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Additional file 2: Figure S2. Correlations between heat-shock protein 90 (HSP90), age of the patients and calcification of the valves. A) HSP90 correlated with the age of the patients (y). Additionally, B) calcium area of the total valve area (%) correlated with the relative expression of HSP90 C) The age of the patients correlated with calcium area of the total valve area.

Additional file 1: Figure S1.. An unsupervised clustering analysis (principal component analysis, PCA) on the raw proteomic data was performed to test if valvular anatomy impact on our data. PCA shows the clearest distinction emerges between control, and aortic stenotic group (diseased). Bicuspid valves (1574 and 1575, circulated with red colour) do not cluster together and distinctly from tricuspid valves.