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Background: Looking pattern differences are shown to separate individuals with Autism Spectrum Disorder (ASD) and Typically Developing (TD) controls. Recent studies have shown that, in children with ASD, these patterns change with intellectual and social impairments, suggesting that patterns of social attention provide indices of clinically meaningful variation in ASD. Method: We conducted a naturalistic study of children with ASD (n = 55) and typical development (TD, n = 32). A battery of eye-tracking video stimuli was used in the study, including Activity Monitoring (AM), Social Referencing (SR), Theory of Mind (ToM), and Dyadic Bid (DB) tasks. This work reports on the feasibility of spatial and spatiotemporal scanpaths generated from eye-gaze patterns of these paradigms in stratifying ASD and TD groups. Algorithm: This article presents an approach for automatically identifying clinically meaningful information contained within the raw eye-tracking data of children with ASD and TD. The proposed mechanism utilizes combinations of eye-gaze scan-paths (spatial information), fused with temporal information and pupil velocity data and Convolutional Neural Network (CNN) for stratification of diagnosis (ASD or TD). Results: Spatial eye-gaze representations in the form of scanpaths in stratifying ASD and TD (ASD vs. TD: DNN: 74.4%) are feasible. These spatial eye-gaze features, e.g., scan-paths, are shown to be sensitive to factors mediating heterogeneity in ASD: age (ASD: 2–4 y/old vs. 10–17 y/old CNN: 80.5%), gender (Male vs. Female ASD: DNN: 78.0%) and the mixture of age and gender (5–9 y/old Male vs. 5–9 y/old Female ASD: DNN:98.8%). Limiting scan-path representations temporally increased variance in stratification performance, attesting to the importance of the temporal dimension of eye-gaze data. Spatio-Temporal scan-paths that incorporate velocity of eye movement in their images of eye-gaze are shown to outperform other feature representation methods achieving classification accuracy of 80.25%. Conclusion: The results indicate the feasibility of scan-path images to stratify ASD and TD diagnosis in children of varying ages and gender. Infusion of temporal information and velocity data improves the classification performance of our deep learning models. Such novel velocity fused spatio-temporal scan-path features are shown to be able to capture eye gaze patterns that reflect age, gender, and the mixed effect of age and gender, factors that are associated with heterogeneity in ASD and difficulty in identifying robust biomarkers for ASD.

O objetivo deste estudo foi comparar a percepção subjetiva dos domínios de qualidade de vida de idosas participantes e não participantes de uma intervenção musicoterapêutica para as servidoras aposentadas do Estado do Paraná. O método utilizado foi caráter descritivo, com delineamento transversal do tipo comparativo. A amostra do estudo foi composta por 20 idosas participantes do processo de musicoterapia e 24 idosas não participantes, com média de idade 71,3 (± 7,8). Para avaliação da qualidade vida foram utilizados os questionários WHOQOL-BREF e WHOQOL-OLD. Para os dados descritivos foi utilizada a estatística descritiva, mediante os indicadores de frequência absoluta e relativa. A normalidade dos dados foi verificada por meio do teste de Kolgomorov Smirnov. A comparação dos resultados, entre os grupos, foi realizada com base na mediana e amplitude interquartílica referente a cada domínio dos instrumentos. Para tal, foi utilizado o teste U de Mann-Whitney. Os dados foram tabulados e analisados por meio do software SPSS. Os resultados encontrados por meio do WHOQOL-BREF, constatou-se que participar de grupos de intervenção com musicoterapia mostrou-se significativo nos escores do domínio Físico (p≤0,01), Psicológico (p≤0,01), Social (p≤0,02) e Meio Ambiente (p≤0,01). Por meio do WHOQOL-OLD, a musicoterapia também mostrou-se significativa no grupo das participantes da intervenção musicoterapêutica, tendo efeito nos domínios Funcionamento do Sensório (p≤0,001, Atividades Passadas/Presente/Futuras (p≤0,01), Participação Social (p≤0,001), Morte e Morrer (p≤0,01), Intimidade (p≤0,01) e Escore Geral (p≤0,001). Com isso percebe-se a importância da musicoterapia para pessoas idosas, pois a sua prática pode proporcionar melhoras nas dimensões da qualidade de vida.

With the global COVID-19 pandemic, governments from many countries in the world implemented various restrictions to prevent the SARS-Cov-2 virus's spread, including social distancing measures, quarantine, in-home lockdown, and the closure of services and public spaces. This led to an in-creased use of social media platforms to make people feel more connected, but also to maintain physical activity while self-isolating. Concerns about physical appearance and the desire to keep or reach a muscular and toned ideal body, might have further reinforced the engagement in fitness-related social media activities, like sharing progresses in training achievements or following more fitness contents on popular profiles. To better understand the underlying relation among these factors, the present study investigates 729 responses to the Exercise Addiction Inventory (EAI), the Appearance Anxiety Inventory (AAI), the Self-Compassion Scale (SCS) and their association to social media usage and compares the results cross-culturally in five countries (Spain, Lithuania, United Kingdom, Japan, and Hungary). Findings highlight significant differences between males and females, espe-cially in regard to the time spent online (U = 477.5, p = 0.036). Greater levels of appearance anxiety were associated with the exposure to fitness-related contents on social media. These results strongly confirm the previously highlighted association between fitspiration media and body image anxiety predominantly in females. Clinical implications and future considerations in terms of prevention and treatment in a situation of global emergency are also discussed. Published version This publication is based upon work from the European Network for Problematic Usage of the Internet, supported by COST (European Cooperation in Science and Technology; CA16207). This research was also supported by Fundaç ̃ao para a Ciˆencia e Tecnologia (FCT) through R&D Units funding (UIDB/05210/2020). ZD’s contribution was supported by the Hungarian National Research, Development, and Innovation Office (KKP126835; K134807; ELTE Thematic Excellence Programme, 2020; KP2020-IKA-05). HF’s contribution was supported by “Grant-in-Aid” by the Smoking Research Foundation.

Seismo-electromagnetic signals are electromagnetic signals generated by the propagation of a seismic wave in a porous media containing fluids (Gao & Hu, 2010).These signals can potentially provide useful information on the poro-elastic media and the hosted fluids (Garambois & Dietrich, 2002).Thus, there has been a growing interest in the study of SES in recent years, due to their potential.Researchers are focusing both on modelling and analysis of both passive and active experiments to investigate the characteristics of these signals (e.g. Honkura et al., 2000; Matsushima et al., 2002; Warden et al., 2013; Gao et al., 2016; Balasco et al., 2014; Dzieran et al., 2019).Passive experiments involve the observation and analysis of naturally occurring SES triggered by earthquakes, while active experiments involve the controlled generation of these signals using seismic source.The aim of our work is to present the results deriving from the analysis of SES recorded with both approaches. As for the passive one, the data set consists of the time series recorded by two magnetotelluric stations in continuous monitoring, co-located with two seismic stations, in seismically active areas of Southern Italy (the Gargano promontory and the Agri valley).As for the active one, the data set derives by an active seismic experiment carried out in the caldera of the Phlegrean Fields, the Italian super-volcano.

N-glycanase 1 (NGLY1) Deficiency is a debilitating, ultra-rare autosomal recessive disorder caused by loss of function of NGLY1, a cytosolic enzyme that deglycosylates other proteins. It is characterized by severe global developmental delay and/or intellectual disability, hyperkinetic movement disorder, transient elevation of transaminases, (hypo)alacrima, and progressive, diffuse, length-dependent sensorimotor polyneuropathy. A prospective natural history study (NHS) was conducted to elucidate clinical features and disease course. Twenty-nine participants were enrolled (15 onsite, 14 remotely) and followed for up to 32 months, representing ∼29% of the ∼100 patients identified worldwide. Participants exhibited profound developmental delays, with almost all developmental quotients below 20 on the Mullen Scales of Early Learning, well below the normative score of 100. Increased difficulties with sitting and standing suggested decline in motor function over time. Most patients presented with (hypo)alacrima and reduced sweat response. Pediatric quality of life was poor except for emotional function. Language/communication and motor skill problems including hand use were reported by caregivers as the most bothersome symptoms. Levels of the substrate biomarker, GlcNAc-Asn (aspartylglucosamine; GNA), were consistently elevated in all participants over time, independent of age. Liver enzymes were elevated for some participants but improved especially in younger patients and did not reach levels indicating severe liver disease. Three participants died during the study period. Data from this NHS informs selection of endpoints and assessments for future clinical trials for NGLY1 Deficiency interventions. Potential endpoints include GNA biomarker levels, neurocognitive assessments, autonomic and motor function (particularly hand use), (hypo)alacrima, and quality of life.

Background Heavy menstrual bleeding (HMB) is associated with impaired quality of life and may signal serious health problems. Unresolved challenges in measuring menstrual bleeding and identifying HMB have hampered research and clinical care. Self-reported bleeding histories are commonly used but these may be influenced by recall bias, personal beliefs regarding “normal” flow volume, and the experience of other physical symptoms or disruptions to daily life. The potential usefulness of menstrual-tracking mobile applications, which allow real-time user-entered data recording, for assessing HMB has not been studied. We evaluated recall bias in reported period duration, the relationship of tracked period duration and daily flow volume to subsequently reported period heaviness, variation in quality of life associated with increasing period heaviness, and the advantages and limitations of using app-tracked data for clinical and research purposes. Methods An online questionnaire was distributed to current users of Clue, a commercially available menstrual health tracking app, asking them to characterize their last period. We compared responses to the user’s corresponding Clue app-tracked data. The study sample comprised 6546 U.S.-based users (aged 18–45 years). Results Increasing reported heaviness was associated with increasing app-tracked period length and days of heavy flow, impaired quality-of-life (especially body pain severity), and disrupted activities. Of those reporting having had a heavy/very heavy period, ~ 18% had not tracked any heavy flow, but their period length and quality-of-life indicators were similar to those who had tracked heavy flow. Sexual/romantic activities were the most affected across all flow volumes. Compared to app-tracked data, 44% recalled their exact period length; 83% recalled within ± 1 day. Overestimation was more common than underestimation. However, those with longer app-tracked periods were more likely to underestimate period length by ≥ 2 days, a pattern which could contribute to under-diagnosis of HMB. Conclusion Period heaviness is a complex construct that encapsulates flow volume and, for many, several other bleeding-associated experiences (period length, bodily impairments, disruptions of daily activities). Even very precise flow volume assessments cannot capture the multi-faceted nature of HMB as experienced by the individual. Real-time app-tracking facilitates quick daily recording of several aspects of bleeding-associated experiences. This more reliable and detailed characterization of bleeding patterns and experiences can potentially increase understanding of menstrual bleeding variability and, if needed, help to guide treatment.

Federated learning enables multiple users to build a joint model by sharing their model updates (gradients), while their raw data remains local on their devices. In contrast to the common belief that this provides privacy benefits, we here add to the very recent results on privacy risks when sharing gradients. Specifically, we investigate Label Leakage from Gradients (LLG), a novel attack to extract the labels of the users' training data from their shared gradients. The attack exploits the direction and magnitude of gradients to determine the presence or absence of any label. LLG is simple yet effective, capable of leaking potential sensitive information represented by labels, and scales well to arbitrary batch sizes and multiple classes. We mathematically and empirically demonstrate the validity of the attack under different settings. Moreover, empirical results show that LLG successfully extracts labels with high accuracy at the early stages of model training. We also discuss different defense mechanisms against such leakage. Our findings suggest that gradient compression is a practical technique to mitigate the attack., Comment: to be published in PETS 2022

Debido al elevado número de personas que solicitan ayuda psicológica y a la escasez de recursos profesionales de los que disponen muchos servicios, se hace necesario fomentar la puesta en marcha de modalidades terapéuticas que optimicen dichos recursos; una alternativa prometedora es la adaptación grupal del protocolo unificado de Barlow para el abordaje de los trastornos emocionales (Barlow et al., 2018). No obstante, se precisa identificar qué pacientes pueden beneficiarse con más probabilidades de éxito de este protocolo grupal y qué variables caracterizan a los pacientes con mayor riesgo de abandono en este tipo de intervención. El presente estudio se ha realizado sobre una muestra total de 54 personas que iniciaron una adaptación grupal de dicho protocolo, en el Servicio de Asistencia Psicológica de la Universidad Pontificia de Salamanca. Se ha comparado un grupo de pacientes que completan el tratamiento (n= 37) con un grupo que abandona en algún momento el mismo (n=17). Se tomaron medidas de ansiedad, depresión, variables de personalidad, calidad de vida, interferencia y autocompasión. Los resultados indican la presencia de diferencias estadísticamente significativas en los síntomas de ansiedad y en el nivel de interferencia del problema en la vida diaria siendo éstos más severos en el grupo que abandona el tratamiento; los pacientes que completan el tratamiento puntúan significativamente más alto en la variable humanidad compartida, implicada en los procesos de empatía y pertenencia al grupo; asimismo, se observan diferencias en el límite de la significación estadística, en las variables depresión y calidad de vida, siendo los pacientes del grupo que abandona el tratamiento, los que obtienen puntuaciones más elevadas en depresión y más bajas en calidad de vida. Estos resultados preliminares señalan algunas características para identificar, en la evaluación inicial, a los posibles beneficiarios de este formato y optimizar las alternativas terapéuticas ofrecidas.

Objetivo da pesquisa: Compreender a articulação das emoções às práticas organizacionais em um órgão público de Minas Gerais.Enquadramento teórico: As emoções são estudadas sob os pontos de vista político e construtivista, entendendo-as como produtose produtoras da realidade. Dessa forma, as emoções fazem parte da racionalidade humana e integram as práticas organizacionaisde maneira consciente ou inconsciente (Zietsma & Toubiana, 2018; Oliveira & Cavedon, 2019).Metodologia: Foi realizada uma pesquisa qualitativa, descritiva e exploratória. A coleta de dados ocorreu por meio de entrevistassemiestruturadas com dezesseis servidores do órgão público pesquisado, entre os meses de janeiro e julho de 2021. Os dados foramanalisados por Análise de Conteúdo.Resultados: Foram apontadas algumas relações entre emoções e sentimentos dos entrevistados com práticas comuns naorganização, revelando como a estrutura burocrática e as relações de poder influenciam nas experiências emocionais. A pesquisaconclui que determinados tipos de práticas organizacionais contribuem para uma integração mais saudável e construtiva dasdinâmicas emocionais ao trabalho.Originalidade: Muitos estudos que abordam o tema das emoções nas organizações partem de polarizações entre a razão e asemoções. Nesta pesquisa, demonstramos como as emoções integram as racionalidades nas práticas organizacionais. A grandemaioria parte também de abordagens funcionalistas, negligenciando aspectos políticos e relacionais.Contribuições teóricas e práticas: O presente artigo contribui para ampliar o debate sobre as emoções na Administração e nosEstudos Organizacionais, trazendo como as emoções se articulam às práticas organizacionais e às racionalidades subjacentes. Dessaforma, aponta para possíveis caminhos rumo à construção de ambientes de trabalho mais propícios ao desenvolvimento emocional.

Probabilistic circuits (PCs) are models that allow exact and tractable probabilistic inference. In contrast to neural networks, they are often assumed to be well-calibrated and robust to out-of-distribution (OOD) data. In this paper, we show that PCs are in fact not robust to OOD data, i.e., they don't know what they don't know. We then show how this challenge can be overcome by model uncertainty quantification. To this end, we propose tractable dropout inference (TDI), an inference procedure to estimate uncertainty by deriving an analytical solution to Monte Carlo dropout (MCD) through variance propagation. Unlike MCD in neural networks, which comes at the cost of multiple network evaluations, TDI provides tractable sampling-free uncertainty estimates in a single forward pass. TDI improves the robustness of PCs to distribution shift and OOD data, demonstrated through a series of experiments evaluating the classification confidence and uncertainty estimates on real-world data., Comment: 24 pages, 8 figures, 1 table, 1 algorithm

Dans cet article, nous analysons les pratiques contraceptives des hommes a partir des donnees de l’enquete Fecond 2013. Nos resultats permettent de montrer que le recours a la contraception des hommes en France est structure par la norme contraceptive francaise deja mise en evidence chez les femmes. Par ailleurs, nous montrons que cette norme est genree. En prescrivant le passage du preservatif a la pilule lorsque la relation se stabilise, cette norme contraceptive prescrit egalement le passage d’une responsabilite a priori partagee entre les partenaires a une responsabilite exclusivement feminine de la contraception. Enfin, le recours a des methodes dites masculines de contraception par des hommes en relation stable pourrait etre le resultat d’un processus de « distinction » permettant l’expression de modeles de masculinites differents.

Este estudo teve como objetivo descrever as percepções dos discentes sobre as relações entre seu desempenho acadêmico e seu nível de identificação com o curso de graduação e com a instituição de ensino superior que estudam. O desempenho acadêmico do aluno é um dos fatores associados diretamente à evasão no ensino superior e pode estar associado a fatores sociais, demográficos e àqueles ligados à própria universidade, bem como a fatores psicológicos. Para tanto foi realizada uma pesquisa qualitativa descritiva, em que foram investigados os alunos do curso de graduação em administração da Universidade Federal de Viçosa (campus Florestal). Os dados foram coletados por observação participante, entrevistas semiestruturadas, técnica de escolha com 20 estudantes de diversos períodos. Foi realizada a análise de conteúdo e os dados organizados em três categorias: curso, universidade e desempenho acadêmico. Os resultados indicaram que a maioria dos discentes possui identificação ambivalente com o curso e se sentem superidentificados com a universidade, bem como se consideram com bom desempenho acadêmico. Concluiu-se que os alunos superidentificados tanto com o curso quanto com a universidade possuíam a tendência de ter um desempenho superior.

Dance is a popular activity throughout the world. There are many styles of dance, each having distinct physical demands and injury patterns. Healthcare providers should have some familiarity with the typical injuries seen in the dancer’s foot and ankle. Along with strong physical exam skills, an understanding of the best imaging options is paramount. High-resolution ultrasound can often be used as reliably as MRI for many of these diagnoses. The present article aims to brief the regional anatomy, address the typical presentation, and review exam findings and management options for the care of dancers’ injuries in the foot and ankle.

One of the major dietary problems in Brazil refers to being overweight affects about 25.4% of adolescents and 53.8% of adults. Thus, this paper sought to measure the vulnerability of young adults between 18 and 24 years old using the vulnerability scale proposed by Chi et al. (2017), relating it to the scale of nutritional interest of Balasubramanian and Cole (2002), obtaining n = 564. It was possible to identify more evidence of significance between product knowledge and nutritional interest, reinforcing the importance of information for the satisfactory evaluation of consumers and the reduction of their vulnerability.

More than 420,000 tonnes of plastic waste is produced every year in New York City (NYC). This plastic represents 15% of municipal solid waste in NYC and is in line with New York State and United States averages. This material is managed by NYC’s dual-stream recycling system and industry-leading material recovery facilities. However, not all plastic collected for recycling (diverted) is ultimately sold to be remanufactured into new products (recovered). This study utilizes publicly available data to quantify and compare the diversion and recovery rates of residential plastics in NYC to provide quantitative context of such a process in a large metropolitan area. In 2018, 35.2% of plastics suitable for recycling were diverted, indicating a potential to improve collection. Of these, only 53.4% of plastics diverted for recycling were ultimately recovered through sale into the markets. This is aligned with the theoretical maximum recycling potential described in other scholarly work. The 53.4% recovery rate of diverted plastics indicates that an increase in diversion would not yield an equivalent increase in recovery. Additionally, barriers to the recovery of plastic waste impact the actual recycling rate. The literature and this study recognize that contamination, technology limitations, and the availability of markets all influence the sorting and selling of plastics. Furthermore, plastic recycling has recently received significant attention due to the implementation of China’s National Sword policy. This study demonstrates that from 2017 to 2018, while the sales of plastics #3–7 decreased, the overall recovery rate of plastics in NYC was not impacted by China’s National Sword policy.

Purpose –This research had the aim to analyze if the senses of the work are able to influence the level of satisfaction of federal public servants. Design/methodology/approach – For that, a mixed approach study was carried out with the technical-administrative servants in education of a Federal University, based in countryside of Minas Gerais state. A total of 186 questionnaires were collected, using an adaptation of the Meaningful Work Scale (MWS) and the Work Satisfaction Scale (EST), and 10 semi-structured interviews were conducted. Findings –The correlation analyzes between the two constructs revealed the existence of moderated forces of association, for the most part, between the dimensions of the senses of work and the average score of work satisfaction, whereas linear regression revealed a genuine effect of the meanings of work on job satisfaction indexes. The content analysis of the interviews supported the results found, allowing to conclude that, for the servers surveyed, the identification with the work performed in an environment that values aspects such as ethics, autonomy, relationships and learning ends up influencing directly and positively the level of satisfaction with this job. Originality/value – Understanding the relationship meanings and work satisfaction of public servants, in the context of people management, presents itself as an original and valuable research, contributing to university managers to seek new ways of encouraging employees.

Federica Sola,1,2 Barbara Canonico,1 Mariele Montanari,1 Angela Volpe,2 Chiara Barattini,1,2 Chiara Pellegrino,2 Erica Cesarini,1 Michele Guescini,1 Michela Battistelli,1 Claudio Ortolani,1 Alfredo Ventola,2 Stefano Papa1 1Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, 61029, Italy; 2AcZon Srl, Monte San Pietro, BO, 40050, ItalyCorrespondence: Barbara CanonicoDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Via Ca’ Le Suore 2-4, Urbino, PU, 61029, ItalyTel +39 0722 304280Email barbara.canonico@uniurb.itIntroduction: Since most biologically active macromolecules are natural nanostructures, operating in the same scale of biomolecules gives the great advantage to enhance the interaction with cellular components. Noteworthy efforts in nanotechnology, particularly in biomedical and pharmaceutical fields, have propelled a high number of studies on the biological effects of nanomaterials. Moreover, the determination of specific physicochemical properties of nanomaterials is crucial for the evaluation and design of novel safe and efficient therapeutics and diagnostic tools. In this in vitro study, we report a physicochemical characterisation of fluorescent silica nanoparticles (NPs), interacting with biological models (U937 and PBMC cells), describing the specific triggered biologic response.Methods: Flow Cytometric and Confocal analyses are the main method platforms. However TEM, NTA, DLS, and chemical procedures to synthesize NPs were employed.Results: NTB 700 NPs, employed in this study, are fluorescent core-shell silica nanoparticles, synthesized through a micelle-assisted method, where the fluorescence energy transfer process, known as FRET, occurs at a high efficiency rate. Using flow cytometry and confocal microscopy, we observed that NTB 700 NP uptake seemed to be a rapid, concentration-, energy- and cell type-dependent process, which did not induce significant cytotoxic effects. We did not observe a preferred route of internalization, although their size and the possible aggregated state could influence their extrusion. At this level of analysis, our investigation focuses on lysosome and mitochondria pathways, highlighting that both are involved in NP co-localization. Despite the main mitochondria localization, NPs did not induce a significant increase of intracellular ROS, known inductors of apoptosis, during the time course of analyses. Finally, both lymphoid and myeloid cells are able to release NPs, essential to their biosafety.Discussion: These data allow to consider NTB 700 NPs a promising platform for future development of a multifunctional system, by combining imaging and localized therapeutic applications in a unique tool.Keywords: nanoparticles, uptake, intracellular trafficking, exocytosis, multifunctional tool

Background: Multiple sclerosis (MS) is considered a neurodegenerative disease and an inflammatory demyelinating neuropathology in young population. Procedural memory has been poorly investigated in MS. Objective: We assessed whether the MS group was able to develop a motor-cognitive skill, using a procedural task (PLSC) developed in our laboratory, applying a manual and serial reaction time (RT) paradigm to semantic categorization. Methods: We evaluated 26 MS patients and 26 socio-demographic matched control participants using the PLSC task. Results: Using non-parametric statistical analyses, we observed a significant improvement of semantic categorization RTs with practice (p = 0.002), even with new verbal material to categorize in MS patients (p = 0.006), despite their motor and executive moderate deficits. This same profile of semantic procedural learning in MS was observed in previous studies carried out with Alzheimer’s and Parkinson’s diseases. Moreover, the visual-motor RTs remained stable or slightly improved over the five blocks in both groups, as well as in the AD groups of previous studies. The MS group showed longer visual-motor reaction times than those of the control group (p

This cross-sectional study aimed to explore specific online behaviours and their association with a range of underlying psychological and other behavioural factors during the COVID-19 pandemic. Eight countries (Italy, Spain, the United Kingdom, Lithuania, Portugal, Japan, Hungary, and Brazil) participated in an international investigation involving 2223 participants (M = 33 years old; SD = 11), 70% of whom were females. Participants were surveyed for specific type of Internet use severity, appearance anxiety, self-compassion, and image and use of performance-enhancing drugs (IPEDs). Results were compared cross-culturally. The mean time spent online was 5 h (SD = ±3) of daily browsing during the pandemic. The most commonly performed activities included social networking, streaming, and general surfing. A strong association between these online behaviours and appearance anxiety, self-compassion, and IPEDs use was found after adjustment for possible confounders, with higher scores being associated with specific online activities. Significant cross-cultural differences also emerged in terms of the amount of time spent online during the initial stages of the COVID-19 pandemic.

The purpose of this study is to evaluate adaptive functioning and neurodevelopment study assessments in a prospective study of patients with Dravet syndrome (DS). We present 3-month interim adaptive functioning and neurodevelopment data from the prospective, observational BUTTERFLY study in patients with DS aged 2-18 years.BUTTERFLY enrolled thirty-six patients divided 1:1:1 across three age groups (2-7: 8-12: and 13-18 years). Most enrolled patients were female (61.1%), white (94.4%), and non-Latino (83.3%) with a mean (standard deviation; SD) age of 10.8 (5.2) years and a mean (range) age of seizure onset of 0.4 (0.2-1.0) years. Patients used a mean (SD) of 3.5 (1.63) anti-seizure therapies at baseline. Regression analysis of the baseline Vineland Adaptive Behavior Scale - third edition (VABS-III) composite score indicated that the gap in adaptive function between patients with DS (n = 33) and neurotypical children widens with age. Similarly, developmental quotients calculated for patients who completed all Bayley Scales of Infant Development - third edition (BSID-III) subtests at baseline (n = 15) highlighted a gap in intellectual functioning between patients with DS and neurotypical children that widens with age. More patients in the two older age groups were able to validly complete the Wechsler Preschool and Primary Scale of Intelligence - fourth edition (WPPSI-IV) at baseline compared with the youngest age group. There were trends towards higher raw scores, albeit of low magnitude, in the oldest age group compared with the younger age two groups across multiple VABS-III domains and WPPSI-IV subtests. All three measures showed no significant change in the all-patients analyses and demonstrated relatively low intra-patient variability from baseline to Month 3.Three-month interim data from BUTTERFLY demonstrated the feasibility of utilizing the VABS-III, BSID-III, and WPPSI-IV for the assessment of adaptive function and neurodevelopment in future clinical studies of DS. Moreover, many patients with DS appear to gain neurodevelopmental and adaptive function skills over time, although at a slower rate and lower magnitude than that seen in the neurotypical population.

SummaryThere is no clear genetic etiology or convergent pathophysiology for autism spectrum disorders (ASD). Using cortical organoids and single-cell transcriptomics, we modeled alterations in the formation of the forebrain between sons with idiopathic ASD and their unaffected fathers in thirteen families. Alterations in the transcriptome suggest that ASD pathogenesis in macrocephalic and normocephalic probands involves an opposite disruption of the balance between the excitatory neurons of the dorsal cortical plate and other lineages such as the early-generated neurons from the putative preplate. The imbalance stemmed from a divergent expression of transcription factors driving cell fate during early cortical development. While we did not find probands’ genomic variants explaining the observed transcriptomic alterations, a significant overlap between altered transcripts and reported ASD risk genes affected by rare variants suggests a degree of gene convergence between rare forms of ASD and developmental transcriptome in idiopathic ASD.

The COVID-19 pandemic has brought unique stressors for youth in foster care and recent foster care alumni, particularly those who are also parenting young children. One way the pandemic can be mitigated is through vaccination of the general population. Yet, some young adults have been slow to choose to be vaccinated. As has been demonstrated, simple availability of the COVID-19 vaccine will not guarantee its uptake, especially among marginalized populations. In order to better understand the nuances of vaccination among youth in foster care and recent foster care alumni, we conducted in-depth, semi-structured focus groups and interviews with 23 parenting youth with foster care histories aged 18-26 years. Data regarding vaccine attitudes were analyzed using thematic analysis. Participating youth, who were majority Black, Indigenous, and people of color (BIPOC) and often lived in multigenerational households, had significant concerns about the COVID-19 vaccine. They expressed varying degrees of intention to get vaccinated. Young people, especially those who belong to marginalized populations, need opportunities to openly discuss their vaccination-related questions without judgment. Science communicators should consider these questions and address youths' concerns through diverse voices and channels to ensure youth have the information they need to make an informed decision regarding COVID-19 vaccination.

Independent students pursue higher education without financial, practical, and sometimes emotional support from family. For these students, asking for assistance when needed is key for college persistence. Decisions around help-seeking are shaped by multiple factors but are often portrayed as a solely individual decision. This study examined factors affecting help seeking among independent students enrolled in a four-year university. Within a process evaluation of a campus support program for independent students, we conducted in-depth, individual interviews with 23 independent students ages 18–23, as well as 5 university staff. Students described a range of psychological and relational factors influencing their willingness to seek assistance and identified significant barriers to help-seeking. In contrast, staff interviews focused more on perceived student deficits in help-seeking. Both groups also identified institutional factors that influenced student efforts to seek assistance. Findings can inform the development of effective campus-based services to support the retention of independent students.

Identifying oculomotor behaviors relevant for eye-tracking applications is a critical but often challenging task. Aiming to automatically learn and extract knowledge from existing eye-tracking data, we develop a novel method that creates rich representations of oculomotor scanpaths to facilitate the learning of downstream tasks. The proposed stimulus-agnostic Oculomotor Behavior Framework (OBF) model learns human oculomotor behaviors from unsupervised and semi-supervised tasks, including reconstruction, predictive coding, fixation identification, and contrastive learning tasks. The resultant pre-trained OBF model can be used in a variety of applications. Our pre-trained model outperforms baseline approaches and traditional scanpath methods in autism spectrum disorder and viewed-stimulus classification tasks. Ablation experiments further show our proposed method could achieve even better results with larger model sizes and more diverse eye-tracking training datasets, supporting the model's potential for future eye-tracking applications. Open source code: http://github.com/BeibinLi/OBF., Comment: Accepted ACM ICMI 2021

espanolTeniendo en cuenta los diferentes aspectos biologicos, psicologicos y sociales de cada persona, existe una clara relacion entre los adolescentes y la practica de actividad fisica en la actualidad es flagrante, la cual se ve influenciada por la familia y el profesor de Educacion Fisica de manera mas significativa. Frente a la falta de tiempo argumentada por los sedentarios. Las principales razones para realizarla son: el fomento de las relaciones sociales y la obtencion de placer y diversion. Durante la adolescencia, los jovenes se enfrentan con conductas que suponen un riesgo para la salud, observandose una relacion positiva entre la practica de actividad fisica y habitos saludables, asi como tambien beneficios en el ambito academico. En lineas generales, la poblacion adolescente muestra un nivel muy bajo de practica de actividad fisica, siendo necesario revertir esta tendencia mediante programas de intervencion extracurriculares e incrementando el horario lectivo de Educacion Fisica EnglishTaking into account the different biological, psychological and social aspects of each person, there is a clear relationship between adolescents and the practice of physical activity is currently flagrant, which is influenced by the family and the Physical Education teacher so more meaningful Faced with the lack of time argued by sedentary people, the main reasons for carrying it out are: the promotion of social relations and obtaining pleasure and fun. During adolescence, young people face behaviors that pose a health risk, observing a positive relationship between the practice of physical activity and healthy habits, as well as benefits in the academic field. In general, the adolescent population shows a very low level of physical activity practice, being necessary to reverse this trend through extracurricular intervention programs and increasing the Physical Education teaching schedule

Co-occurring anxiety is common in children with autism spectrum disorder (ASD). However, inconsistencies across parent and child reports of anxiety may complicate the assessment of anxiety in this population. The present study examined parent and child anxiety ratings in children with ASD with and without anxiety disorders and tested the association between parent-child anxiety rating discrepancy and ASD symptom severity. Participants included children aged 8-16 years in three diagnostic groups: ASD with co-occurring anxiety disorders (ASD + Anxiety; n = 34), ASD without co-occurring anxiety disorders (ASD; n = 18), and typically developing healthy controls (TD; n = 50). Parents and children completed ratings of child anxiety using the Multidimensional Anxiety Rating Scale. Patterns of parent and child anxiety ratings differed among the three groups, with parent ratings exceeding child ratings only in the ASD + Anxiety group. Parents reported higher levels of child anxiety in the ASD + Anxiety versus ASD group, whereas children reported comparable levels of anxiety in the two groups. Among children with ASD, ASD symptom severity was positively associated with the degree to which parent ratings exceeded child ratings. Results suggest that children with ASD and co-occurring anxiety disorders endorse some anxiety symptoms but may underreport overall levels of anxiety. In addition, ASD symptom severity might increase discrepancies in parent-child anxiety ratings. These findings suggest a unique and valuable role of child anxiety ratings and suggest that both parent and child anxiety ratings should be considered in light of children's ASD symptom severity and used to guide further assessment. Autism Res 2020, 13: 93-103. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Children with autism spectrum disorder (ASD) commonly experience anxiety; yet, their perceptions of their anxiety might differ from their parents' perceptions. This study found that, while children with ASD and anxiety disorders acknowledge some anxiety, their parents report them as having higher levels of anxiety. Also, child and parent perceptions of anxiety may differ more for children with more severe ASD symptoms. How these findings may guide research and clinical practice is discussed.

INTRODUCTION The purpose of this study is to understand the neurological differences between patients born with combined sagittal and metopic craniosynostosis (SMc) and isolated sagittal craniosynostosis (ISc) by studying aberrations in functional brain connectivity and white matter microstructure, before surgery, utilizing functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI). METHODS The authors collected DTI and resting-state (ie, no sedation and asleep) functional connectivity MRI data in 10 infant patients preoperatively: 5 in the SMc group (4.3 ± 1 months) and 5 in the ISc group (4.8 ± 1.1 months). Resting state fMRI imaging and DTI data were acquired using a 3-T Siemens Trio MRI system (Erlangen, Germany) while the infant patients slept. fMRI data were corrected for movement using SPM, underwent cerebrospinal fluid and white matter signal regression and further analyzed with BioImageSuite. For the DTI data, 3 diffusion runs were averaged, processed utilizing FMRIB Software Library, and analyzed statistically using BioImageSuite. RESULTS Comparing the SMc versus ISc groups, SMc demonstrated that there was increased connectivity, statistically significant differences, in neural networks between children with sagittal synostosis alone versus those with sagittal with metopic synostosis, in the right BA 31 and BA 23 (corresponding to the posterior cingulate cortex (PCC) (P

Placement of a chest tube drains intrapleural fluid and air. The tube should be attached to a drainage system, such as one-, two-, or three-compartment devices, a one-way (Heimlich) valve for ambulatory drainage, a digital system, or a vacuum bottle. The frequently employed three-compartment systems, currently integrated disposable units, allow adjustment of negative pressure or no suction (water seal), and include an air leak meter on the water seal chamber to be used for demonstrating and quantifying air leak. These readings are subjective and prone to interobserver variability. Digital pleural drainage systems offer the benefits of quantification of any air leak and pleural pressure. Indwelling pleural catheters, typically utilized for malignant pleural effusion, can be drained using vacuum bottles. Knowledge of the design and functionality of each device in the setting of an individual patient's specific pleural process facilitates the selection of practical and financially prudent chest tube drainage strategies.

BACKGROUND Pivotal Response Treatment (PRT), an evidence-based and parent-delivered intervention, is designed to improve social communication in individuals with autism spectrum disorder (ASD). OBJECTIVE To assess the feasibility, acceptability, and clinical effects of an online model of PRT delivered via MindNest Health that aims to provide self-directed and engaging online modules, real-time coaching and feedback, and accessible stepped-care to large populations of parents seeking resources for their children with ASD. METHODS Male and female children, ages 2-7 years old with single-word to phrase-level speech, were eligible to participate in the study. Families were randomized to the online parent training condition or control condition. The online component of the intervention consisted of eight 20-minute online courses of content describing parent training principles in PRT. Four 1-hour videoconferences were held after course 1, course 3, course 5, and course 8. Parents were given 1-2 weeks to complete each course. Parents completed the Client Expectancies Questionnaire (CCQ) at Week 2 and endpoint, as well as the Behavioral Intervention Rating Scale (BIRS) at endpoint to assess parental expectancies and treatment acceptability and effectiveness. RESULTS 9 of 14 subjects completed the study curriculum in the online parent training condition, and 6 of 12 subjects completed the control condition. A total of 58% subjects completed study curriculum by study closure. Within the online parent training condition, there was a significant increase in mean CCQ Total Scores from 25.38 ± 3.25 at baseline to 27.5 ± 3.74 at endpoint (P = .04), mean CCQ Confidence Scores from 6.0 ± 1.07 at baseline to 6.75 ± 0.89 at endpoint (P = .02), and mean CCQ Other Improvement Scores 5.25 ± 0.89 at baseline to 6.25 ± 1.28 at endpoint (P = .009). Within the control condition, a modest increase in CCQ scores existed (Confidence △M = +.25; Recommend △M = +.25; Total Score △M = +.50), but no significant results were found (Confidence P = .38; Recommend P = .36; Total Score P = .43). Out of the eleven parents that completed the BIRS at endpoint, 83% parents endorsed they slightly agree or agree with over 93% of the Acceptability factor items on the BIRS. CONCLUSIONS The feasibility of this online treatment is endorsed by the high rate of online module completion and attendance to videoconferences within the online parent training group. Acceptability of treatment is supported by strong ratings on the CCQ and significant improvements in scores as well as strong ratings on the BIRS. This study’s small sample size limits the conclusions that can be drawn, however, the PRT MindNest Health platform holds promise to support parents of children with ASD who are unable to access traditional, in-person parent-mediated intervention for their child.

Background Pivotal response treatment (PRT), an evidence-based and parent-delivered intervention, is designed to improve social communication in autistic individuals. Objective The aim of this study was to assess the feasibility, acceptability, and clinical effects of an online model of PRT delivered via MindNest Health, a telehealth platform that aims to provide self-directed and engaging online modules, real-time coaching and feedback, and accessible stepped-care to large populations of parents seeking resources for their autistic children. Methods Male and female autistic children, aged 2-7 years with single-word to phrase-level speech, and their parents were eligible to participate in the study. Families were randomized to the online parent training condition or control condition. The online component of the intervention consisted of eight 20-minute online courses of content describing parent training principles in PRT. Four 1-hour videoconferences were held after course 1, course 3, course 5, and course 8. Parents were given 1-2 weeks to complete each course. Parents completed the Client Credibility Questionnaire (CCQ) at week 2 and at the study endpoint, as well as the Behavioral Intervention Rating Scale (BIRS) at the study endpoint to assess parental expectancies, and treatment acceptability and effectiveness. Results Nine of 14 participants completed the study curriculum in the online parent training condition, and 6 of 12 participants completed the control condition. Thus, a total of 58% (15/26) participants across both groups completed the study curriculum by study closure. Within the online parent training condition, there was a significant increase in mean CCQ total scores, from 25.38 (SD 3.25) at baseline to 27.5 (SD 3.74) at study endpoint (P=.04); mean CCQ confidence scores, from 6.0 (SD 1.07) at baseline to 6.75 (SD 0.89) at study endpoint (P=.02); and mean CCQ other improvement scores, from 5.25 (SD 0.89) at baseline to 6.25 (SD 1.28) at study endpoint (P=.009). Within the control condition, a modest increase in mean CCQ scores was noted (Confidence, difference=+0.25; Recommend, difference=+0.25; Total Score, difference=+0.50), but the differences were not statistically significant (Confidence P=.38, Recommend P=.36, Total Score P=.43). Among the 11 parents who completed the BIRS at the study endpoint, 82% (n=9) endorsed that they slightly agree or agree with over 93% of the Acceptability factor items on the BIRS. Conclusions The feasibility of this online treatment is endorsed by the high rate of online module completion and attendance to videoconferences within the online parent training group. Acceptability of treatment is supported by strong ratings on the CCQ and significant improvements in scores, as well as strong ratings on the BIRS. This study’s small sample size limits the conclusions that can be drawn; however, the PRT MindNest Health platform holds promise to support parents of autistic children who are unable to access traditional, in-person parent-mediated interventions for their child.

Complex deep learning models have shown their impressive power in analyzing high-dimensional medical image data. To increase the trust of applying deep learning models in medical field, it is essential to understand why a particular prediction was reached. Data feature importance estimation is an important approach to understand both the model and the underlying properties of data. Shapley value explanation (SHAP) is a technique to fairly evaluate input feature importance of a given model. However, the existing SHAP-based explanation works have limitations such as 1) computational complexity, which hinders their applications on high-dimensional medical image data; 2) being sensitive to noise, which can lead to serious errors. Therefore, we propose an uncertainty estimation method for the feature importance results calculated by SHAP. Then we theoretically justify the methods under a Shapley value framework. Finally we evaluate our methods on MNIST and a public neuroimaging dataset. We show the potential of our method to discover disease related biomarkers from neuroimaging data.

Heterogeneous presentation of a neurological disorder suggests potential differences in the underlying pathophysiological changes that occur in the brain. We propose to model heterogeneous patterns of functional network differences using a demographic-guided attention (DGA) mechanism for recurrent neural network models for prediction from functional magnetic resonance imaging (fMRI) time-series data. The context computed from the DGA head is used to help focus on the appropriate functional networks based on individual demographic information. We demonstrate improved classification on 3 subsets of the ABIDE I dataset used in published studies that have previously produced state-of-the-art results, evaluating performance under a leave-one-site-out cross-validation framework for better generalizeability to new data. Finally, we provide examples of interpreting functional network differences based on individual demographic variables.