58 results on '"Xiaofeng Qu"'
Search Results
2. A case of multisystem Erdheim-Chester disease with pericardial effusion as the first symptom: Imaging findings
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Jianbo, Lyu, Zhaohui, Xu, and Xiaofeng, Qu
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Surgery - Published
- 2023
3. Attribute-aware style adaptation for person re-identification
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Xiaofeng Qu, Li Liu, Lei Zhu, and Huaxiang Zhang
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Computer Networks and Communications ,Hardware and Architecture ,Media Technology ,Software ,Information Systems - Published
- 2022
4. Association of sodium intake with adverse left atrial function and left atrioventricular coupling in Chinese
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Lili, Yin, Jiajie, Mei, Jianli, Dong, Xiaofeng, Qu, and Yinong, Jiang
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Adult ,China ,Sodium Radioisotopes ,Physiology ,Internal Medicine ,Humans ,Atrial Function, Left ,Sodium, Dietary ,Middle Aged ,Blood Pressure Monitoring, Ambulatory ,Cardiology and Cardiovascular Medicine ,Aged - Abstract
High sodium intake is strongly associated with hypertension and obesity. This study aims to investigate the relationship between 24-h urinary sodium (a surrogate measure of sodium intake), ambulatory blood pressure parameters, left atrial function, and left atrioventricular coupling. Further, we intend to examine whether blood pressure and BMI might be mediators of the relationship between 24-h urinary sodium and subclinical cardiac function.Our study had 398 participants, all of whom were subjected to 24-h urine collection, 24-h ambulatory blood pressure measurement, and cardiac magnetic resonance imaging.The average age of the participants was 55.70 ± 11.30 years old. The mean urinary sodium of the participants was 172.01 ± 80.24 mmol/24 h. After adjusting for age, sex, history of diabetes, smoking status, alcohol consumption, and use of diuretics, 24-h urinary sodium was correlated with multiple ambulatory blood pressure parameters, BMI, left atrial function, and the left atrioventricular coupling index (LACI) (P 0.05). Mediation analysis showed that BMI explained 16% of the indirect effect of 24-h urinary sodium and left atrial function and 30% of the indirect effect of LACI. Independent of the mediator, 24-h urinary sodium had a significant direct effect on left atrial function and left atrioventricular coupling.Higher 24-h urinary sodium was associated with a greater BMI as well as poor left atrial function and left atrioventricular coupling, and the BMI mediated the relationship between 24-h urinary sodium and subclinical left cardiac function. Furthermore, and more importantly, 24-h urinary sodium may have directly affected the left atrial function and left atrioventricular coupling independent of intermediary factors.
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- 2022
5. Dynamic myocardial perfusion computed tomography with mental stress test to detect changes in myocardial microcirculation in patients with anxiety and no obstructive coronary artery disease
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Weihang Sun, Aodan Zhang, Lingjun Mei, Xiangting Liu, Zhongyan Li, and Xiaofeng Qu
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Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2023
6. Impacts of obesity and metabolic health on global subclinical left cardiac function: TyG index may be a predictor
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Jiajie Mei, Yanhua Li, Jianli Dong, MiaoMiao Bai, Yinong Jiang, Xiaofeng Qu, and Lili Yin
- Abstract
Background: Obesity is a recognized risk factor for heart failure. People with similar weights may have different metabolic health. Notably, insulin resistance is a hallmark of obesity and a feature of heart failure. We aimed to evaluate the effects of obesity and metabolic health status on subclinical left cardiac function. We also investigated whether insulin resistance (TyG index) plays a role in BMI-linked subclinical left cardiac dysfunction. Methods: The study involved 403 volunteers. Multivariate logistic regression models were used to assess associations between obesity, metabolic health, and overall subclinical left cardiac function .Mediating analysis was used to explore the role of the TyG index in the association between BMI and left cardiac function. Finally, ROC analysis was performed to explore the predictive value of the TyG index in subclinical left cardiac dysfunction. Results: The correlation analysis showed that metabolic unhealth increased the risk of subclinical left ventricular (LV) dysfunction; obesity was associated with an increased risk of global left cardiac dysfunction regardless of metabolic health status. The TyG index mediated 25% of the associations between BMI and Left atrial (LA) function. ROC analysis exhibited that the TyG index can be used as a predictor of LA dysfunction (AUC = 0.63), and the optimal cut-off point for the TyG index is 9.33. Conclusions: Even a "non-obese metabolically unhealthy" is a detrimental state of early LV function; obesity remains a major risk factor for global subclinical left cardiac dysfunction. Using the TyG index could allow early identification of individuals at high risk of subclinical left cardiac dysfunction. Registration number:ChiCTR2200057991;Date of registration: 2022-03-25 URL:http://www.chictr.org.cn/showproj.aspx?proj=162316
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- 2023
7. Machine learning-based CT radiomics model to discriminate the primary and secondary intracranial hemorrhage
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Jianbo Lyu, Zhaohui Xu, HaiYan Sun, Fangbing Zhai, and Xiaofeng Qu
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Multidisciplinary - Abstract
It is challenging to distinguish between primary and secondary intracranial hemorrhage (ICH) purely by imaging data, and the two forms of ICHs are treated differently. This study aims to evaluate the potential of CT-based machine learning to identify the etiology of ICHs and compare the effectiveness of two regions of interest (ROI) sketching methods. A total of 1702 radiomic features were extracted from the CT brain images of 238 patients with acute ICH. We used the Select K Best method, least absolute shrinkage, and selection operator logistic regression to select the most discriminable features with a support vector machine to build a classifier model. Then, a ten-fold cross-validation strategy was employed to evaluate the performance of the classifier. From all quantitative CT-based imaging features obtained by two sketch methods, eighteen features were selected respectively. The radiomics model outperformed radiologists in distinguishing between primary and secondary ICH in both the volume of interest and the three-layer ROI sketches. As a result, a machine learning-based CT radiomics model can improve the accuracy of identifying primary and secondary ICH. A three-layer ROI sketch can identify primary versus secondary ICH based on the CT radiomics method.
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- 2023
8. Impacts of obesity and metabolic health on global subclinical left cardiac function: TyG index may be a predictor of subclinical left cardiac dysfunction
- Author
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Jiajie Mei, Yanhua Li, Jianli Dong, MiaoMiao Bai, Yinong Jiang, Xiaofeng Qu, and Lili Yin
- Abstract
Background: Obesity is a recognized risk factor for heart failure. People with similar weights may have different metabolic health. Notably, insulin resistance is a hallmark of obesity and a feature of heart failure. We aimed to evaluate the effects of obesity and metabolic health status on subclinical left cardiac function. We also investigated whether insulin resistance (TyG index) plays a role in BMI-linked subclinical left cardiac dysfunction. Methods: The study involved 403 volunteers. Multivariate logistic regression models were used to assess associations between obesity, metabolic health, and overall subclinical left cardiac function .Mediating analysis was used to explore the role of the TyG index in the association between BMI and left cardiac function. Finally, ROC analysis was performed to explore the predictive value of the TyG index in subclinical left cardiac dysfunction. Results: The correlation analysis showed that metabolic unhealth increased the risk of subclinical left ventricular (LV) dysfunction; obesity was associated with an increased risk of global left cardiac dysfunction regardless of metabolic health status. The TyG index mediated 25% of the associations between BMI and Left atrial (LA) function. ROC analysis exhibited that the TyG index can be used as a predictor of LA dysfunction (AUC = 0.63), and the optimal cut-off point for the TyG index is 9.33. Conclusions: Even a "non-obese metabolically unhealthy" is a detrimental state of early LV function; obesity remains a major risk factor for global subclinical left cardiac dysfunction. Using the TyG index could allow early identification of individuals at high risk of subclinical left cardiac dysfunction. Registration number:ChiCTR2200057991;Date of registration: 2022-03-25 URL:http://www.chictr.org.cn/showproj.aspx?proj=162316
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- 2023
9. A case of pulmonary sequestration with inflammation and phrenic artery-pulmonary arteriovenous fistula: Confirmation by a combination of examinations
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Haiyan Sun, Xiaofeng Qu, Jianbo Lyu, and Linzhuo Cui
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Surgery - Published
- 2023
10. A Joint Optimization Scheme of Task Caching and Offloading for Smart Factories
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Xiaofeng Qu and Huiqiang Wang
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Hardware and Architecture ,Software ,Information Systems ,Theoretical Computer Science - Abstract
In the application scenario of the smart factory, the computing tasks of smart devices are intensive and the tasks are sensitive to delay. The smart device needs to offload the task to the edge server for execution. However, the computing resources of edge servers are limited and there will be workload imbalance among multiple edge servers. To solve these problems, we propose a joint optimization scheme of task caching and offloading based on task scene awareness, which decouples the joint optimization problem of task caching and offloading into two subproblems: task caching and task offloading. For the task caching subproblem, a bilateral auction task caching algorithm based on task scene awareness is proposed. For the task offloading subproblem, a task offloading algorithm based on task scenario offloading preferences is proposed. The experimental results show that the optimization scheme proposed in this paper has obvious performance advantages when the number of tasks is large and the number of intelligent devices is large. This scheme also achieves workload balancing among multiple edge servers.
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- 2023
11. Transanal total mesorectal excision for rectal cancer: A novel bibliometric analysis
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JianBo, Lyu, ZhaoHui, Xu, and XiaoFeng, Qu
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Postoperative Complications ,Proctectomy ,Treatment Outcome ,Bibliometrics ,Rectal Neoplasms ,Rectum ,Humans ,Margins of Excision ,Laparoscopy ,Surgery - Published
- 2022
12. Rechargeable Aqueous Mn‐Metal Battery Enabled by Inorganic–Organic Interfaces
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Qi Yang, Xiaofeng Qu, Huilin Cui, Xincheng He, Yuan Shao, Yong Zhang, Xun Guo, Ao Chen, Ze Chen, Rong Zhang, Duanyang Kong, Zhicong Shi, Jun Liu, Jieshan Qiu, and Chunyi Zhi
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General Chemistry ,General Medicine ,Catalysis - Abstract
Aqueous batteries that use metal anodes exhibit maximum anodic capacity, whereas the energy density is still unsatisfactory partially due to the high redox potential of the metal anode. Current metal anodes are plagued by the dilemma that the redox potential of Zn is not low enough, whereas Al, Mg, and others with excessively low redox potential cannot work properly in aqueous electrolytes. Mn metal with a suitably low redox potential is a promising candidate, which was rarely explored before. Here, we report a rechargeable aqueous Mn-metal battery enabled by a well-designed electrolyte and robust inorganic-organic interfaces. The inorganic Sn-based interface with a bottom-up microstructure was constructed to preliminarily suppress water decomposition. With this bubble-free interface, the organic interface can be formed via an esterification reaction of sucrose triggered by acyl chloride in the electrolyte, generating a dense physical shield that isolates water while permitting Mn
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- 2022
13. Pixel-Level and Affinity-Level Knowledge Distillation for Unsupervised Segmentation of Covid-19 Lesions
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Rui Xu, Yufeng Wang, Xinchen Ye, Pengcheng Wu, Yen-Wei Chen, Fangyi Xu, Wenchao Zhu, Chao Chen, Yong Zhou, Hongjie Hu, Xiaofeng Qu, Shoji Kido, and Noriyuki Tomiyama
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- 2022
14. Fast detection of dam zone boundary based on Otsu thresholding optimized by enhanced harris hawks optimization
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Xiaofeng Qu, Jiajun Wang, Xiaoling Wang, Yike Hu, Tianwen Tan, and Dong Kang
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Multidisciplinary - Abstract
Earth-rock dams are among the most important and expensive infrastructure projects. A key safety issue is dam zone boundary detection to prevent the intrusion of materials from different zones. However, existing detection methods strongly highly depend on human judgement, which is time consuming and labor intensive. To solve this problem, this work proposes a fast boundary detection method based on the Otsu algorithm optimized by enhanced Harris hawks optimization (HHO). Compared with the original Otsu algorithm, the proposed method has a higher computation speed to meet the time requirements of engineering projects. Particle swarm optimization is adopted to enhance the exploration stage of HHO. In addition, a tangent function and chaotic sine map are used to improve the convergence speed and robustness. The application of the proposed method to a real-life project shows that the calculation time can be reduced to 20 s, which is approximately 18.8% of the original calculation time.
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- 2023
15. Gravelly soil uniformity identification based on the optimized Mask R-CNN model
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Xiaofeng Qu, Jiajun Wang, Xiaoling Wang, Yike Hu, Tuocheng Zeng, and Tianwen Tan
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Artificial Intelligence ,General Engineering ,Computer Science Applications - Published
- 2023
16. Peri-procedural variables and outcomes of long-period hemodynamic instability after carotid artery angioplasty and stenting
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Bo Li, Weijian Fan, Yihan Yang, Xiaofeng Qu, Jindong Tong, Yizhi Liu, Jinyun Tan, Weijian Jiang, and Bo Yu
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Radiology, Nuclear Medicine and imaging ,Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Objectives The aim of this study is to identify the peri-procedural risk factors and outcomes of hemodynamic instability (HI) after carotid artery stenting (CAS). Methods A single-center, retrospective study was performed in 168 patients who underwent CAS procedure between September 2017 and September 2020. The presence of HI, as defined by hypertension (systolic blood pressure >160 mmHg), hypotension (systolic blood pressure Results Among 168 patients (mean age, 68.2 ± 8.3 years; 81.5% male), the frequency of post-procedural long-period HI was noted in 42 patients (25.0%). Male was prone to experience HI (odds ratio, 9.156, p = 0.021). Aggressive inflation pressure (>7 atm) and 5 mm balloon for pre-dilatation were risk factors of long-period HI (OR, 7.372, p = 0.035; OR, 3.527, p = 0.023). Intraoperative peak blood pressure and larger-sized stents remained independent predictors for the development of HI (OR, 1.043, p = 0.027, and OR, 1.973, p = 0.015). Patients with prolonged HI were more likely to suffer TIA and stroke compared to other patients and significant difference was found in the occurrence of TIA ( p < 0.05). Non-significance was found in mortality rate and other outcomes. Conclusions CAS-induced HI occurs in a considerable percentage while several peri-procedural variables are determined as independent predictors to develop long-period HI. Patients with prolonged HI are associated with increased risk of neurologic events and thus standardized intervention as well as management of long-period HI are of critical importance during clinical process.
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- 2022
17. Predictive Value of Fibrinogen Level on Long-Term Functional Prognosis after Intravenous Thrombolysis in Acute Ischemic Stroke
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Yaying Xu, Xiaofeng Qu, Taojie Ren, Liling Wang, and Yang Gao
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
18. Study on the Correlation Between Ischemic Leukoaraiosis and Cerebral Large Artery Stenosis Using the Stages of the Preinfarction Period Based on the Result of Computed Tomography Perfusion
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Caifang Ni, Xiaowen Deng, Taojie Ren, Bo Li, Chunxing Li, Yuan Chen, Shifu Sun, and Xiaofeng Qu
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Male ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Leukoaraiosis ,Large artery ,Arteries ,Constriction, Pathologic ,Middle Aged ,medicine.disease ,Correlation ,Perfusion ,Stenosis ,Internal medicine ,Cohort ,medicine ,Cardiology ,Humans ,Stage (cooking) ,Cerebral perfusion pressure ,business ,Tomography, X-Ray Computed ,Computed tomography angiography ,Aged - Abstract
BACKGROUND AND OBJECTIVE The influence of cerebral large artery stenosis (CLAS) on ischemic leukoaraiosis (LA) remains elusive. Based on the proposed stages of the preinfarction period, this study aimed to adopt the staging system to assess the correlation between ischemic LA and CLAS. MATERIALS AND METHODS Patients with unilateral CLAS ≥50% and without cerebral stroke were screened. The severity and distribution of stenosis were evaluated on computed tomography angiography images. The degree of regional cerebral perfusion was rated according to the stages of preinfarction period: 0=normal, 1=stage Ia, 2=stage Ib, 3=stage IIa, 4=stage IIb. Stage I included stage Ia and stage Ib. Stage II included stage IIa and stage IIb. LA was scored with Fazakas scale on T2-weighted image and/or fluid-attenuated inversion recovery sequences. RESULTS The cohort consisted of 212 patients (mean age, 66.89±11.39 y), including 145 (68.40%) males. CLAS severity and distribution did not differ between patients with and without LA (P>0.05). Normal, stage I, and stage II had significantly different incidences of LA and hemispheric LA scores in the left and right hemispheres (P
- Published
- 2021
19. Integrated Management and Control Platform with Big Data Based on IPv6 for Regional Multi-energy Cooperation
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Dongxu Miao, Xiaofeng Qu, Ke Han, Shuangshuang Fan, Yi Fan, and Kun Yao
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Information management ,Warning system ,business.industry ,computer.internet_protocol ,Computer science ,Distributed computing ,Big data ,IPv4 ,Automation ,IPv6 ,The Internet ,business ,Communications protocol ,computer - Abstract
On-line monitoring and fault warning of energy equipment operation performance is very important, and it is also an important part of achieving energy internet. Therefore, the construction of a comprehensive management and control with big data platform system is one of the key research directions of the current energy internet. However, IPv4 network protocol is basically used to the existing application system construction strategy for communication. In the future, there will be scale limitations in the form of big data communication form with multi-energy interconnection. This paper firstly product an integrated management and control platform with big data based on IPv6 for regional multi-energy cooperation, which realizes a method that multiple heterogeneous big data can be saved efficiently and fast in a bandwidth limitation. The platform had realized not only the collection of the complicated multi-energy equipment running data which is structured and unstructured, but also monitoring evaluation and early warning diagnosis to the multi-energy equipment running. That can be referential for the construction of energy internet.
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- 2021
20. Carotid Web Misdiagnosis
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Yang Gao, Shifu Sun, Taojie Ren, and Xiaofeng Qu
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Cerebral infarction ,Digital subtraction angiography ,Fibromuscular dysplasia ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Bypass surgery ,030220 oncology & carcinogenesis ,medicine.artery ,Occlusion ,medicine ,Anterior cerebral artery ,Surgery ,Neurology (clinical) ,Radiology ,business ,Stroke ,030217 neurology & neurosurgery ,Computed tomography angiography - Abstract
Background A carotid web (CW), an atypical fibromuscular dysplasia, is rare and may cause ischemic stroke. It is challenging to recognize a CW promptly and treat it accordingly. We report a case of an initially misdiagnosed CW. Case Description A 48-year-old man with recurrent cerebral infarction was transferred to our hospital for bypass surgery. Imaging performed at our facility showed multiple old infarct lesions and cerebral tissue hypoperfusion in the occluded left middle cerebral artery territory. Bypass surgery was performed without perioperative complications. While searching for the cause of his stroke, we found a thin intraluminal filling defect along the posterior wall of the left carotid bulb just beyond the carotid bifurcation on sagittal maximal intensity projection images, axial thin-cut images, and volume rendering images. The defect was diagnosed as a CW. It was also detected on follow-up ultrasonography. Owing to our initial unawareness, we did not photograph the carotid bulb during preoperative digital subtraction angiography and postoperative computed tomography angiography. Although the patient was treated with bypass, the persistence of the factors underlying the CW may induce further thrombosis and subsequent occlusion of his ipsilateral anterior cerebral artery. Conclusions Clinicians should be aware of CW as a potential cause of ischemic stroke. Head and neck computed tomography angiography is a reliable imaging method to detect CWs.
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- 2020
21. Cloud Service Security Adaptive Target Detection Algorithm Based on Bio-Inspired Performance Evaluation Process Algebra
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Tiantian Wang, Jingting Zhang, Xiaofeng Qu, Yuting Liao, and Guosheng Zhao
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Service (systems architecture) ,Multidisciplinary ,Computer science ,business.industry ,Process calculus ,Process (computing) ,020206 networking & telecommunications ,020207 software engineering ,Cloud computing ,02 engineering and technology ,Action selection ,0202 electrical engineering, electronic engineering, information engineering ,Hit rate ,Table (database) ,Anomaly detection ,business ,Algorithm - Abstract
Combining the principle of antibody concentration with the idea of biological evolution, this paper proposes an adaptive target detection algorithm for cloud service security based on Bio-Inspired Performance Evaluation Process Algebra (Bio-PEPA). The formal modelling of cloud services is formally modded by Bio-PEPA and the modules are transformed between cloud service internal structures and various components. Then, the security adaptive target detection algorithm of cloud service is divided into two processes, the short-term optimal action selection process which selects the current optimal detective action through the iterative operation of the expected function and the adaptive function, and the long-term detective strategy realized through the updates and eliminations of action planning table. The combination of the two processes reflects the self-adaptability of cloud service system to target detection. The simulating test detects three different kinds of security risks and then analyzes the relationship between the numbers of components with time in the service process. The performance of this method is compared with random detection method and three anomaly detection methods by the cloud service detection experiment. The detection time of this method is 50.1% of three kinds of detection methods and 86.3% of the random detection method. The service success rate is about 15% higher than that of random detection methods. The experimental results show that the algorithm has good time performance and high detection hit rate.
- Published
- 2019
22. An automatic personalized internal fixation plate modeling framework for minimally invasive long bone fracture surgery based on pre-registration with maximum common subgraph strategy
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Wen Qi, Xiaofeng Qu, Wenpeng Liu, Yang Yiqian, Bin Liu, Mingzhe Wang, Xiaohui Zhang, and Song Zhang
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Surface (mathematics) ,0209 industrial biotechnology ,medicine.medical_specialty ,Computer science ,medicine.medical_treatment ,Base (geometry) ,Iterative closest point ,020207 software engineering ,02 engineering and technology ,Computer Graphics and Computer-Aided Design ,Industrial and Manufacturing Engineering ,Computer Science Applications ,Surgery ,Visualization ,020901 industrial engineering & automation ,Minimum bounding box ,Principal component analysis ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Fracture (geology) ,Internal fixation - Abstract
In this paper, a visualization and modeling method for the internal fixation plate in personalized and minimally invasive long bone fracture surgery is presented. This framework mainly includes six sub-steps: firstly, the Principal Component Analysis (PCA) method is used to extract the 3D axis of the broken bone; secondly, the Gauss mapping method is utilized to segment the end surfaces of the broken bone; thirdly, the maximum common subgraph strategy is utilized to complete the end surface matching; fourthly, the OBB (Oriented Bounding Box) method is utilized to accomplish the pre-registration of the fracture surface; fifthly, the ICP (Iterative Closest Point) algorithm is utilized to achieve the fracture surface models’ accurate alignment; lastly, the personalized bent internal fixation plate model can be reconstructed based on anchor points. Via this method, doctors can obtain the accurate and personalized internal fixation plate model that has the best matching geometric form to the patient’s broken bones. This method can provide a well technique base and computational solution for the minimally invasive long bone fracture surgery.
- Published
- 2019
23. Asymmetric pathological pachymeningeal enhancement: A new imaging feature for cerebral venous thrombosis
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Ying Liu, Qingwen Sun, Qi Yang, Zhaoyang Fan, Debiao Li, Xiaofeng Qu, and Ce Zhang
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Adult ,Male ,medicine.medical_specialty ,Clinical onset ,03 medical and health sciences ,Sinus Thrombosis, Intracranial ,0302 clinical medicine ,Meninges ,medicine ,Humans ,Thrombus ,Pathological ,Retrospective Studies ,Imaging Feature ,Venous Thrombosis ,medicine.diagnostic_test ,business.industry ,Angiography, Digital Subtraction ,Magnetic resonance imaging ,Retrospective cohort study ,General Medicine ,Phlebography ,Middle Aged ,medicine.disease ,Cerebral Veins ,Magnetic Resonance Imaging ,Venous thrombosis ,Early Diagnosis ,030220 oncology & carcinogenesis ,Case-Control Studies ,Surgery ,Female ,Neurology (clinical) ,Intracranial Atherosclerosis ,Radiology ,Dura Mater ,Intracranial Thrombosis ,business ,030217 neurology & neurosurgery ,Magnetic Resonance Angiography - Abstract
Purpose Cerebral venous thrombosis (CVT) has various clinical presentations and has a median onset delay of 7 days. So it is important to find more identifiable early imaging manifestations for CVT. Method This was a retrospective study. Patients with CVT (CVT group, n = 26) diagnosed by conventional imaging techniques (magnetic resonance imaging and/or digital subtraction angiogram) and patients with symptomatic intracranial atherosclerosis (control group, n = 30) were included. Magnetic resonance black-blood thrombus imaging (MRBTI) technique had been performed in both groups. The CVT group was divided into 3 groups based on the duration of clinical onset: ≤7 days (group 1), between 7 and 30 days (group 2), and >30 days (group 3). Pathological pachymeningeal enhancement and its characteristics were analyzed between the CVT group and the control group. Results Pathological pachymeningeal enhancement was found in 14 CVT patients (54 %) and none in control group (P value = 0.000). The bilateral pathological pachymeningeal enhancement was involved in 10 CVT patients, 6 patients were asymmetric, and 4 patients had ipsilateral enhancement. Asymmetric pathological pachymeningeal enhancement was 71 % and predominantly located on the thrombosed sinus side. Strong enhancement was found in the venous sinus wall beside the thrombus. Pathological pachymeningeal enhancement percentages of three subgroups were 75 % in group 1, 55 % in group 2, and 29 % in group 3 and had no statistical differences (p value = 0.198). Conclusions Current findings suggest asymmetrical pathological pachymeningeal enhancement was associated was CVT and may be a new imaging feature for CVT.
- Published
- 2020
24. Three-dimensional graphene-wrapped porous carbon/sulfur composite for cathode of lithium–sulfur battery
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Xiaofeng Qu, Zhicong Shi, Yating Wang, Changhong Shao, Yinghe Zhang, Jun Liu, Weimin Zhao, Zhang Weiqing, Liu Bin, Wei Zhang, Chen Rongfeng, and Daoyun Lan
- Subjects
Battery (electricity) ,Materials science ,Carbonization ,Graphene ,General Chemical Engineering ,Composite number ,General Engineering ,General Physics and Astronomy ,chemistry.chemical_element ,Lithium–sulfur battery ,Electrolyte ,Sulfur ,law.invention ,chemistry ,Chemical engineering ,law ,Specific surface area ,General Earth and Planetary Sciences ,General Materials Science ,General Environmental Science - Abstract
Lithium–sulfur battery with high theoretical capacity becomes the subject of recent attention. Its commercial progress is impeded by its poor electrical conductivity and high dissolubility of intermediate products in organic electrolyte. In the present work, we report a novel three-dimensional graphene-wrapped porous carbon (3D-G) to accommodate sulfur, which consists of outside highly stable interconnected graphene-like sheets and inner activated porous carbon. The 3D-G was synthesized from cheap polyacrylic acid cation-exchange resin, which introduces nickel ions as catalysts in the carbonization process, as a cost effective, facile and simple method. This 3D-G showed hierarchical pores: 0.7 nm micropores and macropores, providing a large specific surface area of 1375.08 m2 g−1. Benefiting from this unique structure, the 3D-G performed well as host materials to achieve a high sulfur content (75.4 wt%). Such a 3D-G@S composite exhibits capacity-fading rate as low as 0.28% per cycle over 100 cycles at 0.1 C, and good cyclability at various cycling rates (0.1–1 C).
- Published
- 2020
25. Layer-by-layer assembly of polyoxometalate-pyrene-decorated fluorescent microspheres for the suspension immunoassay of Listeria monocytogenes
- Author
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Dehui Yin, Kun Xu, Li Li, Gang Yan, Li Juan, Wen Ju, Yangguang Li, Xiuling Song, Wang Juan, and Xiaofeng Qu
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Detection limit ,Materials science ,Chromatography ,medicine.diagnostic_test ,Biomedical Engineering ,Analytical chemistry ,02 engineering and technology ,General Chemistry ,General Medicine ,Conjugated system ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Photobleaching ,Fluorescence ,0104 chemical sciences ,Matrix (chemical analysis) ,chemistry.chemical_compound ,chemistry ,Immunoassay ,medicine ,Pyrene ,General Materials Science ,0210 nano-technology ,Luminescence - Abstract
A fluorescence microsphere suspension array technique has been developed as a promising tool for the molecular detection of Listeria monocytogene (LM), which is a dangerous food borne pathogen that can cause severe food intoxication in both humans and animals. In such a technique, fluorescent microspheres as the key matrix for detection are often decorated with neutral organic dyes, which usually suffer from instability, easy photobleaching and loss from the matrix. Herein, we design and synthesize a new organic–inorganic hybrid POM–pyrene compound [N(C4H9)4]2[V6O13{(OCH2)3CNH–CH2–C16H9}2] (1), which is employed as a negatively-charged fluorescent material to prepare a new class of fluorescent microspheres by a layer-by-layer electrostatic self-assembly method. As a result, such POM–pyrene-decorated fluorescent microspheres possess obvious luminescence properties, superior photo-stability and long-term stability. Therefore, the POM–pyrene-decorated fluorescent microspheres are conjugated by monoclonal anti-LM antibodies, and introduced into the fluorescence microsphere-based suspension immunoassay system for the detection of LM in food, which exhibits a high sensitivity. The lowest limit of detection (LOD) of LM in artificially contaminated meat is down to 6 CFU g−1 without cross-reactivity with other pathogens. Furthermore, the suspension immunoassay based on PS@POM–pyrene microspheres shows excellent specificity to LM, good repeatability and high efficiency in contrast to the conventional culture-based method.
- Published
- 2020
26. Augmented reality surgical navigation with accurate CBCT-patient registration for dental implant placement
- Author
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Longfei Ma, Guochen Ning, Xiaofeng Qu, Hongen Liao, Weipeng Jiang, Boyu Zhang, and Xinran Zhang
- Subjects
Cone beam computed tomography ,medicine.medical_treatment ,0206 medical engineering ,Biomedical Engineering ,Mandible ,02 engineering and technology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,medicine ,Humans ,Dental implant ,Dental Implants ,Orthodontics ,business.industry ,Human physiology ,Cone-Beam Computed Tomography ,Patient registration ,020601 biomedical engineering ,Computer Science Applications ,Surgery, Computer-Assisted ,3d image ,Calibration ,Augmented reality ,Implant ,business - Abstract
It is challenging to achieve high implant accuracy in dental implant placement, because high risk tissues need to be avoided. In this study, we present an augmented reality (AR) surgical navigation with an accurate cone beam computed tomography (CBCT)-patient registration method to provide clinically desired dental implant accuracy. A registration device is used for registration between preoperative data and patient outside the patient's mouth. After registration, the registration device is worn on the patient's teeth for tracking the patient. Naked-eye 3D images of the planning path and the mandibular nerve are superimposed onto the patient in situ to form an AR scene. Simultaneously, a 3D image of the drill is overlaid accurately on the real one to guide the implant procedure. Finally, implant accuracy is evaluated postoperatively. A model experiment was performed by an experienced dentist. Totally, ten parallel pins were inserted into five 3D-printed mandible models guided by our AR navigation method and through the dentist's experience, respectively. AR-guided dental implant placement showed better results than the dentist's experience (mean target error = 1.25 mm vs. 1.63 mm; mean angle error = 4.03° vs. 6.10°). Experimental results indicate that the proposed method is expected to be applied in the clinic. Graphical abstract ᅟ.
- Published
- 2018
27. Geometric approach to detecting volumetric changes in medical images
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Shichao Cheng, Xin Fan, Emil Saucan, Yehoshua Y. Zeevi, Xiaofeng Qu, and Alexander Naitsat
- Subjects
Applied Mathematics ,020207 software engineering ,Conformal map ,02 engineering and technology ,Topology ,01 natural sciences ,Measure (mathematics) ,Geometric distortion ,Tetrahedral meshes ,010101 applied mathematics ,Computational Mathematics ,Simply connected space ,0202 electrical engineering, electronic engineering, information engineering ,Ball (mathematics) ,0101 mathematics ,Spatial analysis ,Algorithm ,Mathematics - Abstract
We present a new quantitative method for detecting changes in 3D medical images. The dissimilarity between shapes is quantified as a measure of the effort it takes to deform one 3D region into another. Our main tool is an assessment of conformal and isometric distortions of mappings between volumes. Unlike most existing techniques for shape comparison, our algorithm operates both on triangular and tetrahedral meshes, and therefore can be applied both for closed simply connected surfaces, as well as for volumetric domains homeomorphic to a ball, with geometrically complicated boundaries. Furthermore we extend our main geometric distortion measure to higher dimensions, in a manner that allows for the dealing with spatial data at the maximal, as well as at all the lower dimensions.
- Published
- 2018
28. Development of a low-cost paper-based ELISA method for rapid Escherichia coli O157:H7 detection
- Author
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Kaiyue Fu, Xiuling Song, Kun Xu, Hao Bao, Dandan Song, Juan Li, Xiaofeng Qu, Xiangjun Meng, Li Li, Zhuping Zhang, Juan Wang, Chao Zhao, Bo Pang, and Yushen Liu
- Subjects
Paper ,Detection limit ,Chromatography ,Chemistry ,010401 analytical chemistry ,Biophysics ,Enzyme-Linked Immunosorbent Assay ,Pathogenic bacteria ,02 engineering and technology ,Cell Biology ,Paper based ,Escherichia coli O157 ,021001 nanoscience & nanotechnology ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,medicine ,Lower cost ,Elisa method ,0210 nano-technology ,Molecular Biology ,Escherichia coli - Abstract
Escherichia coli O157: H7 (E. coli O157: H7) has become one of the most dangerous foodborne pathogenic bacteria around the world. Currently, because of the tedious, high-cost and stringent laboratory conditions required, the conventional E. coli O157: H7 detection methods, such as culture-based methods and polymerase chain reaction (PCR), have much limitation. Thus, we developed a novel paper-based enzyme-linked immunosorbent assay (p-ELISA) with shorter operation duration, lower cost, relatively higher sensitivity and wider application. This method required less than 3 h and 5 μL of sample to complete the detection. The limit of detection (LOD) for E. coli O157: H7 reached 1 × 104 CFU/mL with high specificity. To be more suitable for on-site testing, the readout could be rapidly obtained without any expensive instruments. In this study, we chose E. coli O157:H7 as the representative, and our method could provide a platform for determination of other pathogenic bacteria.
- Published
- 2018
29. Door Knob Hand Recognition System
- Author
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Xiaofeng Qu, Zhenhua Guo, Guangming Lu, and David Zhang
- Subjects
Biometrics ,Computer science ,business.industry ,Iris recognition ,Feature extraction ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,020206 networking & telecommunications ,02 engineering and technology ,Binary pattern ,Fingerprint recognition ,Computer Science Applications ,Human-Computer Interaction ,Control and Systems Engineering ,Histogram ,Pattern recognition (psychology) ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Computer vision ,Artificial intelligence ,Electrical and Electronic Engineering ,business ,Software - Abstract
Biometric applications have been used globally in everyday life. However, conventional biometrics is created and optimized for high-security scenarios. Being used in daily life by ordinary untrained people is a new challenge. Facing this challenge, designing a biometric system with prior constraints of ergonomics, we propose ergonomic biometrics design model, which attains the physiological factors, the psychological factors, and the conventional security characteristics. With this model, a novel hand-based biometric system, door knob hand recognition system (DKHRS), is proposed. DKHRS has the identical appearance of a conventional door knob, which is an optimum solution in both physiological factors and psychological factors. In this system, a hand image is captured by door knob imaging scheme, which is a tailored omnivision imaging structure and is optimized for this predetermined door knob appearance. Then features are extracted by local Gabor binary pattern histogram sequence method and classified by projective dictionary pair learning. In the experiment on a large data set including 12 000 images from 200 people, the proposed system achieves competitive recognition performance comparing with conventional biometrics like face and fingerprint recognition systems, with an equal error rate of 0.091%. This paper shows that a biometric system could be built with a reliable recognition performance under the ergonomic constraints.
- Published
- 2017
30. Recanalization of symptomatic chronic internal carotid artery occlusions by hybrid treatment
- Author
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Jianjie Rong, Bo Li, Bingxin Jiang, Yizhi Liu, Xiaofeng Qu, and Weijian Fan
- Subjects
Adult ,Male ,medicine.medical_specialty ,Subarachnoid hemorrhage ,medicine.medical_treatment ,Carotid endarterectomy ,Revascularization ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,medicine ,Humans ,Carotid Stenosis ,Stroke ,Aged ,Retrospective Studies ,Endarterectomy, Carotid ,business.industry ,Endovascular Procedures ,Montreal Cognitive Assessment ,General Medicine ,Perioperative ,Middle Aged ,medicine.disease ,Surgery ,Treatment Outcome ,030220 oncology & carcinogenesis ,Reperfusion ,Female ,Stents ,Neurology (clinical) ,Internal carotid artery ,business ,030217 neurology & neurosurgery ,Postoperative Hypertension - Abstract
To evaluate the efficacy and safety of hybrid revascularization by carotid endarterectomy and endovascular intervention in the treatment of chronic internal carotid artery occlusion (ICAO).We performed a retrospective analysis of patients who received hybrid treatment for symptomatic chronic ICAO between December 2016 and December 2018. Fifty-six patients with long-segment ICAO were enrolled and divided into the short duration (1-3 months) and long ICAO duration (3 months) groups, and their clinical and angiographic data were analyzed.The mean duration was 106.8 ± 36.1 days from the date of ICAO diagnosis to revascularization. Totally, 10 patients (17.8%, n = 56) in the short duration group while no patients in the long duration group failed recanalization (n = 7). Perioperative complications included intraoperative thromboembolism in 1 (1.8%) patient and subarachnoid hemorrhage in 2 (3.6%) patients. Early phase postoperative hypertension was noted in 11 (19.6%) patients and cervical hemorrhage in 1 (1.8%) patient. No severe neurological deficits occurred. Overall, the 6-month modified Rankin score, Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in patients with successful recanalization significantly improved versus the baseline (P 0.05). After successful recanalization, the long duration group demonstrated more stents for revascularization compared with the short duration group (P 0.05). Five (10.8%) patients had recurrent transient ischemic attack, and 1 (2.2%) patient developed stroke in the successful revascularization group during 6 months of follow-up. ICA restenosis occurred in 5 (8.9%) patients and re-occlusion was noted in 1 (1.8%) patient.Hybrid operation may be feasible and effective for patients with symptomatic chronic complete ICAO according to our limited data. The original occlusion site from the carotid bifurcation and the duration of ICAO should be considered as independent indicators for successful recanalization as well as perioperative outcomes.
- Published
- 2021
31. A Novel Line-Scan Palmprint Acquisition System
- Author
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Xiaofeng Qu, David Zhang, and Guangming Lu
- Subjects
Biometrics ,Computer science ,business.industry ,Interface (computing) ,020208 electrical & electronic engineering ,Volume (computing) ,Word error rate ,02 engineering and technology ,Computer Science Applications ,Human-Computer Interaction ,Control and Systems Engineering ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Computer vision ,Artificial intelligence ,Electrical and Electronic Engineering ,Image sensor ,business ,Software - Abstract
Biometric recognition systems have been widely used globally. However, one effective and highly accurate biometric authentication method, palmprint recognition, has not been popularly applied as it should have been, which could be due to the lack of small, flexible and user-friendly acquisition systems. To expand the use of palmprint biometrics, we propose a novel palmprint acquisition system based on the line-scan image sensor. The proposed system consists of a customized and highly integrated line-scan sensor, a self-adaptive synchronizing unit, and a field-programmable gate array controller with a cross-platform interface. The volume of the proposed system is over 94% smaller than the volume of existing palmprint systems, without compromising its verification performance. The verification performance of the proposed system was tested on a database of 8000 samples collected from 250 people, and the equal error rate is 0.048%, which is comparable to the best area camera-based systems.
- Published
- 2016
32. shallowCNN-LE: A shallow CNN with Laplacian Embedding for face anti-spoofing
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Jiwen Dong, Xiaofeng Qu, and Sijie Niu
- Subjects
021110 strategic, defence & security studies ,Computer science ,business.industry ,0211 other engineering and technologies ,Pattern recognition ,02 engineering and technology ,Facial recognition system ,Convolutional neural network ,Face (geometry) ,Softmax function ,0202 electrical engineering, electronic engineering, information engineering ,Embedding ,020201 artificial intelligence & image processing ,Artificial intelligence ,Complex wavelet transform ,Face detection ,business ,Replay attack - Abstract
Identity authentication based on face recognition has been significantly improved due to the outstanding ability of face detection, thus it plays an important role in society. However, face recognition system might be deceived by malicious face spoof attacks raising risk from both safety and property. The algorithm to accurately detect face anti-spoofing in identity authentication system is becoming crucial. In this paper, a shallow convolutional neural network with laplacian embedding (shallowCNN-LE) is proposed for face anti-spoofing. Two different types of features are concatenated to accurately detect the face liveness, including depth features and dynamic texture features. First, the developed shallow CNN model contains four layers which make the model faster. Second, we integrate dynamic texture features extracted by using the dual tree complex wavelet transform (DT-CWT) with the depth features as input features to feed into the proposed model. Finally, we propose a laplacian embedding algorithm, which can maintain the inter-class discrimination and penalize the distance of intra-class. When embedding the laplacian loss with the softmax loss, the proposed method can obtain much more discriminative features, which is helpful to detect face anti-spoofing. Experimental results on public databases of CASIA FASD, Replay attack and MSU USSA database demonstrate that our proposed method outperforms the state-of-the-art methods for face anti-spoofing detection.
- Published
- 2019
33. Evaluation of the 3D Augmented Reality-Guided Intraoperative Positioning of Dental Implants in Edentulous Mandibular Models
- Author
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Longfei Ma, Yingwei Fan, Hongen Liao, Xiaofeng Qu, Boyu Zhang, Xinran Zhang, and Weipeng Jiang
- Subjects
Computer science ,medicine.medical_treatment ,Point cloud ,Overlay ,Mandible ,Stereotaxic Techniques ,03 medical and health sciences ,User-Computer Interface ,0302 clinical medicine ,Imaging, Three-Dimensional ,medicine ,Humans ,Maxillary central incisor ,Computer vision ,030212 general & internal medicine ,Dental implant ,Dental Implants ,business.industry ,Phantoms, Imaging ,030206 dentistry ,General Medicine ,Surgery, Computer-Assisted ,Virtual image ,Printing, Three-Dimensional ,Augmented reality ,Artificial intelligence ,Implant ,Tomography ,Oral Surgery ,Mouth, Edentulous ,business ,Tomography, X-Ray Computed - Abstract
PURPOSE This research aimed to propose a three-dimensional (3D) augmented reality navigation method with point cloud-based image-patient registration that could merge virtual images in the real environment for dental implants using a 3D image overlay and to evaluate its feasibility. MATERIALS AND METHODS A total of 12 rapid prototyping mandibular models were fabricated using a 3D printing method and were divided into two groups: 3D augmented reality-guided group and traditional two-dimensional (2D) image-guided group. A point cloud-based preoperative image-to-patient registration method was introduced to replace the traditional point-to-point registration. After the registration, dental implant surgery was performed in the two model groups using an augmented reality-guided navigation method and a traditional two-dimensional image-guided navigation method. The planned and actual postoperative implant positions were compared for measuring positional implantation errors. The surgery time was also recorded and compared between the two groups. RESULTS In the model experiment, the root-mean-square deviation of registration was 0.54 mm, and the implant surgery results showed < 1.5-mm mean linear deviation and < 5.5-degree angular deviation. The augmented reality-guided implantation showed smaller horizontal, vertical, and angular errors in the apical areas of the central incisor and the canine region. The surgery time using the augmented reality-guided navigation method was significantly shorter than that using the two-dimensional (2D) image-guided navigation method (P < .05). Moreover, the volunteer experiment demonstrated that the preoperative 3D models in situ accurately overlaid onto the surgical site. CONCLUSION The proposed point cloud-based registration method can achieve excellent registration accuracy. Dental implant placement guided by the proposed 3D augmented reality navigation method showed better accuracy and applicability, as well as higher efficiency, than the traditional 2D image navigation method.
- Published
- 2018
34. Early Detection and Quantification of Cerebral Venous Thrombosis by Magnetic Resonance Black-Blood Thrombus Imaging
- Author
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Xiaoming Bi, Xiaofeng Qu, Qi Yang, Christopher Nguyen, Yibin Xie, Kuncheng Li, Xiangying Du, Debiao Li, Jiangang Duan, Zhaoyang Fan, and Xunming Ji
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Signal-To-Noise Ratio ,Sensitivity and Specificity ,Article ,Magnetic resonance angiography ,030218 nuclear medicine & medical imaging ,Cohort Studies ,Sinus Thrombosis, Intracranial ,Young Adult ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,medicine ,Medical imaging ,Humans ,Prospective Studies ,Thrombus ,Child ,Prospective cohort study ,Aged ,Aged, 80 and over ,Venous Thrombosis ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Cerebral Angiography ,Venous thrombosis ,Early Diagnosis ,Intracranial Thrombosis ,Case-Control Studies ,Child, Preschool ,Female ,Neurology (clinical) ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Magnetic Resonance Angiography ,030217 neurology & neurosurgery ,Cerebral angiography - Abstract
Background and Purpose— Early diagnosis of cerebral venous thrombosis (CVT) is currently a major clinical challenge. We proposed a novel magnetic resonance black-blood thrombus imaging technique (MRBTI) for detection and quantification of CVT. Methods— MRBTI was performed on 23 patients with proven CVT and 24 patients with negative CVT confirmed by conventional imaging techniques. Patients were divided into 2 groups based on the duration of clinical onset: ≤7 days (group 1) and between 7 and 30 days (group 2). Signal/noise ratio was calculated for the detected thrombus, and contrast/noise ratio was measured between thrombus and lumen and also between thrombus and brain tissue. The feasibility of using MRBTI for thrombus volume measurement was explored, and total thrombus volume was calculated for each patient. Results— In 23 patients with proven CVT, MRBTI correctly identified 113 of 116 segments with a sensitivity of 97.4%. Thrombus signal/noise ratio was 153±57 and 261±95 for group 1 (n=10) and group 2 (n=13), respectively ( P P Conclusions— The current findings support that with effectively suppressed blood signal, MRBTI allows selective visualization of thrombus as opposed to indirect detection of venous flow perturbation and can be used as a promising first-line diagnostic imaging tool.
- Published
- 2016
35. microRNA-331-3p maintains the contractile type of vascular smooth muscle cells by regulating TNF-α and CD14 in intracranial aneurysm
- Author
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Chuanyong Li, Qiang Zhang, Xiaofeng Qu, Weijian Fan, Yalan Wang, Zhichang Pan, Yizhi Liu, Guangfeng Zheng, and Jianjie Rong
- Subjects
Adult ,Male ,0301 basic medicine ,Vascular smooth muscle ,CD14 ,Myocytes, Smooth Muscle ,Lipopolysaccharide Receptors ,Rats, Sprague-Dawley ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,In vivo ,microRNA ,Animals ,Humans ,Luciferase ,Aged ,Aged, 80 and over ,Pharmacology ,Tumor Necrosis Factor-alpha ,Cell growth ,Chemistry ,Intracranial Aneurysm ,Middle Aged ,musculoskeletal system ,Immunohistochemistry ,Phenotype ,Rats ,Cell biology ,MicroRNAs ,030104 developmental biology ,cardiovascular system ,Female ,Ligation ,030217 neurology & neurosurgery ,Muscle Contraction ,Signal Transduction - Abstract
Dysfunction of vascular smooth muscle cells (VSMCs) may be linked to intracranial aneurysm (IA) formation. VSMCs possess a phenotypic plasticity, capable of changing from a mature, contractile to a less differentiated, synthetic phenotype. In this study, we identify a microRNA candidate miR-331-3p that participates in regulating differentiation properties of VSMCs. The expression of TNF-α and CD14 was quantified in IA wall tissues obtained from 96 IA patients and their associations with clinicopathological features of IA were assessed. Then the interactions between miR-331-3p, TNF-α and CD14 were evaluated by determination of luciferase activity. Differentiated properties of VSMCs were assessed from phenotypic markers of contractile VSMCs, a-SMA and E-cadherin, and of synthetic VSMCs, ICAM-1, MCP-1, IL-6, MMP-2 and MMP-9. Rat IA models by ligation of left carotid artery and left renal artery and histological analysis of induced IAs were performed. The TNF-α and CD14 was highly expressed in IA wall tissues and associated with the type and diameter of aneurysm. Depletion of TNF-α or CD14 retarded VSMC apoptosis and transformation to the synthetic type but facilitated cell proliferation. Elevations in miR-331-3p, a direct negative regulator of both TNF-α and CD14, also reduced VSMC apoptosis and prevented VSMCs from synthetic type and increase their proliferation. Furthermore, miR-331-3p was demonstrated to inhibit the formation of IA by down-regulating TNF-α and CD14 in vivo. In conclusion, miR-331-3p maintains the contractile type of VSMCs, thus possibly inhibiting the progression of IA. These findings provide potential new strategies for the clinical treatment of IA.
- Published
- 2020
36. Augmented-Reality Surgical Navigation System for Better Healthcare Visualization
- Author
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Xiaofeng Qu, Longfei Ma, Xinran Zhang, Hongen Liao, and Boyu Zhang
- Subjects
Computer science ,0206 medical engineering ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Navigation system ,02 engineering and technology ,Overlay ,020601 biomedical engineering ,Surgical planning ,030218 nuclear medicine & medical imaging ,Visualization ,03 medical and health sciences ,0302 clinical medicine ,Human–computer interaction ,Autostereoscopy ,Augmented reality ,Coordination game ,Videography - Abstract
Nowadays, good medical services are located in the high-level hospitals. The uneven regional distribution and the unbalanced medical quality between different hospitals bring obstacles to patients for better healthcare. In the community hospital, surgeons may lack advanced surgical skills. Considering the clinical needs, we present an augmented-reality (AR) navigation system using 3-D image overlay technology for better healthcare visualization. Autostereoscopic 3-D images of anatomic structures, which are reproduced by employing integral videography technology, are superimposed on the patient via a half-silvered mirror to form an AR navigation scene. The proposed system can generate the vivid autostereoscopic 3-D medical images and realize in situ image overlay, which eliminates the hand-eye coordination problem. By using our system, surgeons can intuitively observe the operative area, the marked high-risky tissue, surgical tools and surgical planning pathway, which make the surgical operation more convenient and intuitive. To consider the demands of clinical applications, we design a new semi-streamlined prototype combining adjustment mechanism and servomotors, which can broaden the visual field. Results illustrate that the navigation system can enhance the surgeons’ operation of the facilitation, as well as the design is more integrated and commercialized, which are more suitable for clinical applications. It is advanced to realize remote visual display and intuitive guidance to solve the uneven distribution of medical resources. What’s more, the system can be used for surgical skill training under the guidance of the 3-D images. Thus, the AR system is beneficial to healthcare, especially in the resource-scare communities.
- Published
- 2018
37. Development of atherosclerotic-moyamoya syndrome with genetic variant of RNF213 p.R4810K and p.T1727M: A case report
- Author
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Xueying Wu, Yongzhong Lin, Zhaoyang Fan, Lele Zhong, Jingdan Cheng, Xiaofeng Qu, and Ying Liu
- Subjects
medicine.medical_specialty ,Exacerbation ,media_common.quotation_subject ,Ubiquitin-Protein Ligases ,Magnetic resonance angiography ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Internal medicine ,medicine ,Anterior cerebral artery ,Humans ,Genetic Predisposition to Disease ,030212 general & internal medicine ,media_common ,Adenosine Triphosphatases ,Daughter ,Adult female ,medicine.diagnostic_test ,business.industry ,Haplotype ,Genetic variants ,General Medicine ,Middle Aged ,medicine.disease ,Stenosis ,Cerebrovascular Disorders ,Mutation ,Cardiology ,Surgery ,Female ,Neurology (clinical) ,Moyamoya Disease ,business ,030217 neurology & neurosurgery ,Magnetic Resonance Angiography - Abstract
Objective We report a rare case of atherosclerotic-moyamoya syndrome (A-MMS) in an adult female with genetic variant of both ring finger 213 (RNF213) p.R4810K and p.T1727M. Case report A 46-year-old previously healthy, right-handed woman displayed transient slurred speech, which started to worsen four years ago. Initial magnetic resonance angiography (MRA) revealed stenosis in left middle cerebral artery (MCA), bilateral anterior cerebral artery (ACA), and left posterior cerebral artery (PCA). The patient subsequently underwent catheter angiography, which confirmed the formation of moyamoya vessels, with Suzuki's angiographic staging of grade-3 on the left side. Although the patient had been on both anti-platelet and statin therapy at the time, a follow-up examination showed further exacerbation of left MCA stenosis, along with enhanced moyamoya vessel formation. On black-blood imaging using DANTE-SPACE, there were eccentric, evolving lesions in the left MCA. We next screened for potential genetic variants, using genomic DNA samples isolated from both the patient and her immediate family members. The results showed that the patient, along with her mother, sister, and brother, possessed the heterozygous variant of the RNF213 gene, including c.14429G > A (p.R4810K) and c.5180C > T (p.T1727M). The patient's daughter did not have the variant. Conclusion Collectively, we present a unique case of A-MMS with genetic variant of RNF213 p.R4810K and p.T1727M, manifesting as progression. Based on the family tree, these two mutations are on the same RNF213 haplotype. Whether atherosclerosis is the cause of A-MMS or it further exacerbates the injury of MMD to the A-MMS patients with RNF213 gene variant is a question to be investigated.
- Published
- 2017
38. Color tattoo segmentation based on skin color space and K-mean clustering
- Author
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Jiwen Dong, Hengjian Li, and Xiaofeng Qu
- Subjects
Segmentation-based object categorization ,business.industry ,media_common.quotation_subject ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,k-means clustering ,Scale-space segmentation ,Image segmentation ,Art ,Region growing ,Lab color space ,Segmentation ,Computer vision ,Artificial intelligence ,Cluster analysis ,business ,media_common - Abstract
Tattoos, a soft biometrie trait, are gradually being used to identify suspects in forensic science. Based on LAB color space and K-mean clustering, we propose a novel segmentation algorithm to improve the segmentation accuracy of color tattoos. The process consists of three parts. Firstly, we use K-mean clustering and human skin color segmentation in LAB color space to detect the skin area. Then, we employ the mathematical morphology processing to smooth the clear graphic image of the tattoo segment. Finally, we extract and detect the color tattoos segmentation according to the connectivity of tattoo regions. Compared with the existing methods, this method has low computational complexity. And results of extensive experiments show that the proposed algorithm not only overcomes the limitations of single algorithm, but also improves segmentation accuracy.
- Published
- 2017
39. Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
- Author
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Juan Wang, Wei Nie, Fenglan Niu, Hao Bao, Jinhua Li, Chao Zhao, Xiuling Song, Juan Li, Xiaofeng Qu, Kun Xu, and Li Li
- Subjects
Male ,Salmonella typhimurium ,Acute oral toxicity ,Administration, Oral ,02 engineering and technology ,Pharmacology ,Kidney ,010402 general chemistry ,medicine.disease_cause ,Antiviral Agents ,01 natural sciences ,lcsh:RA1190-1270 ,In vivo ,Oral administration ,Toxicity Tests, Acute ,medicine ,Animals ,Subchronic oral toxicity ,Pharmacology (medical) ,Prospective Studies ,Rats, Wistar ,lcsh:Toxicology. Poisons ,Mice, Inbred ICR ,Polyoxometalate ,Micronucleus Tests ,business.industry ,lcsh:RM1-950 ,Toxicity Tests, Subchronic ,Tungsten Compounds ,021001 nanoscience & nanotechnology ,Acute toxicity ,Rats ,0104 chemical sciences ,Bioavailability ,lcsh:Therapeutics. Pharmacology ,medicine.anatomical_structure ,Liver ,Toxicity ,Micronucleus test ,Female ,Genotoxicity ,0210 nano-technology ,business ,Mutagens ,Research Article - Abstract
Background Cs2K4Na [SiW9Nb3O40] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. Electronic supplementary material The online version of this article (doi:10.1186/s40360-017-0133-x) contains supplementary material, which is available to authorized users.
- Published
- 2017
40. Face Anti-spoofing Algorithm Based on Gray Level Co-occurrence Matrix and Dual Tree Complex Wavelet Transform
- Author
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Jiwen Dong, Xiaofeng Qu, and Hengjian Li
- Subjects
Discrete wavelet transform ,021110 strategic, defence & security studies ,Computer science ,business.industry ,Stationary wavelet transform ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,0211 other engineering and technologies ,Wavelet transform ,Cascade algorithm ,Pattern recognition ,02 engineering and technology ,Wavelet packet decomposition ,Co-occurrence matrix ,Wavelet ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Artificial intelligence ,Complex wavelet transform ,business ,Algorithm - Abstract
By analyzing the difference of facial texture features between living face and photo, we propose a novel face anti-spoofing algorithm based on gray level co-occurrence matrix (GLCM) and dual-tree complex wavelet tree (DT-CWT). Firstly, inspired by the co-occurrence matrix, we extract five texture features including angle second moment, entropy, contrast, correlation and local uniformity to represent the gray direction, interval and amplitude information for the face texture information. Secondly, DT-CWT has the advantages of approximate translation invariance and good direction selectivity. Therefore, the coefficients of DT-CWT can enhance the texture information and edge information in the frequency domain. At last, the SVM classification is used to distinguish between true and fake face. Our algorithm is demonstrated on the published NUAA database. Compared with the existing methods, the feature dimension is reduced. The experimental results show that the proposed algorithm improves the detection accuracy.
- Published
- 2017
41. Additional file 1: of Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
- Author
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Xiaofeng Qu, Xu, Kun, Zhao, Chao, Xiuling Song, Jinhua Li, Li, Li, Nie, Wei, Bao, Hao, Wang, Juan, Fenglan Niu, and Li, Juan
- Abstract
Supporting information for POM93 characterization (Figures S1-S2) and subchronic toxicity (Table S1-S2). (DOCX 54Â kb)
- Published
- 2017
- Full Text
- View/download PDF
42. Effect of phosphodiesterase type 5 inhibitors on prostate cancer risk and biochemical recurrence after prostate cancer treatment: A systematic review and meta-analysis
- Author
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Qingqing Qian, Ju Xia, Yang Wang, Yang Hong, Xiaofeng Qu, Yougen Wu, and Yuting Gu
- Subjects
Male ,Oncology ,Biochemical recurrence ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Endocrinology ,Erectile Dysfunction ,Risk Factors ,Internal medicine ,medicine ,Humans ,Prostatectomy ,030219 obstetrics & reproductive medicine ,business.industry ,Prostatic Neoplasms ,General Medicine ,Odds ratio ,Phosphodiesterase 5 Inhibitors ,Prostate-Specific Antigen ,medicine.disease ,Radiation therapy ,Erectile dysfunction ,Relative risk ,Meta-analysis ,Neoplasm Recurrence, Local ,business - Abstract
Recent studies have examined the impact of phosphodiesterase type 5 inhibitors (PDE5-Is) use on the risk of prostate cancer, and biochemical recurrence (BCR) in prostate cancer patients, but the results were inconsistent. A meta-analysis was conducted to assess the associations with all published studies. Databases (PubMed, Web of Science and MEDLINE) were retrieved to identify relevant studies which explored the impact of PDE5-Is use on the risk of prostate cancer, and BCR in prostate cancer patients. The summary results along with 95% confidence intervals (CIs) were calculated. Nine articles were eligible for the inclusion criteria. The pooled analysis showed that PDE5-Is use was not related to the increased risk of prostate cancer (odds ratio (OR), 0.71; 95% CI, 0.40-1.29). Moreover, PDE5-Is use was not linked to BCR risk in prostate cancer patients with erectile dysfunction (ED) following radical prostatectomy or radiation therapy (relative risk (RR), 1.09; 95% CI, 0.89-1.34). The heterogeneity test suggested moderate heterogeneity across studies. PDE5-Is use does not influence the risk of prostate cancer, and BCR in prostate cancer patients. More well-designed studies are warranted to confirm the findings of our analyses.
- Published
- 2018
43. Additional file 1: Table S3. of A novel multi-epitope recombined protein for diagnosis of human brucellosis
- Author
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Dehui Yin, Li, Li, Xiuling Song, Li, Han, Wang, Juan, Ju, Wen, Xiaofeng Qu, Dandan Song, Yushen Liu, Xiangjun Meng, Hongqian Cao, Weiyi Song, Rizeng Meng, Jinhua Liu, Li, Juan, and Xu, Kun
- Subjects
information science ,bacteria ,natural sciences ,bacterial infections and mycoses ,complex mixtures - Abstract
The Accession Numbers of OMPs of Brucella spp. in NCBI Protein database. (DOC 32Â kb)
- Published
- 2016
- Full Text
- View/download PDF
44. Additional file 2: Fig S1. of A novel multi-epitope recombined protein for diagnosis of human brucellosis
- Author
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Dehui Yin, Li, Li, Xiuling Song, Li, Han, Wang, Juan, Ju, Wen, Xiaofeng Qu, Dandan Song, Yushen Liu, Xiangjun Meng, Hongqian Cao, Weiyi Song, Rizeng Meng, Jinhua Liu, Li, Juan, and Xu, Kun
- Abstract
IELISA assay analysis of serum samples in negative controls, healthy individuals and patients with other bacterial infection. (DOC 1403Â kb)
- Published
- 2016
- Full Text
- View/download PDF
45. Additional file 4: Table S1. of A novel multi-epitope recombined protein for diagnosis of human brucellosis
- Author
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Dehui Yin, Li, Li, Xiuling Song, Li, Han, Wang, Juan, Ju, Wen, Xiaofeng Qu, Dandan Song, Yushen Liu, Xiangjun Meng, Hongqian Cao, Weiyi Song, Rizeng Meng, Jinhua Liu, Li, Juan, and Xu, Kun
- Subjects
mental disorders ,psychological phenomena and processes - Abstract
Specimen characteristics of positive and negative. (DOC 30Â kb)
- Published
- 2016
- Full Text
- View/download PDF
46. Additional file 4: Table S1. of A novel multi-epitope recombined protein for diagnosis of human brucellosis
- Author
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Dehui Yin, Li, Li, Xiuling Song, Li, Han, Wang, Juan, Ju, Wen, Xiaofeng Qu, Dandan Song, Yushen Liu, Xiangjun Meng, Hongqian Cao, Weiyi Song, Rizeng Meng, Jinhua Liu, Li, Juan, and Xu, Kun
- Subjects
mental disorders ,psychological phenomena and processes - Abstract
Specimen characteristics of positive and negative. (DOC 30Â kb)
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- 2016
- Full Text
- View/download PDF
47. Additional file 3: Table S2. of A novel multi-epitope recombined protein for diagnosis of human brucellosis
- Author
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Dehui Yin, Li, Li, Xiuling Song, Li, Han, Wang, Juan, Ju, Wen, Xiaofeng Qu, Dandan Song, Yushen Liu, Xiangjun Meng, Hongqian Cao, Weiyi Song, Rizeng Meng, Jinhua Liu, Li, Juan, and Xu, Kun
- Abstract
Isotype specific reactivity positive results from the sera of brucellosis patients(146 samples) and controls(102 samples) in ELISA. (DOC 30Â kb)
- Published
- 2016
- Full Text
- View/download PDF
48. Additional file 1: Table S3. of A novel multi-epitope recombined protein for diagnosis of human brucellosis
- Author
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Dehui Yin, Li, Li, Xiuling Song, Li, Han, Wang, Juan, Ju, Wen, Xiaofeng Qu, Dandan Song, Yushen Liu, Xiangjun Meng, Hongqian Cao, Weiyi Song, Rizeng Meng, Jinhua Liu, Li, Juan, and Xu, Kun
- Subjects
information science ,bacteria ,natural sciences ,bacterial infections and mycoses ,complex mixtures - Abstract
The Accession Numbers of OMPs of Brucella spp. in NCBI Protein database. (DOC 32Â kb)
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- 2016
- Full Text
- View/download PDF
49. Additional file 3: Table S2. of A novel multi-epitope recombined protein for diagnosis of human brucellosis
- Author
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Dehui Yin, Li, Li, Xiuling Song, Li, Han, Wang, Juan, Ju, Wen, Xiaofeng Qu, Dandan Song, Yushen Liu, Xiangjun Meng, Hongqian Cao, Weiyi Song, Rizeng Meng, Jinhua Liu, Li, Juan, and Xu, Kun
- Abstract
Isotype specific reactivity positive results from the sera of brucellosis patients(146 samples) and controls(102 samples) in ELISA. (DOC 30Â kb)
- Published
- 2016
- Full Text
- View/download PDF
50. A novel multi-epitope recombined protein for diagnosis of human brucellosis
- Author
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Jinhua Liu, Wen Ju, Juan Wang, Xiangjun Meng, Dehui Yin, Han Li, Dandan Song, Yushen Liu, Kun Xu, Juan Li, Xiaofeng Qu, Rizeng Meng, Weiyi Song, Hongqian Cao, Li Li, and Xiuling Song
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Recombinant protein ,030106 microbiology ,Blotting, Western ,Immunoblotting ,Enzyme-Linked Immunosorbent Assay ,Brucella ,Sensitivity and Specificity ,Epitope ,Brucellosis ,Serology ,law.invention ,03 medical and health sciences ,Epitopes ,Medical microbiology ,Antigen ,law ,Diagnosis ,medicine ,Humans ,Antigens, Bacterial ,biology ,business.industry ,medicine.disease ,biology.organism_classification ,Recombinant Proteins ,030104 developmental biology ,Infectious Diseases ,Parasitology ,ROC Curve ,Immunology ,Recombinant DNA ,business ,Research Article - Abstract
Background In epidemic regions of the world, brucellosis is a reemerging zoonosis with minimal mortality but is a serious public hygiene problem. Currently, there are various methods for brucellosis diagnosis, however few of them are available to be used to diagnose, especially for serious cross-reaction with other bacteria. Method To overcome this disadvantage, we explored a novel multi-epitope recombinant protein as human brucellosis diagnostic antigen. We established an indirect enzyme-linked immunosorbent assay (ELISA) based on this recombinant protein. 248 sera obtained from three different groups including patients with brucellosis (146 samples), non-brucellosis patients (82 samples), and healthy individuals (20 samples) were tested by indirect ELISA. To evaluate the assay, a receiver-operating characteristic (ROC) analysis and immunoblotting were carried out using these characterized serum samples. Results For this test, the area under the ROC curve was 0.9409 (95 % confidence interval, 0.9108 to 0.9709), and a sensitivity of 88.89 % and a specificity of 85.54 % was given with a cutoff value of 0.3865 from this ROC analysis. The Western blot results indicate that it is feasible to differentiate human brucellosis and non-brucellosis with the newly established method based on this recombinant protein. Conclusion Our results obtained high diagnostic accuracy of the ELISA assay which encourage the use of this novel recombinant protein as diagnostic antigen to implement serological diagnosis of brucellosis. Electronic supplementary material The online version of this article (doi:10.1186/s12879-016-1552-9) contains supplementary material, which is available to authorized users.
- Published
- 2015
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