1. IgG intrathecal synthesis and specific antibody index in patients with neurocysticercosis
- Author
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Ednéia Casagranda Bueno, Adelaide José Vaz, Sylvia Regina Mielli, J. P. S. Nobrega, Vitória Bastouly, Luís dos Ramos Machado, and José Antonio Livramento
- Subjects
hemaglutinação passiva ,Adult ,Male ,passive hemagglutination ,Adolescent ,IgG ,Leukocytosis ,Neurocysticercosis ,síntese intratecal ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Intrathecal ,cerebrospinal fluid ,lcsh:RC321-571 ,cisticercose ,specific antibody index ,Cerebrospinal fluid ,Blood serum ,líquido cefalorraqueano ,Medicine ,Humans ,índice de anticorpos específicos ,In patient ,Prospective Studies ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Aged ,business.industry ,cysticercosis ,oligoclonal bands ,neurocysticercosis ,Cysticercosis ,Gamma globulin ,Syndrome ,Middle Aged ,medicine.disease ,intrathecal synthesis ,bandas oligoclonais ,Specific antibody ,Neurology ,Immunoglobulin G ,Immunology ,neurocisticercose ,ELISA ,Female ,Neurology (clinical) ,gamma-Globulins ,business ,RC321-571 - Abstract
We analyzed cerebrospinal fluid (CSF) and blood serum from 55 patients with neurocysticercosis (NC) at different clinical stages. According to inflammatory activity in the CSF, three stages were identified: (1) reactive, when there was at least an increase in the number of cells; (2) weakly reactive, when significant alterations were found in the CSF, including an increase in gamma globulins, albeit without hypercytosis; (3) non-reactive, when there was neither hypercytosis nor increase in gamma globulins. Nineteen patients had the reactive form; 18 had the weakly reactive form; 18 displayed the non-reactive form. Local immunoproduction was intense in the reactive group, moderate in the weakly reactive group, and absent in the non-reactive group. The specific antibody index was raised in approximately 2/3 of patients with the reactive form, 2/3 in those with the weakly reactive form, and 1/3 in those with the non-reactive form. In conclusion: (1) the classical CSF syndrome in NC can present both in complete and partial modes; (2) local immunoproduction can occur in weakly reactive forms; (3) a raised specific antibody index can occur in the absence of an inflammatory reaction in the CSF. Analisamos o líquido cefalorraqueano (LCR) e o soro sanguíneo de 55 pacientes com neurocisticercose (NC) em diversas fases de evolução. De acordo com a atividade inflamatória no LCR, foram consideradas três formas: (1) reativa, quando havia pelo menos aumento do número de células; (2) fracamente reativa, quando havia alterações no LCR, incluindo aumento de globulinas gama, mas sem pleocitose; (3) não reativa, quando não havia pleocitose nem aumento de globulinas gama. Dezenove pacientes apresentavam a forma reativa, 18 a forma fracamente reativa, 18 a não reativa. O índice de anticorpos específicos estava aumentado em cerca de 2/3 dos pacientes das formas reativa, em 2/3 na forma fracamente reativa e em 1/3 na forma não reativa. Conclusão: (1) a síndrome do LCR na NC pode apresentar-se tanto de modo completo quanto de modo parcial; (2) imunoprodução local de anticorpos específicos pode ocorrer também em pacientes sem aumento de células; (3) índice de anticorpos específicos elevado pode ocorrer mesmo na ausência de reação inflamatória no LCR.
- Published
- 2002