1. Simultaneous determination of propacetamol and paracetamol by derivative spectrophotometry
- Author
-
M.I. Albero, Concepción Sánchez-Pedreño, V. Ródenas, and M.S. García
- Subjects
Chromatography ,medicine.diagnostic_test ,Hydrochloride ,Analytical chemistry ,Derivative ,Dosage form ,Analytical Chemistry ,chemistry.chemical_compound ,chemistry ,Spectrophotometry ,medicine ,Chemical stability ,Quantitative analysis (chemistry) ,Parenteral solutions ,Propacetamol - Abstract
A first-derivative spectrophotometric method for the simultaneous determination of propacetamol hydrochloride (PRO) and paracetamol (PA) is described. Measurements are made at the zero-crossing wavelengths at 242.0 for PRO and 239.0 nm for PA. The calibration graphs were linear up to 20.0 and 15.0 mg l −1 of PRO and PA, respectively, the limits of quantification were 0.75 and 0.46 mg l −1 . The possible interfering effects of other substances were studied. The method was applied to determining the stability of PRO in ethanolic solutions and in glucose and saline parenteral solutions.
- Published
- 2000