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The aim of this study is to develop and validate a reliable, fast, and precise High-performance liquid chromatography (HPLC) method for the assay of diclofenac sodium (DIC) from previously optimized new orodispersible tablets (ODTs) developed with co-processed excipients.The method was conducted on an HPLC Agilent 1200, Zorbax C18 column, mobile phase of orthophosphoric acid solutions 0.1%, acetonitrile and methanol in the ratio (40:50:10 v/v/v) with a flow rate of 1.5 mL/min with isocratic elution and a total run time of 5 min. Detection of diclofenac sodium was carried out at 276 nm. The method was validated for linearity, precision, accuracy, robustness as per international guidelines. The developed method was found to be accurate, precise, fast, without interference from the co-processed excipients and can be useful for routine quality control analysis of diclofenac sodium in ODTs.

"The floral tips of the plant species Lythrum salicaria L. represent a rich source of total polyphenols, among which with the largest share we mention tannins, and this is why this plant material has a standardized monograph in the European Pharmacopoeia 10.0th edition. According to the literature accessed so far, the plant material has antioxidant, anti-inflammatory, hemostatic, antibacterial and antifungal properties, along with modulatory action on carbohydrate metabolism. Powder microscopic examination is an important step in establishing the identity of the plant species used, highlighting elements specific to the aerial part such as spiral vessels of the stem, fragments of the spongy mesophyll with calcium oxalate clusters cells and anomocytic stomata. The application of the SeDeM method on dried plant extracts represents an innovative trend in pharmaceutical technology and contributes to the collection of data in a structured and standardized form. In this paper, the functions and applications of the SeDeM expert system are illustrated upon the freeze-dried extract of Lythri herba for the purpose of easier identification and standardization. Future applications may include obtaining chewable gums or tablets by direct compression."

Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in different ratio (Avicel PH 102, magnesium stearate and coprocessed excipient Pharmaburst™ 500, 70% and 80% w/w). The obtained batches were analyzed for appearance, tablet thickness, uniformity of weight, hardness, friability, disintegration time, and non-compendial methods (wetting time). Co-processed Pharmaburst™ 500 excipient 70% used for sodium diclofenac ODT obtaining determined good results for quality control tests evaluation.