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1. Metabolic demands of the posteromedial default mode network are shaped by dorsal attention and frontoparietal control networks

Author

GM Godbersen, S Klug, W Wadsak, V Pichler, J Raitanen, A Rieckmann, L Stiernman, L Cocchi, M Breakspear, M Hacker, R Lanzenberger, and A Hahn

Abstract

Although BOLD signal decreases in the default mode network (DMN) are commonly observed during attention-demanding tasks, their neurobiological underpinnings are not fully understood. Previous work has shown decreases but also increases in glucose metabolism that match with or dissociate from these BOLD signal decreases, respectively. To resolve this discrepancy, we analyzed functional PET/MRI data from 50 healthy subjects during the performance of the visuo-spatial processing game Tetris® and combined this with previously published data sets of working memory as well as visual and motor stimulation. Our findings show that the glucose metabolism of the posteromedial DMN is dependent on the metabolic demands of the correspondingly engaged task-positive brain networks. Specifically, the dorsal attention (involved in Tetris®) and frontoparietal networks (engaged during working memory) shape the glucose metabolism of the posteromedial DMN in opposing directions. External attention-demanding tasks lead to a downregulation of the posteromedial DMN with consistent decreases in the BOLD signal and glucose metabolism, whereas working memory is subject to metabolically expensive mechanisms of BOLD signal suppression. We suggest that the former finding is mediated by decreased glutamate signaling, while the latter results from active GABAergic inhibition, regulating the competition between self-generated and task-driven internal demands. The results demonstrate that the DMN relates to cognitive processing in a flexible manner and does not always act as a cohesive task-negative network in isolation.

Published
2022
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2. Effects of gender-affirming hormone therapy on gray matter density, microstructure and monoamine oxidase A levels in transgender subjects

Author

PA Handschuh, MB Reed, M Murgaš, C Vraka, U Kaufmann, L Nics, M Klöbl, M Ozenil, ME Konadu, EM Klebermass, B Spurny-Dworak, W Wadsak, A Hahn, M Hacker, M Spies, P Baldinger-Melich, GS Kranz, and R Lanzenberger

Abstract

Alterations in gray matter (GM) and monoamine oxidase A (MAO-A) distribution across the brain have been found in various neuropsychiatric conditions. MAO-A catalyzes the oxidative degradation of various monoamines and is thus implicated in neuroplastic processes that influence GM density (GMD) and microstructure (GMM) of the brain. Sex-specific differences in these patterns are well documented, however studying the long-term effects of certain sex steroids on the brain are limited due to hormonal fluctuations under naturalistic conditions. Due to the exact monitoring of plasma hormone levels and sex steroid intake, transgender individuals undergoing gender-affirming hormone therapy represent a valuable cohort to investigate such changes of GM and concomitant MAO-A density. Here, we investigated the effects of long-term gender-affirming hormone therapy over a median time period of 4.5 months on GMD and GMM as well as MAO-A distribution volume. To this end, 20 cisgender women, 11 cisgender men, 20 transgender women and 10 transgender men were recruited. All participants underwent two MRI scans in a longitudinal design. PET scans using [11C]harmine were performed before each MRI session in a subset of 35 individuals. Between baseline and follow-up imaging, transgender subjects underwent gender-affirming hormone therapy. GM changes determined by diffusion weighted imaging (DWI) metrics for GMM and voxel based morphometry (VBM) for GMD were estimated using repeated measures ANOVA. Regions showing significant changes of both GMM and GMD were used for the subsequent analysis of MAO-A density. These involved the fusiform gyrus, rolandic operculum, inferior occipital cortex, middle and anterior cingulum, bilateral insula, cerebellum and the lingual gyrus (post-hoc tests: pFWE+Bonferroni < 0.025). In terms of MAO-A distribution volume, no significant effects were found. The present results are indicative of a reliable influence of gender-affirming hormone therapy on GMD and GMM following an interregional pattern. Nevertheless, future studies with larger sample sizes are needed to further investigate the relationship between sex steroids, gray matter alterations and MAO-A density.

Published
2022
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5. Sex-differences in [

Author

A, Leisser, K, Lukic, M, Nejabat, W, Wadsak, M, Mitterhauser, M, Mayerhöfer, G, Karnaikas, M, Raderer, M, Hacker, and A R, Haug

Subjects
Male, Aging, Sex Characteristics, Diabetes Mellitus, Organometallic Compounds, Humans, Biological Transport, Female, Tissue Distribution, Middle Aged, Octreotide
Abstract

Still little is known about factors, influencing the organ uptake of somatostatin receptor (SSTR)-targeting radiopharmaceuticals. The aim of this study was to assess the influence of gender on [In 118 studies of patients with a [[Factors such as gender, diabetes and age influence [

Published
2019

6. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1

Author

Amardeep Ghosh Dastidar, Rebecca Kozor, Zorba Blázquez Bermejo, L.M. Desroche, J. Broncano, Heerajnarain Bulluck, Peter P Swoboda, A Barison, Chrysanthos Grigoratos, Sheraz A. Nazir, S. Oebel, R. Kockova, Giulia Careri, Estefania De Garate, Patrizia Pedrotti, Antonella Meloni, Gianluca Pontone, F. Macaione, R. Murdoch, F. Valente, Komal S Safdar, Tobias Rutz, Shimon Kolker, Stephanie Funk, D. Beitzke, P. Garg, Alexandros Kallifatidis, Upasana Tayal, Andrew D Scott, Rick Wage, Pedro Ferreira, Dudley Pennell, Xiaodong Zhong, Fred Epstein, David Firmin, Sanjay Prasad, Anastasios Prousalis, Sophia-Anastasia Mouratoglou, George Giannakoulas, Xenia Deligianni, Michail Bakaloudis, Nikolaos Magganaris, George Sianos, Haralampos Karvounis, Francesco Santini, R. Aziz, J.R.J. Foley, G. Fent, T.A. Musa, P. Haaf, L. Dobson, P.P. Swoboda, J.P. Greenwood, S. Plein, R.J.V.D. Geest, J.J.M. Westenberg, S. Rasul, W. Wadsak, M. Mitterhauser, R. Nolz, M. Stelzmueller, C. Loewe, M. Hacker, Josephine Kermer, Serkan Dogangüzel, Florian von Knobelsdorff-Brenkenhoff, Jeanette Schulz-Menger, Giora Weisz, Naama Bogot, Irit Hadas Halpern, Arik Wolak, Giulia Ginami, Davide Piccini, Simone Coppo, Gabriella Vincenti, Matthias Stuber, Jürg Schwitter, Xuexin Gao, Stephanie Ambach, Michal D Taylor, Ryan Moore, Robin J Taylor, Olga Toro-Salazar, John L Jeffries, Cheryl Bartone, Subha V Raman, Wojciech Mazur, J.F. Rodriguez-Palomares, L. Gutierrez, V. Pineda, B. Agliano, L. Galian, G. Teixido, M.T. Gonzalez-Alujas, A. Evangelista, D. Garcia-Dorado, S. Gandy, R. Nicholas, G. Houston, P. Martin, J. Muir, S. Matthew, P. Guntur- Ramkumar, I. Cavin, A. Barison, I. Pescetelli, F. Pali, F. Pizzino, A. Terrizzi, D. Di Lisi, G. Novo, G. Todiere, P. Assennato, S. Novo, G.D. Aquaro, Elisa McAlindon, Jonathan Rodrigues, Anna Baritussio, Alessandra Scatteia, Chris Benny Lawton, Tamas Erdei, Gergely Szantho, Mark Hamilton, Chiara Bucciarelli-Ducci, Daniele Andreini, Cristina Rota, Marco Guglielmo, Saima Mushtaq, Andrea Baggiano, Virginia Beltrama, Anna Solbiati, Andrea I. Guaricci, Mauro Pepi, Konstantinos Bratis, Markus Henningson, Matteo Dell'Omodarme, Valentina O. Puntmann, Eike Nagel, Nicola Giunta, Pietro Giuliano, Maria Giovanna Neri, Gennaro Restaino, Stefania Renne, Alessandra Quota, Vincenzo Positano, Daniele De Marchi, Alessia Pepe, Paola Campadello, Gabriella Masciocco, Rita Facchetti, Angela Milazzo, Giuseppina Quattrocchi, Cristina Giannattasio, Maria Frigerio, Alberto Roghi, Ornella Rimoldi, Antonio Amadu, Giuseppe Venuti, Jonathan C. Rodrigues, Serenella Castelvecchio, Antonia Camporeale, Francesco Secchi, Lorenzo Menicanti, Massimo Lombardi, K. Sedlacek, D. Wichterle, V. Sikula, J. Tintera, L. Sukupova, D. Kautznerova, M. Segetova, A. Praveckova, R. Langova, L. Kryze, W. El-Husseini, J. Kautzner, B. Dinov, A. Arya, S. Hilbert, P. Sommer, A. Bollmann, G. Hindricks, I. Paetsch, C. Jahnke, John P. Greenwood, Abhishek Shetye, Jamal N. Khan, Anvesha Singh, Prathap Kanagala, Daniel Swarbrick, Gaurav Gulsin, Matthew Graham-Brown, Anthony Gershlick, Gerry P. McCann, Riccardo Liga, Elena Bennatti, Andrea Barison, Giancarlo Todiere, Giovanni Donato Aquaro, Michele Emdin, Pier Giorgio Masci, A Ortalda, G Todiere, C Grigoratos, G Vergaro, G Mirizzi, N Martini, D De Marchi, P Keilberg, C Passino, GD Aquaro, M Emdin, Adam K McDiarmid, Bara Erhayiem, Graham J Fent, Laura E Dobson, Pankaj Garg, Tarique A Musa, James R Foley, Stephen P Page, John P Greenwood, Sven Plein, Stefania Rosmini, Amna Abdel-Gadir, Anish Bhuva, Thomas A Treibel, Steven K White, Marianna Fontana, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna Herrey, Charlotte Manisty, Derek M Yellon, Peter Kellman, James C Moon, Derek J Hausenloy, A. Luna, T. Martin – Noguerol, P. Caro, R. Toro-Cebada, J. Sanchez – Gonzalez, O. Milleron, B. Safar, Y. Lavie-Badie, D. Millischer, J. Abtan, G. Jondeau, Emilio Cuesta, Sandra O. Rosillo, Gabriela Guzmán, Inmaculada Pinilla, Óscar González, Juan Caro, Inés Ponz, Teresa López, Elena Refoyo, Sabrina Nordin, Silvia Castelleti, Gabriella Captur, Rick Steeds, Shanat Baig, Stuart M Grieve, Gemma A Figtree, Priyanka Singhal, Julian Strange, Angus Nightingale, Andreas Baumbach, Tom Johnson, and Victoria Delgado

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2016
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7. Abstracts of the 33rd International Austrian Winter Symposium

Author

K. Binzel, A. Adelaja, C. L. Wright, D. Scharre, J. Zhang, M. V. Knopp, E. J. Teoh, D. Bottomley, A. Scarsbrook, H. Payne, A. Afaq, J. Bomanji, N. van As, S. Chua, P. Hoskin, A. Chambers, G. J. Cook, V. S. Warbey, A. Chau, P. Ward, M. P. Miller, D. J. Stevens, L. Wilson, F. V. Gleeson, K. Scheidhauer, C. Seidl, M. Autenrieth, F. Bruchertseifer, C. Apostolidis, F. Kurtz, T. Horn, C. Pfob, M. Schwaiger, J. Gschwend, C. D’Alessandria, A. Morgenstern, C. Uprimny, A. Kroiss, C. Decristoforo, E. von Guggenberg, B. Nilica, W. Horninger, I. Virgolini, S. Rasul, N. Poetsch, A. Woehrer, M. Preusser, M. Mitterhauser, W. Wadsak, G. Widhalm, M. Mischkulnig, M. Hacker, T. Traub-Weidinger, E. J. Wuthrick, E. D. Miller, P. Maniawski, Sebastijan Rep, Marko Hocevar, Janja Vaupotic, Urban Zdesar, Katja Zaletel, Luka Lezaic, S. Mairinger, Thomas Filip, M. Sauberer, S. Flunkert, T. Wanek, J. Stanek, N. Okamura, O. Langer, C. Kuntner, M. C. Fornito, R. Balzano, V. Di Martino, S. Cacciaguerra, G. Russo, D. Seifert, M. Kleinova, A. Cepa, J. Ralis, P. Hanc, O. Lebeda, M. Mosa, S. Vandenberghe, E. Mikhaylova, D. Borys, V. Viswanath, M. Stockhoff, N. Efthimiou, P. Caribe, R. Van Holen, J. S. Karp, P. M. Haller, C. Farhan, E. Piackova, B. Jäger, P. Knoll, A. Kiss, B. K. Podesser, J. Wojta, K. Huber, S. Mirzaei, A. Traxl, K. Komposch, Elisabeth Glitzner, M. Sibilia, M. Russello, S. Sorko, H. J. Gallowitsch, S. Kohlfuerst, S. Matschnig, M. Rieser, M. Sorschag, P. Lind, L. Ležaič, S. Rep, J. Žibert, N. Frelih, S. Šuštar, R. P. Baum, T. Langbein, A. Singh, M. Shahinfar, C. Schuchardt, G. F. Volk, H. R. Kulkarni, G. V. Di Martino, W. H. Thomson, M. Kudlacek, M. Karik, H. Rieger, W. Pokieser, K. Glaser, V. Petz, C. Tugendsam, W. Buchinger, B. Schmoll-Hauer, I. P. Schenk, K. Rudolph, M. Krebs, G. Zettinig, V. Zoufal, M. Krohn, T. Filip, J. Pahnke, F. Weitzer, B. Pernthaler, S. Salamon, R. Aigner, P. Koranda, L. Henzlová, M. Kamínek, Mo. Váchalová, P. Bachleda, D. Summer, J. Garousi, M. Oroujeni, B. Mitran, K. G. Andersson, A. Vorobyeva, J.n Löfblom, A. Orlova, V. Tolmachev, P. Kaeopookum, T. Orasch, B. Lechner, M. Petrik, Z. Novy, C. Rangger, and H. Haas

Subjects
Siderophore, Biochemistry, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Bifunctional chelator, business, Egfr expression, Conjugate
Abstract

Aim: Zirconium-89 has gained great interest for PET, when imaging at late time points is required. Desferrioxamine B (DFO), is mostly used for this radionuclide as bifunctional chelator (BFC) and w ...

Published
2018
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9. Simple and rapid quantification of serotonin transporter binding using [

Author

G, Gryglewski, L, Rischka, C, Philippe, A, Hahn, G M, James, E, Klebermass, M, Hienert, L, Silberbauer, T, Vanicek, A, Kautzky, N, Berroterán-Infante, L, Nics, T, Traub-Weidinger, M, Mitterhauser, W, Wadsak, M, Hacker, S, Kasper, and R, Lanzenberger

Subjects
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Benzylamines, Brain, Double-Blind Method, Positron-Emission Tomography, Injections, Intravenous, Humans, Female, Tissue Distribution, Carbon Radioisotopes, Radiopharmaceuticals, Infusions, Intravenous
Abstract

In-vivo quantification of serotonin transporters (SERT) in human brain has been a mainstay of molecular imaging in the field of neuropsychiatric disorders and helped to explore the underpinnings of several medical conditions, therapeutic and environmental influences. The emergence of PET/MR hybrid systems and the heterogeneity of SERT binding call for the development of efficient methods making the investigation of larger or vulnerable populations with limited scanner time and simultaneous changes in molecular and functional measures possible. We propose [[A KWe have optimized the equilibrium method with [

Published
2016

10. 32nd International Austrian Winter Symposium

Author

W Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti, L Imamovic, G Rendl, D Hackl, O Tsybrovsky, K Emmanuel, F Moinfar, C Pirich, A Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, B Niederle, M Hartenbach, T Beyer, K Herrmann, J Czernin, I Rausch, P Rust, MD DiFranco, M Lassen, A Stadlbauer, ME Mayerhöfer, M Hacker, K Binzel, R Magnussen, W Wei, MU Knopp, DC Flanigan, C Kaeding, MV Knopp, A Leisser, M Nejabat, G Kramer, M Krainer, A Haug, Wencke Lehnert, Karl Schmidt, Sharok Kimiaei, Marcus Bronzel, Andreas Kluge, CL Wright, J Zhang, Evan Wuthrick, Piotr Maniawski, M Blaickner, E Rados, A Huber, M Dulovits, H Kulkarni, S Wiessalla, C Schuchardt, RP Baum, B Knäusl, D Georg, M Bauer, B Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O Langer, M Feldmann, R Karch, MJ Koepp, M-C Asselin, E Pataraia, M Zeilinger, M Dumanic, F Pichler, J Pilz, M Mitterhauser, L Nics, B Steiner, A Traxl, Thomas Wanek, Kushtrim Kryeziu, Severin Mairinger, Johann Stanek, Walter Berger, Claudia Kuntner, Oliver Langer, S Mairinger, T Wanek, M Krohn, J Stanek, T Filip, M Sauberer, C Kuntner, J Pahnke, D Svatunek, C Denk, M Wilkovitsch, C Kuntner-Hannes, J Fröhlich, H Mikula, T Balber, J Singer, J Fazekas, C Rami-Mark, N Berroterán-Infante, E Jensen-Jarolim, H Viernstein, B Sohr, S Pfaff, E Halilbasic, M Visentin, B Stieger, M Trauner, P Lam, M Aistleitner, R Eichinger, C Artner, H Eidherr, C Vraka, H Kvaternik, R Müller, D Hausberger, C Zink, RM Aigner, U Cossío, M Asensio, A Montes, S Akhtar, Y te Welscher, R van Nostrum, V Gómez-Vallejo, J Llop, F VandeVyver, T Barclay, N Lippens, M Troch, L Hehenwarter, B Egger, J Holzmannhofer, M Rodrigues-Radischat, N Pötsch, D Wilhelm, M Weber, J Furtner, A Wöhrer, T Traub-Weidinger, T Cassou-Mounat, S Balogova, V Nataf, M Calzada, V Huchet, K Kerrou, J-Y Devaux, M Mohty, L Garderet, J-N Talbot, S Stanzel, G Pregartner, T Schwarz, V Bjelic-Radisic, B Liegl-Atzwanger, R Aigner, F Quehenberger, A Koljević Marković, Milica Janković, V Miler Jerković, M Paskaš, G Pupić, R Džodić, D Popović, MC Fornito, D Familiari, P Koranda, H Polzerová, I Metelková, L Henzlová, R Formánek, E Buriánková, M Kamínek, WH Thomson, C Lewis, J O’Brien, G James, A Notghi, H Huber, I Stelzmüller, R Wunn, M Mandl, F Fellner, B Lamprecht, M Gabriel, G Leonardi, J Hudzietzová, J Sabol, and M Fülöp

Subjects
Prostate cancer, medicine.medical_specialty, business.industry, General surgery, medicine, MEDLINE, Radiology, Nuclear Medicine and imaging, urologic and male genital diseases, medicine.disease, business, Meeting Abstracts, Cardiac imaging, 3. Good health
Abstract

Table of contents A1 68Ga-PSMA PET/CT in staging and restaging of Prostate Cancer Patients: comparative study with 18F-Choline PET/CT W Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti A2 F18 Choline PET – CT: an accurate diagnostic tool for the detection of parathyroid adenoma? L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel, F Moinfar, C Pirich, W Langsteger A3 [18F]Fluoro-DOPA-PET/CT in the primary diagnosis of medullary thyroid carcinoma A Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, B Niederle, M Hartenbach A4 Variations of clinical PET/MR operations: An international survey on the clinical utilization of PET/MRI T Beyer, K Herrmann, J Czernin A5 Standard Dixon-based attenuation correction in combined PET/MRI: Reproducibility and the possibility of Lean body mass estimation I Rausch, P Rust, MD DiFranco, M Lassen, A Stadlbauer, ME Mayerhöfer, M Hartenbach, M Hacker, T Beyer A6 High resolution digital FDG PET/MRI imaging for assessment of ACL graft viability K Binzel, R Magnussen, W Wei, MU Knopp, DC Flanigan, C Kaeding, MV Knopp A7 Using pre-existing hematotoxicity as predictor for severe side effects and number of treatment cycles of Xofigo therapy A Leisser, M Nejabat, M Hartenbach, G Kramer, M Krainer, M Hacker, A Haug A8 QDOSE – comprehensive software solution for internal dose assessment Wencke Lehnert, Karl Schmidt, Sharok Kimiaei, Marcus Bronzel, Andreas Kluge A9 Clinical impact of Time-of-Flight on next-generation digital PET imaging of Yttrium-90 radioactivity following liver radioembolization CL Wright, K Binzel, J Zhang, Evan Wuthrick, Piotr Maniawski, MV Knopp A10 Snakes in patients! Lessons learned from programming active contours for automated organ segmentation M Blaickner, E Rados, A Huber, M Dulovits, H Kulkarni, S Wiessalla, C Schuchardt, RP Baum, B Knäusl, D Georg A11 Influence of a genetic polymorphism on brain uptake of the dual ABCB1/ABCG2 substrate [11C]tariquidar M Bauer, B Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O Langer A12 Outcome prediction of temporal lobe epilepsy surgery from P-glycoprotein activity. Pooled analysis of (R)-[11C]-verapamil PET data from two European centres M Bauer, M Feldmann, R Karch, W Wadsak, M Zeitlinger, MJ Koepp, M-C Asselin, E Pataraia, O Langer A13 In-vitro and in-vivo characterization of [18F]FE@SNAP and derivatives for the visualization of the melanin concentrating hormone receptor 1 M Zeilinger, C Philippe, M Dumanic, F Pichler, J Pilz, M Hacker, W Wadsak, M Mitterhauser A14 Reducing time in quality control leads to higher specific radioactivity of short-lived radiotracers L Nics, B Steiner, M Hacker, M Mitterhauser, W Wadsak A15 In vitro 11C-erlotinib binding experiments in cancer cell lines with epidermal growth factor receptor mutations A Traxl, Thomas Wanek, Kushtrim Kryeziu, Severin Mairinger, Johann Stanek, Walter Berger, Claudia Kuntner, Oliver Langer A16 7-[11C]methyl-6-bromopurine, a PET tracer to measure brain Mrp1 function: radiosynthesis and first PET evaluation in mice S Mairinger, T Wanek, A Traxl, M Krohn, J Stanek, T Filip, M Sauberer, C Kuntner, J Pahnke, O Langer A17 18F labeled azidoglucose derivatives as “click” agents for pretargeted PET imaging D Svatunek, C Denk, M Wilkovitsch, T Wanek, T Filip, C Kuntner-Hannes, J Fröhlich, H Mikula A18 Bioorthogonal tools for PET imaging: development of radiolabeled 1,2,4,5-Tetrazines C Denk, D Svatunek, T Wanek, S Mairinger, J Stanek, T Filip, J Fröhlich, H Mikula, C Kuntner-Hannes A19 Preclinical evaluation of [18F]FE@SUPPY- a new PET-tracer for oncology T Balber, J Singer, J Fazekas, C Rami-Mark, N Berroterán-Infante, E Jensen-Jarolim, W Wadsak, M Hacker, H Viernstein, M Mitterhauser A20 Investigation of Small [18F]-Fluoroalkylazides for Rapid Radiolabeling and In Vivo Click Chemistry C Denk, D Svatunek, B Sohr, H Mikula, J Fröhlich, T Wanek, C Kuntner-Hannes, T Filip A21 Microfluidic 68Ga-radiolabeling of PSMA-HBED-CC using a flow-through reactor S Pfaff, C Philippe, M Mitterhauser, M Hartenbach, M Hacker, W Wadsak A22 Influence of 24-nor-ursodeoxycholic acid on hepatic disposition of [18F]ciprofloxacin measured with positron emission tomography T Wanek, E Halilbasic, M Visentin, S Mairinger, B Stieger, C Kuntner, M Trauner, O Langer A23 Automated 18F-flumazenil production using chemically resistant disposable cassettes P Lam, M Aistleitner, R Eichinger, C Artner A24 Similarities and differences in the synthesis and quality control of 177Lu-DOTA-TATE, 177Lu -HA-DOTA-TATE and 177Lu-DOTA-PSMA (PSMA-617) H Eidherr, C Vraka, A Haug, M Mitterhauser, L Nics, M Hartenbach, M Hacker, W Wadsak A25 68Ga- and 177Lu-labelling of PSMA-617 H Kvaternik, R Müller, D Hausberger, C Zink, RM Aigner A26 Radiolabelling of liposomes with 67Ga and biodistribution studies after administration by an aerosol inhalation system U Cossío, M Asensio, A Montes, S Akhtar, Y te Welscher, R van Nostrum, V Gómez-Vallejo, J Llop A27 Fully automated quantification of DaTscan SPECT: Integration of age and gender differences F VandeVyver, T Barclay, N Lippens, M Troch A28 Lesion-to-background ratio in co-registered 18F-FET PET/MR imaging – is it a valuable tool to differentiate between low grade and high grade brain tumor? L Hehenwarter, B Egger, J Holzmannhofer, M Rodrigues-Radischat, C Pirich A29 [11C]-methionine PET in gliomas - a retrospective data analysis of 166 patients N Pötsch, I Rausch, D Wilhelm, M Weber, J Furtner, G Karanikas, A Wöhrer, M Mitterhauser, M Hacker, T Traub-Weidinger A30 18F-Fluorocholine versus 18F-Fluorodeoxyglucose for PET/CT imaging in patients with relapsed or progressive multiple myeloma: a pilot study T Cassou-Mounat, S Balogova, V Nataf, M Calzada, V Huchet, K Kerrou, J-Y Devaux, M Mohty, L Garderet, J-N Talbot A31 Prognostic benefit of additional SPECT/CT in sentinel lymph node mapping of breast cancer patients S Stanzel, G Pregartner, T Schwarz, V Bjelic-Radisic, B Liegl-Atzwanger, R Aigner A32 Evaluation of diagnostic value of TOF-18F-FDG PET/CT in patients with suspected pancreatic cancer S Stanzel, F Quehenberger, RM Aigner A33 New quantification method for diagnosis of primary hyperpatahyroidism lesions and differential diagnosis vs thyropid nodular disease in dynamic scintigraphy A Koljević Marković, Milica Janković, V Miler Jerković, M Paskaš, G Pupić, R Džodić, D Popović A34 A rare case of diffuse pancreatic involvement in patient with merkel cell carcinoma detected by 18F-FDG MC Fornito, D Familiari A35 TSH-stimulated 18F-FDG PET/CT in the diagnosis of recurrent/metastatic radioiodine-negative differentiated thyroid carcinomas in patients with various thyroglobuline levels P Koranda, H Polzerová, I Metelková, L Henzlová, R Formánek, E Buriánková, M Kamínek A36 Breast Dose from lactation following I131 treatment WH Thomson, C Lewis A37 A new concept for performing SeHCAT studies with the gamma camera WH Thomson, J O’Brien, G James, A Notghi A38 Whole body F-18-FDG-PET and tuberculosis: sensitivity compared to x-ray-CT H Huber, I Stelzmüller, R Wunn, M Mandl, F Fellner, B Lamprecht, M Gabriel A39 Emerging role 18F-FDG PET-CT in the diagnosis and follow-up of the infection in heartware ventricular assist system (HVAD) MC Fornito, G Leonardi A40 Validation of Poisson resampling software WH Thomson, J O’Brien, G James A41 Protection of PET nuclear medicine personnel: problems in satisfying dose limit requirements J Hudzietzová, J Sabol, M Fülöp

Published
2016
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11. Response assessment using 68Ga-PSMA ligand PET-parameters in patients undergoing 177Lu-PSMA radioligand therapy for metastatic castration resistant prostate cancer

Author

Gero Kramer, Francesco Soria, M. Hartenbach, Alexander Haug, David D'Andrea, S. Pfaff, John W. Babich, Karl Hermann Grubmüller, Bernhard Grubmüller, S.F. Shariat, W. Wadsak, F. Berndl, M. Hacker, Theresa Balber, Pascal A. T. Baltzer, M. Mitterhauser, and Christian Seitz

Subjects
Response assessment, Prostate cancer, business.industry, Urology, Cancer research, Radioligand, 68ga psma, Medicine, In patient, Castration resistant, Ligand (biochemistry), business, medicine.disease
Published
2018
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12. Prospective evaluation of the performance of 68Ga-PSMA 11-PET CT/MRI imaging for lymph node staging in patients with biochemical recurrence after radical prostatectomy

Author

Andrea Haitel, Bernhard Grubmüller, S. Pfaff, S.F. Shariat, Alexander Haug, Mohammad Abufaraj, W. Wadsak, Pascal A. T. Baltzer, Alberto Briganti, M. Hartenbach, and Gero Kramer

Subjects
Biochemical recurrence, PET-CT, medicine.medical_specialty, Mri imaging, Prostatectomy, business.industry, Urology, medicine.medical_treatment, 030232 urology & nephrology, Prospective evaluation, 68Ga-PSMA-11, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, In patient, Radiology, Lymph node staging, business
Published
2018
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13. Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier

Author

M, Bauer, K, Römermann, R, Karch, B, Wulkersdorfer, J, Stanek, C, Philippe, A, Maier-Salamon, H, Haslacher, C, Jungbauer, W, Wadsak, W, Jäger, W, Löscher, M, Hacker, M, Zeitlinger, and O, Langer

Subjects
Adult, Male, animal structures, ATP Binding Cassette Transporter, Subfamily B, Brain, Pilot Projects, Polymorphism, Single Nucleotide, Clinical Trial, Neoplasm Proteins, Young Adult, Verapamil, Blood-Brain Barrier, Positron-Emission Tomography, Tetrahydroisoquinolines, embryonic structures, Quinolines, ATP Binding Cassette Transporter, Subfamily G, Member 2, Acridines, Humans, Female, Tissue Distribution, sense organs
Abstract

ABCB1 and ABCG2 work together at the blood-brain barrier (BBB) to limit brain distribution of dual ABCB1/ABCG2 substrates. In this pilot study we used positron emission tomography (PET) to assess brain distribution of two model ABCB1/ABCG2 substrates ([(11) C]elacridar and [(11) C]tariquidar) in healthy subjects without (c.421CC) or with (c.421CA) the ABCG2 single-nucleotide polymorphism (SNP) c.421CA. Subjects underwent PET scans under conditions when ABCB1 and ABCG2 were functional and during ABCB1 inhibition with high-dose tariquidar. In contrast to the ABCB1-selective substrate (R)-[(11) C]verapamil, [(11) C]elacridar and [(11) C]tariquidar showed only moderate increases in brain distribution during ABCB1 inhibition. This provides evidence for a functional interplay between ABCB1 and ABCG2 at the human BBB and suggests that both ABCB1 and ABCG2 need to be inhibited to achieve substantial increases in brain distribution of dual ABCB1/ABCG2 substrates. During ABCB1 inhibition c.421CA subjects had significantly higher increases in [(11) C]tariquidar brain distribution than c.421CC subjects, pointing to impaired cerebral ABCG2 function.

Published
2015

14. Parameter evaluation and fully-automated radiosynthesis of [(11)C]harmine for imaging of MAO-A for clinical trials

Author

C, Philippe, M, Zeilinger, M, Mitterhauser, M, Dumanic, R, Lanzenberger, M, Hacker, and W, Wadsak

Subjects
Quality Control, Clinical Trials as Topic, Radiosynthesis, Monoamine oxidase, Brain, Carbon-11, Chemistry Techniques, Synthetic, [11C]harmine, Article, MAO-A, Harmine, PET, Positron-Emission Tomography, Humans, Carbon Radioisotopes, Radiopharmaceuticals
Abstract

The aim of the present study was the evaluation and automation of the radiosynthesis of [11C]harmine for clinical trials. The following parameters have been investigated: amount of base, precursor concentration, solvent, reaction temperature and time. The optimum reaction conditions were determined to be 2–3 mg/mL precursor activated with 1 eq. 5 M NaOH in DMSO, 80 °C reaction temperature and 2 min reaction time. Under these conditions 6.1±1 GBq (51.0±11% based on [11C]CH3I, corrected for decay) of [11C]harmine (n=72) were obtained. The specific activity was 101.32±28.2 GBq/µmol (at EOS). All quality control parameters were in accordance with the standards for parenteral human application. Due to its reliability and high yields, this fully-automated synthesis method can be used as routine set-up., Highlights • Preparation of [11C]harmine on a commercially available synthesizer for the routine application. • High reliability: only 4 out of 72 failed syntheses; 5% due to technical problems. • High yields: 6.1±1 GBq overall yield (EOS). • High specific activities: 101.32±28.2 GBq/µmol.

Published
2014

20. Cold pressure testing 99 Tc MIBI-SPECT useful detecting abnormal coronary vasoreactivity in asymptomatic population with moderate risk of cardiovascular events. PARADIGMA multicenter study

Author

J.P. Hellermann, S. Svetlana Sazonova, Thierry C. Gillebert, Stephan G. Nekolla, R. Seabra-Gomes, Rob S. Beanlands, S. Mot, N. Avigni, S. Kumar, M. El-Gabaly, K. Sawinski, T. K. Ip, M. Mehdi Namdar, M. Popiel, Deborah Katten, Alexander Battler, R. T. Robert Tuttle, A. Ferro, Jung-Joon Min, C. Claudia Medrea, Poul Flemming Høilund-Carlsen, M. Cappagli, Shin Young Jeong, Jean N. DaSilva, D. Baranov, S. Grajek, M. Cafiero, Bruce Darrow, R. Berta, Leonie Gordon, H. Iida, L. A. Providência, Gérald Vanzetto, Tuvia Ben-Gal, W. Dafoe, L. E. Mastrocolla, M. I. Miyamoto, A. Imperiale, W. Yasunori, P. Malagutti, Mario Beretta, Y. Ohta, M. Komarnicki, M. Lupo, E. Nariaki, A. Oliveira, P. Beraldo, P. G. Danias, J. Jae-Tae Lee, S. Lima, M. Beheshti, Matthias Pfisterer, M. Valgimigli, Torsten Toftegaard Nielsen, A. L. Patroncini, Y. Kou, H. Haddad, S. Werden, M. Shkolnikova, J. C. R. Pereira, M. Møldrup, W. Watanabe Yasuhi, P De Bondt, D. Horstkotte, D. Baller, J. Jens Hedega Kristensen, G. Storto, Linda Garrard, Olivier De Winter, A. Alexandru Naum, Palaniswamy Shanmuga Sundaram, R. Czepczynski, Fawad Kazi, A. Lazar, Philipp A. Kaufmann, E. Inglese, Gregory S. Thomas, M. Mariana Vasconcelos, W. Acampa, J. H. Bae, A. Ventosa, H. W. Christensen, G. De Backer, S. Panareo, Mette Madsen, Alan W. Ahlberg, Nili Zafrir, L. Feggi, Rosa Levy, H. Hanne Sondergaard, M. Balducelli, A. Amir Ausef, V. Larionova, A. W. Ahlberg, C. A. Molina, O. Berkovich, T. Faria, Jennifer J. Thomas, Senta Graf, Claudio Marcassa, D. Cragnolino, T. Yasuhiko, C. R. E. Sampaio, E. Ernest Podrasky, E. Shlyakhto, A. Rener, Alfredo R. Galassi, Patrick T. Siegrist, D. L. Rice, A. Meretta, P. Chacon, G. Moscatelli, V. Oikonen, N. Bartenstein, Frank M. Bengel, Gerald Maurer, C. Tamburino, M. Ferreira, L. Vidal, O. Masoli, A. Epps, S. Akihiro, C. Grasso, A. Cieslinski, A. Zarrilli, P. Calza, M. De Buyzere, I. Esipovich, G. Porenta, M. Oettinger, P. Smanio, C. Pollack, W. Burchert, P. T. Siegrist, D. Bernard, R. Ferrari, A. Thom, F. Bertagna, Y. Akio, H. Eidherr, L. Grynberg, David M. O’Sullivan, T. Kunimasa, J. Sowinski, M. Petretta, J. Lima, L. Corrado, Gary V. Heller, D. B. Kramer, V. Timoshin, I. Leka, N. Henke, M. Salvatore, P. Breborowicz, Keiichiro Yoshinaga, A. Whalen, Ho-Chun Song, C. Gatti, B. Lamp, Werner Vach, C. Van de Wiele, M. J. Järvisalo, T. Zornitzki, T. Kimio, M. Maeng, J. Candell-Riera, R. Delaloye, M. Giganti, R. deKemp, Tatsuhiko Furuhashi, Pascal Koepfli, Taher El-Kady, Heikki Ukkonen, J. Kemppainen, S. Padma, E. V. Lima, R. Capilneanu, R. Couto, T. Ivashchenko, W. Wadsak, Gavin L Noble, Heinz Sochor, C. Corbelli, S. Traverso, C Lourenço, Stefano Severi, Pasquale Perrone Filardi, William E. Boden, P. Wielepp, Jan Mueller-Brand, P. Jacon, J. Alvarez-Sabin, K. Kruschke, Shung Chull Chae, M. S. Laaksonen, A. Poliakov, A. Kammeier, Y. J. Heo, J. Knuuti, U. Schurr, S. Vered, Torben Haghfelt, E. Fricke, M. Namdar, M. Polimeno, Masao Moroi, J. Holzinger, M. El-Sayed, Hiroshi Watabe, A. Cuocolo, L. Raposo, Byeong-Cheol Ahn, J. H. Seo, J. Wolfram, G. Vecchi, D. Faraggi, C. Poetzi, F. Rodrigues, C. Rappallo, A. Caspi, M. Lesiak, Alejandro Solodky, E. Elisabetta Varani, M.L. De Rimini, Ian G. Burwash, R. Bogdan, Kurt Kletter, A. Czyz, J. Hausleiter, K. Khaled Elsaban, May Aung, H. Fukuda, A. Johansen, S. Chiarameda, P.L Pieri, M. Rehling, N. Reichek, R. C. Thompson, P. Giannuzzi, Georgios I Papaioannou, A. Ferrer-Antunes, M. Redruello, G. Medolago, J. Montaner, P. Nuutila, Rudi Dierckx, G. Brevetti, C. A. R. Oliveira, E. Martins, T. Hayashi, V. Vickenty Kozulin, D. Fagret, R. Campini, G. Cyr, Kathryn Williams, S. Dellegrottaglie, Hans Erik Bøtker, K. B. Lee, A. Panov, Anja Velghe, G. V. Heller, G. De Leon, S. Sachin Navare, M. Garcia, Santiago Aguadé-Bruix, U. M. Mortensen, L. S. Linda Shaw, Morten Bøttcher, P. E. Smanio, Alberto Cuocolo, F. Buccoliero, D. Glogar, G. Percoco, C. Aguiar, V. Gil, A. Szeto, Regina S. Druz, R. Grathwohl, M. Gyongyosi, M. Souvatzoglou, R. Davies, Corrado Cittanti, Israel Mats, Benjamin J.W. Chow, S. Chuprova, J. S. Berg, N. Teramoto, H. Tuunanen, K.K. Haridas, M. Zachariah, F. Rocha-Gonçalves, A. Rovira, Hee-Seung Bom, C. Roque, J. De Sutter, Justin Lundbye, J. Calqueiro, A. Yehia, Michael W. Hanson, Néstor Perez Baliño, J. M. Rossi, M. Gordeev, N. Burova, S. Moshiri, Markus Schwaiger, P. Sullo, E. Zaklyazminskaya, N.R. Van de Veire, O. O. Akinboboye, M. Chiariello, S. Viňas, Salvador Borges-Neto, Paulo Schiavom Duarte, A. Gonzalez, A. Ausef, E. Bagatin, M. Langlois, E. Leotta, R. Casanova, Aliasghar Khorsand, Ole Schmitz, D. Rosa, J. Machecourt, Shay Livschitz, C. A. Wyss, Terence D. Ruddy, K. Ryou, H. Knobler, G. Romero-Farina, S. Azzarelli, I. Vidal, P. C. Burger, A. Maresta, P. F. Poul F. Høilund-Carlsen, J. Vogt, J. F. Arenillas, J. Pereira, Michael J. Zellweger, A. António Ferreira, G. Karanikas, Kenneth Nichols, and O. Lindner

Subjects
business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Medical emergency, Cardiology and Cardiovascular Medicine, business, medicine.disease, Outcome (game theory)
Published
2005
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