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Additional file 11. Review history.

Additional file 6: Table S5. The sequence of the primers used in this study.

Additional file 7: Table S6. The sequence of the crRNAs and gRNAs used in this study.

Additional file 1. Supplementary figures.

Additional file 8. Uncropped western blot images.

The development of mobile devices and positioning technology has facilitated the rapid growth of location-based social networks (LBSNs). Users in these networks can share geo-related information in real-time, including locations, trajectories, geo-tagged pictures, and tweets. LBSNs record massive amounts of spatiotemporal data and offer a great opportunity to analyze human and location-specific spatiotemporal characteristics. It plays an important role in various applications, such as marketing, recommendations, and urban planning. In this study, we collect relevant literature about LBSNs research in the past 10 years and use a topic model, latent Dirichlet allocation (LDA), to uncover the highly heterogeneous area of research related to LBSNs. Then, we conduct a systematic review of those works. In doing so, we organize identified literature into eight fine-grained directions. For each direction, we sum up the major research focus and contributions. We also systematize future research into four main themes concerning data simulation and fusion, privacy-aware methods, new applications and services, and technological innovations.

Truthful spectrum auction is believed to be an effective method for spectrum redistribution. However, privacy concerns have largely hampered the practical applications of truthful spectrum auctions. In this paper, to make the applications of double spectrum auctions practical, we present a privacy-preserving and socially efficient double spectrum auction design, SDSA. Specifically, by combining three security techniques: homomorphic encryption, secret sharing and garbled circuits, we design a secure two-party protocol computing a socially efficient double spectrum auction, TDSA, without leaking any information about sellers' requests or buyers' bids beyond the auction outcome. We give the formal security definition in our context, and theoretically prove the security that our design achieves. Experimental results show that our design is also efficient in performance, even for large-scale double spectrum auctions., Comment: 11 pages, 6figures

This paper is devoted to the existence and Lipschitz continuity of global conservative weak solutions in time for the modified two-component Camassa-Holm system on the real line. We obtain the global weak solutions via a coordinate transformation into the Lagrangian coordinates. The key ingredients in our analysis are the energy density given by the positive Radon measure and the proposed new distance functions as well., Comment: 23 pages with no figure