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Rabbits and monkeys immunized with HIV type 1 (HIV-1) native-like BG505 SOSIP.664 (BG505s) glycoprotein trimers are known to induce antibodies that can neutralize the autologous tier-2 virus. Here, we assessed the induction of HIV-1 trimer binding and neutralizing antibody (nAb) titres when BG505s trimers were also delivered by non-replicating simian (chimpanzee) adenovirus and non-replicating poxvirus modified vaccinia virus Ankara (MVA) vaccine vectors. First, we showed that approximately two-thirds and one-third of the trimers secreted from the ChAdOx1.BG505s (C) and MVA.BG505s (M) vaccine-infected cells, respectively, were cleaved and in a native-like conformation. Rabbits were immunized intramuscularly with these vaccine vectors and in some cases boosted with ISCOMATRIXTM–adjuvanted BG505s protein trimer (P), using CCC, MMM, PPP, CPP, MPP and CMP vaccine regimens. We found that the peak trimer-binding antibody and tier-1A and autologous tier-2 nAb responses induced by the CC, CM, PPP, CPP, MPP and CMP regimens were comparable, although only PPP induced autologous tier-2 nAbs in all the immunized animals. Three animals developed weak heterologous tier-2 nAbs. These results demonstrate that ChAdOx1 and MVA vectors are useful delivery modalities for not only T-cell, but also antibody, vaccine development.

On 22nd April, 1967, the participants in the Third International Conference on Cartography visited Delft, where they were addressed in turn by Professor van der Weele, Dr. H. G. Jerie, Drs. D. Eckhard, and Dr. H. Th. Verstappen, of the International Institute for Aerial Survey and Earth Sciences, which retains the initials “I.T.C.” from its former designation of International Training Centre for Aerial Survey. A report on that visit, prepared by Cornelis Koeman, was published in the International Yearbook of Cartography (VII) for 1967. This summary of Professor van der Weele's address is taken from that report.