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Additional file 1.

Additional file 2: Table S1. Co-infected respiratory virus (ITTI population).

Additional file 5: Table S4. Duration of symptoms and fever by age group and influenza virus type (subtype) (ITTI population N = 137).

Additional file 4: Table S3. Adverse events occurring in ≥2% of patients in any age group (safety population).

Additional file 6: Table S5. List of IRBs that gave ethical approval for the clinical trials JapicCTI-163,417 and JapicCTI-173,811.

Additional file 3: Table S2. Patient demographics and baseline characteristics by age groups < 2 years, ≥2 to < 6 years, and ≥ 6 to < 12 years (ITTI population).

Additional file 1: Supplementary Table 1. Demographic characteristics of the children and parents excluded in the analysis. Supplementary Table 2. The Pearson correlation matrix of the 18 subscales of the Early Child Behavior Questionnaire. Supplementary Table 3. Associations of 18 subscales of the Early Child Behavior Questionnaire and expressive language scores at 40 months: regression coefficients in z-score, 95% confidence intervals and p-values. Supplementary Table 4. Associations of 18 subscales of the Early Child Behavior Questionnaire and receptive language scores 40 months: regression coefficients in z-score, 95% confidence intervals and p-values.

Additional File 6. Table S3 - Independent and interaction effects of birth weight categories and polygenic risk score for ADHD with ADHD total score among Japanese children at age 8-9 years.

Additional File 1. Figure S1 - Distribution of polygenic risk score for ADHD in HBC study.

Additional File 9. Table S6 - Association of birth weight categories and genetic risk with ADHD total score among Japanese children at age 8-9 years after multiple imputation of missing polygenic risk score for 137 children.

Additional file 1. Supporting Table 1. Difference in changes of metabolites level between oxytocin and placebo.

Additional File 11. Table S8 - Sensitivity analysis for the association of birth weight categories and genetic risk with ADHD total score among Japanese children at age 8-9 years after recoding missing PRS to the end of the spectrum.

Additional File 5. Table S2 - Association of birth weight (continuous) and polygenic risk with ADHD scores among Japanese children at age 8-9 years.

Additional File 12. Table S9 - Sensitivity analysis for the association of birth weight categories and genetic risk with inattention and hyperactivity scores among Japanese children at age 8-9 years after recoding missing PRS to the end of the spectrum.

Additional File 2. Table S1 - Background characteristics of study participants according to birth weight categories.

Additional File 4. Figure S3 - Distribution of scores on inattention traits and hyperactivity traits between birth weight categories.

Additional File 8. Table S5 - Little’s test for Missing Completely at random and test for covariate-dependent missingness.

Additional file 2. Supporting Table 2. Difference in changes of metabolites level between time-course change- and placebo-administered groups.

Additional File 10. Table S7 - Association of birth weight categories and genetic risk with inattention and hyperactivity scores among Japanese children at age 8-9 years after multiple imputation of missing polygenic risk score for 137 children.

Additional File 3. Figure S2 - Distribution of ADHD total scores between birth weight categories.

Additional File 7. Table S4 - Comparison of background characteristics of children included in the analysis and those excluded from the analysis due missing information on ADHD-RS or PRS.

A rationale for the design of Gazefinder.

The Banda Islands lie about 1,500 miles from Jakarta, more or less the same distance from the Indonesian capital as Bangkok. The main town on the islands, Bandaneira, is set on an island, Neira (sometimes Naira), only a few kilometers from end to end. Across its harbor is an almost perfect cone, the volcanic mountain Gunung Api, whose slopes enter the sea with only the slightest flange at their base. Less than 700 meters in height, its dwarf size and its perfect shape make it seem more an emblem of a volcano than a mountain whose eruptions have caused disaster. A third, longer island, Lontor or Banda Besar, wraps itself around the back of Neira. Entering the harbor, the harbor mouths disappear into the folds formed by Gunung Api and Lontor; one seems to find oneself on a lake. The clarity of the waters, the profusion of coral and multicolored fish, the ease with which the fish are obtained, the self sufficiency of these remote islands, which even during the difficulties of the Japanese occupation are said not to have experienced hunger; all this makes one feel that utopia is rightly set on a distant island.