the co-occurrence frequencies of a DMN-dominated dFC state and a DMN-dominated dfALFF state were also significantly different between SCD and MCI patients. These two dynamic features were both significantly positively correlated with Mini-Mental State Examination scores. Conclusion Our findings revealed novel fMRI-based neural signatures of cognitive decline from recurrent and concurrent patterns of dfALFF and dFC, providing strong evidence supporting SCD as the transition phase between normal aging and MCI. This finding holds potential to differentiate SCD patients from HCs via both dFC and dfALFF as objective neuroimaging biomarkers, which may aid in the early diagnosis and intervention of Alzheimer’s disease.
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- 2020
7. Self-weighted Multi-task Learning for Subjective Cognitive Decline Diagnosis
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Jiahui Su, Yichen Wei, Gaoxiong Duan, Nina Cheng, Denao Deng, Zhiguo Zhang, Xiucheng Nong, Lihua Zhao, Baiying Lei, Bihan Yu, Wei Mai, Chong Li, Tianfu Wang, and Alejandro F. Frangi
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Computer science ,business.industry ,Multi-task learning ,Feature selection ,02 engineering and technology ,Machine learning ,computer.software_genre ,Task (project management) ,03 medical and health sciences ,Identification (information) ,0302 clinical medicine ,Neuroimaging ,Discriminative model ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Artificial intelligence ,Cognitive decline ,business ,Cognitive impairment ,computer ,030217 neurology & neurosurgery - Abstract
Subjective cognitive decline (SCD) is an early stage of mild cognitive impairment (MCI) and may represent the first symptom manifestation of Alzheimer’s disease (AD). Early diagnosis of MCI is important because early identification and intervention can delay or even reverse the progression of this disease. This paper proposes an automatic diagnostic framework for SCD and MCI. Specifically, we design a new multi-task learning model to integrate neuroimaging functional and structural connectivity in a predictive framework. We construct a functional brain network by sparse low-rank brain network estimation methods, and a structural brain network is constructed using fiber bundle tracking. Subsequently, we use multi-task learning methods to select features for integrated functional and structural connections, the importance of each task and the balance between both modalities are automatically learned. By integrating both functional and structural information, the most discriminative features of the disease are obtained for diagnosis. The experiments on the dataset show that our proposed method achieves good performance and is superior to the traditional algorithms. In addition, the proposed method can identify the most discriminative brain regions and connections. These results follow current clinical findings and add new findings for disease detection and future medical analysis.
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- 2020
8. Auto-weighted centralised multi-task learning via integrating functional and structural connectivity for subjective cognitive decline diagnosis
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Bihan Yu, Chong Li, Nina Cheng, Alejandro F. Frangi, Zhiguo Zhang, Tianfu Wang, Wei Mai, Baiying Lei, Gaoxiong Duan, Xiucheng Nong, Lingyan Liang, Demao Deng, Lihua Zhao, Yichen Wei, and Jiahui Su
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Computer science ,Multi-task learning ,Neuroimaging ,Health Informatics ,Feature selection ,Machine learning ,computer.software_genre ,Task (project management) ,Alzheimer Disease ,Humans ,Cognitive Dysfunction ,Radiology, Nuclear Medicine and imaging ,Cognitive decline ,Interpretability ,Brain network ,Radiological and Ultrasound Technology ,business.industry ,Brain ,Magnetic Resonance Imaging ,Computer Graphics and Computer-Aided Design ,Computer Vision and Pattern Recognition ,Artificial intelligence ,Construct (philosophy) ,business ,computer - Abstract
Early diagnosis and intervention of mild cognitive impairment (MCI) and its early stage (i.e., subjective cognitive decline (SCD)) is able to delay or reverse the disease progression. However, discrimination between SCD, MCI and healthy subjects accurately remains challenging. This paper proposes an auto-weighted centralised multi-task (AWCMT) learning framework for differential diagnosis of SCD and MCI. AWCMT is based on structural and functional connectivity information inferred from magnetic resonance imaging (MRI). To be specific, we devise a novel multi-task learning algorithm to combine neuroimaging functional and structural connective information. We construct a functional brain network through a sparse and low-rank machine learning method, and also a structural brain network via fibre bundle tracking. Those two networks are constructed separately and independently. Multi-task learning is then used to identify features integration of functional and structural connectivity. Hence, we can learn each task's significance automatically in a balanced way. By combining the functional and structural information, the most informative features of SCD and MCI are obtained for diagnosis. The extensive experiments on the public and self-collected datasets demonstrate that the proposed algorithm obtains better performance in classifying SCD, MCI and healthy people than traditional algorithms. The newly proposed method has good interpretability as it is able to discover the most disease-related brain regions and their connectivity. The results agree well with current clinical findings and provide new insights into early AD detection based on the multi-modal neuroimaging technique.
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- 2021
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