1. NEPHROPROTECTIVE ACTIVITY OF ASPARAGUS RACEMOSUS AGAINST CISPLATIN-INDUCED NEPHROTOXICITY AND RENAL DYSFUNCTION IN EXPERIMENTAL RATS
- Author
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Yadav Av and Upasani Cd
- Subjects
Pharmacology ,Creatinine ,medicine.medical_specialty ,biology ,Vitamin E ,medicine.medical_treatment ,Albumin ,Pharmaceutical Science ,Renal function ,04 agricultural and veterinary sciences ,Malondialdehyde ,biology.organism_classification ,040401 food science ,Nephrotoxicity ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Endocrinology ,chemistry ,Internal medicine ,medicine ,Asparagus racemosus ,Pharmacology (medical) ,Blood urea nitrogen - Abstract
Objective: The current study was designed to evaluate the protective effect of standardized hydroalcoholic extract of Asparagus racemosus (AR) against cisplatin (CP)-induced nephrotoxicity in Wistar rats.Methods: AR extract was administered orally at three dose levels (100, 200, and 400 mg/kg). Vitamin E (250 mg/kg) was used as a standard nephroprotective agent. The kidney function test (estimation of serum creatinine, albumin, and blood urea nitrogen [BUN]), oxidative stress study (estimation of superoxide dismutase and malondialdehyde [MDA] activity), and histological examination of kidneys were conducted.Results: The efficacy of AR was compared with CP-treated group. Serum creatinine and BUN were significantly (p
- Published
- 2018
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