5 results on '"Turakhia, Mintu P"'
Search Results
2. Termination of persistent atrial fibrillation by ablating sites that control large atrial areas
- Author
-
Bhatia, Neal K, Rogers, Albert J, Krummen, David E, Hossainy, Samir, Sauer, William, Miller, John M, Alhusseini, Mahmood I, Peszek, Adam, Armenia, Erin, Baykaner, Tina, Brachmann, Johannes, Turakhia, Mintu P, Clopton, Paul, Wang, Paul J, Rappel, Wouter-Jan, and Narayan, Sanjiv M
- Subjects
Focal ,Drivers ,Clinical Sciences ,Electric Countershock ,Multiwavelet re-entry ,Middle Aged ,Ablation ,Cardiovascular ,Atrial fibrillation ,Rotational ,Heart Disease ,Cardiovascular System & Hematology ,Catheter Ablation ,Mechanisms ,Humans ,Heart Atria ,Aged - Abstract
AimsPersistent atrial fibrillation (AF) has been explained by multiple mechanisms which, while they conflict, all agree that more disorganized AF is more difficult to treat than organized AF. We hypothesized that persistent AF consists of interacting organized areas which may enlarge, shrink or coalesce, and that patients whose AF areas enlarge by ablation are more likely to respond to therapy.Methods and resultsWe mapped vectorial propagation in persistent AF using wavefront fields (WFF), constructed from raw unipolar electrograms at 64-pole basket catheters, during ablation until termination (Group 1, N = 20 patients) or cardioversion (Group 2, N = 20 patients). Wavefront field mapping of patients (age 61.1 ± 13.2 years, left atrium 47.1 ± 6.9 mm) at baseline showed 4.6 ± 1.0 organized areas, each separated by disorganization. Ablation of sites that led to termination controlled larger organized area than competing sites (44.1 ± 11.1% vs. 22.4 ± 7.0%, P
- Published
- 2020
3. Comparison of Patient-Reported Care Satisfaction, Quality of Warfarin Therapy, and Outcomes of Atrial Fibrillation: Findings From the ORBIT - AF Registry
- Author
-
Perino, Alexander C, Shrader, Peter, Turakhia, Mintu P, Ansell, Jack E, Gersh, Bernard J, Fonarow, Gregg C, Go, Alan S, Kaiser, Daniel W, Hylek, Elaine M, Kowey, Peter R, Singer, Daniel E, Thomas, Laine, Steinberg, Benjamin A, Peterson, Eric D, Piccini, Jonathan P, and Mahaffey, Kenneth W
- Subjects
Male ,Time Factors ,Hemorrhage ,patient-centered care ,Cardiorespiratory Medicine and Haematology ,patient-reported outcome ,Medication Adherence ,patient‐centered care ,Atrial Fibrillation ,80 and over ,Humans ,International Normalized Ratio ,Patient Reported Outcome Measures ,Mortality ,anticoagulation ,Aged ,Quality of Health Care ,patient‐reported outcome ,Age Factors ,Anticoagulants ,Middle Aged ,Hospitalization ,Stroke ,warfarin ,Patient Satisfaction ,Multivariate Analysis ,Female ,Anti-Arrhythmia Agents - Abstract
Background Patient satisfaction with therapy is an important metric of care quality and has been associated with greater medication persistence. We evaluated the association of patient satisfaction with warfarin therapy to other metrics of anticoagulation care quality and clinical outcomes among patients with atrial fibrillation ( AF ). Methods and Results Using data from the ORBIT - AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) registry, patients were identified with AF who were taking warfarin and had completed an Anti-Clot Treatment Scale ( ACTS ) questionnaire, a validated metric of patient-reported burden and benefit of oral anticoagulation. Multivariate regressions were used to determine association of ACTS burden and benefit scores with time in therapeutic international normalized ratio range ( TTR ; both ≥75% and ≥60%), warfarin discontinuation, and clinical outcomes (death, stroke, major bleed, and all-cause hospitalization). Among 1514 patients with AF on warfarin therapy (75±10 years; 42% women; CHA 2 DS 2- VAS c 3.9±1.7), those most burdened with warfarin therapy were younger and more likely to be women, have paroxysmal AF , and to be treated with antiarrhythmic drugs. After adjustment for covariates, ACTS burden scores were independent of TTR ( TTR ≥75%: odds ratio, 1.01 [95% CI , 0.99-1.03]; TTR ≥60%: odds ratio, 1.01 [95% CI , 0.98-1.05]), warfarin discontinuation (odds ratio, 0.99; 95% CI , 0.97-1.01), or clinical outcomes. ACTS benefit scores were also not associated with TTR , warfarin discontinuation, or clinical outcomes. Conclusions In a large registry of patients with AF taking warfarin, ACTS scores provided independent information beyond other traditional metrics of oral anticoagulation care quality and identified patient groups at high risk for dissatisfaction with warfarin therapy.
- Published
- 2019
4. Safety and Clinical Outcomes of Catheter Ablation of Atrial Fibrillation in Patients With Chronic Kidney Disease
- Author
-
Ullal, Aditya J., Kaiser, Daniel W., Fan, Jun, Schmitt, Susan, Than, Claire T., Winkelmayer, Wolfgang C., Heidenreich, Paul A., Piccini, Jonathon P., Perez, Marco V., Wang, Paul J., and Turakhia, Mintu P.
- Subjects
Adult ,Male ,Time Factors ,Adolescent ,Databases, Factual ,Comorbidity ,Kaplan-Meier Estimate ,Patient Readmission ,Article ,Disease-Free Survival ,Young Adult ,Recurrence ,Risk Factors ,Atrial Fibrillation ,Humans ,Renal Insufficiency, Chronic ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Heart Failure ,Incidence ,Middle Aged ,United States ,Treatment Outcome ,Chronic Disease ,Multivariate Analysis ,Catheter Ablation ,Female - Abstract
Data regarding catheter ablation of atrial fibrillation (AF) in patients with chronic kidney disease (CKD) is limited. We therefore assessed the association of CKD with common safety and clinical outcomes in a nationwide sample of ablation recipients.Using MarketScanOf 21,091 patients included, 1,593 (7.6%) had CKD. Patients with CKD were older (64 years vs. 59 years, P0.001) with higher CHAAmong patients selected for AF ablation, those with and without CKD had similar rates of postprocedural complications although they were more likely to be re-admitted for heart failure. CKD was not independently associated with AF hospitalization, cardioversion, and repeat ablation. These findings can inform clinical decision-making in patients with AF and CKD.
- Published
- 2016
5. Wolff-Parkinson-White syndrome: where is the pathway?
- Author
-
Turakhia, Mintu P, Scheinman, Melvin, and Badhwar, Nitish
- Subjects
Interesting ECG ,pre-excitation ,Heart Disease ,Cardiovascular System & Hematology ,coronary sinus ablation ,Medical Physiology ,cardiovascular system ,cardiovascular diseases ,accessory pathway ,Cardiovascular ,ablation ,Heart Disease - Coronary Heart Disease ,Wolff-Parkinson-White - Abstract
A 31-year old male presented with atrial fibrillation and ventricular preexcitation that was positive in leads V1-V4, negative in lead II, and positive in lead AVR. The patient was cardioverted and invasive electrophysiologic study was performed. Based on the ECG findings, the coronary sinus and its branches were interrogated during orthodromic atrioventricular reentrant tachycardia. The earliest local activation was seen in the true coronary sinus lumen at the bifurcation of the posterolateral branch. Radiofrequency energy application at this area led to loss of preexcitation. When localizing left septal and posterior accessory pathways, ventricular preexcitation that is both negative in II and positive in AVR has been shown in previous studies to be highly sensitive and specific for a subepicardial location. Therefore, investigation of the coronary sinus and its branches may allow for effective ablation without the need for left ventricular access.
- Published
- 2009
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.