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We reported the catalytic asymmetric construction of the axially chiral 3,4′-indole–pyrazole skeleton, a bis-pentatomic heteroaryl scaffold in many bioactive molecules.

A stereoselective organocatalytic strategy was developed to synthesize the axially chiral naphthoquinone thioglycosides from aryl-naphthoquinones and thiosugars. The reaction pathway involves atroposelective addition and stereoretentive oxidation.

Additional file 1: Supplementary Table S1. Summary statistics of SNPs used in GRS construction. Supplementary Table S2. RNAm_SNPs identified for RA. Supplementary Table S3. The linkage disequilibrium of the identified RNAm-SNPs with the HLA-DRB1 SNP. Supplementary Table S4. Associations between RNAm-SNPs and gene expressions in blood cells. Supplementary Table S5. Associations between gene expressions in blood cells and RA identified in SMR analysis. Supplementary Table S6. Associations between RA-associated RNAm-SNPs and plasma protein levels.

Developing efficient strategies for synthesizing novel diazocine compounds is valuable because their use has been limited by their synthetic accessibility. This work describes the catalytic (4+3) cycloaddition reaction of carbonyl ylides with azoalkenes generated

Additional file 1. S1: Radiomics feature extraction. Table S1: Radiomic features used in this study. Table S2: Available options for each step in the radiomics model development pipeline. S2: Details of the radiomics modeling pipelines.

An efficient formal (3 + 1 + 1) carboannulation strategy of Morita-Baylis-Hillman (MBH) carbonates with pyridinium ylides was developed for constructing diversely functionalized spiro-cyclopentadiene oxindoles. The reaction initiates with an SN2' olefination of MBH carbonates with pyridinium ylides. The in situ generated dienes then engage in a challenging (4 + 1) ylide carboannulation, which has been rarely reported before. The reaction features broad substrate scope as well as high chemo- and regioselectivity. (3 + 1 + 1) carboannulation products could be easily transformed into interesting spiro-cyclopenta[c]furan oxindoles.