1. Clinical features and prognosis of Boston type I keratoprosthesis-associated corneal melt
- Author
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Esen K. Akpek, Jonathan H. Tzu, Canan Asli Utine, Utine, CA, Tzu, JH, Akpek, EK, and Yeditepe Üniversitesi
- Subjects
Male ,medicine.medical_specialty ,Boston keratoprosthesis ,Keratoprosthesis ,medicine.medical_treatment ,Corneal Diseases ,Corneal Transplantation ,Prosthesis Implantation ,Endophthalmitis ,Postoperative Complications ,toxic epidermal necrolysis ,Ophthalmology ,medicine ,Immunology and Allergy ,Humans ,Fungal keratitis ,Stevens Johnson syndrome ,Corneal transplantation ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Retrospective cohort study ,Prostheses and Implants ,Eye infection ,Middle Aged ,medicine.disease ,Toxic epidermal necrolysis ,eye diseases ,Surgery ,Sjogren's Syndrome ,Treatment Outcome ,Sjogren's syndrome ,Female ,sense organs ,Artificial Organs ,Immunotherapy ,business ,Eye Infections, Fungal ,corneal melt - Abstract
Purpose: To describe the clinical features and outcomes of corneal melt associated with Boston type I keratoprosthesis (KPro) implantation. Methods: Medical records of patients who experienced corneal melt following KPro implantation were reviewed retrospectively. Results: Sixty-six adult patients had KPro implantation from January 2004 to November 2010. Six patients had an underlying inflammatory ocular surface disorder. Four experienced corneal melt (6.1%) 5-42 months after the initial surgery. One patient was diagnosed with Sjogren's syndrome as a result of diagnostic workup following melt. Three patients were treated with systemic immunomodulatory therapy; two experienced fungal keratitis and subsequent endophthalmitis. KPro had to be explanted and replaced with donor cornea in all cases. Conclusions: KPro-associated corneal melt is uncommon and appears to occur in patients with preexisting inflammatory disorders, which might not have been previously diagnosed. Timely explantation of KPro and replacement with donor cornea may prevent a poor outcome.
- Published
- 2011