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3 results on '"Tsaprouni, Loukia"'

1. The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

Author

Jahangiri, Leila, Pucci, Perla, Ishola, Tala, Trigg, Ricky M., Williams, John A., Pereira, Joao, Cavanagh, Megan L., Turner, Suzanne D., Gkoutos, Georgios V., and Tsaprouni, Loukia

Subjects
autophagy, lncRNAs, MYC, gene regulatory networks (GRNs), 3. Good health
Abstract

MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.

2. The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

Author

Jahangiri, Leila, Pucci, Perla, Ishola, Tala, Trigg, Ricky M, Williams, John A, Pereira, Joao, Cavanagh, Megan L, Turner, Suzanne D, Gkoutos, Georgios V, and Tsaprouni, Loukia

Subjects
Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, autophagy, lncRNAs, Animals, Humans, Gene Regulatory Networks, RNA, Long Noncoding, MYC, RNA, Neoplasm, gene regulatory networks (GRNs), 3. Good health
Abstract

MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.

3. The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

Author

John A. Williams, Perla Pucci, Suzanne D. Turner, Loukia Tsaprouni, Tala Ishola, Georgios V. Gkoutos, Megan L Cavanagh, João D. Pereira, Ricky M Trigg, Leila Jahangiri, Jahangiri, Leila [0000-0003-0235-8447], Pucci, Perla [0000-0003-1264-3487], Williams, John A. [0000-0002-0357-5454], Turner, Suzanne D. [0000-0002-8439-4507], Gkoutos, Georgios V. [0000-0002-2061-091X], Tsaprouni, Loukia [0000-0002-4740-3099], Apollo - University of Cambridge Repository, Williams, John A [0000-0002-0357-5454], Turner, Suzanne D [0000-0002-8439-4507], and Gkoutos, Georgios V [0000-0002-2061-091X]

Subjects
autophagy, Programmed cell death, QH301-705.5, Angiogenesis, lncRNAs, Gene regulatory network, Review, MYC, Biology, Genome, Catalysis, Proto-Oncogene Proteins c-myc, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Mitophagy, medicine, Animals, Humans, Gene Regulatory Networks, RNA, Neoplasm, Biology (General), Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Transcription factor, Spectroscopy, 030304 developmental biology, 0303 health sciences, Organic Chemistry, Autophagy, Cancer, General Medicine, gene regulatory networks (GRNs), medicine.disease, 3. Good health, Computer Science Applications, Cell biology, Gene Expression Regulation, Neoplastic, Chemistry, 030220 oncology & carcinogenesis, RNA, Long Noncoding
Abstract

MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.

Published
2021

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