6 results on '"Tucker, Andrew"'
Search Results
2. Arrhythmias and Adaptations of the Cardiac Conduction System in Former National Football League Players
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Aagaard, Philip, Sharma, Shishir, McNamara, David A, Joshi, Parag, Ayers, Colby R, de Lemos, James A, Lincoln, Andrew E, Baranowski, Bryan, Mandsager, Kyle, Hill, Elizabeth, Castle, Lon, Gentry, James, Lang, Richard, Dunn, Reginald E, Alexander, Kezia, Tucker, Andrew M, and Phelan, Dermot
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Adult ,Male ,Physiological ,European Continental Ancestry Group ,Football ,Cardiorespiratory Medicine and Haematology ,Cardiovascular ,White People ,Heart Conduction System ,Atrial Fibrillation ,Prevalence ,athlete's heart ,Humans ,Adaptation ,Aged ,conduction disease ,African Americans ,Whites ,Prevention ,athletes heart ,National Football League ,Middle Aged ,United States ,Black or African American ,Cross-Sectional Studies ,Heart Disease - Abstract
Background Habitual high-intensity endurance exercise is associated with increased atrial fibrillation (AF) risk and impaired cardiac conduction. It is unknown whether these observations extend to prior strength-type sports exposure. The primary aim of this study was to compare AF prevalence in former National Football League (NFL) athletes to population-based controls. The secondary aim was to characterize other conduction system parameters. Methods and Results This cross-sectional study compared former NFL athletes (n=460, age 56±12years, black 47%) with population-based controls of similar age and racial composition from the cardiovascular cohort Dallas Heart Study-2 (n=925, age 54±9years, black 53%). AF was present in 28 individuals (n=23 [5%] in the NFL group; n=5 [0.5%] in the control group). After controlling for other cardiovascular risk factors in multivariable regression analysis, former NFL participation remained associated with a 5.7 (95% CI: 2.1-15.9, P
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- 2019
3. Design of crystal-like aperiodic solids with selective disorder–phonon coupling
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Alistair R. Overy, Andrew B. Cairns, Matthew J. Cliffe, Arkadiy Simonov, Matthew G. Tucker, Andrew L. Goodwin
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- 2016
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4. A scholarly edition of the poems of John Henry Newman: 'Verses on Various Occasions'
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Tucker, Andrew
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- 2006
- Full Text
- View/download PDF
5. A functional autophagy pathway is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs)
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Zhao, Xia, Huang, Bo, Wang, Hao, Ni, Na, He, Fang, Liu, Qing, Shi, Deyao, Chen, Connie, Zhao, Piao, Wang, Xi, Wagstaff, William, Pakvasa, Mikhail, Tucker, Andrew Blake, Lee, Michael J., Wolf, Jennifer Moriatis, Reid, Russell R., Hynes, Kelly, Jason Strelzow, Ho, Sherwin H., Yu, Tengbo, Yang, Jian, Shen, Le, He, Tong-Chuan, and Zhang, Yongtao
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Original Article - Abstract
Mesenchymal stem cells (MSCs) are capable of differentiating into bone, cartilage and adipose tissues. We identified BMP9 as the most potent osteoinductive BMP although detailed mechanism underlying BMP9-regulated osteogenesis of MSCs is indeterminate. Emerging evidence indicates that autophagy plays a critical role in regulating bone homeostasis. We investigated the possible role of autophagy in osteogenic differentiation induced by BMP9. We showed that BMP9 upregulated the expression of multiple autophagy-related genes in MSCs. Autophagy inhibitor chloroquine (CQ) inhibited the osteogenic activity induced by BMP9 in MSCs. While overexpression of ATG5 or ATG7 did not enhance osteogenic activity induced by BMP9, silencing Atg5 expression in MSCs effectively diminished BMP9 osteogenic signaling activity and blocked the expression of the osteogenic regulator Runx2 and the late marker osteopontin induced by BMP9. Stem cell implantation study revealed that silencing Atg5 in MSCs profoundly inhibited ectopic bone regeneration and bone matrix mineralization induced by BMP9. Collectively, our results strongly suggest a functional autophagy pathway may play an essential role in regulating osteogenic differentiation induced by BMP9 in MSCs. Thus, restoration of dysregulated autophagic activity in MSCs may be exploited to treat fracture healing, bone defects or osteoporosis.
6. Building a Transdisciplinary Expert Consensus on the Cognitive Drivers of Performance Under Pressure: An International Multi-panel Delphi Study
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Lucy Albertella, Rebecca Kirkham, Amy Adler, John Crampton, Sean Drummond, Gerard Fogarty, James Gross, Leonard Zaichkowsky, Judith Andersen, Paul (T) Bartone, Danny Boga, Jeffrey Bond, Tad Brunyé, Mark Campbell, Liliana Ciobanu, Scott Clark, Monique CRANE, Arne Dietrich, Tracy Doty, James Driskell, Ivar Fahsing, Stephen Fiore, Rhona Flin, Joachim Funke, Justine Gatt, Peter Hancock, Craig Harper, Andrew Heathcote, Kristin Heaton, Werner Helsen, Erika Hussey, Rob Jackson, Sangeet Khemlani, William Killgore, Sabina Kleitman, Andrew Lane, Shayne Loft, Clare MacMahon, Samuele Marcora, Frank McKenna, Carla Meijen, Vanessa Moulton, Gene Moyle, Eugene Nalivaiko, Donna O’Connor, Dorothea O’Conor, Debra Patton, Mark Piccolo, Coleman Ruiz, Linda Schücker, Ronald Smith, Sarah Smith, Chava Sobrino, Melba Stetz, Damien Stewart, Paul Taylor, Andrew Tucker, Haike van Stralen, Joan Vickers, Troy Visser, Frederick Walker, Mark Wiggins, Mark Williams, Leonard Wong, Eugene Aidman, Murat Yucel, Albertella, Lucy, Kirkham, Rebecca, Adler, Amy B, Crampton, John, Drummond, Sean P A, Fogarty, Gerard J, Gross, James J, Zaichkowsky, Leonard, Andersen, Judith P, Bartone, Paul T, Boga, Danny, Bond, Jeffrey W, Brunyé, Tad T, Campbell, Mark J, Ciobanu, Liliana G, Clark, Scott R, Crane, Monique F, Dietrich, Arne, Doty, Tracy J, Driskell, James E, Fahsing, Ivar, Fiore, Stephen M, Flin, Rhona, Funke, Joachim, Gatt, Justine M, Hancock, P A, Harper, Craig, Heathcote, Andrew, Heatown, Kristin J, Helsen, Werner F, Hussey, Erika K, Jackson, Robin C, Khemlani, Sangeet, Killgore, William D S, Kleitman, Sabina, Lane, Andrew M, Loft, Shayne, MacMahon, Clare, Marcora, Samuele M, McKenna, Frank P, Meijen, Carla, Moulton, Vanessa, Moyle, Gene M, Nalivaiko, Eugene, O'Connor, Donna, O'Conor, Dorothea, Patton, Debra, Piccolo, Mark D, Ruiz, Coleman, Schücker, Linda, Smith, Ron A, Smith, Sarah J R, Sobrino, Chava, Stetz, Melba, Stewart, Damien, Taylor, Paul, Tucker, Andrew J, van Stralen, Haike, Vickers, Joan N, Visser, Troy A W, Walker, Rohan, Wiggins, Mark W, Williams, Andrew Mark, Wong, Leonard, Aidman, Eugene, and Yücel, Murat
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cognition ,expert consensus ,assessment ,ATTENTION ,expert consensu ,Social Sciences ,SCIENCE ,SPORT ,DESIGN ,Psychology, Multidisciplinary ,SKILLS ,Psychology ,ANXIETY ,transdisciplinary ,General Psychology ,FUTURE-DIRECTIONS ,high performance - Abstract
IntroductionThe ability to perform optimally under pressure is critical across many occupations, including the military, first responders, and competitive sport. Despite recognition that such performance depends on a range of cognitive factors, how common these factors are across performance domains remains unclear. The current study sought to integrate existing knowledge in the performance field in the form of a transdisciplinary expert consensus on the cognitive mechanisms that underlie performance under pressure.MethodsInternational experts were recruited from four performance domains [(i) Defense; (ii) Competitive Sport; (iii) Civilian High-stakes; and (iv) Performance Neuroscience]. Experts rated constructs from the Research Domain Criteria (RDoC) framework (and several expert-suggested constructs) across successive rounds, until all constructs reached consensus for inclusion or were eliminated. Finally, included constructs were ranked for their relative importance.ResultsSixty-eight experts completed the first Delphi round, with 94% of experts retained by the end of the Delphi process. The following 10 constructs reached consensus across all four panels (in order of overall ranking): (1) Attention; (2) Cognitive Control—Performance Monitoring; (3) Arousal and Regulatory Systems—Arousal; (4) Cognitive Control—Goal Selection, Updating, Representation, and Maintenance; (5) Cognitive Control—Response Selection and Inhibition/Suppression; (6) Working memory—Flexible Updating; (7) Working memory—Active Maintenance; (8) Perception and Understanding of Self—Self-knowledge; (9) Working memory—Interference Control, and (10) Expert-suggested—Shifting.DiscussionOur results identify a set of transdisciplinary neuroscience-informed constructs, validated through expert consensus. This expert consensus is critical to standardizing cognitive assessment and informing mechanism-targeted interventions in the broader field of human performance optimization.
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- 2022
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