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1. Age differences in comorbidities, presenting symptoms, and outcomes of influenza illness requiring hospitalization: A worldwide perspective from the global influenza hospital surveillance network

Author

Andrew, Melissa K, Pott, Henrique, Staadegaard, Lisa, Paget, John, Chaves, Sandra S, Ortiz, Justin R, McCauley, John, Bresee, Joseph, Nunes, Marta C, Baumeister, Elsa, Raboni, Sonia Mara, Giamberardino, Heloisa IG, McNeil, Shelly A, Gomez, Doris, Zhang, Tao, Vanhems, Philippe, Koul, Parvaiz A, Coulibaly, Daouda, Otieno, Nancy A, Dbaibo, Ghassan, Almeida, Maria Lourdes Guerrero, Laguna-Torres, Victor Alberto, Drăgănescu, Anca Cristina, Burtseva, Elena, Sominina, Anna, Danilenko, Daria, Medić, Snežana, Diez-Domingo, Javier, Lina, Bruno, and Investigators, on behalf of GIHSN

Subjects
Ecology,Evolution & Ethology, Infectious Disease
Abstract

Background. The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes in patients hospitalized with influenza. Methods. Between November 2018 and October 2019, GIHSN included 19 sites in 18 countries using a standardized surveillance protocol. Influenza infection was laboratory-confirmed with reverse-transcription polymerase chain reaction. A multivariate logistic regression model was utilized to analyze the extent to which various risk factors predict severe outcomes. Results. Of 16 022 enrolled patients, 21.9% had laboratory-confirmed influenza; 49.2% of influenza cases were A/ H1N1pdm09. Fever and cough were the most common symptoms, although they decreased with age (P < .001). Shortness of breath was uncommon among those

Published
2023
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2. Hospital antibiotic prescribing patterns in adult patients according to the WHO Access, Watch and Reserve classification (AWaRe): results from a worldwide point prevalence survey in 69 countries

Author

Pauwels, Ines, Versporten, Ann, Drapier, Nico, Vlieghe, Erika, Goossens, Herman, Koraqi, Andi, Hoxha, Iris, Tafaj, Silva, Cornistein, Wanda, Quiros, Rodolfo, Hojman, Martin, Ghazaryan, Lilit, Horne, Kylie, Cairns, Kelly, Doukas, Fiona, Gottlieb, Thomas, Sermijn, Erica, Verhamme, Katia, Brands, Christiane, Van Herendael, Bruno, Filippin, Lorenzo, Vandewal, Wouter, Konopnicki, Deborah, Maillart, Evelyne, Teixeira Lopes, Liliana, Papin, Pauline, Smits, Ilse, Jansens, Hilde, Bartholomeus, Sofie, Van den Abeele, Anne-Marie, Steyaert, Sophia, Piette, Anne, Buyle, Franky, Cartuyvels, Reinoud, Jonckheere, Stijn, Wybo, Ingrid, Vanneste, Lorenz, Mathieu, Delphine, Firre, Eric, Westelinck, Veerle, Gadisseux, Philippe, Dugernier, Thierry, Bafort, Kristof, Gonissen, Viviane, Vanderper, Vanessa, Gabriels, Patrick, Weekers, Frank, Michel, Philippe, Van Liedekerke, Ann, Costers, Michiel, Catry, Boudewijn, Dedeic-Ljubovic, Amela, Gales, Ana C., Matos Porto, Ana Paula, Figueiredo Costa, Silvia, Keuleyan, Emma, Beidi, Apollinaire, Cissohko, Youssouph, Blakwe, Habsatou, Batchaya Basile, Ngassa, German, Greg J., Lutes, Sarah, Boswell, Jennifer, Mertz, Dominik, Nguyen, Tuyen, MacLaggan, Timothy, Landry, Daniel, Ang, Anita, Thirion, Daniel J.G., Frenette, Charles, Émond, Yannick, Roberts, Jacqueline, Chang, Sandra, Kosar, Justin, Valiquette, Louis, Dutrisac, Ginette, Afra, Kevin, McGeer, Allison, Carrier, Marie, Grant, Jennifer, Labarca, Jaime, Carvajal, Camila, Lin, HongYi, Wang, Qiang, Yang, Jing, Yang, Wenjie, Cortes, Jorge A., Villalobos-Vindas, Juan, Ramírez-Valverde, Carlos, Horvatic, Jasminka, Pristas, Irina, Paphitou, Niki, Rummukainen, Maija-Liisa, Froissart, Antoine, Vanhems, Philippe, Pagava, Karaman, Korinteli, Irma, Brandt, Tobias, Gaertner, Johannes, Enimil, Anthony, Roilides, Emmanuel, Hajdú, Edit, Sengupta, Sharmila, Singh, Sanjeev, Patil, Priyanka, Poojary, Aruna, Soltani, Jafar, Pouladfar, Gholamreza, Jafarpour, Zahra, Alinia, Cyrus, Ameen, Hadi, Fitzgerald, David, Paul, Mical, Maor, Yasmin, Strahilevitz, Jacob, Chowers, Michal, Temkin, Elizabeth, Luca, Arnoldo, Ishibashi, Noriomi, Gu, Yoshiaki, Darwish Elhajji, Feras, Karabukayeva, Aizhan, Raka, Denis, Kambaralieva, Baktygul, Zarakauska, Lelde, Zarb, Peter, Hernandez Chena, Blanca Estela, Gonzalez-Diaz, Esteban, Corona-Meléndez, JuanCarlos, Torres Erazo, Darwin Stalin, Loza-Jalil, Suria Elizabeth, Molina, Julio, Candelas, Jose Antonio, Mijovic, Gordana, Duborija-Kovacevic, Natasa, Jong, Eefje, Kluytmans, Jan, van Elzakker, Erika, Schweitzer, Valentijn, Davies, Nicola, Iregbu, Kenneth, Nwajiobi-Princewill, Philip, Nwafia, Ifeyinwa, Fasuyi, Temitayo, Aboderin, Aaron, Elikwu, Charles John, Fadeyi, Abayomi, Ola-Bello, Olafoyekemi, Oduyebo, Oyinlola, Adedosu, Akin Nelson, Ekuma, Agantem, Shaqiri, Erjona, Saleem, Zikria, De Los Reyes, Mari Rose, Tavares, Luis, Kim, Nam Joong, Rachina, Svetlana, Alharthi, Alwaleed R., Enani, Mushira, Faried, Osama, Mirghani, Mohamed, Carevic, Biljana, Radulovic, Lili, Dragovac, Gorana, Tan, Sock Hoon, Taljaard, Jantjie, Chibabhai, Vindana, Joiner, Jennifer, Caston, Juan Jose, Núñez-Núñez, María, Martínez-Marcos, Francisco Javier, Ojeda-Burgos, Guillermo, Menendez, Maria Dolores, Retamar, Pilar, Corzo, Juan E., Rattanaumpawan, Pinyo, Salou, Mounerou, Mnif, Basma, Oncul, Ahsen, Babigumira, Peter Ahabwe, Olweny, James, Marshall, Emily, McCorry, Ann, Aldeyab, Mamoon, Khanna, Priya, Gormley, Cairine, Maloney, Sara, Cooper, Mandelin, Blackburn, Laura, Gessner-Wharton, Mallory, Vu, Lam, Greer, Nickie, Gawrys, Gerard, Kronmann, Lisha, Rios, Edgar, Hudson, Melissa, Lindholm, David A., The Global-PPS network, Vriendenkring VUB, Clinical sciences, Microbiology and Infection Control, and Clinical Biology

Subjects
Adult, Microbiology (medical), Point prevalence survey, Latin Americans, education, Population, MEDLINE, World Health Organization, Essential medicines, Antibiotic prescribing, Anti-Infective Agents, Environmental health, Prevalence, Humans, AcademicSubjects/MED00740, Medicine, Pharmacology (medical), Medical prescription, Biology, Original Research, Pharmacology, education.field_of_study, Adult patients, business.industry, Pharmacology. Therapy, Hospitals, Anti-Bacterial Agents, Anti-Bacterial Agents/therapeutic use, AcademicSubjects/MED00290, Infectious Diseases, Human medicine, AcademicSubjects/MED00230, business
Abstract

ObjectivesThe WHO Access, Watch and Reserve (AWaRe) classification has been developed to support countries and hospitals in promoting rational use of antibiotics while improving access to these essential medicines. We aimed to describe patterns of worldwide antibiotic use according to the AWaRe classification in the adult inpatient population.MethodsThe Global Point Prevalence Survey on Antimicrobial Consumption and Resistance (Global-PPS) collects hospital antibiotic use data using a standardized PPS methodology. Global-PPS 2015, 2017 and 2018 data, collected by 664 hospitals in 69 countries, were categorized into AWaRe groups to calculate proportional AWaRe use, Access-to-Watch ratios and the most common indications for treatment with selected Watch antibiotics. Only prescriptions for systemic antibiotics on adult inpatient wards were analysed.ResultsRegional Access use ranged from 28.4% in West and Central Asia to 57.7% in Oceania, whereas Watch use was lowest in Oceania (41.3%) and highest in West and Central Asia (66.1%). Reserve use ranged from 0.03% in sub-Saharan Africa to 4.7% in Latin America. There were large differences in AWaRe prescribing at country level. Watch antibiotics were prescribed for a range of very different indications worldwide, both for therapeutic and prophylactic use.ConclusionsWe observed considerable variations in AWaRe prescribing and high use of Watch antibiotics, particularly in lower- and upper-middle-income countries, followed by high-income countries. The WHO AWaRe classification has an instrumental role to play in local and national stewardship activities to assess prescribing patterns and to inform and evaluate stewardship activities.

Published
2021

3. Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study

Author

Luque-Paz, David, Tattevin, Pierre, Loubet, Paul, Bénézit, François, Thibault, Vincent, Lainé, Fabrice, Vanhems, Philippe, Amour, Selilah, Lina, Bruno, Duval, Xavier, L’honneur, Anne-Sophie, Fidouh, Nadhira, Vallejo, Christine, Alain, Sophie, Galtier, Florence, Foulongne, Vincent, Lagathu, Gisèle, Lenzi, Nezha, Lesieur, Zineb, Launay, Odile, Jouneau, Stéphane, Loulergue, P., Momcilovic, S., Mira, J., Marin, N., Charpentier, J., Regent, A., Kanaan, R., Dumas, F., Doumenc, B., Lachatre, M., Szwebel, T., Kansao, J., Costa, Y., Alexandra, J., Becheur, H., Belghalem, K., Bernard, J., Bleibtreu, A., Boisseau, M., Bories, R., Brugiere, O., Brunet, F., Burdet, C., Casalino, E., Caseris, M., Chansiaux, C., Chauchard, M., Chavance, P., Choquet, C., Cloppet-Fontaine, A., Colosi, L., Couset, B., Crestani, B., Crocket, F., Debit, A., Delanoe, K, Descamps, V., Dieude, P., Dossier, A., Douron, N., Dupeyrat, E., Emeyrat, N., Fernet, C., Goulenok, T., Harent, S., Jouenne, R., Justet, A., Leleu, A., Lerat, I., Lilamand, M., Mal, H., Marceau, A., Metivier, A.-C., Oplelatora, K., Papo, T., Pelletier, A.-L., Pereira, L., Pradere, P., Prommier, R, Ralainnazava, P., Ranaivoision, M., Raynaud-Simon, A., Rioux, C., Sacre, K., Verry, V., Vuong, V., Yazdapanah, Y., Houhou, N., Géraud, P., Driss, V., Maugueret, V., Crantelle, L., Agostini, C., Ray, M., Letois, F., Mura, T., Serrand, C., Noslier, S., Giordano, A., Chevassus, H., Nyiramigisha, E., Merle, C., Bourdin, A., Konaté, A., Capdevilla, X., Du Cailar, G., Terminet, A., Blain, H., Leglise, M., Le Quellec, A., Corne, P., Landreau, L., Klouche, K., Bourgeois, A., Sebbane, M., Mourad, G., Leray, H., Postil, D., Alcolea, S., Couve-Deacon, E., Rogez, S., Argaud, L., Cour, M., Hernu, R., Simon, M., Baudry, T., Tazarourte, K., Bui-Xuan, C., Fattoum, J., Valette, M., Rochas, S., Cochennec, S., Thébault, E., Revest, M., Sébillotte, M., Le Bot, A., Baldeyrou, M., Patrat-Delon, S., Cailleaux, M., Pronier, C., CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Virulence Bactérienne et Infections Chroniques (VBIC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Hospices Civils de Lyon (HCL), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre d'Investigation Clinique de Limoges (CIC1435), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM), Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and This work was not funded. The study sites received funding from Sanofi Pasteur and MSD for the FLUVAC study. Vaccine producers had no role in the study design, data analysis, decision to publish or preparation of the manuscript.

Subjects
Adult, Multidisciplinary, [SDV]Life Sciences [q-bio], Respiratory Syncytial Virus Infections, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Adrenal Cortex Hormones, Virus Diseases, Respiratory Syncytial Virus, Human, Influenza, Human, Viruses, Humans, Prospective Studies, Respiratory Tract Infections
Abstract

Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI.

Published
2021

4. Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia

Author

Lakbar, Ines, Medam, Sophie, Ronflé, Romain, Cassir, Nadim, Delamarre, Louis, Hammad, Emmanuelle, Lopez, Alexandre, Lepape, Alain, Machut, Anaïs, Boucekine, Mohamed, Zieleskiewicz, Laurent, Baumstarck, Karine, Savey, Anne, Leone, Marc, Alfandari, Serge, Bailly, Sébastien, Bajolet, Odile, Baldesi, Olivier, Berger-Carbonne, Anne, Bollaert, Pierre-Edouard, Bretonniere, Cedric, Chatelet, Céline, Corne, Philippe, Durand-Joly, Isabelle, Friggeri, Arnaud, Gasan, Gaëlle, Gauzit, Rémy, Giard, Marine, Landelle, Caroline, Lavigne, Thierry, Lepelletier, Didier, Perrigault, Pierre-François, Picos, Santiago, Robaux, Marie-Aline, Stoeckel, Vincent, Timsit, Jean-François, Vanhems, Philippe, Hôpital Nord [CHU - APHM], Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), CHU Toulouse [Toulouse], Assistance Publique - Hôpitaux de Marseille (APHM), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), CCLIN Sud-Est – Centre de Coordination de la Lutte contre les Infections Nosocomiales Sud-Est, Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)

Subjects
Male, medicine.medical_treatment, health care facilities, manpower, and services, law.invention, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, law, Risk Factors, Pneumonia, Staphylococcal, 030212 general & internal medicine, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Multidisciplinary, Confounding, Age Factors, Enterobacteriaceae Infections, Middle Aged, Intensive care unit, 3. Good health, Intensive Care Units, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Medicine, Infectious diseases, Female, Acinetobacter Infections, medicine.medical_specialty, Science, Microbiology, Article, 03 medical and health sciences, Antibiotic resistance, Sex Factors, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Intensive care, Internal medicine, Drug Resistance, Bacterial, Prohibitins, medicine, Pneumonia, Bacterial, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Pseudomonas Infections, Clinical microbiology, Aged, Retrospective Studies, Mechanical ventilation, business.industry, Healthcare-Associated Pneumonia, Retrospective cohort study, Odds ratio, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Pneumonia, 030228 respiratory system, Bacterial infection, business
Abstract

Data on the relationship between antimicrobial resistance and mortality remain scarce, and this relationship needs to be investigated in intensive care units (ICUs). The aim of this study was to compare the ICU mortality rates between patients with ICU-acquired pneumonia due to highly antimicrobial-resistant (HAMR) bacteria and those with ICU-acquired pneumonia due to non-HAMR bacteria. We conducted a multicenter, retrospective cohort study using the French National Surveillance Network for Healthcare Associated Infection in ICUs (“REA-Raisin”) database, gathering data from 200 ICUs from January 2007 to December 2016. We assessed all adult patients who were hospitalized for at least 48 h and presented with ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii. The association between pneumonia caused by HAMR bacteria and ICU mortality was analyzed using the whole sample and using a 1:2 matched sample. Among the 18,497 patients with at least one documented case of ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii, 3081 (16.4%) had HAMR bacteria. The HAMR group was associated with increased ICU mortality (40.3% vs. 30%, odds ratio (OR) 95%, CI 1.57 [1.45–1.70], P P P

Published
2021

5. Additional file 7 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Subjects
virus diseases
Abstract

Additional file 7: Supplemental Figure 1. Influenza strain circulation by year-week for individual sites within the East Europe influenza transmission zone.

Published
2020
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6. Additional file 6 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Subjects
mental disorders, virus diseases
Abstract

Additional file 6: Supplemental Table 6. Characteristics of influenza-positive patients by site (Mexico, Romania, Moscow, St. Petersburg, Serbia, South Africa, and Spain).

Published
2020
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7. SupplementatyFile_TablePop_rev-leg – Supplemental material for How to save time in surveillance without losing quality: comparison of two methods of surgical site infection surveillance in orthopaedic prosthetics in a French university hospital

Author

Kuczewski, Elisabetta, Munier-Marion, Elodie, Sélilah Amour, Bénet, Thomas, Rongieras, Frédéric, Monneuse, Olivier, and Vanhems, Philippe

Subjects
111099 Nursing not elsewhere classified, 111708 Health and Community Services, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, SupplementatyFile_TablePop_rev-leg for How to save time in surveillance without losing quality: comparison of two methods of surgical site infection surveillance in orthopaedic prosthetics in a French university hospital by Elisabetta Kuczewski, Elodie Munier-Marion, Sélilah Amour, Thomas Bénet, Frédéric Rongieras, Olivier Monneuse and Philippe Vanhems in Journal of Infection Prevention

Published
2020
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8. Additional file 9 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 9: Supplemental Figure 3. Proportion of influenza-positive patients admitted to an ICU, requiring mechanical ventilation, or that died while hospitalized by age group.

Published
2020
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9. Additional file 9 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 9: Supplemental Figure 3. Proportion of influenza-positive patients admitted to an ICU, requiring mechanical ventilation, or that died while hospitalized by age group.

Published
2020
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10. Additional file 10 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 10: Supplemental Table 7. Factors associated with ICU admission, mechanical ventilation, and death during hospitalization in influenza-positive patients.

Published
2020
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11. Additional file 6 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Subjects
mental disorders, virus diseases
Abstract

Additional file 6: Supplemental Table 6. Characteristics of influenza-positive patients by site (Mexico, Romania, Moscow, St. Petersburg, Serbia, South Africa, and Spain).

Published
2020
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12. Additional file 8 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Subjects
virus diseases
Abstract

Additional file 8: Supplemental Figure 2. Description of data: Influenza strain circulation by year-week for individual sites within the South West Europe influenza transmission zone.

Published
2020
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13. Additional file 4 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 4: Supplemental Table 4. Characteristics of included patients by age group

Published
2020
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14. Additional file 2 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 2: Supplemental Table 2. Admission diagnoses possibly associated with an influenza infection in patients

Published
2020
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15. Additional file 4 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 4: Supplemental Table 4. Characteristics of included patients by age group

Published
2020
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16. Additional file 1 of A dashboard for monitoring preventive measures in response to COVID-19 outbreak in the Democratic Republic of Congo

Author

Wimba, Patient Mijiriro, Jacques-Aimé Bazeboso, Katchunga, Philippe Bianga, Tshilolo, Léon, Longo-Mbenza, Benjamin, Rabilloud, Muriel, Vanhems, Philippe, Iwaz, Jean, Jean-François Étard, and Écochard, René

Abstract

Additional file 1: Table S1. Statements and scores used by the observers in the streets of Bukavu, DRC, May 2020. Table S2. Spearman correlation coefficient between the main variables of the survey.

Published
2020
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17. Additional file 1 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 1: Supplemental Table 1. Admission diagnoses possibly associated with an influenza infection in patients ≥5 years of age.

Published
2020
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18. Additional file 8 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Subjects
virus diseases
Abstract

Additional file 8: Supplemental Figure 2. Description of data: Influenza strain circulation by year-week for individual sites within the South West Europe influenza transmission zone.

Published
2020
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20. Additional file 2 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 2: Supplemental Table 2. Admission diagnoses possibly associated with an influenza infection in patients

Published
2020
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21. Additional file 3 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Abstract

Additional file 3: Supplemental Table 3. Sample collection.

Published
2020
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22. Additional file 7 of Complicated hospitalization due to influenza: results from the Global Hospital Influenza Network for the 2017–2018 season

Author

Lina, Bruno, Georges, Alexandre, Burtseva, Elena, Nunes, Marta C., Andrew, Melissa K., McNeil, Shelly A., Ruiz-Palacios, Guillermo M., Luzhao Feng, Kyncl, Jan, Vanhems, Philippe, Ortiz, Justin R., Paget, John, and Reiner, Robert C.

Subjects
virus diseases
Abstract

Additional file 7: Supplemental Figure 1. Influenza strain circulation by year-week for individual sites within the East Europe influenza transmission zone.

Published
2020
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24. HIV incidence in the Estonian population in 2013 determined using the HIV-1 limiting antigen avidity assay

Author

Soodla, P., Simmons, R., Huik, K., Pauskar, M., Jõgeda, E. -L., Rajasaar, H., Kallaste, E., Maimets, M., Avi, R., Murphy, G., Porter, K., Lutsar, I., Del Amo, Julia, Meyer, Laurence, Bucher, Heiner C., Chêne, Geneviève, Hamouda, Osamah, Pillay, Deenan, Prins, Maria, Rosinska, Magda, Sabin, Caroline, Touloumi, Giota, Olson, Ashley, Cartier, Andrea, Fradette, Lorraine, Walker, Sarah, Babiker, Abdel, De Luca, Andrea, Fisher, Martin, Muga, Roberto, Kelleher, Tony, Cooper, David, Grey, Pat, Finlayson, Robert, Bloch, Mark, Ramacciotti, Tim, Gelgor, Linda, Smith, Don, Zangerle, Robert, Gill, John, Dabis, Francois, Thiebaut, Rodolphe, Costagliola, Dominique, Guiguet, Marguerite, Vanhems, Philippe, Chaix, Marie-Laure, Ghosn, Jade, Boufassa, Faroudy, Meixenberger, Karolin, Bannert, Norbert, Bartmeyer, Barbara, Antoniadou, Anastasia, Chrysos, Georgios, Daikos, Georgios L., Pantazis, Nikos, Katsarou, Olga, Rezza, Giovanni, Dorrucci, Maria, Monforte, Antonella d'Arminio, Geskus, Ronald, van der Helm, Jannie, Schuitemaker, Hanneke, Sannes, Mette, Brubakk, Oddbjorn, Kran, Anne-Marte Bakken, Rosinska, Magdalena, Tor, Jordi, de Olalla, Patricia Garcia, Cayla, Joan, Moreno, Santiago, Monge, Susana, del Romero, Jorge, Pérez-Hoyos, Santiago, Sönnerborg, Anders, Günthard, Huldrych, Scherrer, Alexandra, Malyuta, Ruslan, Johnson, Anne, Phillips, Andrew, Morrison, Charles, Price, Matt A., Giaquinto, Carlo, Grarup, Jesper, Kirk, Ole, Bailey, Heather, Volny Anne, Alain, Panteleev, Alex, Thorne, Claire, Aboulker, Jean-Pierre, Albert, Jan, Asandi, Silvia, De Wit, Stéphane, Reiss, Peter, Gatell, José, Karpov, Igor, Ledergerber, Bruno, Møller, Claus, Rakhmanova, Aza, Rockstroh, Jürgen, Sandhu, Manjinder, Dedes, Nikos, Pizzuti, David, Faggion, Silvia, Raben, Dorthe, Schwimmer, Christine, Scott, Martin, APH - Global Health, Infectious diseases, Epidemiology and Data Science, Experimental Immunology, APH - Aging & Later Life, and Global Health

Subjects
Male, 0301 basic medicine, HIV Infections, Immunoenzyme Techniques, 0302 clinical medicine, Epidemiology, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, media_common, Aged, 80 and over, education.field_of_study, Transmission (medicine), Incidence, Health Policy, Incidence (epidemiology), virus diseases, Middle Aged, 3. Good health, Infectious Diseases, Female, epidemiology, Viral load, Adult, Estonia, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Eastern Europe, recent infection testing algorithm, Young Adult, recent HIV infection, 03 medical and health sciences, Internal medicine, medicine, Humans, HIV serological assay, media_common.cataloged_instance, European union, Seroconversion, education, Aged, injecting drug users, Diagnostic Tests, Routine, business.industry, Public health, HIV, Immunology, HIV-1, business
Abstract

OBJECTIVES: Estonia has one the highest number of new HIV diagnoses in the European Union, mainly among injecting drug users and heterosexuals. Little is known of HIV incidence, which is crucial for limiting the epidemic. Using a recent HIV infection testing algorithm (RITA) assay, we aimed to estimate HIV incidence in 2013. METHODS: All individuals aged ≥18 years newly-diagnosed with HIV in Estonia January- December 2013, except blood donors and those undergoing antenatal screening, were included. Demographic and clinical data were obtained from the Estonian Health Board and the Estonian HIV-positive patient database. Serum samples were tested for recent infection using the LAg-avidity EIA assay. HIV incidence was estimated based on previously published methods. RESULTS: Of 69,115 tested subjects, 286 (0.41%) were newly-diagnosed with HIV with median age of 33 years (IQR: 28–42) and 65% male. Self-reported routes of HIV transmission were mostly heterosexual contact (n = 157, 53%) and injecting drug use (n = 62, 21%); 64 (22%) were with unknown risk group. Eighty two (36%) were assigned recent, resulting in estimated HIV incidence of 0.06%, corresponding to 642 new infections in 2013 among the non-screened population. Incidence was highest (1.48%) among people who inject drugs. CONCLUSIONS: These high HIV incidence estimates in Estonia call for urgent action of renewed targeted public health promotion and HIV testing campaigns.

Published
2017

25. Additional file 2: of Epidemiology and burden of influenza in healthy children aged 6 to 35â months: analysis of data from the placebo arm of a phase III efficacy trial

Author

Guerche-SÊblain, Clotilde El, Moureau, Annick, Schiffler, Camille, Dupuy, Martin, Pepin, Stephanie, Samson, Sandrine, Vanhems, Philippe, and FrançOis Schellevis

Subjects
body regions, nervous system, fungi
Abstract

Table S1. Medication use associated with confirmed influenza episodes by region (PDF 8 kb)

Published
2019
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29. Additional file 1: of Epidemiology and timing of seasonal influenza epidemics in the Asia-Pacific region, 2010–2017: implications for influenza vaccination programs

Author

Guerche-Séblain, Clotilde El, Caini, Saverio, Paget, John, Vanhems, Philippe, and Schellevis, François

Subjects
virus diseases
Abstract

Table S1. Number and proportion of influenza cases in each influenza transmission zone and country overall, by type, and by subtype/lineage for 2010–2017. (PDF 224 kb)

Published
2019
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30. Additional file 1 of Comparison of the prevalence of respiratory viruses in patients with acute respiratory infections at different hospital settings in North China, 2012–2015

Author

Jianxing Yu, Zhengde Xie, Tiegang Zhang, Yanqin Lu, Hongwei Fan, Donghong Yang, Bénet, Thomas, Vanhems, Philippe, Kunling Shen, Huang, Fang, Jinxiang Han, Taisheng Li, Zhancheng Gao, Ren, Lili, and Jianwei Wang

Abstract

Table S1. Hospitals that participated in the study of acute respiratory infections in North China, 2012–2015. Table S2. Respiratory viruses detected in patients with acute respiratory infections in North China, 2012–2015, by age group and hospital setting. Figure S1. Frequency of co-infected viruses in patients with ARIs in North China, 2012–2015, by age group and hospital settings. (DOCX 391 kb)

Published
2018
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32. Pneumocystis jirovecii genotype associated with increased death rate of HIV-infected patients with pneumonia

Author

Rabodonirina, Meja, Vaillant, Laetitia, Taffé, Patrick, Nahimana, Aimable, Gillibert, René-Pierre, Vanhems, Philippe, Hauser, Philippe M., Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Epidemiology, HIV Infections, DHPS, Pneumocystis carinii, 0302 clinical medicine, MESH: Respiration, Artificial, MESH: Dihydropteroate Synthase, Aged, 80 and over, 0303 health sciences, Fungal protein, MESH: Middle Aged, Coinfection, Pneumonia, Pneumocystis, fungus, MESH: HIV Infections, antimicrobial drugs, Pneumocystis jirovecii pneumonia, MESH: Infant, 3. Good health, Survival Rate, immunocompromised, Child, Preschool, MESH: Fungal Proteins, Microbiology (medical), Article, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, MESH: Pneumocystis jirovecii, pentamidine, Drug Resistance, Fungal, Humans, sulfa resistance, Aged, MESH: Adolescent, Dihydropteroate Synthase, MESH: Humans, 030306 microbiology, lcsh:R, MESH: Child, Preschool, Infant, MESH: Adult, medicine.disease, Respiration, Artificial, respiratory tract diseases, Pneumonia, chemistry, SMX/TMP, Mutation, Immunology, Dihydropteroate synthase, Pneumocystis jirovecii dihydropteroate synthase, MESH: Female, Pentamidine, MESH: Pneumonia, Pneumocystis, sulfamethoxazole/trimethoprim, opportunistic infection, [SDV]Life Sciences [q-bio], lcsh:Medicine, Dapsone, MESH: Trimethoprim-Sulfamethoxazole Combination, chemistry.chemical_compound, MESH: Aged, 80 and over, antibiotic, CME, antifungal drugs, intravenous drug use, Sulfamethoxazole/Trimethoprim, MESH: Aged, biology, homosexuality, Middle Aged, atovaquone, Infectious Diseases, fungal, Female, France, dihydropteroate synthase mutations, medicine.drug, Adult, MESH: Mutation, Adolescent, MESH: Survival Rate, 030231 tropical medicine, virus, MESH: Drug Resistance, Fungal, Fungal Proteins, mental disorders, Trimethoprim, Sulfamethoxazole Drug Combination, parasitic diseases, medicine, Pneumocystis jirovecii, lcsh:RC109-216, dapsone, Research, HIV, biology.organism_classification, MESH: Male, MESH: Coinfection, MESH: France, fungi
Abstract

Comorbidities might predict presence of specific fungal genotypes., Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations have been associated with failure of sulfa prophylaxis; their effect on the outcome of patients with P. jirovecii pneumonia (PCP) remains controversial. P. jirovecii DHPS polymorphisms and genotypes were identified in 112 cases of PCP in 110 HIV-infected patients by using PCR single-strand conformation polymorphism. Of the 110 patients observed, 21 died; 18 of those deaths were attributed to PCP. Thirty-three percent of the PCP cases involved a P. jirovecii strain that had 1 or both DHPS mutations. The presence or absence of DHPS mutations had no effect on the PCP mortality rate within 1 month, whereas P.jirovecii type 7 and mechanical ventilation at PCP diagnosis were associated with an increased risk of death caused by PCP. Mechanical ventilation at PCP diagnosis was also associated with an increased risk of sulfa treatment failure at 5 days.

Published
2013
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