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Fatigue is the subjective sensation of weariness, increased sense of effort, or exhaustion and is pervasive in neurologic illnesses. Despite its prevalence, we have a limited understanding of the neurophysiological mechanisms underlying fatigue. The cerebellum, known for its role in motor control and learning, is also involved in perceptual processes. However, the role of the cerebellum in fatigue remains largely unexplored. We performed two experiments to examine whether cerebellar excitability is affected after a fatiguing task and its association with fatigue. Using a crossover design, we assessed cerebellar inhibition (CBI) and perception of fatigue in humans before and after “fatigue” and “control” tasks. Thirty-three participants (16 males, 17 females) performed five isometric pinch trials with their thumb and index finger at 80% maximum voluntary capacity (MVC) until failure (force SIGNIFICANCE STATEMENTFatigue is one of the most common and debilitating symptoms in neurologic, neuropsychiatric, and chronic illnesses. Despite its epidemiological importance, there is a limited understanding of the neurophysiological mechanisms underlying fatigue. In a series of experiments, we demonstrate that decreased cerebellar excitability relates to lesser physical fatigue perception and worse motor control. These results showcase the role of the cerebellum in fatigue regulation and suggest that fatigue- and performance-related processes might compete for cerebellar resources.

The tremendous development and rapid evolution in computing advancements has urged a lot of organizations to expand their data as well as computational needs. Such type of services offers security concepts like confidentiality, integrity, and availability. Thus, a highly secured domain is the fundamental need of cloud environments. In addition, security breaches are also growing equally in the cloud because of the sophisticated services of the cloud, which cannot be mitigated efficiently through firewall rules and packet filtering methods. In order to mitigate the malicious attacks and to detect the malicious behavior with high detection accuracy, an effective strategy named Multiverse Fractional Calculus (MFC) based hybrid deep learning approach is proposed. Here, two network classifiers namely Hierarchical Attention Network (HAN) and Random Multimodel Deep Learning (RMDL) are employed to detect the presence of malicious behavior. The network classifier is trained by exploiting proposed MFC, which is an integration of multi-verse optimizer and fractional calculus. The proposed MFC-based hybrid deep learning approach has attained superior results with utmost testing sensitivity, accuracy, and specificity of 0.949, 0.939, and 0.947.

Background and Purpose High-grade carotid artery stenosis may alter hemodynamics in the ipsilateral hemisphere, but consequences of this effect are poorly understood. Cortical thinning is associated with cognitive impairment in dementia, head trauma, demyelination, and stroke. We hypothesized that hemodynamic impairment, as represented by a relative time-to-peak (TTP) delay on MRI in the hemisphere ipsilateral to the stenosis, would be associated with relative cortical thinning in that hemisphere.Methods We used baseline MRI data from the NINDS-funded Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis–Hemodynamics (CREST-H) study. Dynamic contrast susceptibility MR perfusion-weighted images were post-processed with quantitative perfusion maps using deconvolution of tissue and arterial signals. The protocol derived a hemispheric TTP delay, calculated by subtraction of voxel values in the hemisphere ipsilateral minus those contralateral to the stenosis.Results Among 110 consecutive patients enrolled in CREST-H to date, 45 (41%) had TTP delay of at least 0.5 seconds and 9 (8.3%) subjects had TTP delay of at least 2.0 seconds, the maximum delay measured. For every 0.25-second increase in TTP delay above 0.5 seconds, there was a 0.006-mm (6 micron) increase in cortical thickness asymmetry. Across the range of hemodynamic impairment, TTP delay independently predicted relative cortical thinning on the side of stenosis, adjusting for age, sex, hypertension, hemisphere, smoking history, low-density lipoprotein cholesterol, and preexisting infarction (P=0.032).Conclusions Our findings suggest that hemodynamic impairment from high-grade asymptomatic carotid stenosis may structurally alter the cortex supplied by the stenotic carotid artery.

Cell-cell interaction dictates cell morphology and organization, which play a crucial role in the micro-architecture of tissues that guides their biological and mechanical functioning. Here, we investigate the effect of cell density on the responses of cells seeded on flat substrates using a novel statistical thermodynamics framework. The framework recognizes the existence of nonthermal fluctuations in cellular response and thereby naturally captures entropic interactions between cells in monolayers. In line with observations, the model predicts that cell area and elongation decrease with increasing cell seeding density-both are a direct outcome of the fluctuating nature of the cellular response that gives rise to enhanced cell-cell interactions with increasing cell crowding. The modeling framework also predicts the increase in cell alignment with increasing cell density: this cellular ordering is also due to enhanced entropic interactions and is akin to nematic ordering in liquid crystals. Our simulations provide physical insights that suggest that entropic cell-cell interactions play a crucial role in governing the responses of cell monolayers.

The growth of Li dendrites in a solid electrolyte is commonly idealized by a pressure‐filled crack. Recent observations in both garnet and sulfide electrolytes show that sparsely filled cracks exist prior to shorting of the cell, thereby invalidating this assumption. Herein, a variational principle that uses the Onsager formalism to couple Li deposition into the crack, elastic deformation of the electrolyte, and cracking of the electrolyte with the electrochemical driving forces and dissipation within the electrolyte and interfaces is developed. Consistent with observations, it is shown that Li ingress and cracking occur together for garnet electrolytes, but the cracks are sparsely filled. This sparse filling is a direct consequence of the mismatch between the elastic opening of the cracks and the deposition of Li into the cracks across the crack flanks. An increase in the resistance of Li ingress into the tips of Li filaments results in crack propagating ahead of the Li filaments, as observed for sulfide electrolytes. In such cases, the cracks are largely dry. The results provide a framework to model Li ingress into solid electrolytes and explain why the observations are qualitatively so different from dendrites in liquid electrolytes.

Aim: Scalp lacerations are commonly found in patients presenting with road trafc accidents to the casualty. These lacerations can be repaired with suturing, stapling, adhesive tapes, or tissue adhesives. In this study, we tried to compare the effectiveness of suturing, stapling, and hair apposition techniques in repairing scalp lacerations of patients who presented to casualty. Materials and Methods: After obtaining approval from the institutional ethics committee, we examined the effects of the techniques in repairing scalp lacerations on wound healing, complication rate, and patient satisfaction by recording data. Results: Out of the 150 patients observed in our study, there was a signicant difference between the scalp repair technique on the 7th and 15th-day patient satisfaction rates in favour of the hair apposition technique (p

Stains and dyes are very effective diagnostic and therapeutic tools in ophthalmology. Although non-invasive, diagnostic dyes are objectively used to directly visualize, identify and track microscopic ocular structures for anterior, as also posterior segment disorders. These are very useful, both for anterior and posterior segment disorders. Diagnosis and management of retinal vascular disorders have been revolutionised, ever since the introduction of fluorescein. It is used in an array of disorders of the anterior segment also. The term staining is used to describe epithelial disruption and other pathophysiological changes which can be seen when we use the dyes topically. The dyes used topically are called vital stains.

To address cybersecurity threats that organizations are facing today, there is an urgent need for an interdisciplinary approach in educational programming to prepare the next generation of indispensable workers who are often dispersed, such as law enforcement and military personnel. Extensive data breaches and even low profile but high impact cybercrimes present immense challenges for law enforcement, military, and local government agencies. These agencies, by nature, are some of the primary targets of cyberattacks, and hence, cybersecurity awareness and cyber investigation-related education are crucial for meeting the demanding requirements of their job duties and responsibilities. This paper describes the pedagogy of current educational programs for military and law enforcement toward identifying existing gaps in the adult pedagogy used to prepare the workforce. The paper concludes with a proposed framework based on recommendations on domain-specific topics and pedagogical formats for the most effective cybersecurity learning for these dispersed groups.

Frailty is a clinical syndrome characterized by a reduction in metabolic reserves leading to increased susceptibility to adverse outcomes following invasive surgical interventions. The 5-item modified frailty index (mFI-5) validated in prior studies has shown high predictive accuracy for all surgical specialties, including vascular procedures. In this study, we aim to utilize the mFI-5 to predict outcomes in Transcarotid Revascularization (TCAR).All patients who underwent TCAR from November 2016 to April 2021 in the Vascular Quality Initiative (VQI) Database were included. The mFI-5 was calculated as a cumulative score divided by 5 with 1 point each for poor functional status, presence of diabetes, chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), and hypertension. Patients were stratified into two groups based on prior studies: low mFI-5 (0.6) and high (≥0.6). Primary outcomes included in-hospital death, extended length of postoperative stay (1 day), and nonhome discharge. Secondary outcomes included in-hospital stroke, transient ischemic attack (TIA), myocardial infarction (MI), a composite endpoint of stroke/death, stroke/TIA, and stroke/death/MI. Univariate and multivariable logistic regression were used to assess the association between mFI-5 and postoperative outcomes. Secondary analysis stratified by symptomatic status was performed.Out of the 17,983 patients who underwent TCAR, 4526(25.2%) had mFI-5 score of ≥0.6 and considered clinically frail. Compared to the nonfrail group, frail patients were more likely to be female (38.7% vs. 35.6%, P 0.001), have poor functional status (43.6 vs. 8.3%, P 0.001), and present with significant comorbidities, including diabetes (75.3% vs. 26.1%, P 0.001), hypertension (98.9% vs. 88.5%, P 0.001), CHF (52.2% vs. 5.6, P 0.001), and COPD (60.3% vs. 14.2%, P 0.001). They were also more likely to be active smokers (25.4% vs. 20.4%, P 0.001) and symptomatic prior to intervention (28.7% vs. 25.3%, P 0.001). On univariate analysis, frail patients were at significantly higher risk to experience adverse outcomes, including in-hospital mortality, TIA, MI, stroke/death, stroke/TIA, stroke/death/MI, discharge to nonhome facility, and extended LOS. After adjusting for potential confounders, frail patients remained at significantly higher risk of in-hospital mortality [aOR 2.26(1.41,3.61), P = 0.001], TIA [aOR 1.65(1.08, 2.54), P = 0.040], nonhome discharge [aOR 1.99(1.71,2.32) P 0.001], and extended LOS [aOR 1.41(1.27, 1.55) P 0.001]. On further stratified analysis based on symptomatic status, the increased risk of stroke/death, TIA, and death was observed only in symptomatic patients.Modified Frailty Index is a reliable tool that can be used to identify high-risk patients for TCAR prior to intervention. This could help vascular surgeons, patients, and families in informed decision making to further optimize perioperative care and medical management in frail patients.

Strategies of balloon dilation during transfemoral carotid artery stenting include prestent dilation only (PRE), post-stent dilation only (POST), or both predilation and postdilation (PRE+POST). Concerns over higher neurological risk have been raised with POST and PRE+POST during transfemoral carotid artery stenting. Whether these concerns are applicable to transcarotid artery revascularization (TCAR), which uses proximal clamping and cerebral blood flow reversal during stent deployment and balloon angioplasty remains unknown. Our aim is to analyze outcomes of PRE, POST, or PRE+POST balloon dilation strategies during TCAR.We analyzed the prospectively collected data from the ROADSTER1 (pivotal), ROADSTER2 (US Food and Drug Administration indicated postmarket), and ROADSTER Extended Access TCAR trials. All trial patients had a high risk anatomic or clinical factors for carotid endarterectomy and were included, unless they did not undergo stent deployment or balloon dilation. For trial inclusion, asymptomatic patients had a carotid stenosis of more than 80%, and symptomatic patients had stenosis of more than 50%. Primary outcome measures were stroke, death, and myocardial infarction (MI) at 30 days. Data were statistically analyzed with χThere were 851 patients (566 male) who underwent dilation by PRE (n = 216), POST (n = 249), or PRE+POST (n = 386). Patients had carotid stenosis of greater than 70% (n = 828, 97%), and 207 (24%) were symptomatic. Flow reversal times were longer in the PRE+POST group (PRE 10.2 minutes, POST 9.8 minutes, and PRE+POST 13.3 minutes; P .001). The 30-day stroke rate for the whole cohort was 1.9%, mortality was 0.5%, and MI rate was 0.94%. Stroke rates for the PRE cohort (1.9%), POST cohort (2.0%), and PRE+POST cohort (1.8%; P = .98) were similar. Also, death rates at 30 days, and composite stroke, death, and MI rates were similar in the three cohorts. No significant differences in adverse outcomes were noted among the various dilation strategies for both symptomatic and asymptomatic patients.Based on these prospective trial data, there is no difference in neurological complications owing to balloon dilation strategy during TCAR. The balloon dilation technique best suited to the patient's specific lesion morphology should be used. Further studies are needed to evaluate the relationship of these dilation strategies to long-term outcomes, including stent patency, restenosis, and reintervention.

Single crystal, Ni-rich layered lithium metal oxides are promising candidates for next-generation cathodes in lithium-ion batteries. However, these Ni-rich materials display anisotropic swelling and contraction during cycling, and this may lead to the generation of internal stresses and thereby to fracture and capacity loss. In this work, the spatio-temporal evolution of lithium concentration and stress state within a LiNi 0.8 Mn 0.1 Co 0.1 O 2 (NMC811) single crystal are predicted using a fully coupled chemo-mechanical model. The stress state in the crystal arises from a spatially non-uniform distribution of Li concentration, and from a non-linear dependence of intercalation strain upon lithium concentration. The peak tensile stress is greatest near top-of-charge, due to the high sensitivity of intercalation strain upon lithium occupancy at low concentrations, and the peak tensile stress increases with both cycling rate and particle dimension. Significantly, the predicted peak tensile stress is insufficient to cause basal plane fracture of single crystals when their diameter is below 2.5 μm and the charging and discharging rates are below 5C. This suggests that intraparticle fracture is not a significant degradation mode for well-designed NMC811 single crystals.

Our assessments of effort are critically shaped by experiences of exertion. However, it is unclear how the nervous system transforms physical exertion into assessments of effort. Availability of the neuromodulator dopamine influences features of motor performance and effort-based decision-making. To test dopamine’s role in the translation of effortful exertion into assessments of effort, we had participants with Parkinson’s disease, in dopamine depleted (OFF dopaminergic medication) and elevated (ON dopaminergic medication) states, exert levels of physical exertion and retrospectively assess how much effort they exerted. In a dopamine-depleted state, participants exhibited increased exertion variability and over-reported their levels of exertion, compared to the dopamine-supplemented state. Increased exertion variability was associated with less accurate effort assessment and dopamine had a protective influence on this effect, reducing the extent to which exertion variability corrupted assessments of effort. Our findings provide an account of dopamine’s role in the translation of features of motor performance into judgments of effort, and a potential therapeutic target for the increased sense of effort observed across a range of neurologic and psychiatric conditions.

Experiences of physical exertion guide our assessments of effort. While these assessments critically influence our decisions to engage in daily activities, little is known about how they are generated. We had female and male human participants exert grip force and assess how effortful these exertions felt; and used magnetic resonance spectroscopy to measure their brain GABA concentration. We found that variability in exertion (i.e., the coefficient of variation in their force exertion profile) was associated with increases in assessments of effort, making participants judge efforts as more costly. GABA levels in the sensorimotor cortex (SM1) moderated the influence of exertion variability on overassessments of effort. In individuals with higher sensorimotor GABA, exertion variability had a diminished influence on overassessments of effort. Essentially, sensorimotor GABA had a protective effect on the influence of exertion variability on inflations of effort assessment. Our findings provide a neurobiological account of how the brain's GABAergic system integrates features of physical exertion into judgments of effort, and how basic sensorimotor properties may influence higher-order judgments of effort. SIGNIFICANCE STATEMENT Feelings of effort critically shape our decisions to partake in activities of daily living. It remains unclear how the brain translates physical activity into judgments about effort (i.e., “How effortful did that activity feel?”). Using modeling of behavior and neuroimaging, we show how the nervous system uses information about physical exertion to generate assessments of effort. We found that higher variability in exertion was associated with increases in assessments of effort, making participants judge efforts as more costly. GABA, the brain's main inhibitory neurotransmitter, moderated the influence of exertion variability on overassessments of effort. These findings illustrate how low-level features of motor performance and sensorimotor neurochemistry influence higher-order cognitive processes related to feelings of effort.

Objectives: The aim of our study is to evaluate the effects of perinatal asphyxia and subsequent treatment with therapeutic hypothermia (TH) especially on gastrointestinal system in newborns diagnosed with moderate-to-severe Hypoxic-Ischemic Encephalopathy (HIE). The primary objective was to determine the time for initiation of enteral feeds, enhancing the feeds and achieving full feeds in a group of newborns with HIE undergoing TH with secondary objectives to determine the risk of necrotising enterocolitis (NEC), late onset sepsis and duration of hospital stay. Methods: This is a retrospective study done at Neonatal Intensive Care Unit (NICU), Sarji hospital, a tertiary care centre in Shivamogga, India. A review of the medical records for feeding charts of the babies who underwent TH between December 2018 and October 2021 was carried out. A total of 50 newborns either in-born (n = 3) or out-born and referred (n = 47) to our NICU were included. Results: Among the 50 babies (both hemodynamically stable and unstable) undergoing TH, feeds were initiated at Day 2 of life. All hemodynamically stable babies were on full feeds by 5th day of life, while 14 out of 16 unstable babies were on full feeds by 8th day of life. For the remaining 2 babies, we could achieve full feeds by 11th day of life. Conclusion: This study not only supports the recent studies, but also highlights the safety of achieving complete enteral nutrition in neonates (both hemodynamically stable and unstable) undergoing TH without the risk of late-onset sepsis or NEC.

Nature has been a source of medicinal agents for thousands of years and a moving number of modern drugs have been isolated from natural sources they have plays an important role in the treatment and management of different diseases. The practice of herbal medicine has existed since prehistoric times as the primary source of medicine. In recent technology has very much advanced, herbal medicines still show and are finding exceptional acceptance in both the developing and the developed countries due to their natural origin and lesser side effects. Traditional herbal remedies as alternative medicine play a significant role. Ginger has an Antiviral effect, Antioxidant effect & Anti-inflammatory effect given. Garlic is an ayurvedic medicinal herb that has been widely used as a medication and as a taste enhancer of the food. In traditional remedies, coriander was used for the relief of gastrointestinal conditions. Turmeric shows different biological activities such as Anti-inflammatory, Anti-viral, Anti-oxidant, anti-cancer, Anti-bacterial, Antiarthritis, Anti-diabetic, Fennel shows carminative and stimulant activities as well as spasmolytic activity due to its volatile and non-volatile compounds. Cardamom is used as a home remedy it helps cure various ailments like indigestion, nausea, headache, etc. Clove is a flavouring agent, antibacterial, stimulant, carminative, fragrant, and antiseptic. It's also used as an antiemetic and an anodyne. Dentists use clove oil to sterilize root canals and as an oral anesthetic. Cinnamon is used in coughs and colds, In brief, the information on medicinal herbs will be helpful to create more interest in this medicinal species by defining novel pharmacological and clinical applications and it may be helpful in developing new drug formulations in the future. Keywords: Medicinal herbs, health, Ginger, Garlic, Coriander, Turmeric, Clove, Cinnamon, Fennel, Cardamom

A simple, specific, accurate, and precise reverse phase high performance liquid chromatography (RP-HPLC0 method was developed and validated to analyse Rivaroxaban bulk dosage form. Using Sun Q C18 HPLC column separation was carried out. This was maintained at ambient temperature. During separation mobile phase consist of Acetonitrile : Buffer(sodium acetate buffer) 80:20 was delivered at a flow rate of 1mL/min. Using UV detector analysis was carried out at the wavelength 249 nm. RP-HPLC method was validated by using various parameter like system suitability, linearity, specificity, precision, limit of detection, limit of quantification and robustness. The RP-HPLC method was found to be linear over the concentration range from 5-30 µg/mL (r2 =0.994). Retention time for bulk rivaroxaban was found to be 3.69 min. LOQ of method was 1.331 µg/mL and LOD 0.439 µg/mL. Thus the developed RP-HPLC method was found to be robust which can be applied for the regular analysis of Rivaroxaban in the bulk as well as pharmaceutical dosage form

Purpose This study aims to investigate the threat phenomenon as perceived by Internet of Things (IoT) users and examines the role of anxiety, desire and personal innovativeness in the behavioral intention toward the usage of IoT devices. Design/methodology/approach A unified research model is developed based on the protection motivation theory, theory of reasoned action, theory of self-regulation and the review of relevant theoretical, empirical and practitioner literature. Data were collected from 315 assistive IoT device users and analyzed using partial least squares structural modeling. Findings The results indicate strong support for the proposed research model. All relationships, except one, were significant at the 0.05 level. Desire was found to play a direct as well as a moderating role between fear and behavioral intention to continue using assistive IoT devices, which was also directly influenced by anxiety and personal innovativeness. Research limitations/implications Understanding the security behaviors of IoT users will help researchers and practitioners develop preventive measures and robust security solutions for the IoT devices to avert any threats from cyber-attacks and to boost users’ confidence levels. Future research will benefit from replicating the study using longitudinal data. Originality/value This study is one of the first studies that integrate multiple perspectives to present a holistic research model. To the authors’ knowledge, anxiety, desire and personal innovativeness, key factors influencing fear and behavioral intention, have not been studied in the domain of adoption of IoT assistive devices. Additionally, the study offers a new dimension to IoT users’ security behaviors.

Adherent cells seeded on substrates spread and evolve their morphology while simultaneously displaying motility. Phenomena such as contact guidance, viz. the alignment of cells on patterned substrates, are strongly linked to the coupling of morphological evolution with motility. Here, we employ a recently developed statistical thermodynamics framework for modelling the non-thermal fluctuating response of cells to probe this coupling. This thermodynamic framework is first extended via a Langevin style model to predict temporal responses of cells to unpatterned and patterned substrates. The Langevin model is then shown to not only predict the different experimentally observed temporal scales for morphological observables such as cell area and elongation but also the interplay of morphology with motility that ultimately leads to contact guidance.

A promising progenitor scenario for Type Ia supernovae (SNeIa) is the thermonuclear detonation of a white dwarf in a close binary system with another white dwarf. After the primary star explodes, the surviving donor can be spontaneously released as a hypervelocity runaway. One such runaway donor candidate is LP 398-9, whose orbital trajectory traces back $\approx 10^5$ years to a known supernova remnant. Here we report the discovery of carbon-rich circumstellar material around LP 398-9, revealed by a strong infrared excess and analyzed with follow-up spectroscopy. The circumstellar material is most plausibly composed of inflated layers from the star itself, mechanically and radioactively heated by the past companion's supernova. We also detect a 15.4 hr periodic signal in the UV and optical light curves of LP 398-9, which we interpret as surface rotation. The rotation rate is consistent with theoretical predictions from this supernova mechanism, and the brightness variations could originate from surface inhomogeneity deposited by the supernova itself. Our observations strengthen the case for this double-degenerate SNIa progenitor channel, and motivate the search for more runaway SNIa donors., Accepted to MNRAS

In our work we develop a base-driven ligand stripping method for metal oxide nanocrystals, replacing oleate ligands with hydroxyls to create an aqueous dispersion. We generalize this method across a range of material compositions, particle sizes, and particle shapes to get stable dispersions.

Background: Pyruvate dehydrogenase complex deficiency (PDCD) is a mitochondrial disorder that presents with lactic acidemia and neurological manifestations. It is a very rare genetic disorder, a potentially life-threatening one with the usual presentation of hypotonia, lethargy, and developmental delay. It is commonly associated with structural brain abnormalities. We report a very rare case of transient severe symptomatic hypoglycaemia probably due to pyruvate dehydrogenase E3 deficiency; a component of pyruvate dehydrogenase complex (PDC). Case Presentation: Our patient is a 12-day-old neonate with lethargy, and vomiting presented with severe symptomatic hypoglycaemia with a critical sample suggestive of hyperinsulinism and raised lactate levels. A TMS-GCMS for metabolic abnormality screening was normal, however, a whole genome sequencing(nuclear + mitochondrial) revealed heterozygous missense variants (c.763A>C) in exon 9 of the DLD gene that results in the amino acid substitution from Methionine to Leucine at codon 255 (p.Met255Leu) and another heterozygous mutation of heterozygous missense variant (c.5277A>T) in exon 34 of the LAMB1 gene that results in the amino acid substitution from Glutamine to Histidine at codon 1759 (p.Gln1759His). Conclusion: There is no effective treatment for PDCD but reports of treatment with supplements like thiamine, biotin, and coenzyme Q may play a role in preventing the severity of the disease.

We report the first experimental observations of a single-mode Kelvin-Helmholtz instability in a flowing dusty plasma in which the flow is compressible in nature. The experiments are performed in an inverted $$\Pi$$ Π -shaped dusty plasma experimental device in a DC glow discharge Argon plasma environment. A gas pulse valve is installed in the experimental chamber to initiate directional motion to a particular dust layer. The shear generated at the interface of the moving and stationary layers leads to the excitation of the Kelvin-Helmholtz instability giving rise to a vortex structure at the interface. The growth rate of the instability is seen to decrease with an increase in the gas flow velocity in the valve and the concomitant increase in the compressibility of the dust flow. The shear velocity is further increased by making the stationary layer to flow in an opposite direction. The magnitude of the vorticity is seen to become stronger while the vortex becomes smaller with such an increase of the shear velocity. A molecular dynamics simulation provides good theoretical support to the experimental findings.

Elevational gradient, slope, and aspect offer a unique opportunity to explore the response of plant species under changing environmental conditions. The present study aimed to analyze the species diversity and distribution patterns with respect to altitude, aspect, and habitat types in the Kashmir Himalayas. Considering major aspects and habitats, a total of 123 representative sites were selected along the elevational gradients for the present study. The plant species composition of each selected site was studied by organized sampling following the standard ecological methods. During the present study, a total of 361 vascular plant species belonging to 71 families and 214 genera were identified in the study area. At the lower altitudes, the southern aspect and drier habitats showed the highest diversity. Moreover, a significant amount of compositional dissimilarity was observed between the studied aspects, habitats, and elevation belts and was mainly due to species turnover rather than the nestedness component. Further, among the studied variables, altitude was the most important contributing variable, explaining the greatest variation in the species composition. The paired effects of altitude and habitat explained the maximum variation in plant species composition. It may be concluded that floristic diversity should be studied not only with reference to elevational gradients but should also include aspects and habitats. The current study will act as a reference in this direction. A similar study must be replicated in other parts of the Himalayan region in the future to improve our understanding of the distribution and preferences of plant species in mountainous zones. This, in turn, will be immensely helpful in the conservation and sustainable utilization of resources in these ecologically fragile regions.

We review a broad range of topics related to the interplay of electrochemistry and mechanics in all solid-state batteries. The modeling frameworks that exist in the literature are varied in terms of their sophistication and ability to capture critical observations. Modeling frameworks for diffusion induced stress and fracture due to lithiation swelling and shrinkage in storage materials for the cathodes are well-established along with models for lithium-ion transport in solid electrolytes. Similarly, aspects of the effect of stress on the redox reactions at the Li metal/electrolyte interface are well-understood. These models typically modify Butler–Volmer kinetics but neglect the effect of creep or other plastic deformations of the metal electrode on the interface kinetics. Nevertheless, they successfully describe the roughening of the metal electrode/electrolyte interface during deposition or plating. By contrast, Butler–Volmer kinetics accounting only for the interfacial stress are unable to predict voids that have been observed to form in the metal electrode and we discuss a hypothesis that creep deformation of the metal electrode has a more fundamental effect on the redox reactions. Similarly, models for the nucleation and growth of lithium filaments in solid electrolytes are also inconsistent with recent observations which suggest that cracks in solid electrolytes are only partially filled with lithium metal. We conclude by summarizing aspects of the interplay of electrochemistry and mechanics in all solid-state batteries that are well-understood and areas where significant open questions remain.

Crystallization of granular assemblies has broad implications for rapid and scalable creation of architected materials with applications ranging from structural materials to microarchitected battery electrodes. While significant advances have been made in understanding colloidal self‐assembly at nano to micro scale, the governing mechanisms for organization of dry assemblies of hard spheres remain unclear. Here, we investigate crystallization of mono‐size hard spheres with and without imposed vibration. Using X‐ray computed tomographic analysis coupled with discrete‐element simulations, we unravel the roles of gravity and imposed vibration on the three‐dimensional self‐assembly of the dry spheres. We use these insights to introduce gravity‐mediated epitaxial crystal growth with slow pouring of balls on seeding templates. Contrary to vibration‐induced crystallization, this method can form large single crystals with both close‐packed and rather surprisingly, nonclose‐packed metastable particle arrangements. Our results provide insight for the scalable manufacture of defect‐free granular assemblies that can be used as space‐holding templates to manufacture cellular materials, such as inverse opals and other related topologies. Key points: Self‐assembly of hard spheres is a critical step for the scalable manufacture of micro‐architected solids. Via a combination of vibration experiments, 3D X‐ray tomographic observations, and simulations, we elucidate the critical role of gravity in the self‐assembly of hard spheres. We design seeding templates that can not only induce the self‐assembly into stable close‐packed crystal structures but also rather counterintuitively into metastable single crystal structures.

Thermally stimulated depolarisation current (TSDC) of polarised samples of methyl acrylic acid (MAA) doped ethyl cellulose (EC) films of about 25 µm thickness has been recorded as a function of temperature, electric field, heating rates and storage times. Two current maxima in positive direction and found around 60 and 110oC for doped sample with ethyl cellulose. FTIR of doped EC are represented the different phenomena of TSDC. Thermal sampling technique showed that the relaxation is distributed. Differentia thermal analysis gave a second-order transition at bout 345K because of good correlation between both thermal techniques it is concluded that the TSD peak is associated with glass transition of the polymer, and therefore it involves the motion of large parts of the polymer chains.

In our ancient literature of Rasashastra, Parada or Rasa is considered the supreme Dravya out of all Rasoparasa’s, Dhatu’s etc1and described to be of divine origin. The importance of Parada is highlighted mainly for Rasachikitsa. Mercury always comes with natural impurities i.e., “Naisargika dosha”, when mercury is put to trade and commercial use it is adulterated with cheaper metals like Naga and Vanga for more commercial gains. As a result, mercury in the market is often available with this kind of adulterants, which are considered as “Yougi- ka Dosha”. Consumption of impure mercury is considered highly toxic and hazardous. It can be made into medi- cine by adopting proper Shodhana procedures. In Rasashastra process of Shodhana is having greater im- portance. Hence a wide range of purification methods is described for each metal and mineral including Parada. The literary meaning of Shodhana is purification, but in Rasashastra Shodana is a Samskara which essentially improves the potency along with detoxifying the metal or mineral. In our classics, various methods have been told for Shodhana of Parada, in which Patana plays a very important role2. All the different classical references of Urdhva Patana Samskaras are compiled and critically analysed to know their role in Shodhana of Parada. Various media told are Tamra churna, Sarja Kshara, Yava Kshara, Hingu, Panchalavana and Kaashtoaushadis such as Kumari, Nisha churna etc. An attempt is made to analyse the role of various media for the Urdhva Patana of Parada. Keywords: Parada, Shodhana, Urdhva Patana, Mercury

There are a few regions in the world, where climate change impacts are more intense than other regions of the world, and Himalaya is the case. The Himalaya, one of the biodiversity hotspot regions and provider of ecosystem services to billion of people all across the world. Present study reviewed and synthesized climate change studies in the Himalayan region in general and Indian Himalayan region (IHR) in particular. Analysis of the literature indicates exponentially increase in climate change studies 2005 onward in the IHR, and maximum are from Jammu and Kashmir (105) followed by Uttarakhand (100) and Himachal Pradesh (77). Among the subject types, maximum climate change impact was studied on water resources/glacier retreat (141 studies) followed by agriculture (113) and forests/biodiversity (86). Increasing temperature, frequent drought spells, erratic rainfall and declining snowfall are commonly reported indicators of climate change. For instance, temperature is reported to increase by 1.5 °C in the Himalaya than an average increase of 0.74 °C globally in last century; however, it varied in eastern (0.1 °C per decade and western Himalayas (0.09 °C per decade. An increase in temperature between 0.28 and 0.80 °C per decade was reported for North-western Himalaya and 0.20–1.00 °C per decade for Eastern Himalaya. The higher altitude of Himalayan and Trans-Himalayan zone are reported to be warming at higher rates. Many of the glaciers were reported to be retreating in both eastern and western Himalaya. Heavy rainfall is becoming very common in the region often accompanied by cloudbursts that aggravate flood situation many times. Perception-based studies of the region reported to provide firsthand and detailed descriptions of climate change indicators and impacts from rural and remote areas, where no instrumental data are available.

Objective The optimal antiplatelet regimen after lower extremity revascularization in patients with chronic limb-threatening ischemia (CLTI) is unknown because current recommendations are based on extrapolation of data from trials in coronary artery disease and stroke. Methods We identified all patients undergoing an elective lower extremity revascularization for CLTI in the Vascular Quality Initiative registry discharged on a mono antiplatelet agent (MAPT) or dual antiplatelet therapy (DAPT). Results From 2003 to 2018, 50,890 patients underwent revascularization procedures for CLTI, and were discharged on MAPT or DAPT. Of these, 33,781 patients underwent endovascular therapy (EVT), and 17,109 patients underwent open surgery (OS) procedures. The rate of major amputation at 30 days in the target limb in the EVT group was 0.3% and 0.4% in the OS group (P = .22). On Kaplan-Meier analyses, patients on MAPT at discharge had a higher risk of 1-year major amputation compared with DAPT after EVT but not after OS procedures. Patients on MAPT had lower overall survival and amputation-free survival at 30 days and 1 year compared with DAPT after both EVT and OS. At 1 year, the MAPT group was at higher risk for target lesion reintervention after EVT compared with the DAPT group (15.9% vs 13%; P = .0012). There was no significant difference in thrombosis at 1 year between the MAPT and DAPT groups either after EVT (3.9% vs 3.7%; P = .3048) or OS (3.1% vs 3.2%; P = .2893). On Cox regression analysis, DAPT was associated with improved survival but not major amputation after both EVT and OS. Conclusions In patients with CLTI, DAPT at the time of discharge has a positive impact on amputation-free survival and overall survival after both EVT and OS as well as target lesion reintervention after EVT. DAPT was not associated with a positive impact on major amputation after either EVT or OS.

Introduction Aortic infection without prior intervention or aneurysm is exceedingly rare. We report the presentation, diagnosis, management, and outcome of patients with this unusual entity. Methods Retrospective chart and imaging review of patients with primary aortic infection. Results 5 patients (3 male, mean age 71.2 years) presented between 2014 and 2022. All had abdominal, back, or flank pain. Four had constitutional symptoms. All were evaluated with a complete blood count; 3 had leukocytosis. Both serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were elevated in the 4 patients evaluated with these tests. All were studied with peripheral blood culture on the first hospital day prior to any antibiotic administration. Blood culture was positive in only 1 patient. Computed tomography (CT) scan showed periaortic inflammation without aneurysm in all. Fluorodeoxyglucose positron emission tomography (PET) was obtained in 3 and a radiolabeled leukocyte single-photon emission CT (SPECT) scan was performed in 2. All demonstrated periaortic concentration of the radioisotope consistent with inflammation or infection. Intraoperative cultures were positive in 3. One patient who had a negative intraoperative culture was examined with broad range polymerase chain reaction (PCR) and DNA sequencing which identified a causative bacterium. The other patient with a negative intraoperative culture had periaortic abscess but was on antibiotics preoperatively, potentially confounding the culture. All patients underwent in-situ repair with rifampin impregnated polyester (N = 2), cryopreserved aortic allograft (N = 2), or autogenous femoral vein (N = 1). No patient developed recurrent infection or aortic related complications following surgery with an average follow up of 31.8 months (range 8-88 months). Conclusions Patients with primary aortic infection present similarly with the triad of abdominal or back pain, laboratory markers of infection, and imaging demonstrating periaortic inflammation. Patients were treated successfully with in-situ repair. Preoperative identification of a causative organism was difficult, and PCR may be useful to help identify an organism.

Solid lipid nanoparticles (SLNs) were recently developed in 1991 having particle size range from 10 to 1000 nm. SLNs used for novel drug delivery system basically it is colloidal carrier of lipids. In this review proposed of ideal characteristics of SLNs, Advantages & disadvantages of SLNs. This review also discussed the preparation methods of SLNs with diagrammatic representation procedure. Appropriate determination of characterization of SLNs like zeta potential and particle size, SEM, differential scanning Calorimetry and powder x-ray diffraction, etc. Route of administration of SLNs are also discussed in this review. Also added the various applications of SLNs in the advance drug delivery with suitable example. &nbsp

Odontogenic Keratocyst, one of the commonly encountered cyst of odontogenic origin, was introduced by Philipsen in 1956. It is of considerable importance because of its potential for aggressive clinical behavior and recurrence. It is also found in association with Nevoid Basal Cell Carcinoma Syndrome.

Pelvic venous disorders are a group of interrelated conditions characterized by venous incompetence. These conditions often manifest with nonspecific symptoms that overlap with many gynecological, gastrointestinal, and urologic diseases. Clinical diagnosis can be difficult, and imaging can play a vital role in differentiating etiology. Sonographic evaluation is often the first step in evaluating these symptoms. Special attention to possible underlying pelvic venous disorders can reveal characteristic findings, support diagnosis, and guide treatment. Here we review pelvic congestion syndrome, nutcracker syndrome, May-Thurner syndrome, and other venous disorders, with a specific focus on sonographic findings and considerations.

Globally, Indigenous Knowledge Systems (IKSs), which have evolved through rigorously tested methods and practices, are a testimony of human intelligence and endurance. The diversity of goods such as food, beverages, herbs, etc., and its associated systems, which form an integral part of modern cuisine and healthcare systems, are deeply rooted in IKS and immensely contributing to overall well-being of mankind. The present study is an attempt to document and understand the contribution of indigenous and local knowledge to biodiversity conservation and management. Appreciation to the value of traditional and indigenous knowledge is globally recognized for their principles of coexistence and sustainable use practices. Past studies indicate a strong relationship between indigenous knowledge and sustainable development goals. This knowledge is valuable not only to dependent communities, but also to the modern world for ensuring food security and human well-being. The documentation of such valuable knowledge is therefore fundamentally essential for mainstreaming and strengthening the discourses on sustainable ecosystem management, and to address the preponderance of poverty among indigenous communities. Amid the changing scenario of consumption and the trend of revisiting nature-based solutions, the IKS hold a tremendous scope of engaging the community people in sustainable harvest and utilization of natural resources.