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Coronavirus Disease-19 (COVID19) caused by the enormously spreadable SARS- CoV-2 virus has appeared as a global pandemic and leads to high mortalities. Approximately 31,243,339 people have been infected so far with this disease which has led to the death of more than 965,103patients as of 21st Sept 2020. There are many drug molecules under-trials are in phase I and II. The numerous possible candidates for vaccine development against this infectious virus are also in the pipeline. Although, so far no molecule as a therapeutics or vaccine for prevention has been approved. Recent reports have observed that severely ill patients have a differential immunological profile compared to mild COVID-19 infection. Current studies globally observed that the cytokine storm maybe leads to the severity of COVID19 infection. In this article, our focus is to describe the present knowledge and status of differential immune profile among patients infected with COVID19 infection and their association with disease progression mild to severe.

Objective: To study association of Celiac Disease with Insulin Dependent Diabetes and Hypothyroidism in young adults in North-Western Rajasthan. Method: Total eighty-seven newly diagnosed adult patients of celiac disease were included. Sera of all patients were tested for presence of IgA tissue transglutaminase (tTG) antibody by ELISA using commercially available kits. Three to four intestinal mucosal biopsies were obtained with GI endoscopy from the second part of duodenum in patients with presence of tTG antibodies. Fasting blood glucose (FBG) was measured after overnight fasting (8 hours of fasting overnight ). Serum TSH testing was performed on automated immunoassay platforms employing advanced IMA technology. Results: In our study, out of total 87 patients, 46(52.87%) were from serum TTG group 50-200 and 41(47.12%) from serum TTG group >200. Out of total 87 patients, 14 patients had their TSH >4.2 and out of them 12 and 2 patients were from serum TTG group 50-200 and >200 respectively and the difference was statistically significant (p200 respectively. Only 10 patients had their fasting blood sugar >125 and out of them 9 and 1 were from serum TTG group 50-200 and >200 respectively and the difference was found significant (p