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1. A case with severe rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy--a case report

Author

O, Ozdemir, M, Boran, V, Gökçe, Y, Uzun, B, Koçak, and S, Korkmaz

Subjects
Male, Pyridines, Myocardial Ischemia, Hyperlipidemias, Middle Aged, Rhabdomyolysis, Electrocardiography, Fatal Outcome, Renal Dialysis, Diabetes Mellitus, Humans, Drug Interactions, Drug Therapy, Combination, Renal Insufficiency, Gemfibrozil, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypolipidemic Agents
Abstract

Gemfibrozil-statin combination therapy is a well-known risk factor for myopathy and rhabdomyolysis. Cerivastatin is a currently available statin with dual elimination; it is therefore expected to cause less drug-drug interaction. This case is the second reported case with severe rhabdomyolysis caused by cerivastatin-gemfibrozil combination. Moreover, in this case, the rhabdomyolysis was more severe and caused severe renal failure and death. The authors discuss how these drugs cause rhabdomyolysis and how rhabdomyolysis can cause renal failure.

Published
2000

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