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Este proyecto tiene como intención el desarrollo de un sitio web que sirva como plataforma para informar, educar o simplemente mostrar las fases y beneficios de la rehabilitación cardiaca. Se emplea el framework de PHP Laravel junto con tecnologías básicas del desarrollo web como HTML5, CSS3 y Javascript, junto a tecnologías o librerías surgidas de los mismos como Jquery o Bootstrap. El objetivo es realizar el sitio web a medida de los requisitos especificados por el cliente, que pretende comenzar una nueva etapa dentro de su labor docente e informativa utilizando nuevas tecnologías. Dentro de este proyecto se encuentran las explicaciones y descripciones de las diferentes tecnologías utilizadas y las diferentes fases seguidas durante el desarrollo del proyecto. Desde la documentación de requisitos, el diseño a su implementación y aspecto final. Abstract: This final degree project it is aimed to provide its administrator with the capacity of education, inform or just share its knowledge in the Cardio rehabitation field. Laravel PHP Framework it has been used as the primary tool for development with other basic technologies such as HTML5 CSS3 and JavaScript as well. Specific Libraries or new technologies powered by JavaScript and CSS3 like Bootstrap or Jquery have been taken for the development of this Project too. The main goal of this work is the development of a fully functional website shaped entirely by the requirements of this specific client, who wants to start a new stage into his educational labour, focusing on the use of new technologies. Inside this Project, you will find explanations, details, and descriptions of the different technologies and development stages, which conforms the entire process of the software development. Starting with the client requirements documentation process and finishing with the implementation and final overview of the website.

The objective of the current research was to explore the potential prognostic value of readily available clinical and pathologic variables in bladder cancer. The novel association found between cholesterol levels and prognosis may provide the rationale for exploring novel treatments. Patients included had histologically confirmed urothelial bladder cancer and were treated with at least 3 cycles of cisplatin-based neoadjuvant chemotherapy before radical cystectomy with lymphadenectomy. A total of 245 patients at low, intermediate and high risk, presenting with 0-1, 2 or 3-4 risk factors, including positive lymph nodes, Hb 12.8, NLR ≥2.7 and cholesterol levels ≥199, were included. Five-year cancer-specific survival rate was 0.67, 0.78 and 0.94 at high, intermediate and low risk, respectively. Total cholesterol levels at the time of cystectomy may represent a commonly assessable prognostic factor and may be incorporated in a clinically meaningful risk-group classification model.Lay abstract This present study assessed a large group of patients with urothelial bladder cancer treated with chemotherapy followed by radical cystectomy, to capture the predictive power of commonly collected clinical, pathological and biochemical factors. The design of the study highlighted that higher cholesterol levels at the time of cystectomy were associated with shorter cancer-specific survival. This finding suggests that high blood-cholesterol levels truly have a negative influence on surviving cancer. In conclusion, total cholesterol levels at the time of cystectomy may represent a commonly assessable prognostic factor and could be incorporated into a clinically meaningful and valuable risk-group classification model.