1. Palladium-Catalyzed Intramolecular Cross-Coupling of Unactivated C(sp3)–H and C(sp2)–H Bonds
- Author
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Yanghui Zhang, Xueliang Sun, Zhengyang Zhang, Weixin Qi, Zechen Wu, and Zhuo Wu
- Subjects
chemistry.chemical_classification ,Aryl ,Organic Chemistry ,chemistry.chemical_element ,Cleavage (embryo) ,Biochemistry ,Medicinal chemistry ,Catalysis ,Coupling (electronics) ,chemistry.chemical_compound ,chemistry ,Intramolecular force ,Physical and Theoretical Chemistry ,Alkyl ,Palladium - Abstract
Direct C-H/C-H coupling represents an appealing method for the construction of C-C bonds, and the cross-coupling of unactivated C(sp3)-H and C(sp2)-H bonds is challenging and remains to be investigated. We have developed the Pd-catalyzed intramolecular coupling of inert C(sp3)-H and C(sp2)-H bonds. The reaction proceeded by o-methyl oxime-directed aryl C(sp2)-H activation and subsequent alkyl C(sp3)-H cleavage, generating C(sp2),C(sp3)-palladacycles as the key intermediates. Dihydrobenzofurans and indanes were formed as the final products.
- Published
- 2021