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Coherence, similar to amplitude, polarization, and phase, is a fundamental characteristic of the light fields and is dominated by the statistical optical property. Although spatial coherence is one of the pivotal optical dimensions, it has not been significantly manipulated on the photonic platform. Here, we theoretically and experimentally manipulate the spatial coherence of light fields by loading different random phase distributions onto the wavefront with a metasurface. We achieve the generation of partially coherent light with a predefined degree of coherence and continuously modulate it from coherent to incoherent by controlling the phase fluctuation ranges or the beam sizes. This design strategy can be easily extended to manipulate arbitrary phase-only special beams with the same degree of coherence. Our approach provides straightforward rules to manipulate the coherence of light fields in an extra-cavity-based manner and paves the way for further applications in ghost imaging and information transmission in turbulent media.

Long-term atmospheric quality monitoring of PM2.5 and PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) was performed in Wuxi from 2016 to 2021. A total of 504 atmospheric PM2.5 samples were collected, and PM2.5-bound 16 PAHs were detected. The PM2.5 and ∑PAHs level decreased annually from 2016–2021, from 64.3 to 34.0 μg/m3 and 5.27 to 4.22 ng/m3, respectively. The benzo[a]pyrene (BaP) of 42% of the monitoring days in 2017 exceeded the recommended health-based standard of the European Union (EU) at 1ng/m3. Five- and six-ring PAHs, including benz[a]anthracene (Baa), benzo[k] fluoranthene (Bkf), BaP, and benzo[g,h,i]perylene (Bghi), were the dominant components, indicating a prominent petroleum, biomass, and coal combustion contribution by molecular diagnostic ratios and positive matrix factorization analysis. Statistically significant temporal and spatial distribution differences of PM2.5, and ∑PAHs were also found. The toxicity equivalent concentration (TEQ) was 0.70 for total PAHs and the TEQ of BaP (0.178) was the highest, followed by Bkf (0.090), dibenz[a,h]anthracene (Dah) (0.048), and indeno[1,2,3-cd]pyrene (Ind) (0.034). The medians of the incremental lifetime cancer risk (ILCR) for long-term exposure to PAHs were 2.74E-8, 1.98E-8, and 1.71E-7 for children, teenagers, and adults, respectively, indicating that the carcinogenic risk of PAHs pollution in air was acceptable to local residents in this area. Sensitivity analysis showed that BaP, Bkf, and Dah significantly contributed to carcinogenic toxicity. This research supplies comprehensive statistics on the local air persistent organic pollutants profile, helps to identify the principle pollution source and compounds, and contributes to the prevention of regional air pollution.

Plasmonic metasurfaces with giant chiral optical responses are good candidates for chirality study and application, which are usually composed of few-layer or three-dimensional nanostructures. Here, we demonstrate that hybrid bilayer plasmonic metasurfaces simply fabricated via a facile one-step nanofabrication process are good candidates for the realization of intrinsic chiral optical responses and spin-selective transmission. We prove that the intrinsic chiral optical response of the proposed metasurface, which can be easily manipulated, is attributed to the spin-selective collective interference of locally enhanced electric fields caused by the strong interlayer coupling. We further experimentally prove the advantages of fabricated hybrid bilayer plasmonic metasurfaces for optical encryption. With the advantages of compact design, chiral optical response easy to control and lower fabrication demand, the proposed metasurfaces can further expand the applications of chiral plasmonic nanostructures in the area of spin nanophotonics, nonlinear optics, and optical sensing.

Metasurfaces, whose electromagnetic (EM) responses can be artificially designed, are two-dimensional arrays composed of subwavelength nanostructures. Accompanied by various fascinating developments in the past decade, metasurfaces have been proved as a powerful platform for the implementation of EM wave manipulation. However, the planar monoatomic metasurfaces widely used in previous works have limited design freedoms, resulting in some disadvantages for the realization of high-performance and new functional EM wave control. The latest developments show that few-layer metasurfaces and polyatomic metasurfaces are good alternatives to overcome the drawbacks of planar monoatomic metasurfaces and realize high-efficient, multi-band and broadband EM functionalities. They provide additional degrees of design freedom via introducing multilayer layouts or combining multiple meta-atoms into a unit cell respectively. Here, recent advances of few-layer and polyatomic metasurfaces are reviewed. The design strategies, EM properties and main advantages of few-layer metasurfaces and polyatomic metasurfaces are overviewed firstly. Then, few-layer metasurfaces and polyatomic metasurfaces in recent progress for EM wave manipulation are classified and discussed from the viewpoint of their design strategy. At last, an outlook on future development trends and potential applications in these fast-developing research areas is presented.

Sedimentation of particle suspensions in a channel flow into a cavity is analysed numerically using a lattice Boltzmann method coupled with a discrete element method. The work focuses on the entrapment of particles inside a confined cavity and the particle dynamics after entrapment. A close examination of the particle motions reveals three distinct dynamic behaviours: i) resuspension, ii) circulation in the central vortex and iii) deposition to the rear edge of the cavity. The effects of fluid inertia, particle density and cavity size on the infiltration and resuspension behaviours are systematically investigated. The results show that decreasing the Reynolds number, and increasing the length and depth of the cavity all lead to an increase in the trap efficiency. Three distinctive regimes with respect to the trap efficiency were then identified by deriving an empirical dimensionless trap number Tp: a resuspension regime when Tp 2.5.

A four-way coupling CFD-DEM model is originally developed in this work to investigate the sedimentation of adhesive particles in viscous fluids. In this model, the particles are traced by the discrete element method based on the JKR contacting theory, and the fluid flow is resolved by the lattice Boltzmann method combining with large eddy simulation. Three benchmark problems are first investigated to validate the LBM-LES-DEM scheme, and then the sedimentations of non-adhesive and adhesive particles are further discussed in detail. Results indicate that the drafting-kissing-tumbling process identified during the settling of non-adhesive particles is significantly different from that of adhesive ones, and separation will not happen if the vdW adhesion between particles becomes strong enough. Moreover, the settling of adhesive particles is found to be faster than non-adhesive ones, and this can be reasonably interpreted by the agglomeration effect that takes place during the settling of adhesive particles.

To explore the phenotypic spectrum and refine the genotype-phenotype correlation of DYNC1H1-related epilepsy.The clinical data of 15 patients with epilepsy in our cohort and 50 patients with epilepsy from 24 published studies with the DYNC1H1 variants were evaluated.In our cohort, 13 variants were identified from 15 patients (seven males, eight females). Twelve variants were de novo and seven were new. Age at seizure onset ranged from 3 months to 4 years 5 months (median age 1 year). Common seizure types were epileptic spasms, focal seizures, tonic seizures, and myoclonic seizures. Mild-to-severe developmental delay was present in all patients. Six patients were diagnosed with West syndrome and one was diagnosed with epileptic encephalopathy with continuous spikes and waves during slow sleep (CSWS). Collectively, in our cohort and published studies, 17% had ophthalmic diseases, 31% of variants were located in the stalk domain, and 92% patients with epilepsy had a malformation of cortical development (MCD).The phenotypes of DYNC1H1-related epilepsy included multiple seizure types; the most common epileptic syndrome was West syndrome. CSWS is a new phenotype of DYNC1H1-related epilepsy. One-third of the variants in patients with epilepsy were located in the stalk domain. Most patients had a MCD and developmental delay.

BackgroundExosome circRNAs (Exo-circRNAs) regulate cancer progression and intercellular crosstalk in the tumor microenvironment. However, their biological functions and potential clinical importance in colorectal cancer (CRC) remain unknown.MethodsWe used exoRBase 2.0 data to identify significant differentially expressed Exo-circRNAs (Exo-DEcircRNAs) in CRC patients and healthy individuals. The least absolute shrinkage and selector operation algorithm, support vector machine-recursive feature elimination, and multivariate Cox regression analyses were used to select candidate Exo-circRNAs and constructed a diagnostic model. Quantitative reverse transcription-polymerase chain reaction analysis was performed to confirm the expression of Exo-circRNAs in the serum samples of patients. Furthermore, we constructed an exosome circRNA-miRNA-mRNA network for CRC. Upregulated target mRNAs in the exosome competing endogenous RNA (Exo-ceRNA) network were used for functional and pathway enrichment analyses. We identified 22 immune cell types in CRC patients using CIBERSORT. Correlation analysis revealed the relationship between Exo-ceRNA networks and immune-infiltrating cells. The relationship between target mRNAs and immunotherapeutic response was also explored. Finally, using the Kaplan–Meier survival curve, a prognostic upregulated target mRNA was screened. We constructed a survival-related Exo-ceRNA subnetwork and explored the correlation between the Exo-ceRNA subnetwork and immune-infiltrating cells.ResultsThe constructed diagnostic model had a high area under the curve (AUC) value in both the training and validation sets (AUC = 0.744 and AUC = 0.741, respectively). qRT-PCR confirmed that the Exo-circRNAs were differentially expressed in CRC serum samples. We constructed Exo-ceRNA networks based on the interactions among seven upregulated Exo-DEcircRNAs, eight differentially expressed miRNAs, and twenty-two differentially expressed mRNAs in CRC. Functional enrichment analysis revealed that the upregulated target mRNAs were significantly enriched in cytoskeletal motor activity and the PI3K-Akt signaling pathway. Co-expression analysis showed a significant correlation between the Exo-ceRNA networks and immune cells. The significant correlation was observed between target mRNAs and the immunotherapeutic response. Additionally, based on the prognostic upregulated target gene (RGS2), we constructed a survival-related Exo-ceRNA subnetwork (Exosome hsa_circ_0050334-hsa_miR_182_5p-RGS2). CIBERSORT results revealed that the Exo-ceRNA subnetwork correlated with M2 macrophages (P = 4.6e-07, R = 0.31).ConclusionsOur study identified an Exo-diagnostic model, established Exo-ceRNA networks, and explored the correlation between Exo-ceRNA networks and immune cell infiltration in CRC. These findings elucidated the biological functions of Exo-circRNAs and their potential clinical implications.

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Exosomes have great potential as liquid biopsy specimens due to their presence and stability in body fluids. However, the function and diagnostic values of exosomal genes in CRC are poorly understood. In the present study, exosomal data of CRC and healthy samples from the exoRBase 2.0 and Gene Expression Omnibus (GEO) databases were used, and 38 common exosomal genes were identified. Through the least absolute shrinkage and selection operator (Lasso) analysis, support vector machine recursive feature elimination (SVM-RFE) analysis, and logistic regression analysis, a diagnostic model of the training set was constructed based on 6 exosomal genes. The diagnostic model was internally validated in the test and exoRBase 2.0 database and externally validated in the GEO database. In addition, the co-expression analysis was used to cluster co-expression modules, and the enrichment analysis was performed on module genes. Then a protein–protein interaction and competing endogenous RNA network were constructed and 10 hub genes were identified using module genes. In conclusion, the results provided a comprehensive understanding of the functions of exosomal genes in CRC as well as a diagnostic model related to exosomal genes.

The impact of agglomerates on solid surfaces occurs inevitably during the processing of granular materials. In this work, numerical simulations of the surface impact of wet agglomerates are carried out by introducing liquid bridge interactions into a soft-sphere DEM model, and the instantaneous impact behaviors are discussed quantitatively at the single particle scale. Results indicate that the impact process usually includes four stages, i.e., compression, expansion, fragmentation, and re-agglomeration. The expanding radius is found to follow an exponential-law with time, and the number of fragments follows a power-law with impact velocity. Due to liquid bridge interactions, chain-like structures are observed beyond the impact, similar to those formed during the impact of dense suspension droplets. Moreover, the impact behaviors can be generally classified into four groups with respect to impact velocity, i.e., minor compression without splashing, severe compression with minor splashing, severe splashing with minor fragmentation, and severe fragmentation.

MicroRNA-188-5p (miR-188) enhances oncologic progression in various human malignancies. This study aimed to explore its role in colorectal cancer (CRC). Human CRC tissues paired with normal tissues, and several CRC cell lines were utilized. Real-time quantitative PCR was applied to measure the expression of miR-188. Overexpression and knockdown were used to access the function of miR-188 and to investigate whether FOXL1/Wnt signaling mediates such function. The proliferation, migration and invasion of cancer cells were evaluated by CCK8, wound-healing and transwell assays, respectively. Whether FOXL1 acted as a direct target of miR-188 was verified by dual-luciferase reporter assays. Levels of miR-188 were upregulated in CRC tissues than in paired-normal tissues, as well as in various CRC cell lines. High expression of miR-188 was strongly associated with advanced tumor stage, accompanied with significant tumor cell proliferation, invasion and migration. It was confirmed that FOXL1 played positive crosstalk between miR-188 regulation and downstream Wnt/β-catenin signaling activation. All findings indicate that miR-188 promotes CRC cell proliferation and invasion through targeting FOXL1/Wnt signaling and could be served as a potential therapeutic target for human CRC in the future.

Artificial nanostructures, whose spatial symmetry can be arbitrarily designed, play an ever more critical role for the realization of giant chiral optical responses. In order to break the mirror sy...

There is evidence suggesting that immune genes play pivotal roles in the development and progression of colorectal cancer (CRC). Colorectal carcinoma patient data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) were randomly classified into a training set, a test set, and an external validation set. Differentially expressed gene (DEG) analyses, univariate Cox regression, and the least absolute shrinkage and selection operator (LASSO) were used to identify survival-associated immune genes and develop a prognosis model. Receiver operating characteristic (ROC) analysis and principal component analysis (PCA) were used to evaluate the discrimination of the risk models. The model genes predicted were verified using the Human Protein Atlas (HPA) databases, colorectal cell lines, and fresh CRC and adjacent tissues. To understand the relationship between IRGs and immune invasion and the TME, we analyzed the content of immune cells and scored the TME using CIBERSORT and ESTIMATE algorithms. Finally, we predicted the potential sensitive chemotherapeutic drugs in different risk score groups by the Genomics of Drug Sensitivity in Cancer (GDSC). A total of 491 IRGs were screened, and 14 IRGs were identified to be significantly related to overall survival (OS) and applied to construct an immune-related gene (IRG) prognostic signature (IRGSig) for CRC patients. Calibration plots showed that nomograms have powerful predictive ability. PCA and ROC analysis further verified the predictive value of this fourteen-gene prognostic model in three independent databases. Furthermore, we discovered that the tumor microenvironment changed significantly during the tumor development process, from early to middle to late stage, which may be an essential factor for tumor deterioration. Finally, we selected six commonly used chemotherapeutic drugs that have the potential to be useful in the treatment of CRC. Altogether, immune genes were used to construct a prognosis model for CRC patients, and a variety of methods were used to test the accuracy of this model. In addition, we explored the immune mechanisms of CRC through immune cell infiltration and TME in CRC. Furthermore, we assessed the therapeutic sensitivity of many commonly used chemotherapeutic medicines in individuals with varying risk factors. Finally, the immune risk model and immune mechanism of CRC were thoroughly investigated in this paper.

Water elements pollution has attracted public attention globally. Wuxi is located in East China, and its water source, Taihu Lake, has been severely polluted since 2007. Studies of elemental pollution profiles have yet to be conducted in this area. In this study, 56 water samples were collected in 2018, and 33 elements were determined using inductively coupled plasma-mass spectrometry (ICP-MS). The results showed that the levels of 33 elements ranged from 1.35 × 10

Inertial deposition of wet microparticles on a fiber is numerically investigated by means of discrete element method, taking the effects of impact velocity and initial spin into consideration. Results indicate that the overall, normal and tangential coefficients of restitution remain zero as the impact velocity is lower than a critical value, beyond which these restitution coefficients will increase nonlinearly with increasing the impact velocity. As the impact angle increases, the normal critical impact velocity will show a parabolic decrease and the tangential critical impact velocity will increase linearly, different from dry collisions where the critical impact velocities almost keep constant. As the impact velocity increases, the capture efficiency of wet microparticles by the fiber decreases exponentially, meanwhile the deposit microstructures tend to be denser. It becomes much more complex if clockwise or anti-clockwise initial spins are encountered. The rotational coefficient of restitution will first decrease with increasing the rotational rate until reaching a minimum value, beyond which the rotational restitution coefficient will increase as the rotational rate increases further. However, the overall restitution coefficient changes slightly if the rotational rate is less than about 105 rad/s. The effect of clockwise spin on capture efficiency is found to be distinctly different from that of anti-clockwise spin, and it can be reasonably interpreted by their effects on the overall coefficient of restitution.

Perfect absorbers with high quality factors (Q-factors) are of great practical significance for optical filtering and sensing. Moreover, tunable multiwavelength absorbers provide a multitude of possibilities for realizing multispectral light intensity manipulation and optical switches. In this study, we demonstrate the use of vanadium dioxide (VO

Coherence, like amplitude, polarization and phase, is a fundamental characteristic of the light fields and is dominated by the statistical optical property. Generally, accurate coherence manipulation is challenging since coherence as a statistical quantity requires the combination of various bulky optical components and fast tuning of optical media. Spatial coherence as another pivotal optical dimension still has not been significantly manipulated on the photonic platform. Here, we theoretically and experimentally realize accurate manipulation of the spatial coherence of light fields by loading a temporal random phase distribution onto the wave-front on the statistical photonic platform. By quantitatively manipulating the statistical photonic properties, we can successfully achieve the partially coherent light with the pre-defined degree of coherence and continuously modulate it from fully coherent to incoherent. This design strategy can also be easily extended to manipulate the spatial coherence of other special beams such as partially coherent vortex beam generations. Our approach provides straightforward rules to manipulate the coherence of the light fields and paves the way for applications of partially coherent beams in information encryption, ghost imaging, and information transmission in turbulent media.

Aims To investigate the level of implicit care rationing and its association with training needs in nursing homes in Shanghai, China. Background Nursing homes in Shanghai are confronted with a lack of care resources. Implicit care rationing can emerge due to inadequate training of care workers. Methods A cross-sectional survey was conducted between 10 September and 17 November 2020. A total of 374 care workers from 16 randomly were selected nursing homes from each of the administrative districts participated the surveys. The Basel Extent of Rationing of Nursing Care-Nursing Home instrument and the training needs analysis were adopted to measure implicit care rationing and training needs, respectively. Multiple regression techniques were used to explore the factors associated with implicit care rationing. Results Activities related to social care, documentation and activation/rehabilitation (mean rating = 2.8, 1.89 and 1.93 respectively) were mostly likely to be rationed. Training needs of activities of daily living (ADL), activation/rehabilitation and documentation were significantly related to their implicit rationing (β = 0.864, 0.21 and 0.166, respectively, p Conclusion Training needs are crucial determinants of implicit care rationing. Implications for nursing management Quality control systems are needed to ensure care comprehensiveness. The current training system should be re-designed according to results of training needs analysis.

Background Although the appropriateness of hospital utilization of adults and the elderly in China was audited by several studies, the appropriateness of hospital use by children in Shanghai remains to be determined. This study aims to assess the level of inappropriate hospital admissions and hospital days, to detect factors associated with inappropriateness, and to elucidate reasons for inappropriateness. Methods A retrospective review of the records of 291 admissions and 1449 hospital days of children inpatients from a secondary hospital in Shanghai was performed by two reviewers using the Chinese version Pediatric Appropriateness Evaluation Protocol (C-PAEP). Demographics, socio-economic characteristics, and other admission- or hospital stay-related information were collected and analyzed to determine factors associated with inappropriateness utilizing multivariate regression models. Results 38.5% (n = 112) of admissions and 9.5% (n = 137) of hospital days were categorized as inappropriate, according to the C-PAEP. Children who were non-Shanghai residents (p < 0.001), admitted through the emergency sector (p = 0.030), and/or received services in a surgical ward (p < 0.001) had a higher risk of being admitted inappropriately. Payment method (p = 0.006), service type (p < 0.001), comorbidity (p = 0.016), length of stay (p = 0.007), and appropriateness of admission (p < 0.001) were found to be associated with prevalence of inappropriate hospital days. Approximately three-fourths of the inappropriate admissions were premature admissions (75.9%, n = 85). The most frequent reasons for inappropriate hospital days were awaiting test results (34.3%, n = 47), awaiting surgery (19.7%, n = 27), awaiting test execution (10.9%, n = 15), and family unprepared for home care (10.9%, n = 15). Conclusions Although the extent of inappropriate hospital days was moderate compared with that found by previous investigations, the prevalence of inappropriateness of admission was considerable. To enhance the appropriateness of hospital care for children, interventions could be implemented according to the associated factors and identified causes.

Optical chirality plays a key role in optical biosensing and spin-selective optical field manipulation. However, the maximum optical intrinsic chirality, which is represented by near-unity circular dichroism (CD), is yet to be achieved in a wide bandwidth range based on nanostructures. Here, we utilize dielectric bilayer polyatomic metasurfaces to realize the maximum optical intrinsic chirality over a wide bandwidth range. The CD efficiency of the two designed metasurfaces with opposite chirality is 99.9% at 1350 nm and over 98% from 1340 nm to 1361 nm. Our work provides a straightforward and powerful method for the realization of maximum optical intrinsic chirality, which has great potential in spin-selective optical wave manipulation.

Bound states in the continuum (BICs) enabling resonances with high quality ($Q$) factor allow for high-efficiency light-matter interactions and boost various research fields such as nonlinear photonics and optical detecting. However, further improvement of the $Q$ factor of the resonances is challenging since the accurate fabrication of the tiny symmetry defects of meta-atoms is limited by the nanofabrication technology, which is critical for transition from BICs to quasi-BICs in previous works. Here we propose a different approach to trigger the transition of quasi-BICs that does not need to change the space group symmetry of nanostructures. By modulating the periods of the nanostructures, our approach enlarges the unit cell and enriches the ideal BICs eigenstates, achieving multiband quasi-BICs in metasurfaces. By tuning the asymmetry parameters, the selective excitation of multiband quasi-BICs is demonstrated. Thanks to the multi-narrow-band resonances obtained by the unit cell perturbation, a multivariable sensing method is proposed to simultaneously obtain the birefringence property and thickness of a nanoscale layer. The proposed approach exciting multiband quasi-BICs offers a possible solution for ultra-high-$Q$ devices without complex fabrication techniques and may found realistic application in many fields such as harmonic generation, optical detecting, and compact low-threshold lasers.

Realizing full-dimensional arbitrary manipulation of optical waves, which is known to be important for the implementation of optical devices with ondemand functionalities, still remains a challenge. Recently, Metasurfaces have shown unprecedented capabilities for the manipulation of optical waves at the subwavelength scale. Here, we demonstrated the use of chiral mirrors for the implementation of spin-selective multidimensional manipulation of optical waves. we validated that the three dimensions (amplitude, phase and operation wavelength) of optical waves is directly related to the three main structure variables of the designed chiral mirror. By simply and orderly changing the three structural variables of the designed chiral mirror, the spin-selective full and near independent manipulation of amplitude and phase of optical waves with a large and continuous wavelength agility can be implemented

We propose an approach to realize a multi-band on-chip photonic spin Hall effect and selective excitation of whispering gallery modes (WGMs) by integrating metasurfaces with microcavities. Free-space circularly polarized light with opposite spin angular momentum can effectively excite WGMs with opposite propagation directions at fixed wavelengths. Moreover, the different WGMs with different propagation directions and polarizations can be selectively excited by manipulating the number of antennas. We demonstrate that the optical properties (i.e., coupling efficiency, peak positions, and peak widths) of the proposed metasurface-integrated microcavities can be easily tailored by adjusting different geometric parameters. This study enables the realization of chiral microcavities with exciting novel functionalities, which may provide a further step in the development of photonic integrated circuits, optical sensing, and chiral optics.

Inertial migration of a nonneutrally buoyant disk particle in a linear shear flow under thermal convection (TC) is studied numerically. Particle dynamics and equilibrium position depend on competition between the inertial lift force, the gravitational force (buoyancy), and the TC lift force. When the particle is heavier than the fluid, inertial lift-off is observed and a modified phase diagram is established in terms of the channel Reynolds number Re and density ratio \ensuremath{\sigma}. When the particle is lighter than the fluid, TC induced re-suspension and sedimentation are observed, where the normalized critical Grashof number, Gr${}_{\mathrm{crit}}$/\ensuremath{\sigma}, depends linearly on Re for all particle densities studied.

Colors with high saturation are of prime significance for display and imaging devices. So far, structural colors arising from all-dielectric metasurfaces, particularly amorphous silicon and titanium oxide, have exceeded the gamut of standard RGB (sRGB) space. However, the excitation of higher-order modes for dielectric materials hinders the further increase of saturation. Here, to address the challenge, we propose a new design strategy of multipolar-modulated metasurfaces with multi-dielectric stacked layers to realize the deep modulation of multipolar modes. Index matching between layers can suppress the multipolar modes at nonresonant wavelength, resulting in the dramatic enhancement in the monochromaticity of reflection spectra. Ultrahigh-saturation colors ranging from 70% to 90% with full hue have been theoretically and experimentally obtained. The huge gamut space can be realized in an unprecedented way, taking up 171% sRGB space, 127% Adobe RGB space, and 57% CIE space. More interestingly, the coverage for Recommendation 2020 (Rec. 2020) space, which almost has not been successfully realized so far, can reach 90%. We anticipate that the proposed multipolar-modulated metasurfaces are promising for the enlargement of the color range for high-end and advanced display applications.

This paper takes advantage of fractal method to research some soil characteristics through case analysis. The multifractal spectrum and random Sierpinski carpet are used to describe the spatial variability and thermal conductivity of soil quantitatively. On the basis of predecessors, the scatter plots of various types of data have been used to supplement the multifractal results in a more detailed way. It turns out that the content of clay, silt, and coarse sand could reflect the degree of spatial variability of soil. Then based on this case, the effect of porosity on soil thermal conductivity is discussed by using random Sierpinski carpet. The result shows that the effective thermal conductivity of the clay, silt and coarse sand decreases linearly with the increase of porosity, but the degree of reduction is different. Moreover, when the porosity is definite, the effective thermal conductivity of the coarse sand is the largest, that of the clay with the highest thermal conductivity is second, and that of the silt is the smallest.

Longitudinal metagenomics has been widely studied in the recent decade to provide valuable insight for understanding microbial dynamics. The correlation within each subject can be observed across repeated measurements. However, previous methods that assume independent correlation may suffer from incorrect inferences. In addition, methods that do account for intra-sample correlation may not be applicable for count data. We proposed a distribution-free approach, namely CorrZIDF, which extends the current method to model correlated zero-inflated metagenomic count data, offering a powerful and accurate solution for detecting significance features. This method can handle different working correlation structures without specifying each margin distribution of the count data. Through simulation studies, we have shown the robustness of CorrZIDF when selecting a working correlation structure for repeated measures studies to enhance the efficiency of estimation. We also compared four methods using two real datasets, and the new proposed method identified more unique features that were reported previously on the relevant research.

We report, for the first time, the long-awaited detection of diffuse gamma rays with energies between 100 TeV and 1 PeV in the Galactic disk. Particularly, all gamma rays above 398 TeV are observed apart from known TeV gamma-ray sources and compatible with expectations from the hadronic emission scenario in which gamma rays originate from the decay of $\pi^0$'s produced through the interaction of protons with the interstellar medium in the Galaxy. This is strong evidence that cosmic rays are accelerated beyond PeV energies in our Galaxy and spread over the Galactic disk., Comment: Accepted for publication in the Physical Review Letters

We report observations of gamma-ray emissions with energies in the 100 TeV energy region from the Cygnus region in our Galaxy. Two sources are significantly detected in the directions of the Cygnus OB1 and OB2 associations. Based on their positional coincidences, we associate one with a pulsar PSR J2032+4127 and the other mainly with a pulsar wind nebula PWN G75.2+0.1 with the pulsar moving away from its original birthplace situated around the centroid of the observed gamma-ray emission. This work would stimulate further studies of particle acceleration mechanisms at these gamma-ray sources., Accepted for publication in the Physical Review Letters

A series of policies aimed toward rational resource allocation of long‐term care have being actively discussed since the launch of the social long‐term care insurance in Shanghai, and it is important to take a societal perspective for informed decision‐making. This study aims to explore factors that are associated with well‐being of informal caregivers in Shanghai, and to provide empirical evidence of application of an established well‐being valuation method to monetise informal caregivers' well‐being losses in a developing country. 310 informal caregivers of applicants for social long‐term care insurance in Shanghai were interviewed. Univariate and multivariate analyses were conducted to explore the associated factors with life satisfaction of the caregivers. The monetary values of an additional hour of caregiving with and without specification of care tasks were estimated by the well‐being valuation method. Life satisfaction was consistently associated with monthly income, health status, and caring hours of the caregivers. The money needed to compensate one additional hour of caring per week was 12.58 CNY (0.3% of the monthly income), and 96.95 CNY (2.0% of the monthly income) for activities of daily living (ADL) tasks. Income, health status, and caregiving are significantly associated with well‐being of informal caregivers. Caregivers in relatively poor health condition and/or involved in more ADL tasks should be particularly considered in supporting policies in Shanghai.

Sampling and interpolation have been extensively studied, in order to reconstruct or estimate the entire graph signal from the signal values on a subset of vertexes, of which most achievements are about continuous signals. While in a lot of signal processing tasks, signals are not fully observed, and only the signs of signals are available, for example a rating system may only provide several simple options. In this paper, the reconstruction of band-limited graph signals based on sign sampling is discussed and a greedy sampling strategy is proposed. The simulation experiments are presented, and the greedy sampling algorithm is compared with random sampling algorithm, which verify the validity of the proposed approach.

Cosmic rays (protons and other atomic nuclei) are believed to gain energies of petaelectronvolts (PeV) and beyond at astrophysical particle accelerators called 'PeVatrons' inside our Galaxy. Although a characteristic feature of a PeVatron is expected to be a hard gamma-ray energy spectrum that extends beyond 100 teraelectronvolts (TeV) without a cutoff, none of the currently known sources exhibits such a spectrum due to the low maximum energy of accelerated cosmic rays or insufficient detector sensitivity around 100 TeV. Here we report the observation of gamma-ray emission from the supernova remnant G106.3+2.7 above 10 TeV. This work provides flux data points up to and above 100 TeV and indicates that the very-high-energy gamma-ray emission above 10 TeV is well correlated with a molecular cloud rather than the pulsar PSR J2229+6114. Regarding the gamma-ray emission mechanism of G106.3+2.7, this morphological feature appears to favor a hadronic origin via the {\pi}0 decay caused by accelerated relativistic protons over a leptonic one via the inverse-Compton scattering by relativistic electrons. Furthermore, we point out that an X-ray flux upper limit on the synchrotron spectrum would provide important information to firmly establish the hadronic scenario as the mechanism of particle acceleration at the source., Comment: Published in Nature Astronomy