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· The radiomics signature is correlated with the grade of COVID-19 pulmonary lesions. · The radiomics signature enables quickly diagnose the pulmonary lesions. · The developed interpretable model makes it appropriate for clinical use.

Relying on the Biomedical Big Data Center of West China Hospital, this paper makes an in-depth research on the construction method and application of breast cancer-specific database system based on full data lifecycle, including the establishment of data standards, data fusion and governance, multi-modal knowledge graph, data security sharing and value application of breast cancer-specific database. The research was developed by establishing the breast cancer master data and metadata standards, then collecting, mapping and governing the structured and unstructured clinical data, and parsing and processing the electronic medical records with NLP natural language processing method or other applicable methods, as well as constructing the breast cancer-specific database system to support the application of data in clinical practices, scientific research, and teaching in hospitals, giving full play to the value of medical big data of the Biomedical Big Data Center of West China Hospital.

In this paper, a new steel-wood composite column with an H-shaped section was proposed. In order to form an H-shaped cross section, a larch board is fixed on the outer surface of the left and right edges of a hot-rolled H-beam by using physical connection. When the eccentricity is the same, eccentric compression tests were carried out on two types of columns by changing the thickness of the larch board, cross-sectional area of the hot-rolled H-beam, and slenderness ratio in composite columns. Therefore, type A is joined by structural glue only with the larch board and hot-rolled H-beam, and type B is joined by both structural glue and bolts. With the variation of strain and deflection, failure process and failure modes of the hot-rolled H-beam and larch from composite columns under various loads were observed, and the ultimate bearing capacity and stability of composite columns were studied. The test results showed that the overall working performance of the hot-rolled H-beam and larch board was good, and the stability of the hot-rolled H-beam column could be effectively improved. With the increase of wood thickness, cross-sectional area of the hot-rolled H-beam, slenderness ratio of composite columns, and the bearing capacity of the specimens were increased. Moreover, a simplified formula was proposed by the superposition principle. The theoretical analysis accorded with the experimental results, thus providing a reference basis for further study and application of similar steel-wood composite columns.

Aims To investigate the eosinophil cell (EC) expression in peripheral blood of patients infected with severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2) and its clinical significance of diagnosis and prognosis. Methods 95 patients, whose nucleic acid test of SARS‐CoV‐2 was positive to make a definite diagnosis of COVID‐19, were selected as the study group. They were admitted at the Chengdu Public Health Clinical Medical Center from January 21 to March 2, 2020. Another 95 healthy subjects and 95 non‐infectious fever patients during the same period were selected as the control group. The BC‐6900 blood cell analyzer was used to continuously observe and detect ECs in 95 patients with COVID‐19 and the control group. The differences in expression levels of ECs in peripheral blood were analyzed. Results ECs were significantly decreased in 95 (75.8%) COVID‐19 patients (P, Continuous observation and detection of the eosinophil cell (EC) in patients with COVID‐19 showed that ECs decreased significantly in this group. When the condition improved, the ECs returned to normal, while the ECs of the patients who did not improve continued to decline. It is suggested that ECs have clinical significance in the diagnosis and prognosis of covid‐19, and may be a useful index in the early warning of acute infectious diseases. In addition, the decrease of ECs in three kinds of diseases caused by coronavirus, COVID‐19, Middle East respiratory syndrome and severe acute respiratory syndrome, suggests that coronavirus may damage the immune function of human body and cause immune damage syndrome by attacking the cells in bone marrow.