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Summary1. Polycythemic mice and hypophysectomized rats were used as assay animals to measure the erythropoietic stimulating activity of synthetic angiotensin II (A-S) and of angiotensin II made from a crude extract of the hog kidney (A-CE). 2. No increase in erythropoietic activity, as measured by the red blood cell incorporation of Fe59, was found following injection of these substances. The assay animals were responsive to a concentrated sheep plasma erythropoietin. 3. These results suggest that the reninangiotensin system does not encompass erythropoietin but do not rule out the possibility that a second material is released by the juxtaglomerular cells.

Excerpt The value of drastically reducing sodium intake in treating the edema of congestive heart failure is generally accepted. Concerning the optimal water intake during such sodium restriction r...

The physiological effects of oral contraceptives and their predisposition to the development of phlebitis are discussed. 2 major factors that are known to be important in the development of thrombophlebitis are stressed: 1) stasis or reduced velocity of the flow of blood within the affected veins 2) increased coagulability of the blood. Studies done on women during pregnancy and while taking oral contraceptives are reviewed in relation to these 2 factors. The blood vessels were shown to dilate abnormally which in turn caused a reduced flow and stasis. It is pointed out that this chronic dilatation of the veins may lead to varicose veins. When minor degrees of both factors occur together they increase the possibility of thrombophlebitis.