398 results on '"X Ling"'
Search Results
2. Towards More General Loss and Setting in Unsupervised Domain Adaptation
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Changjian Shui, Ruizhi Pu, Gezheng Xu, Jun Wen, Fan Zhou, Christian Gagné, Charles X. Ling, and Boyu Wang
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Computational Theory and Mathematics ,Computer Science Applications ,Information Systems - Published
- 2023
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3. Lung Function and the Risk of Exacerbation in the β-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Trial
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Trisha M. Parekh, Erika S. Helgeson, John Connett, Helen Voelker, Sharon X. Ling, Stephen C. Lazarus, Surya P. Bhatt, David M. MacDonald, Takudzwa Mkorombindo, Ken M. Kunisaki, Spyridon Fortis, David Kaminsky, and Mark T. Dransfield
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Pulmonary and Respiratory Medicine ,Pulmonary Disease, Chronic Obstructive ,Forced Expiratory Volume ,Vital Capacity ,Humans ,Lung ,Bronchodilator Agents ,Metoprolol - Published
- 2023
4. Kernel Error Path Algorithm
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Ziran Xiong, Charles X. Ling, and Bin Gu
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Artificial Intelligence ,Computer Networks and Communications ,Software ,Computer Science Applications - Abstract
Tuning the values of kernel parameters plays a vital role in the performance of kernel methods. Kernel path algorithms have been proposed for several important learning algorithms, including support vector machine and kernelized Lasso, which can fit the piecewise nonlinear solutions of kernel methods with respect to the kernel parameter in a continuous space. Although the error path algorithms have been proposed to ensure that the model with the minimum cross validation (CV) error can be found, which is usually the ultimate goal of model selection, they are limited to piecewise linear solution paths. To address this problem, in this article, we extend the classic error path algorithm to the nonlinear kernel solution paths and propose a new kernel error path algorithm (KEP) that can find the global optimal kernel parameter with the minimum CV error. Specifically, we first prove that error functions of binary classification and regression problems are piecewise constant or smooth w.r.t. the kernel parameter. Then, we propose KEP for support vector machine and kernelized Lasso and prove that it guarantees to find the model with the minimum CV error within the whole range of kernel parameter values. Experimental results on various datasets show that our KEP can find the model with minimum CV error with less time consumption. Finally, it would have better generalization error on the test set, compared with grid search and random search.
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- 2022
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5. Heart Rate Variability on 10-Second Electrocardiogram and Risk of Acute Exacerbation of COPD: A Secondary Analysis of the BLOCK COPD Trial
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David M. MacDonald, Takudzwa Mkorombindo, Sharon X. Ling, Selcuk Adabag, Richard Casaburi, John E. Connett, Erika S. Helgeson, Janos Porszasz, Harry B. Rossiter, William W. Stringer, Helen Voelker, Dongxing Zhao, Mark T. Dransfield, and Ken M. Kunisaki
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Pulmonary and Respiratory Medicine ,Prevention ,Chronic Obstructive Pulmonary Disease ,BLOCK-COPD ,autonomic nervous system ,Clinical Trials and Supportive Activities ,heart rate variability ,electrocardiogram ,acute exacerbation of COPD ,Origianl Research ,Clinical Research ,Respiratory ,Lung ,circulatory and respiratory physiology - Abstract
Introduction: Autonomic dysfunction is common in chronic obstructive pulmonary disease (COPD), and worse autonomic function may be a marker of risk for acute exacerbations of COPD (AECOPD). Heart rate variability (HRV) is a measure of autonomic function. Our objective was to test whether lower (worse) HRV is a risk factor for AECOPD. Methods: We measured standard deviation of normal RR intervals (SDNN) and root mean square of successive RR interval differences (RMSSD) on 10-second electrocardiograms (ECGs) performed at screening and day 42 in participants in the Beta Blockers for the Prevention of Acute Exacerbations of COPD trial ( BLOCK-COPD), a placebo-controlled trial of metoprolol for prevention of AECOPD. We used Cox-proportional hazards models to test if these HRV measures were associated with risk of any AECOPD, and separately, hospitalized AECOPD. We tested associations using baseline HRV measures and incorporating HRV measures from day 42 as a time-varying covariate. We also tested for interactions with metoprolol assignment. Results: Of 532 trial participants, 529 (forced expiratory volume in 1 second [FEV(1) ]41 ± 16.3 % predicted) were included in this analysis. We did not find a significant association between HRV measures and risk of AECOPD when all participants were analyzed together. There was a significant interaction between RMSSD and assignment to metoprolol on time to first hospitalized AECOPD; in the placebo group greater RMSSD was associated with a lower risk of hospitalized AECOPD (adjusted hazard ratio0.71, 95% confidence interval: 0.52 to 0.96, per 10 ms increase) but there was no association in the metoprolol group. Conclusions: Autonomic dysfunction as measured by HRV may be a risk factor for AECOPD. Future studies should analyze longer HRV recordings and their performance in broader samples of people with COPD, including those on beta-blockers.
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- 2022
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6. Author response for 'Study on the Strontium Isotope Standard in Pig Teeth Excavated from Zaoshugounao Site, Shaanxi Province of China'
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null K. Y. Liu, null X. Ling, null Y. Li, null H. F. Dou, null Y. P. Qian, and null Z. Wang
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- 2023
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7. Dynamic Impact of High-Density Aluminum Foam
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Qian Peng, H. S. Ma, J. Xie, Yueguang Wei, Xiaoli Liu, and X. Ling
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Materials science ,Mechanical Engineering ,Mathematical analysis ,Hydrostatic pressure ,Constitutive equation ,Computational Mechanics ,Stiffness ,Metal foam ,Deformation (meteorology) ,Shear (sheet metal) ,Mechanics of Materials ,medicine ,medicine.symptom ,Energy (signal processing) ,Bar (unit) - Abstract
High-density aluminum foam can provide higher stiffness and absorb more energy during the impact Obtaining the constitutive law of such foam requires tri-axial tests with very high pressure, where difficulty may arise because the hydrostatic pressure can reach more than 30 MPa. In this paper, instead of using tri-axial tests, we proposed three easier tests—tension, compression and shear to obtain the parameters of constitutive model (the Deshpande–Fleck model). To verify the constitutive model both statically and dynamically, we carried out additional triaxial tests and direct impact tests, respectively. Based on the derived model, we performed finite element simulation to study the impact response of the present foam. By dimensional analysis, we proposed an empirical equation for a non-dimensional impact time $${\bar{t}}_{\mathrm {d}}$$ , the impact time divided by the time required for plastic wave travelling from the impact surface to the bottom surface, to determine the deformation characteristic of the aluminum foam after impact. For the case with $${\bar{t}}_{\mathrm {d}}\le 1$$ , the deformation tends to exhibit a shock-type characteristic, while for the case with $${\bar{t}}_{\mathrm {d}}>5$$ , the deformation tends to exhibit an upsetting-type characteristic.
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- 2021
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8. Label shift conditioned hybrid querying for deep active learning
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Jiaqi Li, Haojia Kong, Gezheng Xu, Changjian Shui, Ruizhi Pu, Zhao Kang, Charles X. Ling, and Boyu Wang
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Information Systems and Management ,Artificial Intelligence ,Software ,Management Information Systems - Published
- 2023
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9. Amphiphilic Block Copolymer-Catalyzed Cell Membrane Sealing Is Linked to Decreased Membrane Tension
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Raphael C. Lee, Christopher Maatouk, Colin A. McFaul, Michael Cho, Igor Titushkin, and Michelle X. Ling
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Chemistry ,Cell ,Biomedical Engineering ,Membrane structure ,Medicine (miscellaneous) ,Cell Biology ,Polyethylene glycol ,Poloxamer ,Biomaterials ,Cell membrane ,chemistry.chemical_compound ,medicine.anatomical_structure ,Membrane ,Pulmonary surfactant ,medicine ,Biophysics ,Viability assay - Abstract
The cell plasma membrane suffers structural disruptions from both daily environmental stresses and trauma. Rapid loss of cell viability occurs if membrane integrity is not rapidly restored. Physiological membrane sealing involves alteration of local intermolecular thermodynamics that is manifested by changes in membrane tension which precede reassembly of the membrane planar bilayer structure. Certain block copolymer surfactants, including poloxamer 188 (P188), have been proven to seal-disrupted cell membranes. However, the specific molecular mechanics of poloxamer-mediated membrane sealing remains a target of investigation. A decrease in membrane tension precedes membrane sealing by natural intrinsic cell sealing processes. The effect of P188 on the quasistatic membrane tension of Madin-Darby canine kidney (MDCK) and Swiss 3T3 fibroblasts cells under normal and saponin-permeabilized conditions was measured using laser optical tweezer (LOT)-extracted membrane tethers. The tether trap length of saponin-permeabilized MDCK cell membranes decreased from an uninjured control of 11.28 ± 1.1 μm to 6.43 ± 0.67 μm. Treatment with P188 (0.2 mM) significantly increased the tether trap length to 9.69 ± 1.0 μm (p < 0.05) while the control polymer, polyethylene glycol (0.2 mM) resulted in tether trap length of 7.02 ± 0.73 μm that was not significantly different. Similar observations were made in the saponin-permeabilized fibroblasts. Corresponding fluorescence cell viability assays revealed that P188-treated cells had a higher survival rate. Thus, surfactant copolymer membrane sealing restores the membrane integrity by decreasing the membrane tension. Cells quickly become non-viable when plasma membrane integrity is lost. Restoring or healing the cell membrane requires alteration in the forces that stabilize the membrane structure. The membrane defect healing processes are preceded by a decrease in membrane interfacial tension. This study demonstrated that amphiphilic block copolymer surfactants, such as poloxamer 188 (P188), reduce membrane tension and promote cell survival. Using laser optical tweezers, this work quantified the effect of surfactant copolymer-catalyzed sealing. Our work utilized laser optical tweezers to demonstrate that copolymer-catalyzed membrane sealing corresponds with a decrease in membrane tension, much like the physiologic response to membrane injury.
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- 2021
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10. Copolymer Surfactant Poloxamer 188 Accelerates Post-axonotemetic Sciatic Nerve Regeneration
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Raphael C. Lee, Hannes Prescher, and Michelle X. Ling
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Neurofilament ,Chemistry ,Biomedical Engineering ,Medicine (miscellaneous) ,Nerve fiber ,Cell Biology ,Nerve injury ,Pharmacology ,medicine.disease ,Biomaterials ,Cell membrane ,medicine.anatomical_structure ,nervous system ,Peripheral nerve injury ,medicine ,Crush injury ,Sciatic nerve ,Axon ,medicine.symptom - Abstract
Trauma-mediated peripheral nerve axon injury invariably involves structural alteration of the axonal plasmalemma cell membrane. Increased axonal membrane permeability to electrolytes results in metabolic stress and axonal degeneration if the axon does not seal. Poloxamer 188 (P188) is a linear multiblock copolymer composed of a hydrophobic polyoxypropylene (POP) block in the middle with polyethylene glycol (PEG) blocks on both ends. The central POP block concentrates at sites of cell membrane disruption and catalyzes sealing of disrupted cellular membranes. We tested the hypothesis that intravenously administered P188 (9800 Da, 0.2 mM) can accelerate distal axon recovery after sciatic nerve crush injury using an established axonotemetic model. A crush injury was performed on the sciatic nerve of thirty female Sprague-Dawley rats. Rats were randomized to receive either 0.2 mM P188 or Dextran, administered 1 h after crush injury. Compound nerve action potentials (CNAP) and density of neurofilament distal to the point of injury were analyzed on post-crush day (PCD) 4, 14, and 21. A significant improvement in axonal conduction for animals treated with P188 was observed for PCD 4 and PCD 14 (p
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- 2020
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11. Electromuscular Incapacitation Current Induced Neuromuscular Tissue Injury
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Michelle X. Ling, Colin A. McFaul, Martha Meng, and Raphael C. Lee
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medicine.medical_specialty ,Swine ,Physiology ,Biophysics ,Action Potentials ,02 engineering and technology ,Rectus femoris muscle ,Rhabdomyolysis ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Maximal energy ,Internal medicine ,Lactate dehydrogenase ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,Muscle, Skeletal ,Acidosis ,biology ,business.industry ,Electric Conductivity ,Skeletal muscle ,020206 networking & telecommunications ,General Medicine ,medicine.disease ,Troponin ,medicine.anatomical_structure ,Gene Expression Regulation ,chemistry ,Shock (circulatory) ,Cardiology ,biology.protein ,medicine.symptom ,business - Abstract
Electrical stun devices (ESDs) serve a basic role in law enforcement and provide an alternative to lethal options for target control by causing electromuscular incapacitation (EMI). A fundamental concern is the adverse health consequences associated with their use. The capability of EMI electric field pulses to disrupt skeletal muscle cells (i.e. rhabdomyolysis) was investigated over the operational range commonly used in commercial EMI devices. Functional and structural alteration and recovery of muscle and nerve tissue were assessed. In an anesthetized swine model, the left thigh was exposed to 2 min of electrical pulses, using a commercially available ESD or a custom-made EMI signal power amplifier. Serum creatinine phosphokinase (CPK), troponin, aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels were monitored intermittently for 6 h post-EMI exposure. A standard external cardiac defibrillator served as a positive control. Muscle and nerve tissue histology adjacent to the EMI contacts were examined. Post-EMI shock skeletal muscle function was evaluated by analyzing the compound muscle action potentials (CMAPs) of the rectus femoris muscle. Maximal energy cardiac defibrillator pulses resulted in rhabdomyolysis and marked elevation of CPK, LDH, and AST 6 h post-shock. EMI field pulses resulted in the animals developing transient acidosis. CMAP amplitudes decreased approximately 50% after EMI and recovered to near-normal levels within 6 h. Within 6 h post-EMI exposure, blood CPK was mildly increased, LDH was normal, and no arrhythmia was observed. Minimal rhabdomyolysis was produced by the EMI pulses. These results suggest that EMI exposure is unlikely to cause extremity rhabdomyolysis in normal individuals. Bioelectromagnetics. © 2020 Bioelectromagnetics Society.
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- 2020
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12. An optimal model with a lower bound of recall for imbalanced speech emotion recognition
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Xusheng Ai, Charles X. Ling, Wei Fang, and Victor S. Sheng
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Recall ,Artificial neural network ,Computer Networks and Communications ,Computer science ,Speech recognition ,020207 software engineering ,02 engineering and technology ,Function (mathematics) ,Upper and lower bounds ,Hardware and Architecture ,0202 electrical engineering, electronic engineering, information engineering ,Media Technology ,Emotion recognition ,F1 score ,Software - Abstract
In an early complain warning system, we encounter a common problem - the lack of angry emotions for training classification models. Moreover, the recognition of angry emotion is more important than that of no-anger emotion. Based on this, the main purpose of this paper is to train an optimal model which achieves a high recall above a lower bound and a maximum of F1 score. It is divided into three aspects: 1) A variant of F1 score (TF1 score) takes recall above a lower bound and F1 score into consideration; 2) A Single Emotion Deep Neural Network (SEDNN) and its training process are designed to find an optimal model with a maximum of TF1 score. 3) A performance comparison of different methods is conducted on IEMOCAP and Emo-DB database. Extensive experiments show that when a BCE loss function or a focal loss function is used, the training process can find a model with a recall above a high threshold and a maximum of F1 score. Especially, SEDNN with the focal loss function performs better than SEDNN with the BCE loss function.
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- 2020
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13. Region-Based Global Reasoning Networks
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Peilun Du, Huadong Ma, Charles X. Ling, Huiyuan Fu, and Chuanming Wang
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0209 industrial biotechnology ,Focus (computing) ,Computer science ,business.industry ,02 engineering and technology ,General Medicine ,Semantics ,Machine learning ,computer.software_genre ,020901 industrial engineering & automation ,0202 electrical engineering, electronic engineering, information engineering ,Benchmark (computing) ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,computer - Abstract
Global reasoning plays a significant role in many computer vision tasks which need to capture long-distance relationships. However, most current studies on global reasoning focus on exploring the relationship between pixels and ignore the critical role of the regions. In this paper, we propose an novel approach that explores the relationship between regions which have richer semantics than pixels. Specifically, we design a region aggregation method that can gather regional features automatically into a uniform shape, and adjust theirs positions adaptively for better alignment. To achieve the best performance of global reasoning, we propose various relationship exploration methods and apply them on the regional features. Our region-based global reasoning module, named ReGr, is end-to-end and can be inserted into existing visual understanding models without extra supervision. To evaluate our approach, we apply ReGr to fine-grained classification and action recognition benchmark tasks, and the experimental results demonstrate the effectiveness of our approach.
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- 2020
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14. Issues in Comparing Symbolic and Connectionist Models
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Charles X. Ling
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- 2022
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15. 45P DCVAC/LuCa with chemotherapy in patients with stage IV, non-squamous NSCLC without EGFR/ALK aberrations: Five-year survival update
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X. Ling, R. Zhong, S. Cao, L. Zhang, J. Xu, B. Zhang, X. Zhang, H. Wang, B. Han, and H. Zhong
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2023
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16. EP08.01-052 Toripalimab in Combination with CIK Cells in Patients with Advanced NSCLC: An Exploratory Study
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B. Han, X. Ling, and R. Zhong
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
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17. Calibrated dynamic borrowing using capping priors
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Sharon X. Ling, Brian P. Hobbs, Alexander M. Kaizer, and Joseph S. Koopmeiners
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Pharmacology ,Statistics and Probability ,Research Design ,Sample Size ,Humans ,Pharmacology (medical) ,Bayes Theorem ,Computer Simulation ,Article - Abstract
Multisource exchangeability models (MEMs), a Bayesian approach for dynamically integrating information from multiple clinical trials, are a promising approach for gaining efficiency in randomized controlled trials. When the supplementary trials are considerably larger than the primary trial, care must be taken when integrating supplementary data to avoid overwhelming the primary trial. In this paper, we propose “capping priors,” which controls the extent of dynamic borrowing by placing an a priori cap on the effective supplemental sample size. We demonstrate the behavior of this technique via simulation, and apply our method to four randomized trials of very low nicotine content cigarettes.
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- 2022
18. Recovery capability evaluation of multi-energy distribution system based on heterogeneous information network
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S. Shi, J. Zhou, X. ling, Y. Cui, Q. Zhang, J. Zhu, and Q. Ai
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- 2022
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19. Contact Engineering for High-Performance N-Type 2D Semiconductor Transistors
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Y. Lin, P.-C. Shen, C. Su, A.-S. Chou, T. Wu, C.-C. Cheng, J.-H. Park, M.-H. Chiu, A.-Y. Lu, H.-L. Tang, M. M. Tavakoli, G. Pitner, X. Ji, C. McGahan, X. Wang, Z. Cai, N. Mao, J. Wang, Y. Wang, W. Tisdale, X. Ling, K. E. Aidala, V. Tung, J. Li, A. Zettl, C.-I. Wu, Jing Guo, H. Wang, J. Bokor, T. Palacios, L.-J. Li, and J. Kong
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- 2021
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20. Accelerated long-term aging study of new antioxidant plastic scintillators
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H. Song, X. Li, B. Yu, C. Yang, X. Ling, Z. Zhu, T. Hu, T. Zhao, B. Jin, and H. Zhang
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Instrumentation ,Mathematical Physics - Abstract
In this paper, the smaller plastic scintillator (polystyrene as solvent) tiles are polymerized and shaped by two methods, i.e. injection molding technology and thermal pressing technology by domestic manufacturer, to be operated for more than 10 years in the hadron calorimeter of the Circular Electron Position Collider (CEPC) or other purposes. Other benefits include, researching aging problems, by adding 0.1% material antioxidants of 2,6-Di-tert-butyl-4-methylphenol (BHT) and without BHT, and according to Van't Hoff rule of equivalent chemical reaction rate of high temperature, the 10 years aging study is simulated in short term. A strobed coincidence setup is arranged to test the light yield of the tile to be measured with silicon photomultipliers (SiPMs) with ADC read out and a simple trigger system with small solid angle acceptance is adopted. The light yields of measured tiles without BHT decrease by about 26.6% (injection molding technology) and 43.3% (thermal polymerization technology) after ten-year equivalent aging time. Meanwhile, the light yields of the tiles with BHT almost did not change after ten-year equivalent aging time.
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- 2023
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21. First Wide Field-of-view X-Ray Observations by a Lobster-eye Focusing Telescope in Orbit
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C. Zhang, Z. X. Ling, X. J. Sun, S. L. Sun, Y. Liu, Z. D. Li, Y. L. Xue, Y. F. Chen, Y. F. Dai, Z. Q. Jia, H. Y. Liu, X. F. Zhang, Y. H. Zhang, S. N. Zhang, F. S. Chen, Z. W. Cheng, W. Fu, Y. X. Han, H. Li, J. F. Li, Y. Li, P. R. Liu, X. H. Ma, Y. J. Tang, C. B. Wang, R. J. Xie, A. L. Yan, Q. Zhang, B. W. Jiang, G. Jin, L. H. Li, X. B. Qiu, D. T. Su, J. N. Sun, Z. Xu, S. K. Zhang, Z. Zhang, N. Zhang, X. Z. Bi, Z. M. Cai, J. W. He, H. Q. Liu, X. C. Zhu, H. Q. Cheng, C. Z. Cui, D. W. Fan, H. B. Hu, M. H. Huang, C. C. Jin, D. Y. Li, H. W. Pan, W. X. Wang, Y. F. Xu, X. Yang, B. Zhang, M. Zhang, W. D. Zhang, D. H. Zhao, M. Bai, Z. Ji, Y. R. Liu, F. L. Ma, J. Su, J. Z. Tong, Y. S. Wang, Z. J. Zhao, C. Feldman, P. O’Brien, J. P. Osborne, R. Willingale, V. Burwitz, G. Hartner, A. Langmeier, T. Müller, S. Rukdee, T. Schmidt, E. Kuulkers, and W. Yuan
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Space and Planetary Science ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) - Abstract
As a novel X-ray focusing technology, lobster eye micro-pore optics (MPO) feature both a wide observing field of view and true imaging capability, promising sky monitoring with significantly improved sensitivity and spatial resolution in soft X-rays. Since first proposed by Angel (1979), the optics have been extensively studied, developed and trialed over the past decades. In this Letter, we report on the first-light results from a flight experiment of the Lobster Eye Imager for Astronomy ($LEIA$), a pathfinder of the wide-field X-ray telescope of the Einstein Probe mission. The piggyback imager, launched in July 2022, has a mostly un-vignetted field of view of $18.6^\circ \times 18.6^\circ $. Its spatial resolution is in the range of 4$-$7 arcmin in FWHM and the focal spot effective area is 2$-$3 cm$^2$, both showing only mild fluctuations across the field of view. We present images of the Galactic center region, Sco X-1 and the diffuse Cygnus Loop nebular taken in snapshot observations over 0.5$-$4 keV. These are truly wide-field X-ray images of celestial bodies observed, for the first time, by a focusing imaging telescope. Initial analyses of the in-flight data show excellent agreement between the observed images and the on-ground calibration and simulations. The instrument and its characterization are briefly described, as well as the flight experiment. The results provide a solid basis for the development of the present and proposed wide-field X-ray missions using lobster eye MPO., Comment: 11 pages, 4 figures. Accepted for publication in Astrophysical Journal Letter
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- 2022
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22. Recent progress in solid polymer electrolytes with various dimensional fillers: a review
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S. Jian, Y. Cao, W. Feng, G. Yin, Y. Zhao, Y. Lai, T. Zhang, X. Ling, H. Wu, H. Bi, and Y. Dong
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Renewable Energy, Sustainability and the Environment ,General Materials Science ,General Chemistry - Published
- 2022
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23. Safety and efficacy of dendritic cell-based immunotherapy (DCVAC/LuCa) combined with carboplatin/pemetrexed for patients with advanced non-squamous non-small-cell lung cancer without oncogenic drivers
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R. Zhong, X. Ling, S. Cao, J. Xu, B. Zhang, X. Zhang, H. Wang, B. Han, and H. Zhong
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Cancer Research ,Lung Neoplasms ,Dendritic Cells ,Pemetrexed ,Acetylcysteine ,Carboplatin ,Oncology ,non-small-cell lung cancer ,Carcinoma, Non-Small-Cell Lung ,Antineoplastic Combined Chemotherapy Protocols ,DCVAC/LuCa ,Humans ,dendritic cell vaccination ,Immunotherapy ,Prospective Studies ,Original Research - Abstract
Background Our prospective, open-label, single-arm phase II study investigated the safety and efficacy of DCVAC/LuCa (dendritic cell vaccines for lung cancer) combined with standard carboplatin/pemetrexed in advanced non-squamous (nsq) non-small-cell lung cancer (NSCLC). Patients and methods Eligible patients had stage IV nsq NSCLC without oncogenic drivers and had not received prior systemic cancer therapy. Treatment consisted of carboplatin/pemetrexed for up to 6 cycles followed by 21 cycles of pemetrexed maintenance or until progression or intolerance. Non-progression patients after two cycles of chemotherapy started to receive DCVAC/LuCa subcutaneously (s.c.) on day 15 of cycle 3, and thereafter q3w (day 15 of chemotherapy cycles) for up to 15 doses. Dosing of DCVAC/LuCa s.c. varied among patients depending on the baseline number of leucocytes but remained constant for each single patient. Safety was assessed by adverse events (AEs), treatment-related adverse events (TRAEs), serious adverse events (SAEs), and adverse events of special interest (AESIs). Efficacy was measured by overall survival (OS), progression-free survival (PFS), time to progression (TTP), and objective response rate (ORR). Results Sixty-one patients were enrolled. In the safety population (n = 60), eight patients (13.33%) had grade 3 or greater TRAEs, and six patients (10.0%) showed SAEs which were not related to leukapheresis or DC vaccination. Six grade 1 AEs were considered to be related to leukapheresis. No AESIs or DCVAC/LuCa-induced AEs were observed. The 2-year survival rate in the modified intention-to-treat population (n = 44) was 52.57%. Median OS was not reached. Median PFS was 8.0 months, median TTP was 10.2 months, and the ORR was 31.82%. Conclusion In treatment-naïve stage IV nsq NSCLC patients without oncogenic drivers, the combination of carboplatin/pemetrexed and DCVAC/LuCa was well tolerated and showed promising efficacy. Therefore, a study to prove our immunotherapeutic concept in a randomized phase III trial is planned., Highlights • We investigated the safety and efficacy of DCVAC/LuCa combined with standard carboplatin/pemetrexed in nsq NSCLC. • The combination therapy showed a favorable tolerability profile in a selected Chinese population. • The 2-year survival rate in the modified intention-to-treat population (n = 44) was 52.57%.
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- 2021
24. P347 Development and external validation of a prognostic model for survival of people living with HIV/AIDS initiating antiretroviral therapy
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J Wang, J Xu, Q Zhu, H Zou, Q Li, L Fu, W Keusters, X Ling, H Ding, L Li, W Cai, X Tang, T Yuan, and H Hong
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medicine.medical_specialty ,Acquired immunodeficiency syndrome (AIDS) ,business.industry ,Prognostic model ,External validation ,Medicine ,business ,Intensive care medicine ,medicine.disease ,Antiretroviral therapy - Published
- 2021
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25. MSR15 A Bayesian Approach for Handling Missing Items in Trial-Based Cost-Effectiveness Analysis with Multi-Item Questionnaires
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X Ling, A Gabrio, A Mason, and G Baio
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Health Policy ,Public Health, Environmental and Occupational Health - Published
- 2022
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26. CaneFX-An Interactive White Cane Learning Tool for People with Visual Impairment
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Michael Evans, Derrick K. X. Ling, Aylwin Bing Chun Chai, Lil Deverell, and Bee Theng Lau
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Computer science ,business.industry ,Visual impairment ,Process (computing) ,Usability ,Accelerometer ,Motion capture ,Motion (physics) ,Visualization ,Microcontroller ,medicine ,Computer vision ,Artificial intelligence ,medicine.symptom ,business - Abstract
This paper discusses an interactive white cane learning tool for children with visual impairment to familiarize themselves with the use of the white cane. A prototype, named CaneFX, was designed based on motion capture technology which utilizes an accelerometer to understand the motion of the white cane. A microcontroller was implemented to process the data obtained from the accelerometer. Three modes were implemented to detect different white cane motions which are sweeping, tapping and hitting motions and for each motion, a sound is associated with it. Experimental testing was conducted to find an optimal setup of the proposed prototype and evaluate its usability. The results show that the prototype is capable of detecting the motions in real-time with high accuracy on a rough floor surface.
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- 2020
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27. A retrospective cohort study of early mortality among patients with HIV/TB co-infection in Shanghai municipality
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Yi-Wei Tang, Lu Ming Liu, Hong Lu, J J Sun, Renfang Zhang, Jun Chen, Tangkai Qi, Zhenyan Wang, J Y Yang, Yinzhong Shen, J R Wang, Y X Ling, S B Xu, and Wei Song
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,China ,Rifabutin ,Tuberculosis ,HIV Infections ,Mycobacterium tuberculosis ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Prevalence ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Antibiotics, Antitubercular ,Aged ,Retrospective Studies ,biology ,Proportional hazards model ,business.industry ,Coinfection ,Health Policy ,Public health ,Retrospective cohort study ,Odds ratio ,Middle Aged ,biology.organism_classification ,medicine.disease ,030112 virology ,Confidence interval ,Hospitalization ,Infectious Diseases ,Regression Analysis ,Female ,Rifampin ,business ,medicine.drug - Abstract
OBJECTIVES Tuberculosis (TB) is the most common and fatal opportunistic co-infection among HIV-infected individuals. While TB-associated mortality predominantly occurs in the first 90 days after admission, such a correlation remains unclear in HIV/TB co-infected patients. Thus, we aimed to investigate the 90-day mortality and associated risk factors among HIV/TB co-infected patients in China. METHODS Adult patients with HIV and a newly confirmed TB diagnosis admitted to the Shanghai Public Health Clinical Center between September 2009 and August 2017 were enrolled. Clinical and laboratory characteristics, key treatments and outcomes were collected retrospectively. The associations between different factors and early mortality were analysed. RESULTS Of the 485 laboratory-confirmed HIV/TB patients [median (range) age = 39 (19-79) years], 413 (85.15%) were male. Diagnosis was confirmed by culture, pathology and acid-fast bacilli smear alone in 362 (74.6%), 6 (1.2%) and 117 (24.1%) patients, respectively. Multiple drug-/rifampin-resistant TB was detected in 21 (5.8%) of the 367 patients with a positive culture. Rifampin or rifabutin was administered to 402 (82.9%) patients. Additionally, 66 (13.6%) and 86 (17.7%) died within 90 days and 1 year of admission, respectively. Of the 64 TB-related deaths, 59 (92.2%) occurred within 90 days of admission. In Cox regression, central nervous system (CNS) TB [odds ratio (OR) = 2.49, 95% confidence interval (CI): 1.46-4.23, P
- Published
- 2020
28. Battery lifetime enhancement via smart hybrid energy storage plug-in module in standalone photovoltaic power system
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M. L. Dennis Wong, Wenlong Jing, Chean Hung Lai, W. S. H. Wong, and Derrick K. X. Ling
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Battery (electricity) ,Renewable Energy, Sustainability and the Environment ,Computer science ,business.industry ,020209 energy ,Photovoltaic system ,Energy Engineering and Power Technology ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Solar energy ,Load profile ,Energy storage ,Automotive engineering ,Renewable energy ,Electric power system ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,0210 nano-technology ,Lead–acid battery ,business - Abstract
Standalone photovoltaic power system is one of the feasible solutions in rural electrification. However, due to the intermittent nature of solar energy and significant demand variations due to small load size, energy storage devices are needed to ensure power quality and reliability. Lead-acid battery bank has been widely used in such systems to act as the intermediate buffer to compensate the power mismatch between generation and demand, despite the poor lifetime characteristics and relatively short service life compared to other energy storage devices. Most charge controllers only provide basic battery charging functionality and prevent the battery bank from overcharging and deep-discharging. While other notable aging factors such as frequent charge-discharge transition, high C-rate and surge power are often neglected. This paper presents a smart hybrid energy storage plug-in module that aims to enhance the service life of Lead-acid battery in standalone photovoltaic-battery power systems by mitigating life-limiting factors such as current fluctuations and surge current. This module is designed as a plug-in module that can be adopted directly in existing infrastructure in installed standalone PV-battery power system. The effectiveness of the proposed plug-in module in mitigating battery stresses is simulated in Matlab Simulink with actual solar irradiance data and estimated load profile for a rural community in Sarawak Malaysia. The simulation results are validated experimentally with the scaled-down photovoltaic-battery power system. The effectiveness in mitigating battery stress is quantitatively evaluated with battery health cost function, while the reduction in overall battery cost is analyzed and discussed.
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- 2019
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29. Generalized error path algorithm
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Bin Gu and Charles X. Ling
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Computer science ,Model selection ,02 engineering and technology ,01 natural sciences ,Cross-validation ,Support vector machine ,Random search ,Lasso (statistics) ,Artificial Intelligence ,0103 physical sciences ,Signal Processing ,Path (graph theory) ,Hyperparameter optimization ,0202 electrical engineering, electronic engineering, information engineering ,Piecewise ,020201 artificial intelligence & image processing ,Computer Vision and Pattern Recognition ,010306 general physics ,Algorithm ,Software - Abstract
Model selection with cross validation (CV) is very popular in machine learning. However, CV with grid and other common search strategies cannot guarantee to find the model with minimum CV error, which is often the ultimate goal of model selection. Recently, various solution path algorithms have been proposed for several important learning algorithms including support vector classification, Lasso, and so on. However, they still do not guarantee to find the model with minimum CV error. In this paper, we first show that the solution paths produced by various algorithms have the property of piecewise linearity. Then, we prove that a large class of error (or loss) functions are piecewise constant, linear, or quadratic w.r.t. the regularization parameter, based on the solution path. Finally, we propose a new generalized error path algorithm (GEP), and prove that it will find the model with minimum CV error in a finite number of steps for the entire range of the regularization parameter. The experimental results on a variety of datasets not only confirm our theoretical findings, but also show that the best model with our GEP has better generalization error on the test data, compared to the grid search, manual search, and random search.
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- 2021
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30. 66P Camrelizumab combined with paclitaxel and nedaplatin in the first-line treatment of locally advanced/advanced esophageal squamous cell carcinoma: A phase II, single-arm, exploratory research
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X. Wang, J. Ma, J. Zhang, Y. Yang, D. Zheng, H. Liang, L. Zhang, Y. Xin, X. Ling, C. Fang, H. Jiang, and W. Zheng
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Oncology ,Hematology - Published
- 2021
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31. 101MO Efficacy and safety of DCVAC/LuCa with chemotherapy for patients with stage IV NSCLC: A prospective, open-label, single-arm, phase II study
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Runbo Zhong, Baohui Han, H. Zhong, Jianrong Xu, and X. Ling
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Internal medicine ,medicine ,Phases of clinical research ,Open label ,Stage iv ,business - Published
- 2021
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32. P76.96 START: Real-world Prospective Study on Sequential Therapy with First-Line Afatinib in Chinese Patients with EGFRm+ Advanced NSCLC
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Z. Xue, Jiaojiao Zhou, X. Ling, Yi-Long Wu, and Q. Li
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,business.industry ,Afatinib ,Internal medicine ,First line ,medicine ,Prospective cohort study ,business ,medicine.drug - Published
- 2021
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33. The convergence of linear classifiers on large sparse data
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Huaimin Wang, Bin Gu, Xiang Li, and Charles X. Ling
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business.industry ,Computer science ,Cognitive Neuroscience ,02 engineering and technology ,010501 environmental sciences ,Recommender system ,Machine learning ,computer.software_genre ,Missing data ,01 natural sciences ,Computer Science Applications ,Naive Bayes classifier ,ComputingMethodologies_PATTERNRECOGNITION ,Artificial Intelligence ,Convergence (routing) ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Artificial intelligence ,Data mining ,business ,computer ,0105 earth and related environmental sciences ,Sparse matrix - Abstract
Large sparse datasets are very common in product recommendation applications. For the scalability reason, linear classifiers are preferred in classification tasks on such datasets. Our previous work Li et al. (2016) has studied how sparsity affects naive Bayes classification under typical data missing mechanisms. In this paper, we greatly expand our previous work by including all linear classifiers, and explore practical strategies to improve accuracy of large sparse data classification. Using real-world and synthetic experiments, we observe different learning curve behaviors under different missing mechanisms. We also study the theoretic reasons for all our observations. Our studies provide a practical guideline to determine if or when obtaining more data and/or obtaining missing values in the data is worthwhile or not. This can be very valuable in the recommendation system applications.
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- 2018
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34. THE PERFORMANCE AND EXTRACELLULAR POLYMERIC SUBSTANCES VARIATIONS OF AN ANAEROBIC-ANOXIC-OXIC WASTEWATER TREATMENT PROCESS SUBJECTED TO ORGANIC CARBON AND AMMONIA NITROGEN SHOCK LOADINGS
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M. S. Zhang, L. H. Zhang, L. X. Ling, Z. C. Chen, and J. B. Guo
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Total organic carbon ,Chemistry ,0208 environmental biotechnology ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,Anoxic waters ,020801 environmental engineering ,Ammonia nitrogen ,Extracellular polymeric substance ,Environmental chemistry ,Shock (circulatory) ,medicine ,Sewage treatment ,medicine.symptom ,Agronomy and Crop Science ,Anaerobic exercise ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences - Published
- 2018
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35. Molecular Dynamics Modeling of Surfactant Block Copolymer Catalysis of Protein Disaggregation and Refolding
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Michelle X. Ling, Kyle McCollum, and Raphael C. Lee
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Pulmonary surfactant ,Chemical engineering ,Chemistry ,Biophysics ,Copolymer ,Molecular dynamics modeling ,Catalysis - Published
- 2021
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36. GLOBAL PATCH MATCHING
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X. Huang, K. Hu, X. Ling, Y. Zhang, Z. Lu, and G. Zhou
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lcsh:Applied optics. Photonics ,Smoothness (probability theory) ,lcsh:T ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,lcsh:TA1501-1820 ,02 engineering and technology ,Function (mathematics) ,lcsh:Technology ,Term (time) ,symbols.namesake ,Quadratic equation ,lcsh:TA1-2040 ,Matrix function ,0202 electrical engineering, electronic engineering, information engineering ,Piecewise ,Taylor series ,symbols ,020201 artificial intelligence & image processing ,lcsh:Engineering (General). Civil engineering (General) ,Algorithm ,Global optimization ,ComputingMethodologies_COMPUTERGRAPHICS - Abstract
This paper introduces a novel global patch matching method that focuses on how to remove fronto-parallel bias and obtain continuous smooth surfaces with assuming that the scenes covered by stereos are piecewise continuous. Firstly, simple linear iterative cluster method (SLIC) is used to segment the base image into a series of patches. Then, a global energy function, which consists of a data term and a smoothness term, is built on the patches. The data term is the second-order Taylor expansion of correlation coefficients, and the smoothness term is built by combing connectivity constraints and the coplanarity constraints are combined to construct the smoothness term. Finally, the global energy function can be built by combining the data term and the smoothness term. We rewrite the global energy function in a quadratic matrix function, and use least square methods to obtain the optimal solution. Experiments on Adirondack stereo and Motorcycle stereo of Middlebury benchmark show that the proposed method can remove fronto-parallel bias effectively, and produce continuous smooth surfaces.
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- 2017
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37. A Deeper Look at Bongard Problems
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Xinyu Yun, Tanner A. Bohn, and Charles X. Ling
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Contextual image classification ,Computer science ,business.industry ,Deep learning ,05 social sciences ,Supervised learning ,Feature extraction ,Visual reasoning ,Machine learning ,computer.software_genre ,Convolutional neural network ,050105 experimental psychology ,03 medical and health sciences ,Task (computing) ,0302 clinical medicine ,0501 psychology and cognitive sciences ,Artificial intelligence ,Set (psychology) ,business ,computer ,030217 neurology & neurosurgery - Abstract
Machine learning, especially deep learning, has been successfully applied to a wide array of computer vision classification tasks in recent years. Infamous for requiring massive amounts of data to perform well at image classification problems, deep learning has so far been unable to solve Bongard problems (BPs), a set of abstract visual reasoning tasks invented in the 1960s. Each BP can be seen as a supervised learning task, with few training samples (6 for positive and 6 for negative), and often requiring highly abstract features to learn well. Automatically solving Bongard problems directly from images remains an ambitious goal, with very little machine learning literature on the topic. In this paper, we discuss several special properties of BPs as well as what it means to solve a BP. Making use of an expanded set of BP-like tasks to allow for a more careful evaluation of automated solvers, we develop and benchmark a deep learning based approach to solve these problems. To encourage work on this interesting problem, we also make freely available a dataset of over 200 BPs (https://github.com/XinyuYun/bongard-problems).
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- 2020
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38. Catching Attention with Automatic Pull Quote Selection
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Charles X. Ling and Tanner A. Bohn
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Computer science ,media_common.quotation_subject ,05 social sciences ,010501 environmental sciences ,01 natural sciences ,Automatic summarization ,050105 experimental psychology ,Readability ,Task (project management) ,Presentation ,Identification (information) ,Human–computer interaction ,Selection (linguistics) ,0501 psychology and cognitive sciences ,0105 earth and related environmental sciences ,media_common - Abstract
To advance understanding on how to engage readers, we advocate the novel task of automatic pull quote selection. Pull quotes are a component of articles specifically designed to catch the attention of readers with spans of text selected from the article and given more salient presentation. This task differs from related tasks such as summarization and clickbait identification by several aspects. We establish a spectrum of baseline approaches to the task, ranging from handcrafted features to a neural mixture-of-experts to cross-task models. By examining the contributions of individual features and embedding dimensions from these models, we uncover unexpected properties of pull quotes to help answer the important question of what engages readers. Human evaluation also supports the uniqueness of this task and the suitability of our selection models. The benefits of exploring this problem further are clear: pull quotes increase enjoyment and readability, shape reader perceptions, and facilitate learning. Code to reproduce this work is available at https://github.com/tannerbohn/AutomaticPullQuoteSelection.
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- 2020
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39. The Schematic Design of Large Antenna by Model-Based Systems Engineering
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C. G. Li, Zhen Wang, S. H. Zhou, Zhiping Chen, and X. Ling
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Engineering drawing ,Use Case Diagram ,Computer science ,Systems Modeling Language ,Systems design ,Schematic ,Block diagram ,Activity diagram ,Functional decomposition ,Requirement Diagram - Abstract
Large antenna plays an important role in exploring outer space, which is a typical representative of complex systems. In this paper, the method of applying MBSE into the system design of large antenna is addressed, and the reasoning processes of requirement analysis, function decomposition and architecture mapping are represented by system data models. Requirement diagram of SysML is taken to exhibit requirement architecture of different relationships visually. Use case diagram of SysML builds a bridge between stakeholder needs and functional decomposition, and use case is decomposed level by level to sub-functions by activity diagram of SysML. The Block Definition Diagram (BDD) of SysML is generated form the mapping of function, and the Internal Block Diagram (IBD) is used to analyze the communication of different components. By virtue of MBSE, a front new pattern of schematic design is developed in the conceptual design of large antenna, which will be very helpful to elevate design quality and efficiency.
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- 2019
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40. Design and Detection Algorithm of White-Light Markers in Close-Range Photogrammetry
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Chen Zhiping, Z. J. Sun, Y. Wang, Z. W. Li, C. L. Huang, X. Ling, and X. X. Lin
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Center of gravity ,Brightness ,Photogrammetry ,Matching (graph theory) ,Computer science ,Position (vector) ,Feature (computer vision) ,Process (computing) ,Algorithm ,Collar - Abstract
In the process of close-range photogrammetry, it is hard to stick markers directly on the surface of the object to be measured at times. Projecting optical markers is a good solution. However, there are some problems for the existing optical markers such as difficulty in automatic matching and splicing. Therefore, this paper proposes the design and detection algorithm of white-light markers. White-light marker is composed of collar coded targets and circular non-coded targets. Collar coded targets are designed in the middle of the white-light marker, which can enhance the brightness of the coded strip and improve the recognition accuracy. Circular non-coded targets are designed around the collar coded targets, which can realize matching of non-coded targets among multiple images. Based on Canny operator, feature edges are extracted from the images. According to the criterions of scale, form, etc., the edges of markers are screened out. Markers containing coded strip is decoded to determine the identity. Center of gravity method is used to make the center position of white-light makers come true. The designed white-light marker is applied to the deformation detection experiment of crane girder. Its deformation curve is basically similar with the curve of sticking markers, which verifies the feasibility of the deformation detection of crane girder based on white-light markers.
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- 2019
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41. Predicting Irregular Past Tenses
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Charles X. Ling
- Published
- 2019
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42. Adherence to Maintenance Medications Among Chinese Chronic Obstructive Pulmonary Disease (COPD) Patients: A Retrospective Claims Database Study
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Y. Gao, X. Ling, Rongchang Chen, X. You, H. Shang, H. Wang, N. Shen, and J. Xuan
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medicine.medical_specialty ,Copd patients ,business.industry ,medicine ,Pulmonary disease ,Claims database ,Intensive care medicine ,business - Published
- 2019
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43. Association of Inhaled Corticosteroid Combination Adherence with Resource Use and Cost Among COPD Patients: A Retrospective Database Study
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H. Wang, J. Xuan, X. Ling, H. Shang, Rongchang Chen, N. Shen, Y. Gao, and X. You
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medicine.medical_specialty ,business.industry ,medicine.drug_class ,Copd patients ,Internal medicine ,Medicine ,Corticosteroid ,Resource use ,business ,Retrospective database - Published
- 2019
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44. 204 Age and circadian regulation of cutaneous innate antiviral immunity at homeostasis
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David L. Corcoran, Vivian Lei, Amanda S. MacLeod, X. Ling, J. Kwock, and S. Kirchner
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Antiviral immunity ,Circadian regulation ,Immunology ,Cell Biology ,Dermatology ,Biology ,Molecular Biology ,Biochemistry ,Homeostasis - Published
- 2021
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- View/download PDF
45. P48.11 Anlotinib Versus Chemotherapy as a Third-Line or Further Treatment for Advanced Small Cell Lung Cancer
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Wei Nie, Ying Zhou, X. Ling, Jianjun Li, S. Cao, Yungui Wang, and Hua Zhong
- Subjects
Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,Chemotherapy ,Text mining ,Third line ,business.industry ,medicine.medical_treatment ,Internal medicine ,medicine ,Non small cell ,business - Published
- 2021
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46. Leveraging clustering to improve collaborative filtering
- Author
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Charles X. Ling and Nima Mirbakhsh
- Subjects
Computer Networks and Communications ,Computer science ,Computation ,media_common.quotation_subject ,02 engineering and technology ,Recommender system ,Machine learning ,computer.software_genre ,Theoretical Computer Science ,Matrix decomposition ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Collaborative filtering ,Quality (business) ,Cluster analysis ,media_common ,business.industry ,Aggregate (data warehouse) ,020201 artificial intelligence & image processing ,Artificial intelligence ,Data mining ,business ,computer ,Software ,Predictive modelling ,Information Systems - Abstract
Extensive work on matrix factorization (MF) techniques have been done recently as they provide accurate rating prediction models in recommendation systems. Additional extensions, such as neighbour-aware models, have been shown to improve rating prediction further. However, these models often suffer from a long computation time. In this paper, we propose a novel method that applies clustering algorithms to the latent vectors of users and items. Our method can capture the common interests between the cluster of users and the cluster of items in a latent space. A matrix factorization technique is then applied to this cluster-level rating matrix to predict the future cluster-level interests. We then aggregate the traditional user-item rating predictions with our cluster-level rating predictions to improve the rating prediction accuracy. Our method is a general "wrapper" that can be applied to all collaborative filtering methods. In our experiments, we show that our new approach, when applied to a variety of existing matrix factorization techniques, improves their rating predictions and also results in better rating predictions for cold-start users. Above all, in this paper we show that better quality and more quantity of these clusters achieve a better rating prediction accuracy.
- Published
- 2016
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47. A microscopic elasto-plastic damage model for characterizing transverse responses of unidirectional fiber-reinforced polymer composites
- Author
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P.H. Chen, N. Li, and X. Ling
- Subjects
Yield (engineering) ,Materials science ,Tension (physics) ,Mechanical Engineering ,Constitutive equation ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Fibre-reinforced plastic ,Compression (physics) ,0201 civil engineering ,Transverse plane ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Ultimate tensile strength ,Composite material ,Material properties ,Civil and Structural Engineering - Abstract
A phenomenological-based micromechanical method, comprising the coupling of the matrix constitutive model and the cohesive zone (CZM) model at fiber-matrix interfaces, is presented to investigate the mechanical behaviors of unidirectional (UD) fiber-reinforced polymer (FRP) composites subjected to transverse tension and compression. The key point of this method is the establishment of a novel elasto-plastic damage constitutive model using a fracture plane based yield criterion. Both plastic deformation and progressive failure procedure is incorporated in the implicit simulation. Special focus is given to the determination of the input values of constituent material properties, suggesting that directly using the macroscopic matrix properties to characterize the mechanical responses at the microscale level may bring large discrepancies in homogenized stress-strain responses of UD composites. A parametrical study is also carried out to calibrate cohesive parameters. The numerical results, in good agreement with experimental measurements, clearly reveal the damage scenarios and the dominant failure mechanisms. It can be concluded that the debonding of the fiber-matrix interfaces is responsible for the ultimate transverse tensile strength, while compression failure is governed by two possible modes, i.e. matrix compressive failure if matrix failure firstly occurs, and matrix tensile and interface debonding failure when debonding initiates first. Besides, the distribution of fracture plane angles in matrix is examined to further validate the predictive capacity of the proposed model.
- Published
- 2020
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48. 877P Genetic testing and results in Chinese gynecological tumour patients
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lingling Xie, Y. Chen, Z. Lin, and X. ling
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Oncology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Internal medicine ,medicine ,Hematology ,business ,Genetic testing - Published
- 2020
- Full Text
- View/download PDF
49. 814 Circadian factors BMAL1 and CLOCK control transcriptional innate antiviral immunity programs in response to skin wounding
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Vivian Lei, P. Rosa Coutinho Goulart Borges Mariottoni, X. Ling, Amanda S. MacLeod, D. Hughes, Chelsea Handfield, D. Waters, S. Kirchner, K. Dzirasa, J. Shannon, Margaret Coates, and David L. Corcoran
- Subjects
Antiviral immunity ,Clock control ,Immunology ,Cell Biology ,Dermatology ,Circadian rhythm ,Biology ,Molecular Biology ,Biochemistry - Published
- 2020
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50. 341 Age and circadian regulation of cutaneous innate antimicrobial immunity
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S. Kirchner, Vivian Lei, Amanda S. MacLeod, X. Ling, and J. Kwock
- Subjects
Circadian regulation ,Immunity ,Immunology ,Cell Biology ,Dermatology ,Biology ,Antimicrobial ,Molecular Biology ,Biochemistry - Published
- 2020
- Full Text
- View/download PDF
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