1. Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium
- Author
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Raul R. Gainetdinov, Tatyana Vladimirovna Zhilyaeva, Ivan Y. Iourov, N G Neznanov, A.E. Nikolishin, Thomas G. Schulze, Elza Khusnutdinova, Vera Golimbet, Svetlana G. Vorsanova, Irina P Anokhina, Kaleda Vg, G V Rukavishnikov, Arkady V Semke, Igor N. Lebedev, Lilia I. Abramova, Z. I. Kekelidze, Lyubomir I. Aftanas, Vadim M Brodyansky, Anzhelika V Sergeeva, Vadim Stepanov, E D Kasyanov, Аnastasia Levchenko, Edwin Zvartau, Anna Blagonravova, Anna Gryaznova, Аleksandr О Kibitov, Igor V Oleichik, Tatyana V Klimenko, S. Ivanova, R. F. Nasyrova, Ilgiz F Timerbulatov, Yury B Yurov, Yulia A. Nasykhova, Olga Yu Fedorenko, T. P. Klyushnik, Elena Blokhina, G. G. Simutkin, Nikolay А Bokhan, Аnna E Gareeva, Аndrey S Glotov, G E Mazo, and Evgeny Krupitsky
- Subjects
0301 basic medicine ,Biomedical Research ,New horizons ,media_common.quotation_subject ,Population ,Addiction ,Scientific literature ,Russia ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Political science ,Humans ,education ,Intersectoral Collaboration ,Molecular Biology ,Psychiatric genetics ,media_common ,education.field_of_study ,Depression ,business.industry ,Mental Disorders ,virus diseases ,Diagnostic markers ,Public relations ,Mental health ,3. Good health ,Psychiatry and Mental health ,Mental Health ,030104 developmental biology ,Multiculturalism ,Perspective ,Schizophrenia ,Russian federation ,business ,geographic locations ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
We provide an overview of the recent achievements in psychiatric genetics research in the Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, and pharmacogenetic studies, with an emphasis on genome-wide association studies. The genetic backgrounds of mental illnesses in the polyethnic and multicultural population of the Russian Federation are still understudied. Furthermore, genetic, genomic, and pharmacogenetic data from the Russian Federation are not adequately represented in the international scientific literature, are currently not available for meta-analyses and have never been compared with data from other populations. Most of these problems cannot be solved by individual centers working in isolation but warrant a truly collaborative effort that brings together all the major psychiatric genetic research centers in the Russian Federation in a national consortium. For this reason, we have established the Russian National Consortium for Psychiatric Genetics (RNCPG) with the aim to strengthen the power and rigor of psychiatric genetics research in the Russian Federation and enhance the international compatibility of this research.The consortium is set up as an open organization that will facilitate collaborations on complex biomedical research projects in human mental health in the Russian Federation and abroad. These projects will include genotyping, sequencing, transcriptome and epigenome analysis, metabolomics, and a wide array of other state-of-the-art analyses. Here, we discuss the challenges we face and the approaches we will take to unlock the huge potential that the Russian Federation holds for the worldwide psychiatric genetics community.
- Published
- 2019
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