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1. Peanut���induced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry

Author

Maris, Ioana, D��lle���Bierke, Sabine, Renaudin, Jean���Marie, Lange, Lars, Koehli, Alice, Spindler, Thomas, Hourihane, Jonathan, Scherer, Kathrin, Nemat, Katja, Kemen, C., Neust��dter, Irena, Vogelberg, Christian, Reese, Thomas, Yildiz, Ismail, Szepfalusi, Zsolt, Ott, Hagen, Straube, Helen, Papadopoulos, Nikolaos G., H��mmerling, Susanne, Staden, Ute, Polz, Michael, Mustakov, Tihomir, Cichocka���Jarosz, Ewa, Cocco, Renata, Fiocchi, Alessandro Giovanni, Fernandez���Rivas, Montserrat, Worm, Margitta, Gr��nhagen, J, Wittenberg, M, Beyer, K, Henschel, A, K��per, S, M��ser, A, Fuchs, T, Ru��ff, F, Wedi, B, Hansen, G, Buck, T, B��sselberg, J, Dr��gerdt, R, Pfeffer, L, Dickel, H, K��rner���Rettberg, C, Merk, H, Lehmann, S, Bauer, A, Nordwig, A, Zeil, S, Hannapp, C, Wagner, N, Rietschel, E, Hunzelmann, N, Huseynow, I, Treudler, R, Aurich, S, Prenzel, F, Klimek, L, Pfaar, O, Reider, N, Aberer, W, Varga, E, Bogatu, B, Schmid���Grendelmeier, P, Guggenheim, R, Riffelmann, F, Kreft, B, Kinaciyan, K, Hartl, L, Ebner, C, Horak, F, Brehler, R, Witte, J, Buss, M, Hompes, S, Bieber, T, Gernert, S, B��cheler, M, Rabe, U, Brosi, W, Nestoris, S, Hawranek, T, Lang, R, Bruns, R, Pf��hler, C, Eng, P, Schweitzer���Krantz, S, Meller, S, Rebmann, H, Fischer, J, Stichtenoth, G, Thies, S, Gerstlauer, M, Utz, P, Neust��dter, I, Klinge, J, Volkmuth, S, Plank���Habibi, S, Schilling, B, Kleinheinz, A, Br��ckner, A, Sch��kel, K, Manolaraki, I, Kowalski, M, Solarewicz���Madajek, K, Tscheiller, S, Seidenberg, J, Cardona, V, Garcia, B, Bilo, M, Caba��es Higuero, N, Vega Castro, A, Poziomkowska���G��sicka, I, B��sing, S, Virchow, C, Christoff, G, Jappe, U, M��ller, S, Kn��pfel, F, Correard, A���K, Rogala, B, Montoro, A, Brandes, A, Muraro, A, Zimmermann, N, Hernandez, D, Minale, P, Niederwimmer, J, Zahel, B, Dahdah, L, Arasi, S, Reissig, A, Eitelberger, F, Asero, R, Hermann, F, Zeidler, S, Pistauer, S, Gei��ler, M, Ensina, L, Plaza Martin, A, Meister, J, Stieglitz, S, Hamelmann, E, and Network For Online Registration Of Anaphylaxis (NORA)

Subjects
0301 basic medicine, Allergy, medicine.medical_specialty, Adolescent, Arachis, Epinephrine, Immunology, Peanut allergy, Peanut-induced anaphylaxis, paediatrics, 03 medical and health sciences, 0302 clinical medicine, Food allergy, Internal medicine, medicine, anaphylaxis, Humans, Immunology and Allergy, Peanut Hypersensitivity, In patient, Registries, Child, Asthma, food allergy, business.industry, food and beverages, medicine.disease, Comorbidity, 030104 developmental biology, 030228 respiratory system, business, Anaphylaxis, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Background Peanut allergy has a rising prevalence in high-income countries, affecting 0.5%-1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents. Methods Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre. Results 3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p < .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004). Conclusions The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.

Published
2021
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2. Food-induced anaphylaxis and cofactors – data from the anaphylaxis registry

Author

Worm, M., Scherer, K., Köhli-Wiesner, A., Ruëff, F., Mahler, V., Lange, L., Treudler, R., Rietschel, E., Szepfalusi, Z., Lang, R., Rabe, U., Reese, T., Schwerk, N., Beyer, K., Hompes, S., Bircher, A., Przybilla, B., Hawranek, T., Hansen, G., Friedrichs, F., Merk, H., Tenbrock, K., Lehmann, S., Gerstlauer, M., Kleine-Tebbe, J., Niggemann, B., Dickel, H., Bücheler, M., Bieber, T., Hanfland, J., Schmitt-Grohe, S., Vlajnic, D., Heckmann, V., Nemat, K., Schäkel, K., Nordwig, A., Schuster, A., Schweitzer-Krantz, S., Hillen, U., Kopp, M., Szliska, C., Klinge, J., Neustädter, I., Fuchs, T., Bruns, R., Marsch, C., Kreft, B., Coors, E., Rebien, W., Wedi, B., Pföhler, C., Rett, M., Henzgen, M., Vöhringer, P., Fölster-Holst, R., Hunzelmann, N., Siebenhaar, G., Nestoris, S., Schirpke, C., Grabbe, J., Stichtenoth, G., Ring, J., Brockow, K., Brehler, R., Yildiz, I., Volkmuth, S., Geißler, M., Polz, M., Riffelmann, F., Thies, S., Lepp, U., Rebmann, H., Spindler, T., Klimek, L., Pfaar, O., Brosi, W., Aberer, W., Varga, E., Reider, N., Huttegger, I., Kinaciyan, T., Hoffmann-Sommergruber, K., Eng, P., Helbling, A., Eigenmann, P., Guggenheim, R., and Schmid-Grendelmeier, P.

Subjects
medicine.medical_specialty, Pediatrics, Allergy, Food induced anaphylaxis, Physical activity, registry, food allergens, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Internal medicine, anaphylaxis, cofactors, medicine, Insect venom, Food allergens, General Environmental Science, 2. Zero hunger, business.industry, General Engineering, Allergic asthma, Atopic dermatitis, medicine.disease, 3. Good health, 030228 respiratory system, Concomitant, General Earth and Planetary Sciences, business, Anaphylaxis, Research Article
Abstract

Food allergens are frequent causes of anaphylaxis. In particular in children and adolescents they are the most frequent elicitors of severe allergic reactions, and in adults food allergens rank third behind insect venom and drugs. Since July 2006 severe allergic reactions from Germany, Austria, and Switzerland are collected in the anaphylaxis registry. Currently 78 hospitals and private practises are connected. From July 2006 until February 2009 1,156 severe allergic reactions were registered. Among children and adolescents (n = 187, age range from 3 months to 17 years) food allergens were the most frequent triggers, comprising 58% of cases. In the adult group (n = 968, 18 - 85 years) food allergens were in the third position (16.3%) behind insect venom and drugs. In children legumes (31%) and in particular peanuts were frequently responsible food allergens, followed by tree nuts (25%) with hazelnut being the most frequent elicitor. In adults fruits (13.4%) most often induced severe food-dependent anaphylaxis, but also animal products (12.2%); among these most frequently crustaceans and molluscs. Cofactors were often suspected in food-dependent anaphylaxis, namely in 39% of the adult group and in 14% of the pediatric group. In adults drugs (22%) and physical activity (10%) were reported to be the most frequent cofactors, in children physical activity was suspected in 8.7% and drugs in 2.6%. Concomitant diseases like atopic dermatitis, allergic asthma, or allergic rhinoconjunctivitis were reported in 78% of children and adolescents and in 67% of the adults. In conclusion, food-induced anaphylaxis, its cofactors and concomitant diseases are age-dependent. The data offers to identify risk factors of anaphylaxis.

Published
2017

3. Management of hypersensitivity reactions to iodinated contrast media

Author

Brockow, Knut, Christiansen, C., Kanny, G., Clément, O., Barbaud, A., Bircher, A., Dewachter, P., Guéant, J. L., Rodriguez Guéant, R. M., Mouton Faivre, C., Ring, J., Romano, A., Sainte Laudy, J., Demoly, P., Pichler, W. J., Aberer, W., Ballmer Weber, B. K., Bilo, M. B., Birnbaum, J., Blanca, M., Blõmecke, B., Campi, P., De Weck, A., Drouet, M., Dzviga, C., Fernandez, J., Gomez, E., Kapp, A., Kidon, M., Kowalski, M., Laroche, D., Mertès, M., Merk, H., Moneret Vautrin, D. A., Pascual Marcos, C., Rebelo Gomes, E., Rueff, F., Sanz, M. L., Torres, M. J., Vervloet, D., Wedi, B., MARONE, GIANNI, Brockow, Knut, Christiansen, C., Kanny, G., Clément, O., Barbaud, A., Bircher, A., Dewachter, P., Guéant, J. L., Rodriguez Guéant, R. M., Mouton Faivre, C., Ring, J., Romano, A., Sainte Laudy, J., Demoly, P., Pichler, W. J., Aberer, W., Ballmer Weber, B. K., Bilo, M. B., Birnbaum, J., Blanca, M., Blõmecke, B., Campi, P., De Weck, A., Drouet, M., Dzviga, C., Fernandez, J., Gomez, E., Kapp, A., Kidon, M., Kowalski, M., Laroche, D., Marone, Gianni, Mertès, M., Merk, H., Moneret Vautrin, D. A., Pascual Marcos, C., Rebelo Gomes, E., Rueff, F., Sanz, M. L., Torres, M. J., Vervloet, D., and Wedi, B.

Subjects
medicine.medical_specialty, Allergy, Premedication, Immunology, Drug Hypersensitivity, Iodinated contrast media, Skin test, Immediate reaction, Prevalence, Immunology and Allergy, Medicine, In patient, Iodine Compound, business.industry, Contrast media, Risk Factor, ALLERGIC/HYPERSENSITIVITY, Nonimmediate reaction, Diagnostic test, medicine.disease, Dermatology, Surgery, Skin reaction, business, Diagnosi, Human
Abstract

All iodinated contrast media (CM) are known to cause both immediate (≤1 h) and nonimmediate (>1 h) hypersensitivity reactions. Although for most immediate reactions an allergic hypersensitivity cannot be demonstrated, recent studies indicate that the severe immediate reactions may be IgE-mediated, while most of the nonimmediate exanthematous skin reactions, appear to be T-cell mediated. Patients who experience such hypersensitivity reactions are therefore advised to undergo an allergologic evaluation. Several investigators have found skin testing to be useful in confirming a CM allergy, especially in patients with nonimmediate skin eruptions. If a patient with confirmed allergy to a CM needs a new CM exposure, a skin test negative CM should be chosen and premedication may be tried. However, none of these precautional measures is a guarantee against a repeat reaction. More research focusing on pathomechanisms, diagnostic testing and premedication is therefore clearly needed in order to prevent CM-induced hypersensitivity reactions in the future.

Published
2005

4. EAACI/GA2LEN/EDF guideline: management of urticaria

Author

Zuberbier, T, Bindslev Jensen, C, Canonica, Giorgio, Grattan, Ce, Greaves, Mw, Henz, Bm, Kapp, A, Kozel, Mm, Maurer, M, Merk, Hf, Schäfer, T, Simon, D, Vena, Ga, Wedi, B, and Eaaci/ga2len/edf

Subjects
Male, Pathology, medicine.medical_specialty, Urticaria, Immunology, Risk Assessment, Severity of Illness Index, Drug Administration Schedule, Quality of life, Cyclosporin a, Anti-Allergic Agents, Humans, Immunology and Allergy, Medicine, media_common.cataloged_instance, Physical urticaria, European union, Intensive care medicine, Adverse effect, Life Style, Randomized Controlled Trials as Topic, media_common, Dose-Response Relationship, Drug, business.industry, Guideline, medicine.disease, Combined Modality Therapy, Response to treatment, Diet, First line treatment, Treatment Outcome, Histamine H1 Antagonists, Quality of Life, Female, business, Immunosuppressive Agents, Follow-Up Studies
Abstract

This guideline is the result of a consensus reached during a panel discussion at the second International Consensus Meeting on Urticara, Urticaria 2004, a joint initiative of the EAACI Dermatology Section and GA2LEN. Urticaria has a profound impact on the quality of life, and effective treatment is therefore required. The recommended first line treatment are nonsedating H1 antihistamines. They have proven to be effective in double-blind controlled studies, but dosages increased up to fourfold over the recommended doses may be necessary. However, for different urticaria subtypes and in view of individual variation in the course of the disease and response to treatment, additional or alternative therapies may be required. Immunosuppressive drugs like cyclosporin A and corticosteroids are not recommended for long-term treatment due to unavoidable severe adverse effects. This guideline was, in addition, accepted by the European Dermatology Forum (EDF) and formally approved by the European Union of Medical Specialists (UEMS).

Published
2006

5. EAACI/GA2LEN/EDF guideline: definition, classification and diagnosis of urticaria

Author

Zuberbier, T, Bindslev Jensen, C, Canonica, Giorgio, Grattan, Ce, Greaves, Mw, Henz, Bm, Kapp, A, Kozel, Mm, Maurer, M, Merk, Hf, Schäfer, T, Simon, D, Vena, Ga, Wedi, B, and Eaaci/ga2len/edf

Subjects
Hypersensitivity, Immediate, Male, Urticaria, Immunology, Allergens, Sensitivity and Specificity, Severity of Illness Index, Europe, Risk Factors, Prevalence, Humans, Immunology and Allergy, Female, Skin Tests
Abstract

This guideline is the result of a consensus reached during a panel discussion at the 2nd International Consensus Meeting on Urticaria, Urticaria 2004, a joint initiative of the European Academy of Allergology and Clinical Immunology Dermatology Section and the European Union (EU)-funded network of excellence, GA2LEN. It covers the definition and classification of urticaria, taking into account the recent progress in identifying causes, eliciting factors and pathomechanisms of this disease. We have outlined useful diagnostic approaches for different subtypes of urticaria. This guideline was, in addition, accepted by the European Dermatology Forum (EDF) and was formally approved by the European Union of Medical Specialists (UEMS).

Published
2006

13. Molecular genetic investigation of ACE inhibitor induced angioedema

Author

Mathey, C., Forstner, A. F., Maj, C., Borisov, O., Rassmussen, E. R., Anette Bygum, Buchwald, C., Wadelius, M., Hallberg, P., Karawajczyk, M., Eriksson, N., Wedi, B., Wieczorek, D., Amann, P. M., Loeffler, H., Koch, L., Schoeffl, C., Evertz, N., Greve, J., Wurpts, G., Moebus, S., Krawitz, P. M., Stingl, J., Sachs, B., and Noethen, M. M.

14. (Allergo Journal (2009) 18, (508-537))

Author

Joerg Kleine-Tebbe, Bufe, A., Ebner, C., Eigenmann, P., Friedrichs, F., Fuchs, T., Huttegger, I., Jung, K., Klimek, L., Kopp, M., Lässig, W., Merk, H., Niggemann, B., Rabe, U., Saloga, J., Schmid-Grendelmeier, P., Sitter, H., Virchow, J. C., Wagenmann, M., Wedi, B., and Worm, M.

18. Food-induced anaphylaxis and cofactors - Data from the anaphylaxis registry,Nahrungsmittelanaphylaxie und kofaktoren - Daten aus dem anaphylaxie-register

Author

Worm, M., Scherer, K., Köhli-Wiesner, A., Ruëff, F., Mahler, V., Lange, L., Treudler, R., Rietschel, E., Zsolt Szepfalusi, Lang, R., Rabe, U., Reese, T., Schwerk, N., Beyer, K., Hompes, S., Bircher, A., Przybilla, B., Hawranek, T., Hansen, G., Friedrichs, F., Merk, H., Tenbrock, K., Lehmann, S., Gerstlauer, M., Kleine-Tebbe, J., Niggemann, B., Dickel, H., Bücheler, M., Bieber, T., Hanfland, J., Schmitt-Grohe, S., Vlajnic, D., Heckmann, V., Nemat, K., Schäkel, K., Nordwig, A., Schuster, A., Schweitzer-Krantz, S., Hillen, U., Kopp, M., Szliska, C., Klinge, J., Neustädter, I., Fuchs, T., Bruns, R., Marsch, C., Kreft, B., Coors, E., Rebien, W., Wedi, B., Pföhler, C., Rett, M., Henzgen, M., Vöhringer, P., Fölster-Holst, R., Hunzelmann, N., Siebenhaar, G., Nestoris, S., Schirpke, C., Grabbe, J., Stichtenoth, G., Ring, J., Brockow, K., Brehler, R., Yildiz, I., Volkmuth, S., Geißler, M., Polz, M., Riffelmann, F., Thies, S., Lepp, U., Rebmann, H., Spindler, T., Klimek, L., Pfaar, O., Brosi, W., Aberer, W., Varga, E., Reider, N., Huttegger, I., Kinaciyan, T., Hoffmann-Sommergruber, K., Eng, P., Helbling, A., Eigenmann, P., Guggenheim, R., and Schmid-Grendelmeier, P.

20. First data of the piolet phase of the anahylaxis register in German-speaking countries,Erste daten der pilotphase des anaphylaxie-registers im deutsch-sprachigen raum

Author

Hompes, S., Kirschbaum, J., Scherer, K., Treudler, R., Przybilla, B., Henzgen, M., Worm, M., Bircher, A., Merk, H., Kleine-Tebbe, J., Beyer, K., Dickel, H., Bieber, T., Nemat, K., Schäkel, K., Schuster, A., Mahler, V., Hillen, U., Szliska, C., Fuchs, T., Marsch, W. C., Augustin, M., Wedi, B., Fölster-Holst, R., Hunzelmann, N., Rietschel, E., Schirpke, C., Ring, J., Brehler, R., Grabbe, J., Riffelmann, F., Rabe, U., Klimek, L., Friedrichs, F., Rebien, W., Lepp, U., Aberer, W., Reider, N., Huttegger, I., Tamar Kinaciyan, Hoffmann-Sommergruber, K., Helbling, A., Eigenmann, P., Wiesner, A., and Schmid-Grendelmeier, P.

24. Reducing the risk of anaphylaxis during anaesthesia: Guidelines for clinical practice

Author

Mertes, P. M., Laxenaire, M. C., Lienhart, A., Aberer, W., Ring, J., Pichler, W. J., Demoly, P., Decroix, G., Dewachter, P., Guéant, J. L., Guilloux, L., Laroche, D., Leynadier, F., Longrois, D., Malinovsky, J. M., Moneret-Vautrin, D. A., Pecquet, C., Pinaud, M., Tréchot, P., Vervloet, D., Wessel, F., Ballmer-Weber, B. K., Barbaud, A., Bilo, B., Birnbaum, J., Bianca, M., Blömecke, B., Brockow, K., Christiansen, C., Weck, A., Dzviga, C., Drouet, M., Eberlein-König, B., Frew, A. T., Fuchs, T., Guéant-Rodriguez, R. M., Gutgesell, C., Hertl, M., Kanny, G., Kapp, A., Kidon, M., Kowalski, M., Marone, G., Merk, H., Pascual-Marcos, C., Przybilla, B., Rebelo-Gomes, E., Rueff, F., Sabbah, A., Sainte Laudy, J., Sanz, M. L., Tas, E., Romano, A., Torres, M. J., Bettina Wedi, Wüthrich, B., Mertes, Paul Michel, Laxenaire, M. C., Lienhart, A., Aberer, W., Ring, J., Pichler, W. J., Demoly, Pascal, Decroix, G., Dewachter, P., Guéant, J. L., Guilloux, L., Laroche, D., Leynadier, F., Longrois, D., Malinovsky, J. M., Moneret Vautrin, D. A., Pecquet, C., Pinaud, M., Tréchot, P., Vervloet, D., Wessel, F., Ballmer Weber, B. K., Barbaud, A., Bilo, B., Birnbaum, J., Bianca, M., Blömecke, B., Brockow, K., Christiansen, C., De Weck, A., Dzviga, C., Drouet, M., Eberlein König, B., Frew, A. T., Fuchs, T., Guéant Rodriguez, R. M., Gutgesell, C., Hertl, M., Kanny, G., Kapp, A., Kidon, M., Kowalski, M., Marone, Gianni, Merk, H., Pascual Marcos, C., Przybilla, B., Rebelo Gomes, E., Rueff, F., Sabbah, A., Sainte Laudy, J., Sanz, M. L., Tas, E., Romano, A., Torres, M. J., Wedi, B., and Wüthrich, B.

Subjects
Anaesthesia, Skin test, Latex, Anaphylaxi, Neuromuscular blocking agent, Hypersensitivity, Tryptase, Immunology and Allergy, IgE, Histamine, Hypnotic

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