5,613 results on '"Wysocki A"'
Search Results
2. Expert recommendations on diagnostic-therapeutic management of melanoma patients
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Piotr Rutkowski, Piotr J. Wysocki, Katarzyna Kozak, Anna Nasierowska-Guttmejer, Arkadiusz Jeziorski, Wojciech M. Wysocki, Ewa Kalinka, Tomasz Świtaj, Grażyna Kamińska-Winciorek, Anna M. Czarnecka, Hanna Koseła-Paterczyk, Bożena Cybulska-Stopa, Piotr Wiśniewski, Anna Szumera-Ciećkiewicz, Marcin Zdzienicki, Marek Ziobro, Jacek Fijuth, Andrzej Kawecki, Andrzej Tysarowski, Bożena Romanowska-Dixon, Anna Markiewicz, Marek Dedecjus, Tomasz Kubiatowski, Kamil Dolecki, Hanna Tchórzewska-Korba, Lidia Rudnicka, Witold Owczarek, and Maciej Krzakowski
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Oncology - Published
- 2022
3. Justice vis à vis welfare: how Austrian welfare economics should fit in the Austro-libertarian framework
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Igor Wysocki
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Economics and Econometrics ,Sociology and Political Science ,Finance - Abstract
The present work calls for a modification of Austrian welfare economics so that it should be given a distinct role within the Austro-libertarian paradigm. To this end, we clearly distinguish between justice and welfare. We proceed by trying to stick to the spirit of Austro-libertarianism as firmly as possible. In particular, we operate within the universe of voluntary (viz. rights-respecting) exchanges, having assumed the libertarian absolutist side-constraints view of rights. Furthermore, we take for granted the Austrian actual preference satisfaction view. The specific purpose of the present paper is two-fold. First, we subject Austrian rights-based welfare economics to critical scrutiny. Concluding that the above theory begs the question in favor of free market, we assert that to gauge market efficiency we need to resort to some descriptive criterion, which could reasonably be deemed constitutive of welfare. And it is only then that the question of market efficiency is an open question.
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- 2023
4. A Phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of V114 compared with PCV13 in healthy infants (PNEU-PED-EU-1)
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Federico Martinon-Torres, Jacek Wysocki, Leszek Szenborn, Alfonso Carmona-Martinez, Airi Poder, Ron Dagan, Peter Richmond, Christopher Gilbert, Marie-Chantale Trudel, Sheryl Flores, Robert Lupinacci, Richard McFetridge, Richard T. Wiedmann, Qiuxu Chen, Han Gerrits, Natalie Banniettis, Luwy Musey, Kara Bickham, and Janusz Kaminski
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Infectious Diseases ,General Veterinary ,General Immunology and Microbiology ,Public Health, Environmental and Occupational Health ,Molecular Medicine - Published
- 2023
5. Fecal ammonium in mice with CKD: gastrointestinal sequestration by sodium zirconium cyclosilicate
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Fernando Marmol, Mohammed Badaruddin, Athar Baig, Minghao Ye, Jan Wysocki, Ebrahim Tahaei, Paul Welling, Krister Bamberg, and Daniel Batlle
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Physiology - Abstract
Fecal [Formula: see text] excretion in chronic kidney disease is increased and about sixfold higher than urine [Formula: see text] excretion, revealing an important route of elimination of [Formula: see text] that is present in the gastrointestinal tract. Sodium zirconium cyclosilicate (SZC) administration sequesters a substantial portion of [Formula: see text], suggesting that binding of [Formula: see text] by SZC in the gastrointestinal tract offers therapeutic potential in chronic kidney disease and other clinical conditions beyond its known primary action of SZC as a specific K+ binder.
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- 2023
6. Low level of extra-pair paternity in an urban population of blackbirds
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D. Wysocki, M. Cholewa, A. Gwiazdowska, K. Halupka, R. Rutkowski, and M. Szenejko
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Animal Science and Zoology - Published
- 2023
7. Néel Skyrmion Bubbles in La0.7Sr0.3Mn1–xRuxO3 Multilayers
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Jörg Schöpf, Arsha Thampi, Peter Milde, Dmytro Ivaneyko, Svitlana Kondovych, Denys Y. Kononenko, Lukas M. Eng, Lei Jin, Lin Yang, Lena Wysocki, Paul H. M. van Loosdrecht, Kornel Richter, Kostiantyn V. Yershov, Daniel Wolf, Axel Lubk, and Ionela Lindfors-Vrejoiu
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Mechanical Engineering ,General Materials Science ,Bioengineering ,General Chemistry ,Condensed Matter Physics - Published
- 2023
8. Tb2O@C2(13333)-C74: A Non-Isolated Pentagon Endohedral Fullerene Containing a Nearly Linear Tb–O–Tb Unit
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James C. Duchamp, Harry C. Dorn, Aleksander L. Wysocki, Kyungwha Park, Marilyn M. Olmstead, Mrittika Roy, and Alan L. Balch
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Inorganic Chemistry ,Physical and Theoretical Chemistry - Published
- 2023
9. Marcela ANDOKOVÁ, Čierna som a predsa krásna. Tyconiov výklad Piesne piesní 1, 5 (I am Black Yet Beautiful. Tyconius’s Interpretation of Song 1:5), Iris, Bratislava 2020, pp. 226
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Marcin Wysocki
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General Medicine - Abstract
Review of the book: Marcela ANDOKOVÁ, Čierna som a predsa krásna. Tyconiov výklad Piesne piesní 1, 5 (I am Black Yet Beautiful. Tyconius’s Interpretation of Song 1:5), Iris, Bratislava 2020.
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- 2023
10. Coupling of CTF and RELAP5-3D Within an Enhanced Fidelity Nuclear Power Plant Simulator
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Aaron J. Wysocki, Robert K. Salko, and Igor Arshavsky
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Nuclear and High Energy Physics ,Nuclear Energy and Engineering ,Condensed Matter Physics - Published
- 2023
11. Bridge Plating of a First Proximal Phalanx Intra-articular Base Fracture—Benefits Over External Fixation
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Farhan Ahmad, Brian Xu, Joseph Michalski, Xavier C. Simcock, and Robert W. Wysocki
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Rehabilitation ,Surgery ,Orthopedics and Sports Medicine - Published
- 2023
12. Abstract PD11-09: PD11-09 Datopotamab deruxtecan (Dato-DXd) + durvalumab (D) as first-line (1L) treatment for unresectable locally advanced/metastatic triple-negative breast cancer (a/mTNBC): updated results from BEGONIA, a phase 1b/2 study
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Schmid, Peter, Wysocki, Piotr, Ma, Cynthia, Park, Yeon H, Fernandes, Ricardo, Lord, Simon, Baird, Richard D, Prady, Catherine, Jung, Kyung Hae, Asselah, Jamil, Huisden, Robert, Stewart, Ross, Vuković, Petra, Nunes, Ana T, Nowecki, Zbigniew, Baird, Richard [0000-0001-7071-6483], and Apollo - University of Cambridge Repository
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3204 Immunology ,Cancer Research ,Oncology ,Clinical Research ,6.1 Pharmaceuticals ,32 Biomedical and Clinical Sciences ,3211 Oncology and Carcinogenesis ,6 Evaluation of treatments and therapeutic interventions ,Cancer - Abstract
Background: Patients with a/mTNBC have limited treatment options and a poor prognosis (objective response rate [ORR] of 37%, median duration of response 6.5 months, median overall survival 15.5 months for 1L chemotherapy [Rugo, et al. Ann Oncol. 2021 LBA16]). Combining checkpoint inhibitors with 1L chemotherapy modestly improves outcomes but only in PD-L1–positive a/mTNBC, emphasizing a critical unmet need for patients with PD-L1–negative disease and for further improving outcomes in PD-L1–positive disease. BEGONIA (NCT03742102) is an ongoing 2-part, open-label platform study, evaluating safety and efficacy of D, an anti–PD-L1 antibody, combined with other novel therapies in 1L a/mTNBC, including Dato-DXd, an antibody-drug conjugate consisting of a humanized anti-TROP2 antibody covalently linked to a highly potent topoisomerase I inhibitor payload via a stable, tumor-selective, tetrapeptide-based cleavable linker. Early data from BEGONIA of D in combination with Dato-DXd showed promising responses. Here, we report updated results of Dato-DXd + D. Methods: Patients with unresectable a/mTNBC eligible for 1L treatment were enrolled, regardless of PD-L1 or TROP2 status, and received intravenous Dato-DXd 6 mg/kg + D 1120 mg every 3 weeks until progression or unacceptable toxicity. PD-L1, assessed using the VENTANA PD-L1 (SP263) Assay, was defined as high if ≥ 5% of the tumor area was populated by PD-L1–expressing tumor or immune cells. Primary endpoints were safety and tolerability. Secondary endpoints included investigator-assessed ORR (RECIST v1.1) and duration of response. Patients included in the efficacy analysis had ≥ 2 on-treatment disease assessments, progressed, died, or withdrew from the study. Results: As of April 8, 2022, 47 patients received Dato-DXd + D (39 ongoing) and 33 of those were included in the efficacy analysis. Median (range) follow-up was 7.5 (0–11) months. Patient age was a median of 51 years, 57% received prior treatment for early stage TNBC, and 60% had visceral metastases at baseline. Confirmed ORR was 26/33 (79%; 95% CI, 61–91); 2/33 patients (6%) had a complete response and 24/33 (73%) had a partial response. Confirmed response was irrespective of PD-L1 expression (PD-L1 high ORR, 4/5 [80%]; PD-L1 low, 16/21 [76%]; PD-L1 missing, 6/7 [86%] patients). Median duration of response was not reached; 100% of patients with a complete or partial response remained in response at 6 month follow-up, and 96% had an ongoing response at data cutoff. Adverse events (AEs) were manageable and consistent with the known safety profiles of each agent, with treatment-related AEs occurring in 41 patients (87%), any Grade 3/4 AEs in 17 patients (36%), and any serious AEs in 7 patients (15%). The most common all-Grade AEs were gastrointestinal (nausea in 26 patients [55%] and stomatitis in 24 patients [51%]). A low rate of diarrhea was reported (6 patients [13%], all Grade 1 or 2); 4 patients had anemia and 1 had neutropenia. There were no cases of interstitial lung disease/pneumonitis or thrombocytopenia. Nine patients (19%) and 11 patients (23%) underwent Dato-DXd dose reduction and delay, respectively; 14 (30%) had D dose delay. Treatment was discontinued due to an AE for 3 patients (6%). There were no deaths due to treatment-related AEs. Conclusions: In this updated analysis with additional patients and longer follow-up, the combination of Dato-DXd + D in 1L a/mTNBC demonstrated a manageable safety profile and compelling high response rates with promising durability. Although subgroups were small, responses occurred irrespective of PD-L1 expression. Further investigation of this treatment combination is warranted. Analysis of translational data is ongoing. Funding: AstraZeneca/Daiichi Sankyo Citation Format: Peter Schmid, Piotr Wysocki, Cynthia Ma, Yeon H. Park, Ricardo Fernandes, Simon Lord, Richard D. Baird, Catherine Prady, Kyung Hae Jung, Jamil Asselah, Robert Huisden, Ross Stewart, Petra Vuković, Ana T. Nunes, Zbigniew Nowecki. PD11-09 Datopotamab deruxtecan (Dato-DXd) + durvalumab (D) as first-line (1L) treatment for unresectable locally advanced/metastatic triple-negative breast cancer (a/mTNBC): updated results from BEGONIA, a phase 1b/2 study [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr PD11-09.
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- 2023
13. Model-based Cross-correlation Search for Gravitational Waves from the Low-mass X-Ray Binary Scorpius X-1 in LIGO O3 Data
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The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abe, H., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Alfaidi, R. A., Alléné, C., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Ansoldi, S., Antelis, J. M., Antier, S., Apostolatos, T., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Arogeti, M., Aronson, S. M., Asada, H., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Aubin, F., AultONeal, K., Babak, S., Badaracco, F., Badger, C., Bae, S., Bae, Y., Bagnasco, S., Bai, Y., Baier, J. G., Baird, J., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Baltus, G., Banagiri, S., Banerjee, B., Bankar, D., Barayoga, J. C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Basak, S., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Beirnaert, F., Bejger, M., Belahcene, I., Bell, A. S., Benedetto, V., Beniwal, D., Benoit, W., Bentley, J. D., BenYaala, M., Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bhandare, R., Bhandari, A. V., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bianchi, A., Bilenko, I. A., Bilicki, M., Billingsley, G., Bini, S., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boër, M., Bogaert, G., Boldrini, M., Bolingbroke, G. N., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Caneva, G., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. B., Carpinelli, M., Carrillo, G., Carter, J. J., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakalis, W., Subrahmanya, S. Chalathadka, Champion, E., Chan, C. -H., Chan, C., Chan, C. L., Chan, K., Chan, M., Chandra, K., Chang, I. P., Chang, W., Chanial, P., Chao, S., Chapman-Bird, C., Charlton, P., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chen, C., Chen, D., Chen, H. Y., Chen, J., Chen, K., Chen, X., Chen, Y. -B., Chen, Y. -R., Chen, Y., Cheng, H., Chessa, P., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-Y., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Choudhary, R. K., Choudhary, S., Christensen, N., Chu, Q., Chu, Y-K., Chua, S. S. Y., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Clara, F., Clark, J. A., Clarke, T. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Cohen, D. E., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Cornish, N. J., Corsi, A., Cortese, S., Coschizza, A. C., Cotesta, R., Cottingham, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Craig, K., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., Dana, A., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Datta, Sayantani, Dattilo, V., Dave, I., Davier, M., Davis, D., Davis, M. C., Daw, E. J., Dax, M., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Dell'Aquila, D., Del Pozzo, W., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Diab, R., Díaz, M. C., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Diksha, D., Di Lieto, A., Di Michele, A., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., Doleva, P. P., Donahue, L., D'Onofrio, L., Donovan, F., Dooley, K. L., Dooney, T., Doravari, S., Dorosh, O., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dunn, L., Dupletsa, U., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Eassa, C., Easter, P. J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Enomoto, Y., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etzel, T., Evans, M., Evans, T. M., Evstafyeva, T., Ewing, B. E., Fabrizi, F., Faedi, F., Fafone, V., Fair, H., Fairhurst, S., Fan, P. C., Farah, A. M., Farr, B., Farr, W. M., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, A., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Fong, H. K., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Freed, J. P., Frei, Z., Freise, A., Freitas, O., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fujimoto, Y., Fulda, P., Fyffe, M., Gabbard, H. A., Gabella, W. E., Gadre, B. U., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D. -F., Gao, D., Gaonkar, S. G., Garaventa, B., García-Núñez, C., García-Quirós, C., Gardner, K. A., Gargiulo, J., Garufi, F., Gasbarra, C., Gateley, B., Gayathri, V., Ge, G. -G., Gemme, G., Gennai, A., George, J., Gerberding, O., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Tathagata, Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giri, P., Gissi, F., Gkaitatzis, S., Glanzer, J., Gleckl, A. E., Godoy, F. G., Godwin, P., Goetz, E., Goetz, R., Golomb, J., Goncharov, B., González, G., Gosselin, M., Gouaty, R., Gould, D. W., Goyal, S., Grace, B., Grado, A., Graham, V., Granata, M., Granata, V., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W. L., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruson, A. S., Guerra, D., Guidi, G. M., Guimaraes, A. R., Gulati, H. K., Gulminelli, F., Gunny, A. M., Guo, H. -K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gupta, S. K., Gurs, J., Gustafson, R., Gutierrez, N., Guzman, F., Ha, S., Hadiputrawan, I. P. W., Haegel, L., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O., Hansen, H., Hanson, J., Harada, R., Harder, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasegawa, K., Haskell, B., Haster, C. -J., Hathaway, J. S., Hattori, K., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heidmann, A., Heidt, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J. -S., Hennig, M., Henshaw, C., Hernandez, A. G., Vivanco, F. Hernandez, Heurs, M., Hewitt, A. L., Higginbotham, S., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hirata, N., Hirose, C., Ho, T-C., Hochheim, S., Hofman, D., Hohmann, J. N., Holcomb, D. G., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Q., Hough, J., Hourihane, S., Howell, D., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsieh, B-H., Hsieh, H-F., Hsiung, C., Huang, H-Y., Huang, P., Huang, Y-C., Huang, Y. -J., Huang, Y., Hübner, M. T., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Hyland, J., Iandolo, G. A., Ide, S., Idzkowski, B., Iess, A., Inayoshi, K., Inoue, Y., Iosif, P., Irwin, J., Gupta, Ish, Isi, M., Ito, K., Itoh, Y., Iyer, B. R., JaberianHamedan, V., Jacqmin, T., Jacquet, P. -E., Jadhav, S. J., Jadhav, S. P., Jain, T., James, A. L., Jan, A. Z., Jani, K., Janquart, J., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jarov, S., Jaume, R., Jenkins, A. C., Jenner, K., Jeon, C., Jia, W., Jiang, J., Jin, H. -B., Johns, G. R., Johnston, R., Johny, N., Jones, A. W., Jones, D. I., Jones, P., Jones, R., Joshi, P., Ju, L., Jung, K., Jung, P., Junker, J., Juste, V., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kao, Y., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Kato, T., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaur, T., Kawabe, K., Kawaguchi, K., Kéfélian, F., Keitel, D., Key, J. S., Khadka, S., Khalili, F. Y., Khan, S., Khanam, T., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, J., Kim, K., Kim, P., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., King, B., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Klimenko, S., Klinger, T., Knee, A. M., Knust, N., Kobayashi, Y., Koch, P., Koehlenbeck, S. 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Walle, A, van Dongen, J, van Haevermaet, H, van Heijningen, J, Vanosky, J, van Putten, M, van Ranst, Z, van Remortel, N, Vardaro, M, Vargas, A, Varma, V, Vasúth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, P, Venneberg, J, Venugopalan, G, Verdier, P, Verkindt, D, Verma, P, Verma, Y, Vermeulen, S, Veske, D, Vetrano, F, Viceré, A, Vidyant, S, Viets, A, Vijaykumar, A, Villa-Ortega, V, Vinet, J, Virtuoso, A, Vitale, S, Vocca, H, von Reis, E, von Wrangel, J, Vorvick, C, Vyatchanin, S, Wade, L, Wade, M, Wagner, K, Walet, R, Walker, M, Wallace, G, Wallace, L, Wang, J, Wang, W, Ward, R, Warner, J, Was, M, Washimi, T, Washington, N, Watada, K, Watarai, D, Watchi, J, Wayt, K, Weaver, B, Weaving, C, Webster, S, Weinert, M, Weinstein, A, Weiss, R, Weller, C, Weller, R, Wellmann, F, Wen, L, Weßels, P, Wette, K, Whelan, J, White, D, Whiting, B, Whittle, C, Wilk, O, Wilken, D, Williams, C, Williams, D, Williams, M, Williamson, A, Willis, J, Willke, B, Wipf, C, Woan, G, Woehler, J, Wofford, J, Wojtowicz, I, Wong, D, Wong, I, Wright, M, Wu, C, Wu, D, Wu, H, Wysocki, D, Xiao, L, Yadav, N, Yamada, T, Yamamoto, H, Yamamoto, K, Yamamoto, T, Yamashita, K, Yamazaki, R, Yang, F, Yang, K, Yang, L, Yang, Y, Yap, M, Yeeles, D, Yeh, S, Yelikar, A, Yokoyama, J, Yokozawa, T, Yoo, J, Yoshioka, T, Yu, H, Yuzurihara, H, Zadrożny, A, Zanolin, M, Zeidler, S, Zelenova, T, Zendri, J, Zevin, M, Zhan, M, Zhang, H, Zhang, J, Zhang, L, Zhang, R, Zhang, T, Zhang, Y, Zhao, C, Zhao, G, Zhao, Y, Zheng, Y, Zhou, R, Zhu, X, Zhu, Z, Zimmerman, A, Zucker, M, Zweizig, J, The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire des deux Infinis de Toulouse (L2IT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), (Astro)-Particles Physics, Ackley, K [0000-0002-8648-0767], Adhikari, N [0000-0002-4559-8427], Adhikari, RX [0000-0002-5731-5076], Agathos, M [0000-0002-9072-1121], Aguiar, OD [0000-0002-2139-4390], Aiello, L [0000-0003-2771-8816], Ajith, P [0000-0001-7519-2439], Akutsu, T [0000-0003-0733-7530], Allocca, A [0000-0002-5288-1351], Altin, PA [0000-0001-8193-5825], Amato, A [0000-0001-9557-651X], Anderson, SB [0000-0003-2219-9383], Anderson, WG [0000-0003-0482-5942], Andres, N [0000-0002-5360-943X], Andrés-Carcasona, M [0000-0002-8738-1672], Andrić, T [0000-0002-9277-9773], Antelis, JM 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[0000-0002-3373-5236], Mukund, N [0000-0002-8666-9156], Mu niz, EA [0000-0001-8844-421X], Murray, PG [0000-0002-8218-2404], Nagano, K [0000-0001-6686-1637], Nakamura, K [0000-0001-6148-4289], Nakano, H [0000-0001-7665-0796], Nardecchia, I [0000-0001-5558-2595], Naticchioni, L [0000-0003-2918-0730], Nayak, RK [0000-0002-6814-7792], Ng, SWS [0000-0001-5843-1434], Nguyen, C [0000-0001-8623-0306], Quynh, L Nguyen [0000-0002-1828-3702], Ni, W-T [0000-0001-6792-4708], Nishizawa, A [0000-0003-3562-0990], Nitoglia, E [0000-0001-8906-9159], Novak, J [0000-0002-6029-4712], Nuttall, LK [0000-0002-8599-8791], Obayashi, Y [0000-0001-8791-2608], Oelker, E [0000-0002-3916-1595], Oertel, M [0000-0002-1884-8654], Oh, JJ [0000-0001-5417-862X], Oh, K [0000-0002-9672-3742], Oh, SH [0000-0003-1184-7453], Ohashi, M [0000-0001-8072-0304], Ohkawa, M [0000-0002-1380-1419], Ohme, F [0000-0003-0493-5607], Oliveri, R [0000-0002-7497-871X], Oohara, K [0000-0002-7518-6677], O’Reilly, B [0000-0002-3874-8335], Orselli, M [0000-0003-3563-8576], O’Shaughnessy, R [0000-0001-5832-8517], O’Shea, E [0000-0002-0230-9533], Oshino, S [0000-0002-2794-6029], Ossokine, S [0000-0002-2579-1246], Ottaway, DJ [0000-0001-6794-1591], Palomba, C [0000-0002-4450-9883], Pan, K-C [0000-0002-1473-9880], Pannarale, F [0000-0002-7537-3210], Paoletti, F [0000-0001-8898-1963], Parisi, A [0000-0003-0251-8914], Park, J [0000-0002-7510-0079], Parker, W [0000-0002-7711-4423], Pascucci, D [0000-0003-1907-0175], Passaquieti, R [0000-0003-4753-9428], Patricelli, B [0000-0001-6709-0969], Paul, S [0000-0002-4449-1732], Payne, E [0000-0003-4507-8373], Pegna, R [0000-0002-6532-671X], Pe na Arellano, FE [0000-0002-8516-5159], Penn, S [0000-0003-4956-0853], Pereira, T [0000-0003-1856-6881], Périgois, C [0000-0002-9779-2838], Perreca, A [0000-0002-6269-2490], Petermann, J [0000-0002-8949-3803], Pfeiffer, HP [0000-0001-9288-519X], Pham, KA [0000-0002-7650-1034], Phukon, KS [0000-0003-1561-0760], Piccinni, OJ [0000-0001-5478-3950], Pichot, M [0000-0002-4439-8968], Pierini, L [0000-0003-0945-2196], Pierro, V [0000-0002-6020-5521], Pilo, F [0000-0003-4967-7090], Pinto, IM [0000-0002-2679-4457], Pitkin, MD [0000-0003-4548-526X], Placidi, A [0000-0001-8032-4416], Planas, ML [0000-0001-8278-7406], Plastino, W [0000-0002-5737-6346], Poggiani, R [0000-0002-9968-2464], Polini, E [0000-0003-4059-0765], Poulton, R [0000-0003-2049-520X], Pratten, G [0000-0003-4984-0775], Prodi, GA [0000-0001-5256-915X], Punturo, M [0000-0001-8722-4485], Pürrer, M [0000-0002-3329-9788], Qi, H [0000-0001-6339-1537], Raffai, P [0000-0001-7576-0141], Ramirez, KE [0000-0003-2194-7669], Ramos-Buades, A [0000-0002-6874-7421], Ray, A [0000-0002-7322-4748], Raymond, V [0000-0003-0066-0095], Raza, N [0000-0002-8549-9124], Razzano, M [0000-0003-4825-1629], Rei, L [0000-0002-8690-9180], Relton, P [0000-0003-2756-3391], Rettegno, P [0000-0001-8088-3517], Revenu, B [0000-0002-7629-4805], Richardson, JW [0000-0002-1472-4806], Riles, K [0000-0002-6418-5812], Rinaldi, S [0000-0001-5799-4155], Rocchi, A [0000-0002-1382-9016], Rolland, L [0000-0003-0589-9687], Rollins, JG [0000-0002-9388-2799], Romero, A [0000-0003-2275-4164], Ronchini, S [0000-0003-0020-687X], Roocke, TJ [0000-0003-2640-9683], Ross, MP [0000-0002-8955-5269], Rozza, D [0000-0002-7378-6353], Sachdev, S [0000-0002-0525-2317], Sadiq, J [0000-0001-5931-3624], Saha, S [0000-0002-3333-8070], Sakellariadou, M [0000-0002-2715-1517], Salafia, OS [0000-0003-4924-7322], Salces-Carcoba, F [0000-0001-7049-4438], Saleem, M [0000-0002-3836-7751], Salemi, F [0000-0002-9511-3846], Sallé, M [0000-0002-6620-6672], Samajdar, A [0000-0002-0857-6018], Sanchis-Gual, N [0000-0001-5375-7494], Sanuy, A [0000-0002-5767-3623], Sasli, A [0000-0001-7357-0889], Sathyaprakash, BS [0000-0003-3845-7586], Sauter, O [0000-0003-2293-1554], Savage, RL [0000-0003-3317-1036], Savant, V [0000-0002-4117-2269], Sawada, T [0000-0001-5726-7150], Schiworski, MG [0000-0001-9298-004X], Schmidt, P [0000-0003-1542-1791], Schnabel, R [0000-0003-2896-4218], Schwartz, E [0000-0001-8922-7794], Scott, J [0000-0001-6701-6515], Scott, SM [0000-0002-9875-7700], Seglar-Arroyo, M [0000-0001-8654-409X], Sekiguchi, Y [0000-0002-2648-3835], Setyawati, Y [0000-0003-3718-4491], Shahriar, MS [0000-0002-7981-954X], Shaikh, MA [0000-0003-0826-6164], Shao, L [0000-0002-1334-8853], Shawhan, P [0000-0002-8249-8070], Shcheblanov, NS [0000-0001-8696-2435], Shikano, Y [0000-0003-2107-7536], Shimizu, H [0000-0002-4221-0300], Shimode, K [0000-0002-5682-8750], Shinkai, H [0000-0003-1082-2844], Shoda, A [0000-0002-0236-4735], Shoemaker, DH [0000-0002-4147-2560], Shoemaker, DM [0000-0002-9899-6357], Sigg, D [0000-0003-4606-6526], Silenzi, L [0000-0001-7316-3239], Singer, LP [0000-0001-9898-5597], Singh, D [0000-0001-9675-4584], Singh, MK [0000-0001-8081-4888], Singh, N [0000-0002-1135-3456], Singha, A [0000-0002-9944-5573], Sintes, AM [0000-0001-9050-7515], Slagmolen, BJJ [0000-0002-2471-3828], Smith, JR [0000-0003-0638-9670], Smith, RJE [0000-0001-8516-3324], Soldateschi, J [0000-0002-5458-5206], Somala, SN [0000-0003-2663-3351], Somiya, K [0000-0003-2601-2264], Song, I [0000-0002-4301-8281], Soni, K [0000-0001-8051-7883], Soni, S [0000-0003-3856-8534], Sorrentino, N [0000-0002-1855-5966], Spencer, AP [0000-0003-4418-3366], Spera, M [0000-0003-0930-6930], Steer, DA [0000-0002-8781-1273], Steinlechner, S [0000-0003-4710-8548], Strain, KA [0000-0002-2066-5355], Stratta, G [0000-0003-1055-7980], Stuver, AL [0000-0003-0324-5735], Sudhagar, S [0000-0001-8578-4665], Sugimoto, R [0000-0001-6705-3658], Suh, HG [0000-0003-2662-3903], Sullivan, AG [0000-0002-9545-7286], Summerscales, TZ [0000-0002-4522-5591], Sun, L [0000-0001-7959-892X], Sur, A [0000-0001-6635-5080], Suresh, J [0000-0003-2389-6666], Sutton, PJ [0000-0003-1614-3922], Suzuki, Takamasa [0000-0003-3030-6599], Swinkels, BL [0000-0002-3066-3601], Szczepańczyk, MJ [0000-0002-6167-6149], Szewczyk, P [0000-0002-1339-9167], Tacca, M [0000-0003-1353-0441], Tait, SC [0000-0003-0327-953X], Takahashi, H [0000-0003-0596-4397], Takahashi, R [0000-0003-1367-5149], Takeda, H [0000-0001-9937-2557], Tamanini, N [0000-0001-8760-5421], Tanaka, Takahiro [0000-0001-8406-5183], Tanioka, S [0000-0003-3321-1018], Tao, L [0000-0003-4382-5507], San Martín, EN Tapia [0000-0002-4817-5606], Taruya, A [0000-0002-4016-1955], Tasson, JD [0000-0002-4777-5087], Tenorio, R [0000-0002-3582-2587], Terhune, JES [0000-0001-9078-4993], Terkowski, L [0000-0003-4622-1215], Thompson, JE [0000-0002-0419-5517], Tiwari, Shubhanshu [0000-0003-1611-6625], Tiwari, Srishti [0000-0002-3284-6110], Tiwari, V [0000-0002-1602-4176], Tolley, AE [0000-0001-9841-943X], Tomaru, T [0000-0002-8927-9014], Tomura, T [0000-0002-7504-8258], Torres-Forné, A [0000-0001-8709-5118], e Melo, I Tosta [0000-0001-5833-4052], Tournefier, E [0000-0002-5465-9607], Trapananti, A [0000-0001-7763-5758], Travasso, F [0000-0002-4653-6156], Trenado, J [0000-0002-0714-108X], Tringali, MC [0000-0001-5087-189X], Tripathee, A [0000-0002-6976-5576], Trovato, A [0000-0002-9714-1904], Trozzo, L [0000-0002-8803-6715], Tsang, T [0000-0003-3666-686X], Tse, M [0000-0003-1510-4921], Tsuna, D [0000-0002-6347-3089], Tsutsui, T [0000-0002-2909-0471], Turbang, K [0000-0002-9296-8603], Tuyenbayev, D [0000-0002-4378-5835], Ubach, H [0000-0002-0679-9074], Ubhi, AS [0000-0002-3240-6000], Uchikata, N [0000-0003-0030-3653], Uchiyama, T [0000-0003-2148-1694], Udall, RP [0000-0001-6877-3278], Uehara, T [0000-0003-4375-098X], Ueno, K [0000-0003-3227-6055], Ushiba, T [0000-0002-5059-4033], Utina, A [0000-0003-2975-9208], Vahlbruch, H [0000-0003-2357-2338], Vaidya, N [0000-0003-1843-7545], Vajente, G [0000-0002-7656-6882], Valdes, G [0000-0001-5411-380X], Valentini, M [0000-0003-1215-4552], Valsan, V [0000-0003-0315-4091], Beuzekom, M van [0000-0002-0500-1286], Dael, M van [0000-0002-6061-8131], van den Brand, JFJ [0000-0003-4434-5353], Haevermaet, H van [0000-0003-2386-957X], Heijningen, JV van [0000-0002-8391-7513], Ranst, Z van [0000-0002-0460-6224], Remortel, N van [0000-0003-4180-8199], Varma, V [0000-0002-9994-1761], Vasúth, M [0000-0003-4573-8781], Vecchio, A [0000-0002-6254-1617], Veitch, J [0000-0002-6508-0713], Veitch, PJ [0000-0002-2597-435X], Venneberg, J [0000-0002-2508-2044], Venugopalan, G [0000-0003-4414-9918], Verdier, P [0000-0003-3090-2948], Verkindt, D [0000-0003-4344-7227], Verma, Y [0000-0003-4147-3173], Vermeulen, SM [0000-0003-4227-8214], Veske, D [0000-0003-4225-0895], Viceré, A [0000-0003-0624-6231], Viets, AD [0000-0002-4241-1428], Vijaykumar, A [0000-0002-4103-0666], Villa-Ortega, V [0000-0001-7983-1963], Vitale, S [0000-0003-2700-0767], Vorvick, C [0000-0003-1591-3358], Vyatchanin, SP [0000-0002-6823-911X], Wade, M [0000-0002-5703-4469], Wagner, KJ [0000-0002-7255-4251], Wang, J [0000-0002-1830-8527], Was, M [0000-0002-1890-1128], Washimi, T [0000-0001-5792-4907], Watchi, J [0000-0002-9154-6433], Weinstein, AJ [0000-0002-0928-6784], Weller, RA [0000-0002-2280-219X], Wette, K [0000-0002-4394-7179], Whelan, JT [0000-0001-5710-6576], Whiting, BF [0000-0002-8501-8669], Whittle, C [0000-0002-8833-7438], Wilken, D [0000-0002-7290-9411], Williams, D [0000-0003-3772-198X], Williams, MJ [0000-0003-2198-2974], Williamson, AR [0000-0002-7627-8688], Willis, JL [0000-0002-9929-0225], Willke, B [0000-0003-0524-2925], Woan, G [0000-0003-0381-0394], Wofford, JK [0000-0002-4301-2859], Wong, ICF [0000-0003-2166-0027], Wu, C [0000-0003-3191-8845], Wu, DS [0000-0003-2849-3751], Wysocki, DM [0000-0001-9138-4078], Xiao, L [0000-0003-2703-449X], Yamamoto, H [0000-0001-6919-9570], Yamamoto, K [0000-0002-3033-2845], Yamamoto, T [0000-0002-0808-4822], Yang, FW [0000-0001-9873-6259], Yang, KZ [0000-0001-8083-4037], Yang, L [0000-0002-8868-5977], Yang, Y [0000-0002-3780-1413], Yelikar, AB [0000-0002-8065-1174], Yokoyama, J [0000-0001-7127-4808], Yoo, J [0000-0002-3251-0924], Yu, Hang [0000-0002-6011-6190], Yu, Haocun [0000-0002-7597-098X], Zeidler, S [0000-0001-7949-1292], Zevin, M [0000-0002-0147-0835], Zhang, J [0000-0002-3931-3851], Zhang, R [0000-0001-8095-483X], Zhao, C [0000-0001-5825-2401], Zhao, Y [0000-0003-2542-4734], Zheng, Y [0000-0002-5432-1331], Zhu, XJ [0000-0001-7049-6468], Zhu, Z-H [0000-0002-3567-6743], Zimmerman, AB [0000-0002-7453-6372], Zweizig, J [0000-0002-1521-3397], Apollo - University of Cambridge Repository, Grav. waves and fundamental physics, RS: FSE Grav. waves and fundamental physics, and RS: FSE MSP
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[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE] ,NEUTRON-STARS ,FOS: Physical sciences ,O3 ,General Relativity and Quantum Cosmology (gr-qc) ,Astronomy & Astrophysics ,neutron stars ,General Relativity and Quantum Cosmology ,gravitational waves ,ACCRETION ,LIGO ,neutron star ,Gravitational waves,Gravitational wave astronomy,Neutron stars, Low-mass x-ray binary stars ,PRECISION EPHEMERIDES ,High-Energy Phenomena and Fundamental Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Settore FIS/01 ,Gravitational Waves ,Gravitational Waves, Scorpius X1, LIGO, O3 ,Science & Technology ,Settore FIS/03 ,Physics ,Scorpius X1 ,Astronomy and Astrophysics ,SDG 10 - Reduced Inequalities ,MOUNTAINS ,Physics and Astronomy ,Space and Planetary Science ,5101 Astronomical Sciences ,gravitational wave sources ,Physical Sciences ,RADIATION ,MAXIMUM SPIN FREQUENCY ,Astrophysics - High Energy Astrophysical Phenomena ,51 Physical Sciences - Abstract
We present the results of a model-based search for continuous gravitational waves from the low-mass X-ray binary Scorpius X-1 using LIGO detector data from the third observing run of Advanced LIGO, Advanced Virgo and KAGRA. This is a semicoherent search which uses details of the signal model to coherently combine data separated by less than a specified coherence time, which can be adjusted to balance sensitivity with computing cost. The search covered a range of gravitational-wave frequencies from 25Hz to 1600Hz, as well as ranges in orbital speed, frequency and phase determined from observational constraints. No significant detection candidates were found, and upper limits were set as a function of frequency. The most stringent limits, between 100Hz and 200Hz, correspond to an amplitude h0 of about 1e-25 when marginalized isotropically over the unknown inclination angle of the neutron star's rotation axis, or less than 4e-26 assuming the optimal orientation. The sensitivity of this search is now probing amplitudes predicted by models of torque balance equilibrium. For the usual conservative model assuming accretion at the surface of the neutron star, our isotropically-marginalized upper limits are close to the predicted amplitude from about 70Hz to 100Hz; the limits assuming the neutron star spin is aligned with the most likely orbital angular momentum are below the conservative torque balance predictions from 40Hz to 200Hz. Assuming a broader range of accretion models, our direct limits on gravitational-wave amplitude delve into the relevant parameter space over a wide range of frequencies, to 500Hz or more., 19 pages, Open Access Journal PDF
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- 2023
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14. DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers
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Daniela Jimenez-Harrison, Carol J. Huseby, Claire N. Hoffman, Steven Sher, Dalton Snyder, Brayden Seal, Chunhua Yuan, Hongjun Fu, Vicki Wysocki, Flaviano Giorgini, and Jeff Kuret
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Biochemistry - Published
- 2023
15. Stoma close to the abdominal wound: a real technical problem. A description of a novel care strategy
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Maciej Borejsza-Wysocki, Adam Bobkiewicz, Witold Ledwosiński, Krzysztof Szmyt, Tomasz Banasiewicz, and Łukasz Krokowicz
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Surgery ,General Medicine - Abstract
IntroductionIn some clinical scenarios, stoma site may be located close to the abdominal wound edge impeding optimal wound management and stoma care. We present a novel strategy of utility NPWT for management of simultaneous abdominal wound healing with stoma presence. Material and methodsRetrospective analysis of seventeen patients treated with a novel wound care strategy was conducted. Application of NPWT within wound bed, around stoma site and skin between allows for: 1) separating wound from stoma site, 2) maintaining the optimal environment for wound healing, 3) protecting peristomal skin and 4) facilitating application of ostomy appliances.ResultsThe study group comprised of twelve female (70,6 %) and five male (29,4%) with the mean age of 49.1 18.4 years The most common underlying pathology was Crohn s disease (n-5; 29,4%). Since NPWT was implemented, patients had undergone from 1 to 13 surgeries. Thirteen patients (76,5%) required intensive care unit admission. The mean time of hospital stay was 65,3 28,6 days (range: 36 134). The mean session of NPWT was 10.8 5.2 (range: 5 - 24) per patient. The range of the level of negative pressure was from -80 to 125 mmHg. In all patients, progress in wound healing was achieved resulting in granulation tissue formation, minimizing wound retraction and thus reduction of the wound area. As a result of NPWT, wound was granulated entirely, tertiary intension closure were achieved or patients were qualified for reconstructive surgery.DiscussionNPWT is safe and useful therapy for complicated abdominal wounds with the presence of stoma close to wounds edges. A novel care strategy allows for simultaneous technical opportunity to separate stoma from wound bed and facilitate wound healing.
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- 2023
16. Wyzwania w odtworzeniu cigoci przewodu pokarmowego. Jednoorodkowa analiza 91 pacjentw poddanych operacji odtworzenia
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Maciej Borejsza-Wysocki, Adam Bobkiewicz, Witold Ledwosiński, Krzysztof Szmyt, Tomasz Banasiewicz, and Łukasz Krokowicz
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Surgery ,General Medicine - Abstract
IntroductionRestoration of bowel continuity is associated with a significant postoperative morbidity. The aim of the study was to report the outcomes of the restoring the intestine continuity in a large patient cohort.Material and methodsRetrospective analysis of 91 patients with terminal stoma qualified for restoring GI tract continuity between January 2015 and march 2020 were conducted. Demographic and clinical characteristics such as age, gender, BMI, comorbidities, indication for stoma creation, operative time, the need of blood replacement, site and type of the anastomosis, complication and mortality rates were analyzed.ResultsThe study group comprised of 40 women (44%) and 51 men (56%). The mean BMI was 26.8 4.9 kg/m2. The only 29.7% of patients (n-27) were in normal weight (BMI: 18.524.9) and the only 11% of patients (n-10) did not suffer from any comorbidities. The most common indication for index surgery were: complicated diverticulitis (37.4%) and colorectal cancer (21.9%). Stapled technique was used in majority of patients (n-79; 87%). The mean operative time was 191.7 71.4 minutes. Nine patients (9.9%) required blood replacement peri- or postoperatively, whereas three patients (3.3%) required staying in intensive care unit. The overall surgical complication rate and mortality rate was 36.2% (n-33) and 1.1% (n-1), respectively DisscusionRestoration of bowel continuity is quite demanding and complex procedure and thus should be performed by well experienced surgical team. In majority of patients, complication rate is limited to minor complications. The morbidity and mortality rates are acceptable and comparable to other publications.
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- 2023
17. Janusz Mariański, Godność ludzka w narracji społecznej. Studium socjopedagogiczne, Wydawnictwo KUL, Lublin 2021, ss. 302
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Artur Edward Wysocki
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General Medicine - Published
- 2023
18. Safety and immunogenicity of a primary series and booster dose of the meningococcal serogroup B-factor H binding protein vaccine (MenB-FHbp) in healthy children aged 1–9 years: two phase 2 randomised, controlled, observer-blinded studies
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Helen S Marshall, Timo Vesikari, Peter C Richmond, Jacek Wysocki, Leszek Szenborn, Johannes Beeslaar, Jason D Maguire, Paul Balmer, Robert O'Neill, Annaliesa S Anderson, Jean-Louis Prégaldien, Roger Maansson, Han-Qing Jiang, and John L Perez
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Infectious Diseases - Abstract
The meningococcal serogroup B-factor H binding protein vaccine (MenB-FHbp) is licensed for use in children aged 10 years or older for protection against invasive serogroup B meningococcal disease. Because young children are at increased risk of invasive meningococcal disease, MenB-FHbp clinical data in this population are needed.We conducted two phase 2 randomised, controlled, observer-blinded studies including healthy toddlers (age 12-23 months) across 26 Australian, Czech, Finnish, and Polish centres, and older children (age 2-9 years) across 14 Finnish and Polish centres. Exclusion criteria included previous vaccinations against serogroup B meningococcus or hepatitis A virus (HAV), and chronic antibiotic use. Toddlers were randomly allocated (2:1) via an interactive response technology system to receive either 60 μg or 120 μg MenB-FHbp or HAV vaccine and saline (control). Older children were randomly allocated (3:1) to receive 120 μg MenB-FHbp or control, with stratification by age group (2-3 years and 4-9 years). All vaccinations were administered as three doses (0, 2, and 6 months, with only saline given at 2 months in the control group). Toddlers who received 120 μg MenB-FHbp could receive a 120 μg booster dose 24 months after the end of the primary series. The percentages of participants with serum bactericidal activity using human complement (hSBA) titres at or above the lower limit of quantification (LLOQ; all greater than the 1:4 correlate of protection) against four test strains of serogroup B meningococcus 1 month after the third dose (primary immunogenicity endpoint) were measured in the evaluable immunogenicity populations (participants who received the vaccine as randomised, had available and determinate hSBA results, and had no major protocol violations). Not all participants were tested against all strains because of serum sample volume constraints. The frequencies of reactogenicity and adverse events after each dose were recorded in the safety population (all participants who received at least one dose and had safety data available). These studies are registered with ClinicalTrials.gov (NCT02534935 and NCT02531698) and are completed.Between Aug 31, 2015, and Aug 22, 2016, for the toddler study and between Aug 27, 2015, and March 7, 2016, for the older children study, we enrolled and randomly allocated 396 toddlers (60 μg MenB-FHbp group n=44; 120 μg MenB-FHbp group n=220; control group n=132) and 400 older children (120 μg MenB-FHbp group n=294; control group n=106). 1 month after the third dose, the proportions of participants with hSBA titres at or above the LLOQ ranged across test strains from 85·0% (95% CI 62·1-96·8; 17 of 20 participants) to 100·0% (82·4-100·0; 19 of 19) in toddlers receiving 60 μg MenB-FHbp, and from 71·6% (61·4-80·4; 68 of 95) to 100·0% (96·2-100·0; 95 of 95) in toddlers receiving 120 μg MenB-FHbp, and from 79·1% (71·2-85·6; 106 of 134) to 100·0% (97·4-100·0; 139 of 139) in children aged 2-9 years receiving 120 μg MenB-FHbp. hSBA titres peaked at 1 month after the third primary dose of MenB-FHbp and then declined over time. 24 months after the third dose in the toddler study, the proportions with hSBA titres at or above the LLOQ ranged from 0·0% (0·0-17·6; 0 of 19 participants) to 41·2% (18·4-67·1; seven of 17) in those who received 60 μg MenB-FHbp and from 3·7% (0·8-10·4; three of 81) to 22·8% (14·1-33·6; 18 of 79) in those who received 120 μg MenB-FHbp. 1 month after the booster dose in toddlers, the proportions with hSBA titres at or above the LLOQ were higher than at 1 month after the primary series. MenB-FHbp reactogenicity was mostly transient and of mild to moderate severity. Adverse event frequency was similar between the MenB-FHbp and control groups and less frequent following MenB-FHbp booster than following primary doses. Two participants from the toddler study (both from the 120 μg MenB-FHbp group) and four from the older children study (three from the 120 μg MenB-FHbp group and one from the control group) were withdrawn from the study because of adverse events.MenB-FHbp was well tolerated and induced protective immune responses in a high proportion of participants. These findings support a favourable MenB-FHbp immunogenicity and reactogenicity profile in young children, a population at increased risk of adverse invasive meningococcal disease outcomes.Pfizer.
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19. Adult pneumococcal vaccination – new opportunities
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ERNEST KUCHAR, JOANNA CHOROSTOWSKA-WYNIMKO, LESZEK CZUPRYNIAK, ANDRZEJ FAL, ROBERT FLISIAK, ARTUR MAMCARZ, ANETA NITSCH-OSUCH, ANNA SKOCZYŃSKA, MARCIN STAJSZCZYK, JACEK WYSOCKI, MICHAŁ ABENDROT, DOMINIK GOLICKI, KATARZYNA JAŚKOWIAK, and ADAM ANTCZAK
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General Medicine - Published
- 2023
20. Transformers and the Representation of Biomedical Background Knowledge
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Wysocki, Oskar, Zhou, Zili, O'Regan, Paul, Ferreira, Deborah, Wysocka, Magdalena, Landers, Dónal, and Freitas, André
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FOS: Computer and information sciences ,Computer Science - Machine Learning ,Linguistics and Language ,Computer Science - Computation and Language ,Artificial Intelligence (cs.AI) ,Computer Science - Artificial Intelligence ,Artificial Intelligence ,Computation and Language (cs.CL) ,Language and Linguistics ,Machine Learning (cs.LG) ,Computer Science Applications - Abstract
Specialised transformers-based models (such as BioBERT and BioMegatron) are adapted for the biomedical domain based on publicly available biomedical corpora. As such, they have the potential to encode large-scale biological knowledge. We investigate the encoding and representation of biological knowledge in these models, and its potential utility to support inference in cancer precision medicine - namely, the interpretation of the clinical significance of genomic alterations. We compare the performance of different transformer baselines; we use probing to determine the consistency of encodings for distinct entities; and we use clustering methods to compare and contrast the internal properties of the embeddings for genes, variants, drugs and diseases. We show that these models do indeed encode biological knowledge, although some of this is lost in fine-tuning for specific tasks. Finally, we analyse how the models behave with regard to biases and imbalances in the dataset., Comment: 25 pages, 12 figures, supplementary methods, tables and figures at the end of the manuscript
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- 2023
21. First record of American skunk-cabbage Lysichiton americanus Hultén & H. St. John (Araceae) in Poland
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Marian Bochynek, Adrian Wysocki, and Marek Malicki
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Ecology ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
22. Standing waves in a patient with systemic scleroderma
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Michał Piotr Wysocki, Andrzej Szuba, and Jędrzej Fischer
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Cardiology and Cardiovascular Medicine - Published
- 2022
23. 'Is the West?' – Dmytro Dontsov and His Searching for the Ideal of Civilization
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Roman Wysocki
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General Medicine - Published
- 2022
24. Pamięć. Sposoby i cel pamiętania w chrześcijaństwie antycznym (XLVIII Spotkanie Badaczy Antyku Chrześcijańskiego, Instytut Patrystyczny Augustynianum, Rzym, 5-7.05.2022)
- Author
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Marcin Wysocki
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General Medicine - Abstract
Sprawozdanie z 48. spotkania badaczy antyku chrześcijańskiego, które odbyło się w dniach 5-7 maja 2022 w Istytucie Patrystycznym "Augustynianum" w Rzymie i było poświęcone tematowi: "Pamięć. Sposoby i cel pamiętania w chrześcijaństwie antycznym".
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- 2022
25. Chrześcijanie epoki patrystycznej wobec świata przyrody (IV Międzynarodowa Konferencja Patrystyczna, KUL, Lublin, 18-20.10.2022)
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Marcin Wysocki
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General Medicine - Abstract
Sprawozdanie z IV Międzynarodowej Konferencji Patrystycznej, poświęconej tematowi: "Chrześcijanie epoki patrystycznej wobec świata przyrody", która odbyła sie w Katolickim Uniwersytecie Lubelskim Jana Pawła II w dniach 18-20 października 2022.
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- 2022
26. Post-treatment follow-up in common solid malignancies: expert panel recommendations
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Jacek Jassem, Anna Kowalczyk, Aleksander Biesiada, Renata Duchnowska, Rafał Dziadziuszko, Agnieszka Mastalerz-Migas, Andrzej Kawecki, Maciej Krzakowski, Piotr Potemski, Piotr Rutkowski, and Piotr Wysocki
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Cancer Research ,Oncology - Published
- 2022
27. Urinary Angiotensinogen in Patients With Type 1 Diabetes With Microalbuminuria: Gender Differences and Effect of Intensive Insulin Therapy
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Jessica Navarro, Alejandro Sanchez, Sheeba H. Ba Aqeel, Minghao Ye, Mohammed Z. Rehman, Jan Wysocki, Alfred Rademaker, Mark E. Molitch, and Daniel Batlle
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Nephrology - Abstract
Angiotensinogen (AOG) is the precursor of peptides of the renin angiotensin system (RAS). Because insulin up-regulates transcriptional factors that normally repress kidney AOG synthesis, we evaluated urinary AOG (uAOG) in patients with type 1 diabetes (T1D) and microalbuminuria who are receiving either intensive or conventional insulin therapy.Urine samples from participants of the Diabetes Control and Complications Trial (DCCT) were used for the following: (i) uAOG/creatinine measurements in 103 patients with microalbuminuria and 103 patients with normoalbuminuria, matched for age, gender, disease duration, and allocation to insulin therapy; and (ii) uAOG/creatinine measurements from patients with microalbuminuria allocated to intensive insulin therapy (uAOG was higher in patients who started with microalbuminuria than in those with normoalbuminuria (6.65 vs. 4.0 ng/mg creatinine,In patients with T1D and microalbuminuria, uAOG is increased and varies with gender and the type of insulin therapy independently of AER. This suggests that AOG production is increased in females and it is decreased by intensive insulin therapy. The reduction in uAOG with intensive insulin therapy, by kidney RAS downregulation, may contribute to the known renoprotective action associated with intensive insulin and improved glycemic control.
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- 2022
28. De novo design of obligate ABC-type heterotrimeric proteins
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Sherry Bermeo, Andrew Favor, Ya-Ting Chang, Andrew Norris, Scott E. Boyken, Yang Hsia, Hugh K. Haddox, Chunfu Xu, T. J. Brunette, Vicki H. Wysocki, Gira Bhabha, Damian C. Ekiert, and David Baker
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Structural Biology ,Molecular Biology - Abstract
The de novo design of three protein chains that associate to form a heterotrimer (but not any of the possible two-chain heterodimers) and that can drive the assembly of higher-order branching structures is an important challenge for protein design. We designed helical heterotrimers with specificity conferred by buried hydrogen bond networks and large aromatic residues to enhance shape complementary packing. We obtained ten designs for which all three chains cooperatively assembled into heterotrimers with few or no other species present. Crystal structures of a helical bundle heterotrimer and extended versions, with helical repeat proteins fused to individual subunits, showed all three chains assembling in the designed orientation. We used these heterotrimers as building blocks to construct larger cyclic oligomers, which were structurally validated by electron microscopy. Our three-way junction designs provide new routes to complex protein nanostructures and enable the scaffolding of three distinct ligands for modulation of cell signaling.
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- 2022
29. Intravenous metoprolol versus diltiazem for atrial fibrillation with concomitant heart failure
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Chad T, Compagner, Caitlin R, Wysocki, Emily K, Reich, Lisa Hall, Zimmerman, and Jenna M, Holzhausen
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Adult ,Aged, 80 and over ,Male ,Heart Failure ,Adolescent ,Stroke Volume ,General Medicine ,Middle Aged ,Diltiazem ,Heart Rate ,Atrial Fibrillation ,Emergency Medicine ,Humans ,Female ,Aged ,Metoprolol ,Retrospective Studies - Abstract
Atrial fibrillation (Afib) with rapid ventricular response (RVR) is acutely treated with intravenous push (IVP) metoprolol (MET) or diltiazem (DIL). In heart failure (HF) patients, diltiazem is not recommended due to negative inotropic effects. Studies comparing the treatment of atrial fibrillation often exclude HF. Hirschy et al. evaluated HF patients with concomitant Afib with RVR who received IVP metoprolol or diltiazem to determine their effectiveness and safety. They found similar safety and effectiveness outcomes between the two groups.This retrospective, IRB-approved study evaluated patients presenting to the emergency center (EC) with Afib with RVR and HF from January 1, 2018 to July 31, 2021. Included patients were 18 years of age or older, received IVP metoprolol or diltiazem in the EC, and had a recorded baseline ejection fraction (EF). The primary effectiveness outcome was successful heart rate (HR) control 30 min after treatment with either IVP metoprolol or diltiazem, which was defined as HR100 beats per minute (bpm). Secondary effectiveness outcomes included HR control 60 min post-IVP and at EC discharge or transfer and HR reduction20% at 30 min after IVP, 60 min after IVP, and at time of discharge or transfer. Other secondary outcomes included the time to adequate HR control, the total dose of IVP metoprolol or diltiazem given, any additional rate-controlling agents given, and crossover between metoprolol and diltiazem. Safety outcomes included bradycardia, hypotension, shortness of breath, increased oxygen requirements, change in EF, acute kidney injury or renal replacement therapy.Of 2580 evaluated, 193 patients were included (134 DIL vs. 59 MET) with age 73.3 ± 12.2 years, 63% female. The average EF was 48.2 ± 14.2% and 30% of patients had heart failure with reduced ejection fraction (HFrEF) while 64% had heart failure with preserved ejection fraction (HFpEF). Effective heart rate control 30 min post-IVP was not different between the two groups (55% DIL vs. 41% MET, p = 0.063). DIL effectively controlled HR quicker than MET (13 [9, 125] DIL vs. 27 [5, 50] MET, min, p = 0.009). DIL resulted in greater HR reductions at 30 min (33.2 ± 25.4 DIL vs. 19.7 ± 19.7 MET, bpm, p0.001) and at 60 min (31 ± 23.5 DIL vs. 19.6 ± 19.1 MET, bpm, p = 0.002). DIL also more frequently resulted in a HR reduction of 20% or greater at 30 min (63% DIL vs. 27% MET, p0.001), 60 min post-IVP (59% DIL vs. 41% MET, p = 0.019), and at time of patient discharge or transfer from the EC (70% DIL vs. 49% MET, p = 0.005). No differences in safety outcomes were identified.Acute management of patients with Afib with RVR and HF is challenging. While successful rate control at 30 min was not significantly different between diltiazem and metoprolol, IVP diltiazem reduced HR more quickly and reduced HR by 20% or greater more frequently than IVP metoprolol with no safety outcome differences. Further studies are needed to evaluate diltiazem's safety in patients with Afib and HF.
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- 2022
30. Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war
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Asya Agulnik, Roman Kizyma, Marta Salek, Marcin W Wlodarski, Mikhail Pogorelyy, Aleksandra Oszer, Taisiya Yakimkova, Yuliya Nogovitsyna, Malgorzata Dutkiewicz, Jean-Hugues Dalle, Uta Dirksen, Angelika Eggert, Ana Fernández-Teijeiro, Jeanette Greiner, Kathelijne Kraal, Alexandra Mueller, Lucie Sramkova, Marco Zecca, Paul H Wise, Wojciech Mlynarski, Meghana Avula, Mykhaylo V Adyrov, Pablo Berlanga, Christopher Andrew Blackwood, Eric Bouffet, Piotr Stefan Czauderna, Linda A de Koning, Nuno Jorge dos Reis Farinha, Whitney Baer Foster, Dylan Elizabeth Graetz, Sumit Gupta, Wolfgang Holter, Rachael Emma Hough, Khrystyna Kliuchkivska, Alexandra Kolenova, Julia Kołodrubiec, Daniel C Moreira, Sheena Teresa Mukkada, Iryna Mykychak, Anna Raciborska, Zeena S Salman, Andriy Sopilnyak, Sergiy Tyupa, Anna Vinitsky, Natalia Margarete Wobst, Beth Anne Miller, Suheir Subhi Rasul, Carlos Rodriguez-Galindo, Inna Alanbousi, Sarah Weeks Alexander, Anna Apel, Wioletta Anna Bal, Walentyna Aniela Balwierz, Luisa Basset-Salom, Daniel Bastardo Blanco, Karolina Jadwiga Bauer, Ildar T Bayazitov, Nickhill Hitesh Bhakta, Ewa Iwona Bien, Katarzyna Anna Bieniek, Sally Jane Blair, Khrystyna Ihorivna Bodak, Irina Michael Bordeianu, Joao Maria Braganca, Mihaela Silvia Bucurenci, Elżbieta Beata Budny, Andrii Budzyn, Christopher Carl Bumgardner, Raina Nichole Burditt, Victoria Grace Burnside Clapp, Viacheslav Bykov, Adela Cañete, Monica Carnelli, Elena Cela, Zuzanna Paulina Cepowska, Radoslaw Chaber, Anna Cherner-Drieux, Mariya Chubata, Heidi M Clough, Jolanta Czernicka - Siwecka, Krzysztof Czyzewski, Olha Dashchakovska, Bozenna Malgorzata Dembowska-Baginska, Katarzyna Derwich, Rachel Dommett, Olha Dorosh, Katarzyna Anna Drabko, Monica Desiree Dragomir, Michael Dworzak, Sergii Dyma, Julian Darocus Earl, Martin William English, Dmitry A Evseev, Becky S Farren, Nataliia Fedyk, Severyn Ferneza, Leeanna Elizabeth Fox Irwin, Robert Maciej Gałązkowski, Galyna Ganieva, Vasylyna Garanzha, Marina S Gelman, Jan Krzysztof Godzinski, Anne Francoise Goeres, Rodica Golban, Michael J Griksaitis, Michal Andrzej Hampel, Sara Grace Hastings, Delphine Liliane Heenen, Marcela C Hill, Igor Holiuk, Lukasz Marek Hutnik, Ninela Irga-Jaworska, Oleksandr Istomin, Szymon Lech Janczar, Arman Kacharian, Krzysztof Kalwak, Grażyna Malgorzata Karolczyk, Nataliia Mikolaivna Karpenko, Halyna Katsubo, Bernarda Jadwiga Kaznowska, Alex Kentsis, Petra Ketteler, Anita Kienesberger, Roman Kiselev, Zoryana Kizyma, Hryhorii Klymniuk, Yuliia Kostiuk, Tomasz Kowalik, Olena Kozlova, Vladyslav Kozubenko, Tetyana Kramar, Maryna Krawczuk-Rybak, Irina Kulemzina, Paulina Kurkowska, Andriy S Kuzyk, Ruth Lydia Ladenstein, Pawel Jozef Laguna, Alvaro Lassaletta, Kai Lehmberg, Oksana Leontieva, Serhii Liashenko, Loizos G Loizou, Sonia Anna Lucchetta, Matthew William Lupo, Lesya Lysytsia, Oleksandr Lysytsia, Katarzyna Anna Machnik, Jeff A Mainland, Katarzyna Ewa Matczak, Michal Jacek Matysiak, Pierre Mayeur, Anastasia A Minervina, Volha Mishkova, Agnieszka Joanna Mizia-Malarz, Andres Morales La Madrid, Lucas Moreno, Vadim P Moskvin, Katarzyna Maria Muszyńska-Rosłan, Akoya Janae Nelson, Tomasz Ociepa, Stefano Oltolini, Nataliia Onipko, Andrew Pappas, Amit B Patel, Alina Patrahau, Jennifer L Pauley, Yehor Pavlenko, Andrij Pavlovych, Jarosław Peregud-Pogorzelski, Marta Perek-Polnik, Vanesa Perez, Antonio Perez-Martinez, Yana Pikman, Graziano Pitozzi, Rui Gentil Portugal, Victoria Vita Posternak, Arcangelo Prete, Kathy Pritchard-Jones, Alessandra Radaelli, Tegan Reeves, Dirk Reinhardt, Andrey V Reshetnyak, Andrew Jacob Rider, Carmelo Rizzari, Damiano Rizzi, Karen Gabriela Rodriguez Hermosillo, Olena Ronenko, Aneta Olga Rostowska, Liudmyla Rudko, Firas Mohamed Sakaan, Nadezhda Sakhar, Natallia N Savva, Davide Scaccaglia, Elizabeth Hawthorne Schaeffer, Carina Ursula Schneider, Nicole Scobie, Olena Semeniuk, Roksoliana Shevchyk, Ana I Shuler, Stanislav Shvets, Szymon Pawel Skoczen, William John Smeal, Igor Sokolowski, Anna A Sonkin, Alla Ivanivna Stepanjuk, Andrea Spota, Jaroslav Sterba, Jan Styczynski, Olha Svintsova, Andriy V Synyuta, Tomasz Szczepanski, Paweł Kukiz Szczucinski, Bartosz Miroslaw Szmyd, Maria Tasso Cereceda, Alina Teliuk, Iwona Tomanek, Phoebe Topping, Montserrat Torrent, Joanna Trelińska, Olha Troyanovska, Elena Trubnikova, Lyudmila G Tsurkan, Iryna Tsymbalyuk-Voloshyn, Tomasz Franciszek Urasinski, Agnieszka Urbanek-Dadela, Nataliia Vasilieva, Aksana Vasilyeva, Jaime Verdú-Amorós, Natalia Vilcu-Bajurean, Leo Vinitsky, Giovanni Volpe, Oksana Vorobel, Jacek Tadeusz Wachowiak, Marcin Slawomir Wasiak, Lance Allan Wiedower, Lena Isolde Wuenschel, Mariusz Stanislaw Wysocki, Marina Yurieva, Anastasiia Zagurska, Stanislav S Zakharenko, Aelita V Zakharenko, Khrystyna Zapotochna, Joanna Emilia Zawitkowska, Agulnik, A, Kizyma, R, Salek, M, Wlodarski, M, Pogorelyy, M, Oszer, A, Yakimkova, T, Nogovitsyna, Y, Dutkiewicz, M, Dalle, J, Dirksen, U, Eggert, A, Fernandez-Teijeiro, A, Greiner, J, Kraal, K, Mueller, A, Sramkova, L, Zecca, M, Wise, P, Mlynarski, W, Avula, M, Adyrov, M, Berlanga, P, Blackwood, C, Bouffet, E, Czauderna, P, de Koning, L, dos Reis Farinha, N, Foster, W, Graetz, D, Gupta, S, Holter, W, Hough, R, Kliuchkivska, K, Kolenova, A, Kolodrubiec, J, Moreira, D, Mukkada, S, Mykychak, I, Raciborska, A, Salman, Z, Sopilnyak, A, Tyupa, S, Vinitsky, A, Wobst, N, Miller, B, Rasul, S, Rodriguez-Galindo, C, Alanbousi, I, Alexander, S, Apel, A, Bal, W, Balwierz, W, Basset-Salom, L, Bastardo Blanco, D, Bauer, K, Bayazitov, I, Bhakta, N, Bien, E, Bieniek, K, Blair, S, Bodak, K, Bordeianu, I, Braganca, J, Bucurenci, M, Budny, E, Budzyn, A, Bumgardner, C, Burditt, R, Burnside Clapp, V, Bykov, V, Canete, A, Carnelli, M, Cela, E, Cepowska, Z, Chaber, R, Cherner-Drieux, A, Chubata, M, Clough, H, Czernicka - Siwecka, J, Czyzewski, K, Dashchakovska, O, Dembowska-Baginska, B, Derwich, K, Dommett, R, Dorosh, O, Drabko, K, Dragomir, M, Dworzak, M, Dyma, S, Earl, J, English, M, Evseev, D, Farren, B, Fedyk, N, Ferneza, S, Fox Irwin, L, Galazkowski, R, Ganieva, G, Garanzha, V, Gelman, M, Godzinski, J, Goeres, A, Golban, R, Griksaitis, M, Hampel, M, Hastings, S, Heenen, D, Hill, M, Holiuk, I, Hutnik, L, Irga-Jaworska, N, Istomin, O, Janczar, S, Kacharian, A, Kalwak, K, Karolczyk, G, Karpenko, N, Katsubo, H, Kaznowska, B, Kentsis, A, Ketteler, P, Kienesberger, A, Kiselev, R, Kizyma, Z, Klymniuk, H, Kostiuk, Y, Kowalik, T, Kozlova, O, Kozubenko, V, Kramar, T, Krawczuk-Rybak, M, Kulemzina, I, Kurkowska, P, Kuzyk, A, Ladenstein, R, Laguna, P, Lassaletta, A, Lehmberg, K, Leontieva, O, Liashenko, S, Loizou, L, Lucchetta, S, Lupo, M, Lysytsia, L, Lysytsia, O, Machnik, K, Mainland, J, Matczak, K, Matysiak, M, Mayeur, P, Minervina, A, Mishkova, V, Mizia-Malarz, A, Morales La Madrid, A, Moreno, L, Moskvin, V, Muszynska-Roslan, K, Nelson, A, Ociepa, T, Oltolini, S, Onipko, N, Pappas, A, Patel, A, Patrahau, A, Pauley, J, Pavlenko, Y, Pavlovych, A, Peregud-Pogorzelski, J, Perek-Polnik, M, Perez, V, Perez-Martinez, A, Pikman, Y, Pitozzi, G, Portugal, R, Posternak, V, Prete, A, Pritchard-Jones, K, Radaelli, A, Reeves, T, Reinhardt, D, Reshetnyak, A, Rider, A, Rizzari, C, Rizzi, D, Rodriguez Hermosillo, K, Ronenko, O, Rostowska, A, Rudko, L, Sakaan, F, Sakhar, N, Savva, N, Scaccaglia, D, Schaeffer, E, Schneider, C, Scobie, N, Semeniuk, O, Shevchyk, R, Shuler, A, Shvets, S, Skoczen, S, Smeal, W, Sokolowski, I, Sonkin, A, Stepanjuk, A, Spota, A, Sterba, J, Styczynski, J, Svintsova, O, Synyuta, A, Szczepanski, T, Szczucinski, P, Szmyd, B, Tasso Cereceda, M, Teliuk, A, Tomanek, I, Topping, P, Torrent, M, Trelinska, J, Troyanovska, O, Trubnikova, E, Tsurkan, L, Tsymbalyuk-Voloshyn, I, Urasinski, T, Urbanek-Dadela, A, Vasilieva, N, Vasilyeva, A, Verdu-Amoros, J, Vilcu-Bajurean, N, Vinitsky, L, Volpe, G, Vorobel, O, Wachowiak, J, Wasiak, M, Wiedower, L, Wuenschel, L, Wysocki, M, Yurieva, M, Zagurska, A, Zakharenko, S, Zakharenko, A, Zapotochna, K, and Zawitkowska, J
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Neoplasms ,Medizin ,Ethnicity ,cancer ,Humans ,war ,MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Hematology ,Child ,Hematologic Diseases ,blood disorder - Published
- 2022
31. Macrophage Activation Syndrome Complicated by Toxic Epidermal Necrolysis Following SARS-CoV-2 mRNA Vaccination
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Lauren E. Franzblau, Melissa Mauskar, and Christian A. Wysocki
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Immunology ,Immunology and Allergy - Published
- 2022
32. Modeling an immune response to influenza A virus infection in alveolar epithelial cells
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Marissa L. Miller, Deborah M. Brown, and Tadeusz A. Wysocki
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Bioengineering ,Applied Microbiology and Biotechnology ,Biotechnology - Abstract
Influenza A viruses (IAV) have been the cause of several influenza pandemics in history and are a significant threat for the next global pandemic. Hospitalized influenza patients often have excess interferon production and a dysregulated immune response to the IAV infection. Obtaining a better understanding of the mechanisms of IAV infection that induce these harmful effects would help drug developers and health professionals create more effective treatments for IAV infection and improve patient outcomes. IAV stimulates viral sensors and receptors expressed by alveolar epithelial cells, like RIG-I and toll-like receptor 3 (TLR3). These two pathways coordinate with one another to induce expression of type III interferons to combat the infection. Presented here is a queuing theory-based model of these pathways that was designed to analyze the timing and amount of interferons produced in response to IAV single stranded RNA and double-stranded RNA detection. The model accurately represents biological data showing the necessary coordination of the RIG-I and TLR3 pathways for effective interferon production. This model can serve as the framework for future studies of IAV infection and identify new targets for potential treatments.
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- 2022
33. A Sense of National Pride in Central and Eastern Europe Based on Data from EVS and WVS
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Artur Wysocki
- Published
- 2022
34. The Impact of Remote work During the COVID-19 Pandemic on the Development of Competences in Selected Areas of Project Management
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Wiesław Danielak and Robert Wysocki
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General Medicine - Published
- 2022
35. Recovery from open osteocapsular débridement for primary elbow osteoarthritis is rapid and does not depend on preoperative motion
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Farhan Ahmad, Sal Ayala, Nabil Mehta, Mark S. Cohen, Xavier C. Simcock, and Robert W. Wysocki
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Orthopedics and Sports Medicine ,Surgery - Abstract
Osteocapsular débridement is a surgical treatment for functionally limiting primary elbow osteoarthritis (PEOA). We hypothesized that postoperative improvement in range of motion (ROM) following elbow osteocapsular débridement could be grouped into predictable patterns. We also hypothesized that significant improvements in ROM frequently take place for up to 6 months after surgery.A retrospective chart review of patients who underwent open elbow débridement for PEOA was performed. Demographic information and surgical approach were recorded. ROM data were also collected at preoperative, intraoperative, and postoperative intervals of 2 weeks, 6 weeks, 3 months, and 6 months. Growth mixture modeling and latent class growth analysis were performed to identify groups of motion recovery trajectories, while Student's t-tests were performed to compare ROM data between intervals.Our study included 76 patients who underwent open elbow débridement (9 with a lateral approach, 55 medial, and 12 both) for PEOA. The mean preoperative arc of motion was 95° ± 22°. This improved to a mean final motion arc of 127° ± 11 at final follow-up, which was 92% of the mean intraoperative arc. The mean time to achieve final motion was 3 months, with 79% of patients achieving their final ROM arc by this point. Patients achieved an average of 85% of their final arc of motion by the 2-week postoperative visit (92% of final flexion and 61% of final extension). Growth mixture modeling and latent class growth analysis did not identify any statistically significant groupings for postoperative ROM progression trajectories. Arc of motion preoperatively, intraoperatively, and at 2 weeks postoperatively did not correlate with the final arc of motion. There were no characteristics or thresholds of motion which conferred a higher likelihood of achieving a better result postoperatively.ROM recovery after osteocapsular débridement for PEOA is not dependent on preoperative, intraoperative, or 2-week postoperative arcs of motion. Most of the ROM recovery occurs in the early postoperative period, with flexion restored preferentially faster than extension. The final arc of motion can be expected by 3 months postoperatively. This knowledge has potential benefit in affecting patients' personal time commitment to rehabilitation and the overall cost for therapy and splinting beyond the 3-month time point.
- Published
- 2022
36. Computational Insights into Electronic Excitations, Spin–Orbit Coupling Effects, and Spin Decoherence in Cr(IV)-Based Molecular Qubits
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Karolina Janicka, Aleksander L. Wysocki, and Kyungwha Park
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Chemical Physics (physics.chem-ph) ,Condensed Matter - Materials Science ,Quantum Physics ,Physics - Chemical Physics ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Physical and Theoretical Chemistry ,Quantum Physics (quant-ph) - Abstract
The great success of point defects and dopants in semiconductors for quantum information processing has invigorated a search for molecules with analogous properties. Flexibility and tunability of desired properties in a large chemical space have great advantages over solid-state systems. The properties analogous to point defects were demonstrated in Cr(IV)-based molecular family, Cr(IV)(aryl)$_4$, where the electronic spin states were optically initialized, read out, and controlled. Despite this kick-start, there is still a large room for enhancing properties crucial for molecular qubits. Here we provide computational insights into key properties of the Cr(IV)-based molecules aimed at assisting chemical design of efficient molecular qubits. Using the multireference ab-initio methods, we investigate the electronic states of Cr(IV)(aryl)$_4$ molecules with slightly different ligands, showing that the zero-phonon line energies agree with the experiment, and that the excited spin-triplet and spin-singlet states are highly sensitive to small chemical perturbations. By adding spin-orbit interaction, we find that the sign of the uniaxial zero-field splitting (ZFS) parameter is negative for all considered molecules, and discuss optically-induced spin initialization via non-radiative intersystem crossing. We quantify (super)hyperfine coupling to the $^{53}$Cr nuclear spin and to the $^{13}$C and $^1$H nuclear spins, and we discuss electron spin decoherence. We show that the splitting or broadening of the electronic spin sub-levels due to superhyperfine interaction with $^1$H nuclear spins decreases by an order of magnitude when the molecules have a substantial transverse ZFS parameter., 34 pages, 7 figures
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- 2022
37. The effectiveness of modified sodium bicarbonate in the purification of exhaust gases from HCl and HF
- Author
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D. Wysocki and A. Szymanek
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Mechanics of Materials ,General Materials Science ,Industrial and Manufacturing Engineering - Abstract
The effectiveness of gas purification depends on the sorption properties of sorbents. The aim of the research was to determine the ability of sodium sorbents to remove gaseous pollutants such as HCl and HF. The research used baking soda subjected to mechanical and thermal activation, which was introduced into the hot flue gas circuit, similar to the dry flue gas cleaning method used in all kinds of boilers. In almost all cases, mechanical and thermal treatment of baking soda allowed for a significant improvement in the reduction of hydrogen chloride and hydrogen fluoride concentrations in the exhaust gases produced during the combustion of polyethylene terephthalate (PET) bottles. The preparation of sorbents must consider the optimum development of the material's specific surface area, especially during thermal activation, to prevent pores from sintering. In wet and dry flue gas cleaning processes, sodium compounds are used in the power industry. Appropriate preparation of the sorbent allows for improving the effectiveness of reducing the concentration of harmful substances and reducing investment and operating costs. From the point of view of process optimisation, the results obtained will contribute to the identification of optimal operating conditions in dry sorbent injection systems to prevent the pores on the surface of the sorbent from clogging when injected into hot flue gases.
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- 2022
38. Laser powder bed fusion (LPBF) of NiTi alloy using elemental powders: the influence of remelting on printability and microstructure
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Agnieszka Chmielewska, Bartlomiej Adam Wysocki, Elżbieta Gadalińska, Eric MacDonald, Bogusława Adamczyk-Cieślak, David Dean, and Wojciech Świeszkowski
- Subjects
Mechanical Engineering ,Industrial and Manufacturing Engineering - Abstract
Purpose The purpose of this paper is to investigate the effect of remelting each layer on the homogeneity of nickel-titanium (NiTi) parts fabricated from elemental nickel and titanium powders using laser powder bed fusion (LPBF). In addition, the influence of manufacturing parameters and different melting strategies, including multiple cycles of remelting, on printability and macro defects, such as pore and crack formation, have been investigated. Design/methodology/approach An LPBF process was used to manufacture NiTi alloy from elementally blended powders and was evaluated with the use of a remelting scanning strategy to improve the homogeneity of fabricated specimens. Furthermore, both single melt and up to two remeltings were used. Findings The results indicate that remelting can be beneficial for density improvement as well as chemical and phase composition homogenization. Backscattered electron mode in scanning electron microscope showed a reduction in the presence of unmixed Ni and Ti elemental powders in response to increasing the number of remelts. The microhardness values of NiTi parts for the different numbers of melts studied were similar and ranged from 487 to 495 HV. Nevertheless, it was observed that measurement error decreases as the number of remelts increases, suggesting an increase in chemical and phase composition homogeneity. However, X-ray diffraction analysis revealed the presence of multiple phases regardless of the number of melt runs. Originality/value For the first time, to the best of the authors’ knowledge, elementally blended NiTi powders were fabricated via LPBF using remelting scanning strategies.
- Published
- 2022
39. Research of Accuracy of RSSI Fingerprint-Based Indoor Positioning BLE System
- Author
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Michał Wysocki
- Subjects
Electrical and Electronic Engineering - Published
- 2022
40. Relationship Between Preoperative and Postoperative Motion After Four-Corner Wrist Fusion for Osteoarthritis: Clustering and Regression Analyses
- Author
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Farhan Ahmad, Salvador Ayala, Shelby Smith, John J. Fernandez, Mark S. Cohen, Xavier C. Simcock, and Robert W. Wysocki
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Scaphoid Bone ,Wrist Joint ,Osteoarthritis ,Arthrodesis ,Cluster Analysis ,Humans ,Regression Analysis ,Orthopedics and Sports Medicine ,Surgery ,Range of Motion, Articular ,Wrist ,Retrospective Studies - Abstract
Four-corner fusion (4CF) is a surgical option for refractory scapholunate advanced collapse and scaphoid nonunion advanced collapse wrist arthritis. Preoperative range of motion (ROM) predicts outcomes in many orthopedic procedures. This study investigates ROM in a cohort of 4CF patients to examine the relationship between preoperative and postoperative motion and identifies different clinical patterns.We performed a retrospective review of 4CF patients. Patients with a history of inflammatory arthritis and radiographic characteristics of inflammation were excluded. Demographics, prior wrist surgery history, and ROM data were collected at preoperative and postoperative intervals after cast removal at 8 weeks, 3 months, and 8 months. Regression analysis compared the motion before and after 4CF. Subsequent cluster analysis to reduce confounding compared postoperative motion differences in the top 20% to the bottom 20% of patients by preoperative motion.We included 148 patients; 27 had prior surgery on the ipsilateral wrist. Preoperative arc averaged 86° ± 28° (flexion 46° ± 17°, extension 40° ± 15°); 8-week arc 43° ± 19° (flexion 19° ± 12°, extension 24° ± 12°); 3-month arc 62° ± 17° (flexion 30° ± 12°, extension 32° ± 11°); and 8-month arc 74° ± 17° (flexion 36° ± 11°, extension 37° ± 12°). Preoperative and final arcs were (r = 0.39). Clustering by the preoperative arc, the top 20% (mean 124° ± 15°) achieved a mean final arc of 81° ± 16°, while the bottom 20% (mean 47° ± 16°) achieved a mean final arc of 65° ± 19°. Intercluster differences were statistically significant. The bottom 20% gained motion postoperatively. Most patients in the middle 60% did not differ significantly in postoperative motion.Although wrist motion following 4CF correlates positively with preoperative motion, most patients do not differ significantly in postoperative motion. Patients with substantial preoperative motion deficits gain motion after 4CF. This information is important when counseling patients, determining the timing of surgical intervention, and managing expectations related to motion outcomes.Prognostic II.
- Published
- 2022
41. Simulation of Energy-Resolved Mass Spectrometry Distributions from Surface-Induced Dissociation
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Justin T. Seffernick, SM Bargeen Alam Turzo, Sophie R. Harvey, Yongseok Kim, Árpád Somogyi, Shir Marciano, Vicki H. Wysocki, and Steffen Lindert
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Physical Phenomena ,Tandem Mass Spectrometry ,Humans ,Proteins ,Computer Simulation ,Sudden Infant Death ,Analytical Chemistry - Abstract
Understanding the relationship between protein structure and experimental data is crucial for utilizing experiments to solve biochemical problems and optimizing the use of sparse experimental data for structural interpretation. Tandem mass spectrometry (MS/MS) can be used with a variety of methods to collect structural data for proteins. One example is surface-induced dissociation (SID), which is used to break apart protein complexes (via a surface collision) into intact subcomplexes and can be performed at multiple laboratory frame SID collision energies. These energy-resolved MS/MS experiments have shown that the profile of the breakages depends on the acceleration energy of the collision. It is possible to extract an appearance energy (AE) from energy-resolved mass spectrometry (ERMS) data, which shows the relative intensity of each type of subcomplex as a function of SID acceleration energy. We previously determined that these AE values for specific interfaces correlated with structural features related to interface strength. In this study, we further examined the structural relationships by developing a method to predict the full ERMS plot from the structure, rather than extracting a single value. First, we noted that for proteins with multiple interface types, we could reproduce the correct shapes of breakdown curves, further confirming previous structural hypotheses. Next, we demonstrated that interface size and energy density (measured using Rosetta) correlated with data derived from the ERMS plot (
- Published
- 2023
42. Doroczna Konferencja Północnoamerykańskiego Towarzystwa Patrystycznego (NAPS) (Chicago, USA, 26-28.05.2022)
- Author
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Marcin Wysocki
- Subjects
General Medicine - Abstract
Sprawozdanie z dorocznej Konferencji Północnoamerykańskiego Towarzystwa Patrystycznego (NAPS), która odbyła się w dniach 26-28 maja 2022 w Chicago, USA.
- Published
- 2022
43. Synthesis, structure and sulfonamide–sulfonimide tautomerism of sulfonamide–1,2,4-triazine derivatives
- Author
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Danuta Branowska, Waldemar Wysocki, Ewa Wolińska, Karolina Koc, Katarzyna Stańska, Barbara Mirosław, and Zbigniew Karczmarzyk
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Models, Molecular ,Inorganic Chemistry ,Sulfonamides ,Triazines ,Materials Chemistry ,Hydrogen Bonding ,Physical and Theoretical Chemistry ,Crystallography, X-Ray ,Condensed Matter Physics - Abstract
Two new 1,2,4-triazine-containing sulfonamide derivatives, namely, 4-bromo-N-(5,6-diphenyl-2H-1,2,4-triazin-3-ylidene)benzenesulfonamide, C21H15BrN4O4S, 3a, and methyl 2-{[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfamoyl]methyl}benzoate, C24H20N4O4S, 3b, which crystallize in the different sulfonimide and sulfonamide tautomeric forms, respectively, were synthesized and characterized by spectroscopic, X-ray diffraction and theoretical calculation methods. Both molecules adopt a very similar conformation of the common part of the structure and the differences occur within the substituents on the sulfonamide group. The amino groups characteristic for the existing tautomeric forms are involved in strong intermolecular N—H...N and N—H...O hydrogen bonds in 3a and 3b, respectively. The Hirshfeld surface analysis showed that H...H contacts constitute a high percentage of the intermolecular interactions. Theoretical calculations at the ab initio DFT/B3LYP/6-311++G(d,p) level showed that the two tautomeric forms observed for 3a and 3b can co-exist in chloroform, ethanol and water solutions, with a distinct predominance of the sulfonamide form; the participation of the sulfonimide form increases with increasing solvent polarity.
- Published
- 2022
44. Chemical Polishing of Additively Manufactured, Porous, Nickel–Titanium Skeletal Fixation Plates
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Agnieszka Chmielewska, Wojciech Święszkowski, David Dean, Mohammad Elahinia, Ahmadreza Jahadakbar, and Bartłomiej Wysocki
- Subjects
Low modulus ,Materials science ,Nickel titanium ,Materials Science (miscellaneous) ,Pseudoelasticity ,Polishing ,Skeletal fixation ,Shape-memory alloy ,Composite material ,Elasticity (economics) ,Porosity ,Industrial and Manufacturing Engineering - Abstract
Nickel–titanium (NiTi) alloys have shown promise for a variety of biomedical applications because of their unique properties of shape memory, superelasticity, and low modulus of elasticity (Young's...
- Published
- 2022
45. Factors Associated with the Occurrence and Healing of Umbilical Pilonidal Sinus: A Rare Clinical Entity
- Author
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Arda, Isik, Arkadiusz Peter, Wysocki, Ufuk, Memiş, Efe, Sezgin, Assel, Yezhikova, and Yersultan, Islambekov
- Subjects
Male ,Advanced and Specialized Nursing ,Wound Healing ,Pilonidal Sinus ,Umbilicus ,Humans ,Female ,Dermatology ,Skin Diseases ,Retrospective Studies - Abstract
Pilonidal sinus disease (PSD) is a chronic inflammatory condition of skin that is thought to be related to implanted loose hair. Although PSD is most frequently seen in the sacrococcygeal region, it can also occur at the axilla, perineum, suprapubic regions, hands, and umbilicus. The aim of this project was to find factors influencing the development and treatment of umbilical PSD.In this retrospective study, the authors evaluated 82 patients (19 women, 63 men) with a history of umbilical PSD between 2012 and 2020 to determine predisposing factors and treatment modalities.There was a 20% concordance with intergluteal PSD. Smoking was the only modifying factor for recurrence. The three different treatment methods studied (conservative treatment, surgical treatment, silver nitrate) did not differ in recurrence rate (P = .57).Because of its rare nature, umbilical PSD can be misdiagnosed or underdiagnosed. Key aspects of treatment include smoking cessation and a conservative approach.
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- 2022
46. Radiographic Assessment of Ankle Fracture Displacement: A Validation Study
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I. Leah Gitajn, Roman M. Natoli, Clay A. Spitler, Reza Firoozabadi, Lauren M. Tatman, Joshua L. Gary, Michael F. Githens, Richard E. Thompson, Andrea DeLuca, Lisa Reider, Elizabeth Wysocki, and William Obremskey
- Subjects
Humans ,Reproducibility of Results ,Orthopedics and Sports Medicine ,Surgery ,Ankle ,Ankle Fractures ,Ankle Joint ,Talus - Abstract
Background: Ankle fracture displacement is an important outcome in clinical research examining the effectiveness of surgical and rehabilitation interventions. However, the assessment of displacement remains subjective without well-described or validated measurement methods. The aim of this study was to assess inter- and intrarater reliability of ankle fracture displacement radiographic measures and select measurement thresholds that differentiate displaced and acceptably reduced fractures. Methods: Eight fellowship-trained orthopaedic surgeons evaluated a set of 26 postoperative ankle fracture radiographs on 2 occasions. Surgeons followed standardized instructions for making 5 measurements: coronal displacement (3) talar tilt (1), and sagittal displacement (1). Inter- and intraobserver interclass correlations were determined by random effects regression models. Logistic regression was used to determine the optimal sensitivity and specificity for the measurements with the highest correlation. Results: Three of the 5 measures had excellent interobserver reliability (correlation coefficient > 0.75): (1) coronal plane distance between the lateral border of tibia and lateral border of talus, (2) coronal plane talar tilt, and (3) sagittal plane displacement. The threshold that best discriminated displaced from well-aligned fractures was 2 mm for coronal plane distance (sensitivity 82.1%, specificity 85.4%), 3 degrees for talar tilt (sensitivity 80.4%, specificity 82.2%), and 5 mm for sagittal plane distance (sensitivity 83.9%, specificity 84.9%). Conclusion: This study identified 3 reliable measures of ankle fracture displacement and determined optimal thresholds for discriminating between displaced and acceptably reduced fractures. These measurement criteria can be used for the design and conduct of clinical research studying the impact of surgical treatment and rehabilitation interventions.
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- 2022
47. Nucleic Acids Research
- Author
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Hong-Duc Phan, Andrew S Norris, Chen Du, Kye Stachowski, Bela H Khairunisa, Vaishnavi Sidharthan, Biswarup Mukhopadhyay, Mark P Foster, Vicki H Wysocki, and Venkat Gopalan
- Subjects
ribonuclease-p ,Protein Conformation ,Archaeal Proteins ,crystal-structure ,pyrococcus-horikoshii ot3 ,insights ,Ribonuclease P ,Structure-Activity Relationship ,archaeal homolog ,RNA, Transfer ,Methanocaldococcus ,reconstitution ,Genetics ,subunit ,protein-protein ,complex ,furiosus rpp21 - Abstract
RNase P is a ribonucleoprotein (RNP) that catalyzes removal of the 5 ' leader from precursor tRNAs in all domains of life. A recent cryo-EM study of Methanocaldococcus jannaschii (Mja) RNase P produced a model at 4.6-angstrom resolution in a dimeric configuration, with each holoenzyme monomer containing one RNase P RNA (RPR) and one copy each of five RNase P proteins (RPPs; POP5, RPP30, RPP21, RPP29, L7Ae). Here, we used native mass spectrometry (MS), mass photometry (MP), and biochemical experiments that (i) validate the oligomeric state of the Mja RNase P holoenzyme in vitro, (ii) find a different stoichiometry for each holoenzyme monomer with up to two copies of L7Ae, and (iii) assess whether both L7Ae copies are necessary for optimal cleavage activity. By mutating all kink-turns in the RPR, we made the discovery that abolishing the canonical L7Ae-RPR interactions was not detrimental for RNase P assembly and function due to the redundancy provided by protein-protein interactions between L7Ae and other RPPs. Our results provide new insights into the architecture and evolution of RNase P, and highlight the utility of native MS and MP in integrated structural biology approaches that seek to augment the information obtained from low/medium-resolution cryo-EM models. NIH [GM-120582, P41 GM128577, S10OD023582]; NASA [NNX13AI05G]; Virginia Tech Agricultural Experiment Station Hatch Program [CRIS project] [VA160021]; OSU Comprehensive Cancer Center for a Pelotonia Pre-doctoral Fellowship; Virginia Tech Genetics, Bioinformatics, and Computational Biology Doctoral Program Fellowship Published version NIH [GM-120582 to M.P.F., V.H.W., V.G., P41 GM128577 to V.H.W., S10OD023582 to J.E.J.]; NASA [NNX13AI05G to B.M.]; Virginia Tech Agricultural Experiment Station Hatch Program [CRIS project VA160021 to B.M.]; OSU Comprehensive Cancer Center for a Pelotonia Pre-doctoral Fellowship (to H.D.P.); Virginia Tech Genetics, Bioinformatics, and Computational Biology Doctoral Program Fellowship (to B.K.). Funding for open access charge: University funds.
- Published
- 2022
48. Use of hydraulic model in real water loss reduction and water distribution network operational cost lowering
- Author
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Artur Zajkowski, Łukasz Wysocki, Piotr Tuz, Izabela Bartkowska, and Wojciech Kruszynski
- Subjects
Economics and Econometrics ,Ecology ,Management, Monitoring, Policy and Law - Abstract
Most of the small water companies supplying a small number of consumers with water are struggling with the extremely tight budget, often making any large-scale modernisation impossible. In effect network managed by these companies is often very leaky and unreliable. One possible and cheap way of leakage reduction is the reduction of average pressure in the network. Thanks to new computing technologies, the device selection process for pressure reduction is accurate and easy to do. This study uses the hydraulic model to select required pressure-reducing valves and correct locations accurately and adequately approximate the resulting absolute water loss reduction thanks to this approach.
- Published
- 2022
49. Distributions of finite order in the operational calculus
- Author
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Hubert Wysocki
- Subjects
General Mathematics - Published
- 2022
50. The genomics of COVID
- Author
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Diane, Seibert and Kenneth, Wysocki
- Subjects
COVID-19 ,Humans ,Genomics ,General Medicine ,General Nursing - Abstract
Coronaviruses, named for their crown-like appearance, are relative newcomers to the human viral encyclopedia, but they are anything but new to the viral landscape. Initially thought to cause relatively mild disease in humans, it is now clear that coronaviruses can cause significant morbidity and mortality. COVID-19 provided a ringside seat from which to watch scientists use genomics in hundreds of ways to learn about, protect against, and ultimately control the effects of this novel virus. This article provides an overview of how genomics was used from the very first reported case in Wuhan, China to the development of at-home test kits, vaccines, and understanding the genetic association with increased risk for severe illness.
- Published
- 2022
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