1. Translocation of BCL2 and BCL6 to the same immunoglobulin heavy chain locus in a case of follicular lymphoma
- Author
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Hamels J, André Delannoy, Katrina Rack, Gillerot Y, Vannuffel P, and Ravoet C
- Subjects
Cancer Research ,medicine.medical_specialty ,Follicular lymphoma ,Locus (genetics) ,Chromosomal translocation ,Biology ,Translocation, Genetic ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Chromosomes, Human ,Humans ,Lymphoma, Follicular ,In Situ Hybridization, Fluorescence ,Cytogenetics ,Karyotype ,Hematology ,Middle Aged ,medicine.disease ,BCL6 ,Molecular biology ,Lymphoma ,Oncology ,Proto-Oncogene Proteins c-bcl-2 ,Karyotyping ,Chromosome abnormality ,Proto-Oncogene Proteins c-bcl-6 ,Female ,Immunoglobulin Heavy Chains - Abstract
Follicular Lymphoma is a low grade malignancy of mature B-cells. The hallmark chromosome abnormality is the translocation t(14;18) which is observed in 70 – 80% of cases with a translocation t(3;14) present in a further 10%. Rarely both of these translocations, or one of their variants, may be present. These co-incident translocations usually involve different Ig loci or different Ig alleles. We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci. Double oncogene translocations to a single immunoglobulin locus are extremely rare in lymphomas with few cases described to date. To our knowledge this is the first reported case with a complex translocation involving these loci.
- Published
- 2005