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Some studies have suggested a reduced life expectancy in patients with Crohn���s disease (CD) compared with the general population. The evidence, however, is inconsistent. Prompted by such studies, we studied survival of CD patients in ��rebro county, Sweden. From the medical records, we identified all patients diagnosed with CD during 1963���2010 with follow-up to the end of 2011. We estimated: overall survival, net and crude probabilities of dying from CD, relative survival ratio (RSR), and excess mortality rate ratios (EMRR) at 10-year follow-up. The study included 492 patients (226 males, 266 females). Median age at diagnosis was 32 years (3���87). Net and crude probabilities of dying from CD increased with increasing age and were higher for women. Net survival of patients aged ���60 at diagnosis was worse for patients diagnosed during 1963���1985 (54%) than for patients diagnosed during 1986���1999 (88%) or 2000���2010 (93%). Overall, CD patients��� survival was comparable to that in the general population [RSR = 0.98; 95% CI: (0.95���1.00)]. However, significantly lower than expected survival was suggested for female patients aged ���60 diagnosed during the 1963���1985 [RSR = 0.47 (0.07���0.95)]. The adjusted model suggested that, compared with diagnostic period 1963���1985, disease-related excess mortality declined during 2000���2010 [EMRR = 0.36 (0.07���1.96)]; and age ���60 at diagnosis [EMRR = 7.99 (1.64���39.00), reference: age 40���59], female sex [EMRR = 4.16 (0.62���27.85)], colonic localization [EMRR = 4.20 (0.81���21.88), reference: ileal localization], and stricturing/penetrating disease [EMRR = 2.56 (0.52���12.58), reference: inflammatory disease behaviour] were associated with poorer survival. CD-related excess mortality may vary with diagnostic period, age, sex and disease phenotype.Key summaryThere is inconsistent evidence on life expectancy of patients with Crohn���s diseaseCrohn���s disease-specific survival improved over time.Earlier diagnosis period, older age at diagnosis, female sex, colonic disease and complicated disease behaviour seems to be associated with excess Crohn���s disease-related mortality. There is inconsistent evidence on life expectancy of patients with Crohn���s disease Crohn���s disease-specific survival improved over time. Earlier diagnosis period, older age at diagnosis, female sex, colonic disease and complicated disease behaviour seems to be associated with excess Crohn���s disease-related mortality.