1. Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis
- Author
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Yitao Wang, Zhenghang Wang, Changming Wang, Cao Pc, Zie Wang, and Wang Dk
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Aneurysm ,Text mining ,Western blot ,Nerve Growth Factor ,Genetics ,Medicine ,Humans ,cardiovascular diseases ,Aneurysm formation ,Molecular Biology ,Computed tomography angiography ,Aged ,medicine.diagnostic_test ,business.industry ,Intracranial Aneurysm ,General Medicine ,Anatomy ,Middle Aged ,medicine.disease ,Prognosis ,Cerebral Angiography ,Nerve growth factor ,nervous system ,cardiovascular system ,Histopathology ,Female ,business ,Tomography, X-Ray Computed ,Cerebral angiography - Abstract
We sought to investigate the effect of nerve growth factor (NGF) expression on the formation and prognosis of cerebral aneurysms. Forty-eight cases were selected following a diagnosis of cerebral aneurysm using computed tomography angiography and surgical confirmation. Thirty-four cases of healthy deaths were also chosen. The tissue was tested for NGF expression changes by reverse-transcription PCR, Western blot and histopathology, and NGF expression was compared between the cerebral aneurysm and healthy groups. The expression level of NGF in cerebral aneurysm tissue was significantly increased over that observed in control tissue. The abnormal expression of NGF is related to cerebral aneurysms. The elevated expression of NGF in cerebral aneurysms may be associated with a poor prognosis.
- Published
- 2015