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Producing stable nitrite is a necessity for anaerobic ammonium oxidation (anammox) but remains a huge challenge. Here, we describe the design and operation of a hydrogenotrophic denitratation system that stably reduced90% nitrate to nitrite under self-alkaline conditions of pH up to 10.80. Manually lowering the pH to a range of 9.00-10.00 dramatically decreased the nitrate-to-nitrite transformation ratio to20%, showing a significant role of high pH in denitratation. Metagenomics combined with metatranscriptomics indicated that six microorganisms, including a

BACKGROUND Although smartphone application (app) for smoking cessation was considered as a promising strategy, the results of studies about apps were inconsistent, and there were few studies on combinations of usual interventions and apps in smoking cessation. OBJECTIVE To evaluate the efficacy of the Cigarette-Burning application combined with medication intervention for smoking cessation. METHODS A parallel, open-label randomized clinical trial was conducted with a ratio of 1:1 allocation into the bupropion plus app group and bupropion group. All participants received bupropion intervention. Besides, participants in the bupropion plus app group were required to download and use the Cigarette-Burning app, which developed based on smoking cessation guidelines. Follow-up visits were conducted at weeks 1, 2, 4, 9, 12, and 24 after initiation of treatment. RESULTS 400 participants were included in the intention-to-treat analysis from July 2019 to June 2021. The median (IQR) age was 48.0 (38.0-59.0) years, and 374(93.5%) were men. The continuous abstinence rate at 9-12 weeks was significantly higher in the bupropion plus app group (39.5%) than in the bupropion group (27.5%) (OR=1.64, 95%CI 1.04-2.60, P < 0.05). The similar result was found for 24-week sustained abstinence rate. The results of subgroup analysis expressed that the 9-12w continuous abstinence rate was significantly higher in the bupropion plus app group when smokers were at older age, higher education level, higher degree of tobacco dependence or younger age at starting smoking (P < 0.05). CONCLUSIONS This trial provides evidence that the Cigarette-Burning smartphone application significantly increased smoking abstinence when combined with medications and could be an accessible complement to smoking cessation support. CLINICALTRIAL Chinese Clinical Trial Registry (No.: ChiCTR1800016919; http://www.chictr.org.cn).

The oral cavity is the second largest microbial bank in humans after the intestinal canal, colonizing a large number of microorganisms including viruses, bacteria, archaea, fungi and protozoa. The great number of microbial cells, good DNA stability, and individual has a unique microbial community, these characteristics make the human microbiome expected to become a new biomarker for forensic individual identification. This article describes the characteristics of human oral microorganisms and microbial molecular markers in detail, analyzes the potential application value of microorganisms in forensic individual identification, and reviews the research progress of human oral microorganisms in forensic individual identification.口腔是仅次于肠道的人类第二大微生物库，定植了包括病毒、细菌、古核生物、真菌和原生动物等大量微生物。微生物细胞数量多、DNA稳定性好，并且个体具有独特的微生物群落，这些特点使得人类微生物群落有望成为新型法医学个体识别的生物标志。本文阐述了人体口腔微生物的特征和微生物分子标记，分析了微生物在法医学个体识别中的潜在应用价值，并综述了口腔微生物在此方面的研究进展。.

Most of the ONOO- fluorescent probes have restricted applications because of their aggregation-caused quenching (ACQ) effect, long response time and low fluorescence enhancement. Herein, we developed a novel AIEgen fluorescent probe (PE-XY) based on a benzothiazole and quinolin scaffold with high sensitivity and selectivity for imaging of ONOO-. The results indicated that probe PE-XY exhibited fast response towards ONOO- with 2000-fold enhancement of fluorescence intensity ratio in vitro. Moreover, PE-XY exhibited a relatively high sensitivity (limit of detection: 8.58 nM), rapid response (

Using geographic information system (GIS) and the remote sensing techniques (RS), we developed a schistosomiasis database and geographic distribution map in Zhongxiang city,Hubei province in order to display and analyze the endemic situation longitudinally after the water conservancy project is completed.Epidemiological data of schistosomiasis and the correlated climate and hydrology data for the last 30 years were collected and the relevant GIS databases were established under Artificial Neural Networks(ANN) and network training of Landsat TM images.GIS database of schistosomiasis in Zhongxiang city, Hubei province and its vicinity areas were developed including 1 maps regarding the epidemic situation of schistosomiasis. The areas of snail distributing were 4.4 hm2, 8.2 hm2, 24 hm2, 130.4 hm2, 8.13 hm2 and 7.53 hm2, respectively.The maps created by GIS database and RS techniques supported the complicated query on space and property, providing a new way in keeping,updating and analyzing available data. The techniques used should be able to provide evidence for the control of schistosomiasis to this water conservancy project.